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1. 发明授权

US07771931B2 Methods for diagnosing and treating diseases and conditions associated with protein kinase Cλ 失效
标题翻译：诊断和治疗与蛋白激酶Cλ相关的疾病和病症的方法
公开(公告)号：US07771931B2
公开(公告)日：2010-08-10
申请号：US10488292
申请日：2002-09-06
申请人： Randall Peterson , Mark C. Fishman
发明人： Randall Peterson , Mark C. Fishman
IPC分类号： C12Q1/00 , C12Q1/68 , C12P21/06 , C12P19/34 , A61K38/00 , C07H21/00 , C07H21/04
CPC分类号： C12N9/1205 , A61K38/00 , C12Q1/6883 , C12Q1/6886 , C12Q2600/136 , C12Q2600/158
摘要： The invention provides methods of diagnosing diseases and conditions associated with PKCλ, methods for identifying compounds that can be used to treat or to prevent such diseases and conditions, and methods of using these compounds to treat or to prevent such diseases and conditions. Also provided in the invention are animal model systems that can be used in screening methods.
摘要翻译：本发明提供诊断与PKCλ相关的疾病和病症的方法，用于鉴定可用于治疗或预防这些疾病和病症的化合物的方法，以及使用这些化合物治疗或预防这些疾病和病症的方法。本发明还提供了可用于筛选方法的动物模型系统。

2. 发明申请

US20100047246A1 Methods and Compositions for Treating Vascular Disease 审中-公开
标题翻译：治疗血管疾病的方法和组成
公开(公告)号：US20100047246A1
公开(公告)日：2010-02-25
申请号：US12373917
申请日：2007-07-17
申请人： Jing-Wei Xiong , Mark C. Fishman
发明人： Jing-Wei Xiong , Mark C. Fishman
IPC分类号： A61K39/395 , A61K38/45 , C12N9/10 , C12N5/10 , C12N15/63 , A61K38/00 , A61K31/7088 , C07H21/04
CPC分类号： A61K49/0008 , C12N15/1137 , C12N2310/11 , C12N2310/3233 , C12Q1/48 , G01N2333/91057 , G01N2800/32
摘要： This invention relates to compositions and methods for use in treating or preventing vascular disease, as well as diseases and conditions associated with hematopoiesis and cellular proliferation.
摘要翻译：本发明涉及用于治疗或预防血管疾病以及与造血和细胞增殖相关的疾病和病症的组合物和方法。

3. 发明授权

US5543498A Peptides to overcome inhibition of nerve growth 失效
标题翻译：克服抑制神经生长的肽
公开(公告)号：US5543498A
公开(公告)日：1996-08-06
申请号：US417279
申请日：1995-04-05
申请人： Mark C. Fishman , Michihiro Igarashi , Stephen M. Strittmatter
发明人： Mark C. Fishman , Michihiro Igarashi , Stephen M. Strittmatter
IPC分类号： A61K38/00 , C07K14/47 , A61K38/04 , C07K7/06
CPC分类号： C07K14/4702 , A61K38/00
摘要： Inhibition of nerve growth normally helps to prevent aberrant pathway or target selection, but also prevents needed regeneration in the mammalian central nervous system. The responsible inhibitory ligands are unknown, but pertussis toxin-sensitive G proteins, which are enriched in growth cones, appear to be involved in causing the responding growth cones to collapse. GAP-43 is an intracellular protein that can amplify the response to the stimulation of G protein-coupled receptors. We have attempted to modify the sensitivity of nerves to inhibitory signals by the use of GAP-43 peptides. The peptide corresponding to the native amino terminus sequence stimulates G.sub.o and enhances the growth cone collapse induced by inhibitory ligands. Modification of two critical cysteines generates peptides which inhibit G.sub.o and which markedly reduce the degree of inhibitor-mediated growth cone collapse.
摘要翻译：抑制神经生长通常有助于防止异常途径或靶标选择，而且可以防止哺乳动物中枢神经系统中需要的再生。负责的抑制性配体是未知的，但是富含生长锥的百日咳毒素敏感的G蛋白似乎涉及引起响应的生长锥体崩溃。 GAP-43是可以扩增对G蛋白偶联受体刺激反应的细胞内蛋白质。我们试图通过使用GAP-43肽来改变神经对抑制性信号的敏感性。对应于天然氨基末端序列的肽刺激Go，并增强由抑制性配体诱导的生长锥塌陷。两个关键半胱氨酸的修饰产生抑制Go的肽，并显着降低抑制剂介导的生长锥体崩溃的程度。

4. 发明申请

US20090077681A1 Methods for Diagnosing and Treating Heart Disease 审中-公开
标题翻译：诊断和治疗心脏病的方法
公开(公告)号：US20090077681A1
公开(公告)日：2009-03-19
申请号：US12115986
申请日：2008-05-06
申请人： Mark C. Fishman , John Mably
发明人： Mark C. Fishman , John Mably
IPC分类号： C12Q1/68 , C07K14/435 , C07H21/00 , C12N15/63 , C12N5/06 , A01K67/027 , C07K16/00
CPC分类号： G01N33/5088 , A01K2207/15 , A01K2217/00 , A01K2217/05 , A01K2217/075 , A01K2227/105 , A01K2227/40 , A01K2267/03 , C07K14/461 , C12Q1/6883 , C12Q2600/156
摘要： The invention provides methods of diagnosing heart disease, such as heart failure, methods for identifying compounds that can be used to treat or to prevent heart disease, and methods of using these compounds to treat or to prevent heart disease. Also provided in the invention are animal model systems that can be used in screening methods.
摘要翻译：本发明提供诊断心脏病如心力衰竭的方法，用于鉴定可用于治疗或预防心脏病的化合物的方法，以及使用这些化合物治疗或预防心脏病的方法。本发明还提供了可用于筛选方法的动物模型系统。

5. 发明授权

US09296813B2 Compositions and methods of use for antibodies of Dickkopf-1 有权
标题翻译： Dickkopf-1抗体的组合物和使用方法
公开(公告)号：US09296813B2
公开(公告)日：2016-03-29
申请号：US14178892
申请日：2014-02-12
申请人： Janine R. Shulok , Feng Cong , Mark C. Fishman , Seth Ettenberg , Michael Bardroff , Mariel Donzeau , Stefanie Urlinger
发明人： Janine R. Shulok , Feng Cong , Mark C. Fishman , Seth Ettenberg , Michael Bardroff , Mariel Donzeau , Stefanie Urlinger
IPC分类号： A61K39/395 , C07K16/22 , C07K16/18 , A61K31/675 , A61K45/06 , A61K39/00
CPC分类号： C07K16/22 , A61K31/675 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K16/18 , C07K2317/21 , C07K2317/55 , C07K2317/565 , C07K2317/567 , C07K2317/92
摘要： Antibodies and fragments that bind to the protein target Dickkopf (DKK1) are provided, as are methods of use and kits, for treating a target cell, in particular, a cell associated with an osteolytic condition.
摘要翻译：提供与蛋白质靶标Dickkopf（DKK1）结合的抗体和片段，以及用于治疗靶细胞，特别是与溶骨性病症相关的细胞的使用方法和试剂盒。

6. 发明授权

US06991936B2 Gridlock nucleic acid molecules, polypeptides, and diagnostic and therapeutic methods 失效
公开(公告)号：US06991936B2
公开(公告)日：2006-01-31
申请号：US10364012
申请日：2003-02-10
申请人： Mark C. Fishman , Tao P. Zhong
发明人： Mark C. Fishman , Tao P. Zhong
IPC分类号： C12N1/00 , C12N15/00 , C12N15/09 , C12N15/63 , C12N15/70
CPC分类号： C07K16/18 , A61K38/00 , C07K14/47
摘要： The invention provides a novel gene, gridlock, and its encoded protein. gridlock plays a role in vascular development and modeling, and a mutation in gridlock has been associated with an aortic arch disease, coarctation. Thus, gridlock nucleic acid molecules and polypeptides can be used in methods of diagnosing, treating, and preventing gridlock-related diseases and conditions, such as aortic arch diseases.

7. 外观设计

USD689306S1 Shelving unit 有权
公开(公告)号：USD689306S1
公开(公告)日：2013-09-10
申请号：US29446566
申请日：2013-02-25
申请人： Mark C. Fishman , Toshiko Mori , Landon S. Brown
设计人： Mark C. Fishman , Toshiko Mori , Landon S. Brown

8. 发明授权

US06630347B1 Endothelial NOS transgenic animals and methods of use 失效
标题翻译：内皮型NOS转基因动物及其使用方法
公开(公告)号：US06630347B1
公开(公告)日：2003-10-07
申请号：US09692056
申请日：2000-10-20
申请人： Paul L. Huang , Mark C. Fishman , Michael A. Moskowitz
发明人： Paul L. Huang , Mark C. Fishman , Michael A. Moskowitz
IPC分类号： C12N500
CPC分类号： C12N15/8509 , A01K67/0276 , A01K2217/075 , A01K2227/105 , A01K2267/03 , A01K2267/0375 , C12N9/0075 , C12N9/0077
摘要： This invention relates to transgenic non-human animals comprising a disrupted endothelial nitric oxide synthase gene. These animals exhibit abnormal wound-healing properties and hypertension. This invention also relates to methods of using the transgenic animals to screen for compounds having a potential therapeutic utility for vascular endothelial disorders, such as hypertension, cerebral ischemia or stroke, atherosclerosis and wound-healing activities. Moreover, this invention also relates to methods of treating a patient suffering from hypertension and wound-healing abnormalities with the compounds identified using the transgenic animals, and methods of making the transgenic animals. A method of treating a wound using nitroglycerin is also provided.
摘要翻译：本发明涉及包含破坏的内皮一氧化氮合酶基因的转基因非人动物。这些动物表现出异常的伤口愈合特性和高血压。本发明还涉及使用转基因动物筛选具有血管内皮疾病（例如高血压，脑缺血或中风），动脉粥样硬化和伤口愈合活性的潜在治疗效用的化合物的方法。此外，本发明还涉及使用转基因动物鉴定的化合物治疗患有高血压和伤口愈合异常的患者的方法，以及制备转基因动物的方法。还提供了使用硝酸甘油治疗伤口的方法。

9. 发明授权

US06558932B1 Gridlock nucleic acid molecules, polypeptides, and diagnostic and therapeutic methods 失效
公开(公告)号：US06558932B1
公开(公告)日：2003-05-06
申请号：US09705534
申请日：2000-11-03
申请人： Mark C. Fishman , Tao P. Zhong
发明人： Mark C. Fishman , Tao P. Zhong
IPC分类号： C12N900
CPC分类号： C07K16/18 , A61K38/00 , C07K14/47
摘要： The invention provides a novel gene, gridlock, and its encoded protein. gridlock plays a role in vascular development and modeling, and a mutation in gridlock has been associated with an aortic arch disease, coarctation. Thus, gridlock nucleic acid molecules and polypeptides can be used in methods of diagnosing, treating, and preventing gridlock-related diseases and conditions, such as aortic arch diseases.

10. 发明授权

US06310270B1 Endothelial NOS knockout mice and methods of use 失效
标题翻译：内皮NOS敲除小鼠及使用方法
公开(公告)号：US06310270B1
公开(公告)日：2001-10-30
申请号：US08818082
申请日：1997-03-14
申请人： Paul L. Huang , Mark C. Fishman , Michael A. Moskowitz
发明人： Paul L. Huang , Mark C. Fishman , Michael A. Moskowitz
IPC分类号： A01K6700
CPC分类号： C12N15/8509 , A01K67/0276 , A01K2217/075 , A01K2227/105 , A01K2267/03 , A01K2267/0375 , C12N9/0075 , C12N9/0077
摘要： This invention relates to transgenic non-human animals comprising a disrupted endothelial nitric oxide synthase gene. These animals exhibit abnormal wound-healing properties and hypertension. This invention also relates to methods of using the transgenic animals to screen for compounds having a potential therapeutic utility for vascular endothelial disorders, such as hypertension, cerebral ischemia or stroke, atherosclerosis and wound-healing activities. Moreover, this invention also relates to methods of treating a patient suffering from hypertension and wound-healing abnormalities with the compounds identified using the transgenic animals, and methods of making the transgenic animals. A method of treating a wound using nitroglycerin is also provided.
摘要翻译：本发明涉及包含破坏的内皮一氧化氮合酶基因的转基因非人动物。这些动物表现出异常的伤口愈合特性和高血压。本发明还涉及使用转基因动物筛选具有血管内皮疾病（例如高血压，脑缺血或中风），动脉粥样硬化和伤口愈合活性的潜在治疗效用的化合物的方法。此外，本发明还涉及使用转基因动物鉴定的化合物治疗患有高血压和伤口愈合异常的患者的方法，以及制备转基因动物的方法。还提供了使用硝酸甘油治疗伤口的方法。

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