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    • 10. 发明授权
    • Device and method for treating urinary incontinence in females
    • 用于治疗女性尿失禁的装置和方法
    • US06436428B1
    • 2002-08-20
    • US09531856
    • 2000-03-21
    • Anu MahashabdeMartha Francine KayDonald F. Koelmel
    • Anu MahashabdeMartha Francine KayDonald F. Koelmel
    • A61F614
    • A61K9/0036A61K31/216
    • Provided herein is a novel and useful device and method for locally delivering and controllably releasing oxybutynin in the cervical region of a female. A device of the invention comprises a ring comprising trifluoropropylmethyl/dimethyl siloxane elastomer. A pharmaceutical composition comprising oxybutynin and an excipient is placed within a bore located in the ring, wherein the bore runs from the surface of the ring into the ring. The ring has a sufficient size such that it can be inserted into the vaginal canal of a female. A cap comprising is placed over the bore at the surface of the ring in order to contain the pharmaceutical composition within the bore. When the ring is inserted into the vaginal canal, the trifluoropropylmethyl/dimethyl siloxane elastomer controllably releases and locally delivers a therapeutically effective amount of oxybutynin to the detrusor muscle to treat the female's urinary incontinence.
    • 本文提供了一种用于局部递送和可控地释放女性颈部区域中的奥昔布宁的新颖且有用的装置和方法。 本发明的装置包括含有三氟丙基甲基/二甲基硅氧烷弹性体的环。 包含奥昔布宁和赋形剂的药物组合物放置在位于环中的孔中,其中孔从环的表面延伸到环中。 环具有足够的尺寸,使得其可以插入到女性的阴道管中。 将包括的盖子放置在环的表面上的孔上,以将药物组合物包含在孔内。 当环插入阴道内时,三氟丙基甲基/二甲基硅氧烷弹性体可控地释放并局部地将治疗有效量的奥昔布宁输送到逼尿肌以治疗女性的尿失禁。