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1. 发明申请

US20080065014A1 Systems, Methods, and Devices to Facilitate Wire and Device Crossings of Obstructions in Body Lumens 审中-公开
标题翻译：系统，方法和设备，以便于线路和设备穿越体腔内障碍物
公开(公告)号：US20080065014A1
公开(公告)日：2008-03-13
申请号：US11738378
申请日：2007-04-20
申请人： Randolf Von Oepen , Kelly McCrystle
发明人： Randolf Von Oepen , Kelly McCrystle
IPC分类号： A61M29/00
CPC分类号： A61B17/2202 , A61B2017/22001 , A61B2017/22008 , A61B2017/22069 , A61B2017/22085 , A61B2017/22088 , A61B2017/22089 , A61B2018/263
摘要： In one of many possible embodiments, a method for treating an obstruction within a blood vessel includes applying a stimulus to a fluid near the obstruction to disrupt the obstruction. The stimulus may include applying a stimulus to the fluid near the obstruction to breach a proximal cap and applying a stimulus to dilate micro-channels formed within the obstruction. Such stimuli may include causing cavitation within one or more fluid near the device, expanding one or more fluid that is in contact with irregularities in the obstruction, and bombarding the obstruction with particles that undergo a rapid phase change.
摘要翻译：在许多可能的实施例之一中，用于治疗血管内的梗阻的方法包括对阻塞物附近的流体施加刺激以破坏阻塞。刺激可以包括对阻塞物附近的流体施加刺激以破坏近端帽并施加刺激以扩张阻塞内形成的微通道。这样的刺激可能包括在装置附近的一个或多个流体内造成气蚀，使与阻塞物中的不规则接触的一种或多种流体膨胀，并且用经历快速相变的颗粒轰击阻塞物。

2. 发明授权

US08663311B2 Device comprising biodegradable bistable or multistable cells and methods of use 有权
标题翻译：包含可生物降解的双稳态或多态细胞的装置和使用方法
公开(公告)号：US08663311B2
公开(公告)日：2014-03-04
申请号：US11317495
申请日：2005-12-22
申请人： Petrus Antonius Besselink , Travis Yribarren , Randolf Von Oepen
发明人： Petrus Antonius Besselink , Travis Yribarren , Randolf Von Oepen
IPC分类号： A61F2/06
CPC分类号： A61B17/11 , A61F2/0009 , A61F2/064 , A61F2/91 , A61F2/915 , A61F2002/30062 , A61F2002/828 , A61F2002/91541 , A61F2002/91558 , A61F2002/91575 , A61F2210/0004 , A61F2230/0013 , B23K2103/42 , B23K2103/50 , B33Y80/00
摘要： Expandable biodegradable devices formed of bistable and multistable unit cells for use in devices, such as stents and graft systems, are provided, in which the device has two or more stable configurations, including a contracted configuration and an expanded configuration, the contracted stable configuration having a smaller diameter than the expanded configuration.
摘要翻译：提供了用于诸如支架和移植物系统的装置中的双稳态和多单元电池形成的可膨胀的可生物降解的装置，其中装置具有两个或多个稳定的构造，包括收缩构型和扩张构型，收缩的稳定构型具有直径比扩张结构小。

3. 发明授权

US08530783B2 Laser cutting system 有权
标题翻译：激光切割系统
公开(公告)号：US08530783B2
公开(公告)日：2013-09-10
申请号：US12699262
申请日：2010-02-03
申请人： Rodney C. Ow , William E. Webler , Randolf Von Oepen
发明人： Rodney C. Ow , William E. Webler , Randolf Von Oepen
IPC分类号： B23K26/14
CPC分类号： B23K26/38
摘要： A laser cutting system including a chamber configured to provide a controlled environment while the laser is being used to cut a pattern into a material to reduce or eliminate heat and oxygen related changes to the mechanical characteristics of the material. A system for providing a gas to the controlled environment within the chamber, as well as a means for exhausting gas and cutting debris from the chamber is also described. A cutting mandrel that provides for flow of a shielding gas and also provides a means for dispersing a laser beam before it can produce unwanted damage to a section of tubing is also described.
摘要翻译：一种激光切割系统，包括被配置为在激光被用于将图案切割成材料以便减少或消除与材料的机械特性相关的热和氧相关变化时提供受控环境的腔室。还描述了一种用于向室内的受控环境提供气体的系统，以及用于从气室排出气体和切割碎屑的装置。还描述了提供保护气体流动的切割心轴，并且还提供了用于在激光束可以对管道的一部分产生不希望的损坏之前分散激光束的装置。

4. 发明申请

US20120239139A1 MEDICAL IMPLANTS CONTAINING FK506 (TACROLIMUS) METHODS OF MAKING AND METHODS OF USE THEREOF 审中-公开
标题翻译：包含FK506（TACROLIMUS）制造方法的医用植绒及其使用方法
公开(公告)号：US20120239139A1
公开(公告)日：2012-09-20
申请号：US13481129
申请日：2012-05-25
申请人： Stephan Wnendt , Randolf Von Oepen , Bernd Kuttler , Gerhard Lang , Guenter Lorenz , Axel Grandt
发明人： Stephan Wnendt , Randolf Von Oepen , Bernd Kuttler , Gerhard Lang , Guenter Lorenz , Axel Grandt
IPC分类号： A61F2/82 , B05D3/10
CPC分类号： A61L31/16 , A61L2300/416 , A61L2300/606
摘要： Implants and methods of making same are provided for treatment or prophylaxis of coronary or peripheral vascular constrictions or vascular occlusions, and particularly, stenoses or restenoses, that comprise FK506 in chemically covalently bound, non-covalently bound or physically immobilized form.
摘要翻译：提供了植入物及其制备方法，用于治疗或预防化学共价结合，非共价结合或物理固定化形式的冠状或外周血管收缩或血管闭塞，特别是狭窄或再狭窄，其包含FK506。

5. 发明申请

US20120209317A1 VESSEL CLOSURE SYSTEM 有权
标题翻译：船舶关闭系统
公开(公告)号：US20120209317A1
公开(公告)日：2012-08-16
申请号：US13028041
申请日：2011-02-15
申请人： Randolf Von Oepen
发明人： Randolf Von Oepen
IPC分类号： A61B17/03
CPC分类号： A61B17/0057 , A61B17/0644 , A61B17/068 , A61B46/10 , A61B2017/00398 , A61B2017/00668
摘要： A power driven vessel closure device is configured for closing a hole in a wall of a body lumen. The vessel closure device can include a power operated drive system and a closure element delivery system. The closure element delivery system can be removably, operably, couplable with the power operated drive system. That is, the closure element system can be directly or indirectly attached to and removed from the power operated drive system, or components thereof. The operation of the power operated drive system can operate the closure element delivery system so as to move the closure element within the vessel closure device and deploy the closure element to close the hole.
摘要翻译：动力驱动的容器封闭装置构造成用于封闭体腔的壁中的孔。容器封闭装置可以包括动力驱动的驱动系统和闭合元件输送系统。闭合元件输送系统可以与动力驱动的驱动系统可拆卸地，可操作地连接。也就是说，闭合元件系统可以直接或间接附接到动力驱动系统或其部件上并从其移除。动力驱动驱动系统的操作可以操作闭合元件输送系统，以便将封闭元件移动到容器封闭装置内并展开封闭元件以封闭孔。

6. 发明授权

US08226603B2 Expandable member having a covering formed of a fibrous matrix for intraluminal drug delivery 有权
标题翻译：具有由用于管腔内药物递送的纤维基质形成的覆盖物的可膨胀构件
公开(公告)号：US08226603B2
公开(公告)日：2012-07-24
申请号：US12237998
申请日：2008-09-25
申请人： Randolf Von Oepen , John Stankus , Barbara Stamberg , Travis R. Yribarren , Richard R. Newhauser
发明人： Randolf Von Oepen , John Stankus , Barbara Stamberg , Travis R. Yribarren , Richard R. Newhauser
IPC分类号： A61M31/00 , A61M37/00
CPC分类号： A61M25/10 , A61F2/958 , A61F2002/9583 , A61L29/085 , A61M25/1027 , A61M25/1029 , A61M25/1038 , A61M2025/1004 , A61M2025/1031 , A61M2025/105 , A61M2025/1075 , A61M2025/1086 , A61M2025/1088 , Y10T29/49826
摘要： The present invention generally relates to an intraluminal catheter device for use in angioplasty and delivery of a therapeutic agent. Particularly, the present invention is directed to a catheter having an expandable member having a therapeutic agent disposed thereon and a fibrous matrix covering for delivering a therapeutic agent and methods of using the same.
摘要翻译：本发明一般涉及用于血管成形术和治疗剂递送的管腔内导管装置。特别地，本发明涉及具有设置在其上的治疗剂的可膨胀构件的导管和用于递送治疗剂的纤维基质覆盖物及其使用方法。

7. 发明申请

US20120123525A1 RADIOPAQUE INTRALUMINAL STENTS COMPRISING COBALT-BASED ALLOYS CONTAINING ONE OR MORE PLATINUM GROUP METALS, REFRACTORY METALS, OR COMBINATIONS THEREOF 审中-公开
标题翻译：包含含有一种或多种铂族金属，碱金属或其组合的基于钴的合金的放射性体系
公开(公告)号：US20120123525A1
公开(公告)日：2012-05-17
申请号：US13298070
申请日：2011-11-16
申请人： Pamela A. Kramer-Brown , Austin M. Leach , Randolf Von Oepen
发明人： Pamela A. Kramer-Brown , Austin M. Leach , Randolf Von Oepen
IPC分类号： A61F2/82
CPC分类号： A61L31/022 , A61L31/18
摘要： Embodiments are directed to radiopaque implantable structures (e.g., stents) formed of cobalt-based alloys that comprise cobalt, chromium and one or more platinum group metals, refractory metals, or combinations thereof. Platinum group metals include platinum, palladium, ruthenium, rhodium, osmium, and iridium. Here, the term “refractory metals” include zirconium, niobium, rhodium, molybdenum, hafnium, tantalum, tungsten, rhenium, as well as the precious metals silver and gold. In one embodiment, the one or more included platinum group or refractory metals substitute for nickel, such that the alloy is substantially nickel free. The stents exhibit improved radiopacity as compared to similar alloys including greater amounts of nickel.
摘要翻译：实施例涉及由包含钴，铬和一种或多种铂族金属，难熔金属或其组合的钴基合金形成的不透射线的可植入结构（例如，支架）。铂族金属包括铂，钯，钌，铑，锇和铱。这里，术语“难熔金属”包括锆，铌，铑，钼，铪，钽，钨，铼以及贵金属银和金。在一个实施方案中，一种或多种包括的铂族或难熔金属代替镍，使得该合金基本上不含镍。与包括更大量的镍的类似合金相比，支架表现出改善的射线不透性。

8. 发明授权

US08167929B2 System and method for delivering a stent to a bifurcated vessel 有权
标题翻译：将支架输送到分叉血管的系统和方法
公开(公告)号：US08167929B2
公开(公告)日：2012-05-01
申请号：US11683995
申请日：2007-03-08
申请人： Randolf Von Oepen , Thomas Michael Rieth , Lorcan James Coffey , Richard Roy Newhauser , Travis Richard Yribarren
发明人： Randolf Von Oepen , Thomas Michael Rieth , Lorcan James Coffey , Richard Roy Newhauser , Travis Richard Yribarren
IPC分类号： A61F2/06 , A61F2/82
CPC分类号： A61F2/954 , A61F2/91 , A61F2/958 , A61F2002/821 , A61F2250/0098 , A61M25/1002
摘要： A stent delivery catheter system for accurately positioning a stent in a bifurcated vessel is disclosed. The system includes a catheter having a terminal portion and distal tip that is placed in a main branch of the vessel proximate the bifurcation. A fixed guidewire is attached to distal tip. A port is defined in the terminal portion of the catheter. The port is aligned with an ostium of a side branch of the bifurcated vessel to allow the passage of a stent delivery device, such as a balloon catheter having a stent crimped thereon, into the side branch. Radiopaque bands are positioned on opposite ends of the port. A positioning balloon is included on a surface of the catheter opposite the port and is selectively inflatable to position the radiopaque bands adjacent the side branch ostium. The radiopaque bands are referenced to place the stent proximate the side branch ostium.
摘要翻译：公开了一种用于将支架精确定位在分叉血管中的支架输送导管系统。该系统包括具有末端部分和远侧末端的导管，其被放置在靠近分叉处的血管的主分支中。固定的导丝连接到远端。端口被限定在导管的末端部分。端口与分叉血管的侧分支的口对准，以允许支架输送装置（例如具有卷曲在其上的支架的球囊导管）通入侧支。无线电波段位于端口的相对端。定位球囊包括在导管的与端口相对的表面上，并且选择性地可充气以将不透射线的带定位在侧分支口附近。参考不透射线带将支架置于侧分支口附近。

9. 发明申请

US20110208292A1 HINGED SHEATH ASSEMBLY AND METHOD OF USE 审中-公开
标题翻译：铰链式组件及其使用方法
公开(公告)号：US20110208292A1
公开(公告)日：2011-08-25
申请号：US12708666
申请日：2010-02-19
申请人： Randolf Von Oepen , Travis R. Yribarren
发明人： Randolf Von Oepen , Travis R. Yribarren
IPC分类号： A61F2/84
CPC分类号： A61F2/97 , A61F2002/9665
摘要： A sheath assembly is provided for protecting a stent mounted on a catheter. An inner tubular member is positioned over the stent without longitudinal movement of the inner tubular member along the stent surface thereby eliminating the possibility of scraping or scratching a drug coating or polymer coating on the stent surface. An outer tubular member slides over the inner tubular member to firmly compress it onto the stent for further protection. In use, the outer tubular member is removed from over the inner tubular member so that the inner tubular member can open similar to a clamshell opening radially outwardly away from the stent without longitudinal movement along the stent surface.
摘要翻译：提供护套组件用于保护安装在导管上的支架。内部管状构件被定位在支架上方，而不沿着支架表面的内部管状构件的纵向运动，从而消除刮擦或刮擦支架表面上的药物涂层或聚合物涂层的可能性。外部管状构件在内部管状构件上滑动以将其牢固地压缩到支架上用于进一步保护。在使用中，外部管状构件从内部管状构件上方移除，使得内部管状构件可以类似于离开支架径向向外的蛤壳式开口而不沿着支架表面纵向移动而打开。

10. 发明授权

US07993303B2 Stiffening support catheter and methods for using the same 有权
标题翻译：加强支撑导管及其使用方法
公开(公告)号：US07993303B2
公开(公告)日：2011-08-09
申请号：US11738384
申请日：2007-04-20
申请人： Randolf Von Oepen , Ian J. Clark , Lorcan Coffey , Thomas Rieth , Richard Newhauser , Travis Yribarren , Marc Gianotti , Bernhard Uihlein
发明人： Randolf Von Oepen , Ian J. Clark , Lorcan Coffey , Thomas Rieth , Richard Newhauser , Travis Yribarren , Marc Gianotti , Bernhard Uihlein
IPC分类号： A61M29/00
CPC分类号： A61M25/0054 , A61M25/0053 , A61M2025/0006 , A61M2025/0025 , A61M2025/0063
摘要： A support catheter that can puncture a heart septum with a guidewire without buckling and that can access difficult to reach arteries such as carotid or renal arteries from the aorta under difficult circumstances is provided. The support catheter comprises a catheter body having a proximal end, a distal end, and an interior wall surface defining a first lumen extending from the proximal end toward the distal end. A second lumen is disposed between the interior wall surface and an outer surface of the catheter body. A plurality of stiffening members is disposed around the second lumen, the plurality of stiffening members being engageable to selectively stiffen the catheter body. In another configuration, the catheter further comprises a second plurality of stiffening members disposed between the first lumen and the second lumen.
摘要翻译：提供了一种支撑导管，其可以用导线刺穿心脏隔膜而没有屈曲，并且可以在困难的情况下进入难以到达主动脉的颈动脉或肾动脉的动脉。支撑导管包括具有近端，远端和限定从近端朝向远端延伸的第一内腔的内壁表面的导管主体。第二管腔设置在内壁表面和导管主体的外表面之间。多个加强构件设置在第二内腔周围，多个加强构件可接合以选择性地加强导管主体。在另一种构造中，导管还包括设置在第一腔和第二腔之间的第二多个加强构件。

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