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1. 发明申请

US20110091922A1 Bio-Matrix Stretcher 有权
标题翻译：生物基质担架
公开(公告)号：US20110091922A1
公开(公告)日：2011-04-21
申请号：US12675882
申请日：2008-08-28
申请人： Ramaswamy Krishnan , Chan Young Park , Jeffrey Fredberg , Fei Liu , Justin Mih , Daniel Tschumperlin
发明人： Ramaswamy Krishnan , Chan Young Park , Jeffrey Fredberg , Fei Liu , Justin Mih , Daniel Tschumperlin
IPC分类号： C12Q1/02 , C12M1/34
CPC分类号： C12N5/0068 , C12M23/12 , C12N2533/30
摘要： Embodiments provide techniques for measuring and characterizing the dynamics of cell traction forces. Tunable elastic gel substrates can be disposed in multi-well plates. The gels can be of a uniform predetermined thickness. A multi-well plate can be loaded with gels of different shear moduli. An array of punch indenters can be attached to a loading platen such that the each indenter is aligned to a gel substrate. The indenters can apply tensile or compressive strains to the gel substrates. The magnitude, duration, and frequency of the strain can be controlled by a motor assembly coupled to a control system. The apparatus can be disposed in an incubator for long term cell culture experiments. The cell culture can be observed while a strain is applied. A ring-shaped indenter can be mounted on a microscope, coaxial to the objective lens, and lowered by a calibrated amount onto the underlying gel.
摘要翻译：实施例提供了用于测量和表征细胞牵引力的动力学的技术。可调谐的弹性凝胶基材可以设置在多孔板中。凝胶可以具有均匀的预定厚度。多孔板可装载不同剪切模量的凝胶。可以将一组冲头压头连接到加载压板，使得每个压头与凝胶基板对准。压痕可以对凝胶基质施加拉伸或压缩应变。应变的幅度，持续时间和频率可以通过耦合到控制系统的电机组件来控制。该装置可以放置在用于长期细胞培养实验的培养箱中。可以在应用菌株时观察细胞培养物。环形压头可以安装在与物镜同轴的显微镜上，并通过校准量下降到下面的凝胶上。

2. 发明授权

US08993312B2 Bio-matrix stretcher 有权
标题翻译：生物基质担架
公开(公告)号：US08993312B2
公开(公告)日：2015-03-31
申请号：US12675882
申请日：2008-08-28
申请人： Ramaswamy Krishnan , Chan Young Park , Jeffrey Fredberg , Fei Liu , Justin Mih , Daniel Tschumperlin
发明人： Ramaswamy Krishnan , Chan Young Park , Jeffrey Fredberg , Fei Liu , Justin Mih , Daniel Tschumperlin
IPC分类号： C12Q1/02 , C12M1/34 , C12N5/00 , C12M1/32
CPC分类号： C12N5/0068 , C12M23/12 , C12N2533/30
摘要： Embodiments provide techniques for measuring and characterizing the dynamics of cell traction forces. Tunable elastic gel substrates can be disposed in multi-well plates. The gels can be of a uniform predetermined thickness. A multi-well plate can be loaded with gels of different shear moduli. An array of punch indenters can be attached to a loading platen such that the each indenter is aligned to a gel substrate. The indenters can apply tensile or compressive strains to the gel substrates. The magnitude, duration, and frequency of the strain can be controlled by a motor assembly coupled to a control system. The apparatus can be disposed in an incubator for long term cell culture experiments. The cell culture can be observed while a strain is applied. A ring-shaped indenter can be mounted on a microscope, coaxial to the objective lens, and lowered by a calibrated amount onto the underlying gel.
摘要翻译：实施例提供了用于测量和表征细胞牵引力的动力学的技术。可调谐的弹性凝胶基材可以设置在多孔板中。凝胶可以具有均匀的预定厚度。多孔板可装载不同剪切模量的凝胶。可以将一组冲头压头连接到加载压板，使得每个压头与凝胶基板对准。压痕可以对凝胶基质施加拉伸或压缩应变。应变的幅度，持续时间和频率可以通过耦合到控制系统的电机组件来控制。该装置可以放置在用于长期细胞培养实验的培养箱中。可以在应用菌株时观察细胞培养物。环形压头可以安装在与物镜同轴的显微镜上，并通过校准量下降到下面的凝胶上。

3. 发明授权

US5746699A Acoustic imaging 失效
标题翻译：声学成像
公开(公告)号：US5746699A
公开(公告)日：1998-05-05
申请号：US769697
申请日：1996-12-18
申请人： Jeffrey Fredberg , Gary Glass , John Lehr , Bruno Louis
发明人： Jeffrey Fredberg , Gary Glass , John Lehr , Bruno Louis
IPC分类号： A61B5/085 , A61B8/12 , A61B8/00
CPC分类号： A61B8/12 , A61B5/085 , A61B8/445
摘要： Single hand supportable and operable apparatus for providing an output signal characteristic of the morphology of a respiratory tract includes an acoustic pipe for exchanging acoustical energy with the tract. The pipe has an open first end in communication with an opening in the respiratory tract. A transducer, such as a loudspeaker, is coupled to the pipe for launching acoustical energy into the pipe, producing an incident wave towards the opening in the tract and a reflected wave to form a transient wave field in the pipe representative of the morphology of the tract. Preferably, first and second pressure wave sensing transducers, such as microphones, mounted along the length of the pipe in spaced relationship provide first and second transduced signals representative of the transient wave field. A processor processes the first and second transduced signals to provide an output signal characteristic of the morphology of the tract, such as the cross-sectional area as a function of the distance from the opening in the tract.
摘要翻译：用于提供呼吸道形态特征的输出信号的单手支持和可操作的装置包括用于与管道交换声能的声管。管道具有与呼吸道中的开口连通的敞开的第一端。诸如扬声器的传感器耦合到管道，用于将声能发射到管道中，产生朝向管道中的开口的入射波和反射波，以在代表管道的形态的管道中形成瞬态波场道。优选地，以间隔关系沿着管的长度安装的第一和第二压力波感测换能器（例如麦克风）提供表示瞬态波场的第一和第二转导信号。处理器处理第一和第二转导信号以提供特征的道的形态的输出信号，例如横截面积作为与管道中的开口的距离的函数。

4. 发明授权

US5666960A Acoustic imaging 失效
标题翻译：声学成像
公开(公告)号：US5666960A
公开(公告)日：1997-09-16
申请号：US117176
申请日：1994-03-31
申请人： Jeffrey Fredberg , Gary Glass , John Lehr , Bruno Louis
发明人： Jeffrey Fredberg , Gary Glass , John Lehr , Bruno Louis
IPC分类号： A61B5/085 , A61B7/00 , A61B8/12 , A61B5/08
CPC分类号： A61B8/12 , A61B5/085 , A61B7/003
摘要： Single hand supportable and operable apparatus for providing an output signal characteristic of the morphology of a respiratory tract includes an acoustic pipe for exchanging acoustical energy with the tract. The pipe has an open first end in communication with an opening in the respiratory tract. A transducer, such as a loudspeaker, is coupled to the pipe for launching acoustical energy into the pipe, producing an incident wave towards the opening in the tract and a reflected wave to form a transient wave field in the pipe representative of the morphology of the tract. Preferably, first and second pressure wave sensing transducers, such as microphones, mounted along the length of the pipe in spaced relationship provide first and second transduced signals representative of the transient wave field. A processor processes the first and second transduced signals to provide an output signal characteristic of the morphology of the tract, such as the cross-sectional area as a function of the distance from the opening in the tract.
摘要翻译： PCT No.PCT / US93 / 05819 Sec。 371日期1994年3月31日 102（e）1994年3月31日PCT提交1993年6月16日PCT公布。出版物WO94 / 09700 日期1994年5月11日用于提供呼吸道形态特征的输出信号的单手可支撑和可操作的装置包括用于与管道交换声能的声管。管道具有与呼吸道中的开口连通的敞开的第一端。诸如扬声器的传感器耦合到管道，用于将声能发射到管道中，产生朝向管道中的开口的入射波和反射波，以在代表管道的形态的管道中形成瞬态波场道。优选地，以间隔关系沿着管的长度安装的第一和第二压力波感测换能器（例如麦克风）提供表示瞬态波场的第一和第二转导信号。处理器处理第一和第二转导信号以提供特征的道的形态的输出信号，例如横截面积作为与管道中的开口的距离的函数。

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