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1. 发明申请

US20070088437A1 Osteoimplants and methods for their manufacture 有权
标题翻译：骨架植物及其制造方法
公开(公告)号：US20070088437A1
公开(公告)日：2007-04-19
申请号：US11489262
申请日：2006-07-19
申请人： Randal Betz , Scott Boden , Christine Clark , Nanette Forsyth , John Morris , Kathy Traianedes
发明人： Randal Betz , Scott Boden , Christine Clark , Nanette Forsyth , John Morris , Kathy Traianedes
IPC分类号： A61F2/44
CPC分类号： A61F2/28 , A61F2/4455 , A61F2/4644 , A61F2002/2817 , A61F2002/2835 , A61F2002/30059 , A61F2002/30075 , A61F2002/30153 , A61F2002/30329 , A61F2002/30593 , A61F2002/30677 , A61F2002/30805 , A61F2002/30957 , A61F2002/30975 , A61F2002/4649 , A61F2210/0061 , A61F2220/0025 , A61F2230/0019 , A61F2310/00293 , A61F2310/00329 , A61F2310/00365 , A61L27/3608 , A61L27/365 , A61L27/3658 , A61L27/38 , A61L31/005 , A61L2430/02
摘要： An osteoimplant is made up of a coherent aggregate of elongate bone particles.
摘要翻译：骨植入物由细长骨颗粒的相干骨料组成。

2. 发明授权

US09393116B2 Osteoimplants and methods for their manufacture 有权
标题翻译：骨架植物及其制造方法
公开(公告)号：US09393116B2
公开(公告)日：2016-07-19
申请号：US13618599
申请日：2012-09-14
申请人： Randal R. Betz , Scott D. Boden , Christine Clark , Nanette Forsyth , John W. Morris , Kathy Traianedes
发明人： Randal R. Betz , Scott D. Boden , Christine Clark , Nanette Forsyth , John W. Morris , Kathy Traianedes
IPC分类号： A61F2/28 , A61F2/46 , A61L27/36 , A61L27/38 , A61L31/00 , A61F2/44 , A61F2/30
CPC分类号： A61F2/28 , A61F2/4455 , A61F2/4644 , A61F2002/2817 , A61F2002/2835 , A61F2002/30059 , A61F2002/30075 , A61F2002/30153 , A61F2002/30329 , A61F2002/30593 , A61F2002/30677 , A61F2002/30805 , A61F2002/30957 , A61F2002/30975 , A61F2002/4649 , A61F2210/0061 , A61F2220/0025 , A61F2230/0019 , A61F2310/00293 , A61F2310/00329 , A61F2310/00365 , A61L27/3608 , A61L27/365 , A61L27/3658 , A61L27/38 , A61L31/005 , A61L2430/02
摘要： A method of repairing and/or treating bone is provided. The method includes implanting at a repair site an osteoimplant having a coherent aggregate of entangled elongate bone particles mixed with a biocompatible fluid carrier, the osteoimplant being flexible and further being formed as a strip at least one end of which possesses a tab for facilitating combination with another implant.
摘要翻译：提供了修复和/或治疗骨的方法。该方法包括在修复部位植入具有与生物相容性流体载体混合的缠结细长骨颗粒的相干聚集体的骨植入体，所述骨植入物是柔性的并且进一步形成为条带，其至少一端具有用于促进与另一种种植体。

3. 发明申请

US20130013071A1 Osteoimplants and Methods for their Manufacture 有权
标题翻译：植入物及其制造方法
公开(公告)号：US20130013071A1
公开(公告)日：2013-01-10
申请号：US13618599
申请日：2012-09-14
申请人： Randal R. Betz , Scott D. Boden , Christine Clark , Nanette Forsyth , John W. Morris , Kathy Traianedes
发明人： Randal R. Betz , Scott D. Boden , Christine Clark , Nanette Forsyth , John W. Morris , Kathy Traianedes
IPC分类号： A61F2/44 , B29C39/02 , A61F2/28
CPC分类号： A61F2/28 , A61F2/4455 , A61F2/4644 , A61F2002/2817 , A61F2002/2835 , A61F2002/30059 , A61F2002/30075 , A61F2002/30153 , A61F2002/30329 , A61F2002/30593 , A61F2002/30677 , A61F2002/30805 , A61F2002/30957 , A61F2002/30975 , A61F2002/4649 , A61F2210/0061 , A61F2220/0025 , A61F2230/0019 , A61F2310/00293 , A61F2310/00329 , A61F2310/00365 , A61L27/3608 , A61L27/365 , A61L27/3658 , A61L27/38 , A61L31/005 , A61L2430/02
摘要： An osteoimplant is made up of a coherent aggregate of elongate bone particles.
摘要翻译：骨植入物由细长骨颗粒的相干骨料组成。

4. 发明授权

US08268008B2 Osteoimplants and methods for their manufacture 有权
标题翻译：骨架植物及其制造方法
公开(公告)号：US08268008B2
公开(公告)日：2012-09-18
申请号：US11489262
申请日：2006-07-19
申请人： Randal R. Betz , Scott D. Boden , Christine Clark , Nanette Forsyth , John W. Morris , Kathy Traianedes
发明人： Randal R. Betz , Scott D. Boden , Christine Clark , Nanette Forsyth , John W. Morris , Kathy Traianedes
IPC分类号： A61F2/28
CPC分类号： A61F2/28 , A61F2/4455 , A61F2/4644 , A61F2002/2817 , A61F2002/2835 , A61F2002/30059 , A61F2002/30075 , A61F2002/30153 , A61F2002/30329 , A61F2002/30593 , A61F2002/30677 , A61F2002/30805 , A61F2002/30957 , A61F2002/30975 , A61F2002/4649 , A61F2210/0061 , A61F2220/0025 , A61F2230/0019 , A61F2310/00293 , A61F2310/00329 , A61F2310/00365 , A61L27/3608 , A61L27/365 , A61L27/3658 , A61L27/38 , A61L31/005 , A61L2430/02
摘要： An osteoimplant is made up of a coherent aggregate of elongate bone particles.
摘要翻译：骨植入物由细长骨颗粒的相干骨料组成。

5. 发明授权

US07959941B2 Bone graft comprising a demineralized bone matrix and a stabilizing agent 有权
标题翻译：骨移植物包含脱矿骨基质和稳定剂
公开(公告)号：US07959941B2
公开(公告)日：2011-06-14
申请号：US11622955
申请日：2007-01-12
申请人： David Knaack , Kathy Traianedes , Michele Diegman , Nanette Forsyth , John Winterbottom
发明人： David Knaack , Kathy Traianedes , Michele Diegman , Nanette Forsyth , John Winterbottom
IPC分类号： A61F2/28
CPC分类号： A61F2/28 , A61F2002/2817 , A61F2002/2835 , A61F2002/30677 , A61L27/227 , A61L27/3608 , A61L27/3633 , A61L27/365 , A61L27/505 , A61L27/54 , A61L27/58 , A61L2300/414 , A61L2300/434 , A61L2300/602 , A61L2300/802 , A61L2430/02 , B33Y80/00
摘要： An improved demineralized bone matrix (DBM) or other matrix composition is provided that has been mixed with a stabilizing agent that acts as (1) a diffusion barrier, (2) a enzyme inhibitor, (3) a competitive substrate, or (4) a masking moiety. A diffusion barrier acts as a barrier so as to protect the osteoinductive factors found in DBM from being degraded by proteolytic and glycolytic enzymes at the implantation site. Stabilizing agents may be any biodegradable material such as starches, modified starches, cellulose, dextran, polymers, proteins, and collagen. As the stabilizing agents degrades or dissolves in vivo, the osteoinductive factors such as TGF-.beta., BMP, and IGF are activated or exposed, and the activated factors work to recruit cells from the preivascular space to the site of injury and to cause differentiation into bone-forming cells. The invention also provides methods of preparing, testing, and using the inventive improved osteodinductive matrix compositions.
摘要翻译：提供了与稳定剂混合的改进的脱矿质骨基质（DBM）或其它基质组合物，其作为（1）扩散阻挡层，（2）酶抑制剂，（3）竞争性底物，或（4）掩蔽部分。扩散屏障作为屏障，以保护DBM中发现的骨诱导因子不被植入部位的蛋白水解酶和糖酵解酶降解。稳定剂可以是任何可生物降解的材料，例如淀粉，改性淀粉，纤维素，葡聚糖，聚合物，蛋白质和胶原蛋白。当稳定剂在体内降解或溶解时，骨诱导因子如TGF-β，BMP和IGF被活化或暴露，并且活化因子用于将细胞从血管内空间募集到损伤部位并导致分化成骨形成细胞。本发明还提供了制备，测试和使用本发明改进的骨吸收性基质组合物的方法。

6. 发明申请

US20080145392A1 Bone Graft 有权
标题翻译：骨移植
公开(公告)号：US20080145392A1
公开(公告)日：2008-06-19
申请号：US11622955
申请日：2007-01-12
申请人： David Knaack , Kathy Traianedes , Michele Diegman , Nanette Forsyth , John Winterbottom
发明人： David Knaack , Kathy Traianedes , Michele Diegman , Nanette Forsyth , John Winterbottom
IPC分类号： A61F2/28 , A61K35/32 , A61P19/00
CPC分类号： A61F2/28 , A61F2002/2817 , A61F2002/2835 , A61F2002/30677 , A61L27/227 , A61L27/3608 , A61L27/3633 , A61L27/365 , A61L27/505 , A61L27/54 , A61L27/58 , A61L2300/414 , A61L2300/434 , A61L2300/602 , A61L2300/802 , A61L2430/02 , B33Y80/00
摘要： An improved demineralized bone matrix (DBM) or other matrix composition is provided that has been mixed with a stabilizing agent that acts as (1) a diffusion barrier, (2) a enzyme inhibitor, (3) a competitive substrate, or (4) a masking moiety. A diffusion barrier acts as a barrier so as to protect the osteoinductive factors found in DBM from being degraded by proteolytic and glycolytic enzymes at the implantation site. Stabilizing agents may be any biodegradable material such as starches, modified starches, cellulose, dextran, polymers, proteins, and collagen. As the stabilizing agents degrades or dissolves in vivo, the osteoinductive factors such as TGF-.beta., BMP, and IGF are activated or exposed, and the activated factors work to recruit cells from the preivascular space to the site of injury and to cause differentiation into bone-forming cells. The invention also provides methods of preparing, testing, and using the inventive improved osteodinductive matrix compositions
摘要翻译：提供了与稳定剂混合的改进的脱矿质骨基质（DBM）或其它基质组合物，其作为（1）扩散阻挡层，（2）酶抑制剂，（3）竞争性底物，或（4）掩蔽部分。扩散屏障作为屏障，以保护DBM中发现的骨诱导因子不被植入部位的蛋白水解酶和糖酵解酶降解。稳定剂可以是任何可生物降解的材料，例如淀粉，改性淀粉，纤维素，葡聚糖，聚合物，蛋白质和胶原蛋白。当稳定剂在体内降解或溶解时，骨诱导因子如TGF-β，BMP和IGF被活化或暴露，并且活化因子用于将细胞从血管内空间募集到损伤部位并导致分化成骨形成细胞。本发明还提供了制备，测试和使用本发明改进的骨吸收性基质组合物的方法

7. 发明授权

US07163691B2 Bone graft 有权
标题翻译：骨移植
公开(公告)号：US07163691B2
公开(公告)日：2007-01-16
申请号：US10271140
申请日：2002-10-15
申请人： David Knaack , Kathy Traianedes , Michele Diegman , Nanette Forsyth , John Winterbottom
发明人： David Knaack , Kathy Traianedes , Michele Diegman , Nanette Forsyth , John Winterbottom
IPC分类号： A61F2/28
CPC分类号： A61F2/28 , A61F2002/2817 , A61F2002/2835 , A61F2002/30677 , A61L27/227 , A61L27/3608 , A61L27/3633 , A61L27/365 , A61L27/505 , A61L27/54 , A61L27/58 , A61L2300/414 , A61L2300/434 , A61L2300/602 , A61L2300/802 , A61L2430/02 , B33Y80/00
摘要： An improved demineralized bone matrix (DBM) or other matrix composition is provided that has been mixed with a stabilizing agent that acts as (1) a diffusion barrier, (2) a enzyme inhibitor, (3) a competitive substrate, or (4) a masking moiety. A diffusion barrier acts as a barrier so as to protect the osteoinductive factors found in DBM from being degraded by proteolytic and glycolytic enzymes at the implantation site. Stabilizing agents may be any biodegradable material such as starches, modified starches, cellulose, dextran, polymers, proteins, and collagen. As the stabilizing agents degrades or dissolves in vivo, the osteoinductive factors such as TGF-β, BMP, and IGF are activated or exposed, and the activated factors work to recruit cells from the preivascular space to the site of injury and to cause differentiation into bone-forming cells. The invention also provides methods of preparing, testing, and using the inventive improved osteodinductive matrix compositions.
摘要翻译：提供了与稳定剂混合的改进的脱矿质骨基质（DBM）或其它基质组合物，其作为（1）扩散阻挡层，（2）酶抑制剂，（3）竞争性底物，或（4）掩蔽部分。扩散屏障作为屏障，以保护DBM中发现的骨诱导因子不被植入部位的蛋白水解酶和糖酵解酶降解。稳定剂可以是任何可生物降解的材料，例如淀粉，改性淀粉，纤维素，葡聚糖，聚合物，蛋白质和胶原蛋白。当稳定剂在体内降解或溶解时，诸如TGF-β，BMP和IGF的骨诱导因子被活化或暴露，并且活化因子用于将细胞从血管内空间募集到损伤部位并引起分化骨形成细胞。本发明还提供了制备，测试和使用本发明改进的骨吸收性基质组合物的方法。

8. 发明申请

US20060030948A1 Osteoimplant and method of making same 有权
公开(公告)号：US20060030948A1
公开(公告)日：2006-02-09
申请号：US11231954
申请日：2005-09-21
申请人： Albert Manrique , Jean Edwards , Nelson Scarborough , Scott Boden , Kathy Traianedes , Lawrence Shimp , James Russell
发明人： Albert Manrique , Jean Edwards , Nelson Scarborough , Scott Boden , Kathy Traianedes , Lawrence Shimp , James Russell
IPC分类号： A61F2/36
CPC分类号： A61F2/4644 , A61B17/866 , A61F2/28 , A61F2/3094 , A61F2/442 , A61F2/446 , A61F2002/2817 , A61F2002/2835 , A61F2002/2839 , A61F2002/30059 , A61F2002/30075 , A61F2002/30113 , A61F2002/30131 , A61F2002/30153 , A61F2002/30154 , A61F2002/30156 , A61F2002/30158 , A61F2002/302 , A61F2002/30205 , A61F2002/30224 , A61F2002/30225 , A61F2002/30238 , A61F2002/30261 , A61F2002/3028 , A61F2002/30733 , A61F2002/30879 , A61F2002/30891 , A61F2002/30892 , A61F2002/30957 , A61F2002/30971 , A61F2002/4649 , A61F2210/0061 , A61F2230/0006 , A61F2230/0013 , A61F2230/0019 , A61F2230/0021 , A61F2230/0023 , A61F2230/0026 , A61F2230/0063 , A61F2230/0065 , A61F2230/0067 , A61F2230/0069 , A61F2230/0082 , A61F2310/00365 , A61L27/3608 , A61L27/365 , A61L27/3683 , A61L27/3691 , A61L31/005 , A61L2430/02 , B29C41/22 , B29C41/46 , B29K2105/16 , B29K2511/06 , B29L2031/7532
摘要： An osteoimplant is provided which comprises a coherent aggregate of elongate bone particles, the osteoimplant possessing predetermined dimensions and shape. The osteoimplant is highly absorbent and sponge-like in nature. Also provided herein are a method of fabricating the osteoimplant and a method of repairing and/or treating bone defects utilizing the osteoimplant.

9. 发明申请

US20120283618A1 Method of Inducing Cellular Growth and Materials for Use Therewith 审中-公开
标题翻译：诱导细胞生长的方法及其使用的材料
公开(公告)号：US20120283618A1
公开(公告)日：2012-11-08
申请号：US13512321
申请日：2010-11-26
申请人： Stephen Anthony Livesey , Kathy Traianedes
发明人： Stephen Anthony Livesey , Kathy Traianedes
IPC分类号： A61M37/00 , C12N5/00
CPC分类号： A61K35/28 , A01K67/0271 , A01K2207/12
摘要： The present invention relates generally to a method of producing a population of cells and materials for use therewith. More particularly, the present invention is directed to a method of generating the growth of a population of blood-derived cells and materials for use therewith. The method of the present invention facilitates cell growth by virtue of the migration of blood-derived cells from the vasculature of a vascularised receptacle to the acellular tissue support matrix of said receptacle. These findings have now facilitated the design of means for reliably and efficiently deriving cellular populations from blood-derived cells, such as the generation of bone marrow cells including haemopoietic stem cells and mesenchymal stem cells, for use in a wide variety of clinical and research settings. The method of the present invention is particularly useful for the therapeutic or prophylactic treatment of a range of conditions via the administration of the cells generated in accordance with the method of the present invention.
摘要翻译：本发明一般涉及生产与其一起使用的细胞群和材料的方法。更具体地说，本发明涉及一种产生血源细胞群体及其使用材料生长的方法。本发明的方法由于血液源细胞从血管化插管的脉管系统迁移到所述容器的无细胞组织支撑基质而促进细胞生长。这些发现现在有助于设计用于可靠和有效地从血液来源的细胞衍生细胞群的手段，例如产生包括造血干细胞和间充质干细胞在内的骨髓细胞，用于各种临床和研究环境。本发明的方法特别可用于通过施用根据本发明方法产生的细胞来治疗或预防一系列病症。

10. 发明申请

US20180256643A1 METHOD OF EX VIVO CELLULAR GROWTH 审中-公开
公开(公告)号：US20180256643A1
公开(公告)日：2018-09-13
申请号：US15910999
申请日：2018-03-02
申请人： Kathy Traianedes , Stephen Anthony Livesey
发明人： Kathy Traianedes , Stephen Anthony Livesey
IPC分类号： A61K35/14 , A61K35/28 , A61L27/36 , A61L27/38 , A61L27/50
CPC分类号： A61K35/14 , A61K35/28 , A61L27/3633 , A61L27/3834 , A61L27/507
摘要： The present invention relates generally to an ex vivo method of producing a population of cells and materials for use therewith. More particularly, the present invention is directed to an ex vivo method of generating the growth of a population of blood-derived cells and materials for use therewith. The method of the present invention facilitates cell growth by virtue of the migration of blood-derived cells from the vasculature of a vascularised receptacle to the acellular tissue support matrix of said receptacle. These findings have now facilitated the design of means for reliably and efficiently deriving cellular populations from blood-derived cells, such as the generation of bone marrow cells including haemopoietic stem cells and mesenchymal stem cells, for use in a wide variety of clinical and research settings. The method of the present invention is particularly useful for the therapeutic or prophylactic treatment of a range of conditions via the administration of the cells generated in accordance with the method of the present invention.

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