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1. 发明授权

US08647702B2 Maintaining a fixed distance by providing an air cushion during coating of a medical device 有权
标题翻译：通过在医疗装置的涂覆期间提供气垫来保持固定的距离
公开(公告)号：US08647702B2
公开(公告)日：2014-02-11
申请号：US13158101
申请日：2011-06-10
申请人： Randy Shen , Michael J. Leonard , Anthony S. Andreacchi
发明人： Randy Shen , Michael J. Leonard , Anthony S. Andreacchi
IPC分类号： A61M25/00
CPC分类号： A61M25/1029 , A61M2025/1031 , A61M2025/105 , B05B13/0442 , B05C5/00 , B05D3/00
摘要： System and method for coating an expandable member of a medical device comprising a support structure to support the expandable member and an applicator positioned with at least one outlet proximate a surface of an expandable member. A drive assembly establishes relative movement between the at least one outlet and the surface of the expandable member to apply fluid on the surface of the expandable member along a coating path. A positioning device maintains a substantially fixed distance between the at least one outlet and the surface of the expandable member during relative movement therebetween by ejecting a pressurized medium against the surface of the expandable member.
摘要翻译：用于涂覆医疗装置的可膨胀构件的系统和方法，包括支撑结构以支撑可膨胀构件，以及施加器，其定位成邻近可扩张构件的表面的至少一个出口。驱动组件在至少一个出口和可膨胀构件的表面之间建立相对运动，以沿着涂覆路径向可扩张构件的表面施加流体。定位装置通过相对于可膨胀构件的表面喷射加压介质而在相对运动期间在至少一个出口和可膨胀构件的表面之间保持基本上固定的距离。

2. 发明申请

US20120315375A1 Maintaining A Fixed Distance By Providing An Air Cushion During Coating Of A Medical Device 有权
标题翻译：通过在医疗器械涂层期间提供空气垫片来维持固定距离
公开(公告)号：US20120315375A1
公开(公告)日：2012-12-13
申请号：US13158101
申请日：2011-06-10
申请人： Randy Shen , Michael J. Leonard , Anthony S. Andreacchi
发明人： Randy Shen , Michael J. Leonard , Anthony S. Andreacchi
IPC分类号： A61M25/10 , B05C11/00
CPC分类号： A61M25/1029 , A61M2025/1031 , A61M2025/105 , B05B13/0442 , B05C5/00 , B05D3/00
摘要： System and method for coating an expandable member of a medical device comprising a support structure to support the expandable member and an applicator positioned with at least one outlet proximate a surface of an expandable member. A drive assembly establishes relative movement between the at least one outlet and the surface of the expandable member to apply fluid on the surface of the expandable member along a coating path. A positioning device maintains a substantially fixed distance between the at least one outlet and the surface of the expandable member during relative movement therebetween by ejecting a pressurized medium against the surface of the expandable member.
摘要翻译：用于涂覆医疗装置的可膨胀构件的系统和方法，包括支撑结构以支撑可膨胀构件，以及施加器，其定位成邻近可扩张构件的表面的至少一个出口。驱动组件在至少一个出口和可膨胀构件的表面之间建立相对运动，以沿着涂覆路径向可扩张构件的表面施加流体。定位装置通过相对于可膨胀构件的表面喷射加压介质而在相对运动期间在至少一个出口和可膨胀构件的表面之间保持基本上固定的距离。

3. 发明授权

US09662677B2 Drug-coated balloon with location-specific plasma treatment 有权
公开(公告)号：US09662677B2
公开(公告)日：2017-05-30
申请号：US12883024
申请日：2010-09-15
申请人： Anthony S. Andreacchi , Stephen D. Pacetti , John Stankus , Victoria M. Gong , Michael J. Leonard , Binh Nguyen
发明人： Anthony S. Andreacchi , Stephen D. Pacetti , John Stankus , Victoria M. Gong , Michael J. Leonard , Binh Nguyen
IPC分类号： B05D3/06 , C23C14/02 , A61F2/00 , B05D3/14 , B05D7/02 , C08J7/12 , A61F2/82
CPC分类号： B05D3/144 , A61F2/82 , B05D7/02 , C08J7/123
摘要： Method of coating an expandable member, e.g. balloon, is provided, the method comprising providing an expandable member having an outer surface. The method includes a plasma treatment with a supply of gas performed on at least a portion of the outer surface of the expandable member. A therapeutic agent is applied on at least the plasma treated portion of the outer surface of the expandable member after the plasma treatment is performed. The plasma treatment can reduce the adhesion of therapeutic agent to the surface of the expandable member. A medical device made by the disclosed method is also provided.

4. 发明申请

US20120064141A1 Drug-Coated Balloon With Location-Specific Plasma Treatment 有权
标题翻译：具有位置特异性等离子体处理的药物涂层气球
公开(公告)号：US20120064141A1
公开(公告)日：2012-03-15
申请号：US12883024
申请日：2010-09-15
申请人： Anthony S. Andreacchi , Stephen D. Pacetti , John Stankus , Victoria M. Gong , Michael J. Leonard , Binh Nguyen
发明人： Anthony S. Andreacchi , Stephen D. Pacetti , John Stankus , Victoria M. Gong , Michael J. Leonard , Binh Nguyen
IPC分类号： A61F2/00 , B05D3/06 , C23C14/02
CPC分类号： B05D3/144 , A61F2/82 , B05D7/02 , C08J7/123
摘要： Method of coating an expandable member, e.g. balloon, is provided, the method comprising providing an expandable member having an outer surface. The method includes a plasma treatment with a supply of gas performed on at least a portion of the outer surface of the expandable member. A therapeutic agent is applied on at least the plasma treated portion of the outer surface of the expandable member after the plasma treatment is performed. The plasma treatment can reduce the adhesion of therapeutic agent to the surface of the expandable member. A medical device made by the disclosed method is also provided.
摘要翻译：涂覆可膨胀构件的方法，例如气囊，所述方法包括提供具有外表面的可扩张构件。该方法包括在可扩张构件的外表面的至少一部分上进行气体供应的等离子体处理。在执行等离子体处理之后，至少在可膨胀构件的外表面的等离子体处理部分上施加治疗剂。等离子体处理可以降低治疗剂对可扩张构件表面的粘附。还提供了通过所公开的方法制造的医疗装置。

5. 发明申请

US20110245766A1 Method and Apparatus for Improving Delivery of an Agent to a Kidney 有权
标题翻译：用于改善向肾脏递送药剂的方法和装置
公开(公告)号：US20110245766A1
公开(公告)日：2011-10-06
申请号：US13158757
申请日：2011-06-13
申请人： Michael J. Leonard , Binh T. Nguyen , Paul M. Consigny , Randy Shen
发明人： Michael J. Leonard , Binh T. Nguyen , Paul M. Consigny , Randy Shen
IPC分类号： A61M25/10
CPC分类号： A61M25/10 , A61F2/013 , A61L2300/432 , A61M25/04 , A61M2025/0057 , A61M2025/0073 , A61M2025/105 , A61M2206/14
摘要： Methods for more uniformly delivering drugs or other treatment agents locally to the vasculature of a mammal are disclosed. These methods use one or more strategies to facilitate rapid mixing with the blood flowing past a device or otherwise improve the uniformity of drug delivery. Some of these strategies employ medical devices with diffusion members.
摘要翻译：公开了将哺乳动物的脉管系统中的药物或其它治疗剂局部均匀地递送到脉管系统的方法。这些方法使用一种或多种策略来促进与流过装置的血液的快速混合，或以其它方式改善药物递送的均匀性。其中一些策略采用具有扩散成员的医疗设备。

6. 发明授权

US08308683B2 Perfusion catheter having array of funnel shaped membranes 有权
标题翻译：灌注导管具有漏斗形膜阵列
公开(公告)号：US08308683B2
公开(公告)日：2012-11-13
申请号：US12768431
申请日：2010-04-27
申请人： Michael J. Leonard , Binh T. Nguyen , William Webler
发明人： Michael J. Leonard , Binh T. Nguyen , William Webler
IPC分类号： A61M31/00
CPC分类号： A61M25/1002 , A61M25/0668 , A61M25/104 , A61M2025/0004 , A61M2025/0024 , A61M2025/0037 , A61M2025/0039 , A61M2025/0096 , A61M2025/0681 , A61M2025/105
摘要： An agent delivery catheter configured to deliver an agent to an inner surface of a patient's body lumen wall by forming an array of cells defining agent containment chambers at multiple locations along the catheter's shaft, while minimizing ischemic conditions during the procedure.
摘要翻译：一种药剂递送导管，配置成通过在导管的轴的多个位置处形成限定药剂容纳室的细胞阵列，同时使手术过程中的缺血状况最小化，将药剂递送到患者体腔壁的内表面。

7. 发明授权

US08010324B1 Computer-implemented system and method for storing data analysis models 有权
标题翻译：用于存储数据分析模型的计算机实现的系统和方法
公开(公告)号：US08010324B1
公开(公告)日：2011-08-30
申请号：US11431123
申请日：2006-05-09
申请人： Keith E. Crowe , Michael J. Leonard
发明人： Keith E. Crowe , Michael J. Leonard
IPC分类号： G06F17/10
CPC分类号： G06Q10/10 , G06F17/18 , G06Q30/0201 , G06Q30/0202
摘要： Computer-implemented systems and methods for processing time series data that is indicative of a data generation activity occurring over a period of time. A model specification hierarchical data structure is used for storing characteristics that define a time series model. A fitted model hierarchical data structure stores characteristics that define a fitted time series model. The characteristics of the fitted time series model are defined through an application of the time series model to the time series data.
摘要翻译：用于处理指示在一段时间内发生的数据生成活动的时间序列数据的计算机实现的系统和方法。模型规范层次数据结构用于存储定义时间序列模型的特征。拟合模型分层数据结构存储定义拟合时间序列模型的特征。通过将时间序列模型应用于时间序列数据来定义拟合时间序列模型的特征。

8. 发明申请

US20090293073A1 AUTOMATING ASYNCHRONOUS PROGRAMMING IN SINGLE THREADED SYSTEMS 有权
标题翻译：在单螺纹系统中自动编程
公开(公告)号：US20090293073A1
公开(公告)日：2009-11-26
申请号：US12123472
申请日：2008-05-20
申请人： Adam D. Nathan , Andrew Sterland , Michael J. Leonard , Timothy Rice , John I. Montgomery
发明人： Adam D. Nathan , Andrew Sterland , Michael J. Leonard , Timothy Rice , John I. Montgomery
IPC分类号： G06F9/46
CPC分类号： G06F9/547
摘要： Various technologies and techniques are disclosed for automating asynchronous programming in single threaded systems. A wrapper is automatically generated around an original function. When metadata indicates the wrapper should be utilized for asynchronous data retrieval, the wrapper calls a data retrieving function asynchronously. Asynchronous retrieval of data is initiated from the data retrieving function using a direct callback. A specially marked exception is thrown to cause control to leave and get caught by a special exception in the wrapper. When the direct callback function is called because the data has been retrieved, the data is saved. The wrapper is called again in a synchronous fashion, which causes the wrapper, original function, and data retrieving function to be called again. When the data retrieving function is called again, data that was saved by the direct callback function is retrieved, and then returned to the calling function through the callback function.
摘要翻译：公开了用于在单线程系统中自动化异步编程的各种技术和技术。围绕原始功能自动生成包装器。当元数据指示包装器应用于异步数据检索时，包装器将异步调用数据检索功能。使用直接回调从数据检索功能启动异步检索数据。抛出一个特别标记的异常，导致控件离开并被包装器中的特殊异常所捕获。当直接回调函数被调用，因为数据被检索，数据被保存。再次以同步方式再次调用包装器，这将使包装器，原始功能和数据检索功能再次被调用。当再次调用数据检索功能时，将检索直接回调函数保存的数据，然后通过回调函数返回到调用函数。

9. 发明申请

US20090105644A1 INTRAVASCULAR MEDICAL DEVICE HAVING A READILY COLLAPSIBLE COVERED FRAME 审中-公开
标题翻译：具有可立即覆盖的框架的血管内装置
公开(公告)号：US20090105644A1
公开(公告)日：2009-04-23
申请号：US11876555
申请日：2007-10-22
申请人： Michael J. Leonard , William E. Webler
发明人： Michael J. Leonard , William E. Webler
IPC分类号： A61M29/00 , A61M25/00
CPC分类号： A61M25/0662 , A61F2/013 , A61F2002/011 , A61F2002/016 , A61F2230/0076 , A61F2230/008
摘要： An elongated intravascular device having a frame configured for reversibly expanding in a patient's body lumen, which has a sleeve secured to the frame, and at least one sleeve-folding strut configured to fold the sleeve inwardly as the frame radially collapses in the patient's body lumen. Additional aspects of the invention are directed to methods of recovering such expanded frame type devices, and a recovery catheter configured for collapsing an expanded frame. The devices and methods of the invention facilitate the collapse of expanded frame devices, for repositioning or removal from the patient's body lumen.
摘要翻译：一种细长的血管内装置，其具有被构造用于在患者的体腔中可逆地扩张的框架，所述框架具有固定到所述框架的套筒以及至少一个套筒折叠支柱，所述至少一个套筒折叠支柱构造成当所述框架在患者的体腔内径向塌陷时向内折叠。本发明的另外的方面涉及恢复这种扩展的框架型装置的方法，以及被配置用于塌缩扩展框架的回收导管。本发明的装置和方法有助于扩大的框架装置的塌陷，用于重新定位或从患者体腔移除。

10. 发明授权

US07251589B1 Computer-implemented system and method for generating forecasts 有权
标题翻译：用于产生预测的计算机实现系统和方法
公开(公告)号：US07251589B1
公开(公告)日：2007-07-31
申请号：US11431089
申请日：2006-05-09
申请人： Keith E. Crowe , Rajesh S. Selukar , Michael J. Leonard
发明人： Keith E. Crowe , Rajesh S. Selukar , Michael J. Leonard
IPC分类号： G06F15/00 , G06F17/18
CPC分类号： G06F17/18
摘要： Computer-implemented systems and methods for performing forecast scoring based upon time series data that is indicative of a data generation activity occurring over a period of time. One or more data stores store historical data and future data. The historical data includes historical exogenous inputs. The future data includes future exogenous inputs. A dynamic statistical model receives the historical data and future data that are stored in the one or more data stores. The dynamic statistical model is to provide forecast scoring based upon the historical exogenous inputs and the future exogenous inputs. An optimizer having an objective function iteratively varies the future data, so that forecasts associated with the varying future data values are generated by the dynamic statistical model for evaluation by the objective function.
摘要翻译：用于基于指示在一段时间内发生的数据生成活动的时间序列数据来执行预测评分的计算机实现的系统和方法。一个或多个数据存储存储历史数据和未来数据。历史数据包括历史的外生投入。未来的数据包括未来的外生投入。动态统计模型接收存储在一个或多个数据存储中的历史数据和未来数据。动态统计模型是基于历史外生投入和未来外生投入来提供预测评分。具有目标函数的优化器迭代地改变未来数据，从而通过用于由目标函数进行评估的动态统计模型来生成与变化的未来数据值相关联的预测。

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