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1. 发明授权

US08252017B2 Invertible filter for embolic protection 有权
标题翻译：用于栓塞保护的可逆过滤器
公开(公告)号：US08252017B2
公开(公告)日：2012-08-28
申请号：US11580546
申请日：2006-10-13
申请人： Ram H. Paul, Jr. , John A. Brumleve
发明人： Ram H. Paul, Jr. , John A. Brumleve
IPC分类号： A61M29/00
CPC分类号： A61F2/013 , A61F2/82 , A61F2002/011 , A61F2002/018 , A61F2230/0006 , A61F2230/0078 , A61F2230/008
摘要： A medical device including a guiding member and a filter portion is disclosed. The guiding member includes a lumen configured to slidably engage the filter portion. The filter portion forms a tubular geometry that extends distally from the guiding member. The filter portion is configured to evert to form a proximally facing concave geometry for capturing emboli. Further, the filter portion includes filter openings that are sized to allow blood cells to pass therethrough while preventing the passage of emboli.
摘要翻译：公开了一种包括引导部件和过滤器部分的医疗装置。引导构件包括构造成可滑动地接合过滤器部分的内腔。过滤器部分形成从引导构件向远侧延伸的管状几何形状。过滤器部分构造成转换成形成用于捕获栓塞的面向近侧的凹形几何形状。此外，过滤器部分包括尺寸适于允许血细胞穿过其中同时防止栓塞通过的过滤器开口。

2. 发明申请

US20090171279A1 Balloon catheter assembly and controller therefor 审中-公开
标题翻译：气球导管总成及其控制器
公开(公告)号：US20090171279A1
公开(公告)日：2009-07-02
申请号：US12005176
申请日：2007-12-26
申请人： John A. Brumleve , Frank J. Fischer , Kian Olsen
发明人： John A. Brumleve , Frank J. Fischer , Kian Olsen
IPC分类号： A61M25/10
CPC分类号： A61M25/10184 , A61B1/00068 , A61B1/00082 , A61B1/015 , A61M25/10185 , A61M25/104 , A61M39/22 , A61M2039/229
摘要： A balloon catheter assembly included a catheter provided with a distal end and a proximal end and at least one inflation lumen in the catheter. The inflation lumen includes a distal end and a proximal end. An inflatable balloon is provided at the distal end of the catheter and in fluid communication with the distal end of said inflation lumen. The proximal end of the inflation lumen is able to be coupled to a source of fluid. A flow controller is coupled between the inflation lumen and the fluid source, the flow controller being adjustable by an operator of the balloon catheter assembly so as to adjust the flow of inflation fluid to the balloon. In one embodiment, the flow controller includes a manually operable control actuator and a plurality of discrete flow configurations provided in the form of flow through holes in the flow controller. In another embodiment the flow controller includes a manually operable control actuator and a gradually varying flow passage therethrough by means of a coupling channel within the flow controller of varying channel dimension.
摘要翻译：气囊导管组件包括设置有导管中的远端和近端以及至少一个充气腔的导管。充气腔包括远端和近端。可膨胀气囊设置在导管的远端并且与所述充气腔的远端流体连通。充气腔的近端能够连接到流体源。流量控制器耦合在充气腔和流体源之间，流量控制器可由气囊导管组件的操作者调节，以便调节膨胀流体流向球囊。在一个实施例中，流量控制器包括可手动操作的控制致动器和以流量控制器中的流通孔形式提供的多个离散流配置。在另一个实施例中，流量控制器包括可手动操作的控制致动器以及通过在不同通道尺寸的流量控制器内的耦合通道穿过的逐渐变化的流动通道。

3. 发明申请

US20120253446A1 Valve Device with Inflatable Chamber 审中-公开
标题翻译：带充气舱的阀门装置
公开(公告)号：US20120253446A1
公开(公告)日：2012-10-04
申请号：US13493563
申请日：2012-06-11
申请人： Thomas A. Osborne , Jacob A. Flagle , John A. Brumleve
发明人： Thomas A. Osborne , Jacob A. Flagle , John A. Brumleve
IPC分类号： A61F2/84 , B21D53/00
CPC分类号： A61F2/2418 , A61F2/2409 , A61F2/2412 , A61F2/2475 , A61F2220/0008 , A61F2220/0016 , A61F2230/0026 , A61F2230/0095 , A61F2250/0003 , Y10T29/494
摘要： Prosthetic valve devices for implantation in body vessels are provided. The prosthetic valve device includes at least one flexible member that permits fluid flow in a first direction and substantially prevents fluid flow in a second. The valve device also includes an inflatable chamber at least partially attached to the flexible member. The inflatable chamber is adapted to receive inflating media and is adapted to contact the body vessel. A delivery system is also provided that includes a valve device and a delivery apparatus. The delivery apparatus includes a member adapted for filling the chamber of the valve device with inflating media. A related method of making the valve device is also provided.
摘要翻译：提供用于植入体内血管的假体瓣膜装置。所述人工瓣膜装置包括至少一个柔性构件，其允许流体沿第一方向流动并且基本上防止流体在第二方向流动。阀装置还包括至少部分地附接到柔性构件的可充气室。充气室适于接收充气介质并且适于接触身体容器。还提供了包括阀装置和输送装置的输送系统。输送装置包括适于用充气介质填充阀装置的室的构件。还提供了制造阀装置的相关方法。

4. 发明授权

US08197534B2 Valve device with inflatable chamber 有权
标题翻译：带充气室的阀门装置
公开(公告)号：US08197534B2
公开(公告)日：2012-06-12
申请号：US11394303
申请日：2006-03-30
申请人： Thomas A. Osborne , Jacob A. Flagle , John A. Brumleve
发明人： Thomas A. Osborne , Jacob A. Flagle , John A. Brumleve
IPC分类号： A61F2/24
CPC分类号： A61F2/2418 , A61F2/2409 , A61F2/2412 , A61F2/2475 , A61F2220/0008 , A61F2220/0016 , A61F2230/0026 , A61F2230/0095 , A61F2250/0003 , Y10T29/494
摘要： Prosthetic valve devices for implantation in body vessels are provided. The prosthetic valve device includes at least one flexible member that permits fluid flow in a first direction and substantially prevents fluid flow in a second. The valve device also includes an inflatable chamber at least partially attached to the flexible member. The inflatable chamber is adapted to receive inflating media and is adapted to contact the body vessel. A delivery system is also provided that includes a valve device and a delivery apparatus. The delivery apparatus includes a member adapted for filling the chamber of the valve device with inflating media. A related method of making the valve device is also provided.
摘要翻译：提供用于植入体内血管的假体瓣膜装置。所述人工瓣膜装置包括至少一个柔性构件，其允许流体沿第一方向流动并且基本上防止流体在第二方向流动。阀装置还包括至少部分地附接到柔性构件的可充气室。充气室适于接收充气介质并且适于接触身体容器。还提供了包括阀装置和输送装置的输送系统。输送装置包括适于用充气介质填充阀装置的室的构件。还提供了制造阀装置的相关方法。

5. 发明授权

US09017397B2 Valve device with inflatable chamber 有权
标题翻译：带充气室的阀门装置
公开(公告)号：US09017397B2
公开(公告)日：2015-04-28
申请号：US13493563
申请日：2012-06-11
申请人： Thomas A. Osborne , Jacob A. Flagle , John A. Brumleve
发明人： Thomas A. Osborne , Jacob A. Flagle , John A. Brumleve
IPC分类号： A61F2/24
CPC分类号： A61F2/2418 , A61F2/2409 , A61F2/2412 , A61F2/2475 , A61F2220/0008 , A61F2220/0016 , A61F2230/0026 , A61F2230/0095 , A61F2250/0003 , Y10T29/494
摘要： Prosthetic valve devices for implantation in body vessels are provided. The prosthetic valve device includes at least one flexible member that permits fluid flow in a first direction and substantially prevents fluid flow in a second. The valve device also includes an inflatable chamber at least partially attached to the flexible member. The inflatable chamber is adapted to receive inflating media and is adapted to contact the body vessel. A delivery system is also provided that includes a valve device and a delivery apparatus. The delivery apparatus includes a member adapted for filling the chamber of the valve device with inflating media. A related method of making the valve device is also provided.
摘要翻译：提供用于植入体内血管的假体瓣膜装置。所述人工瓣膜装置包括至少一个柔性构件，其允许流体沿第一方向流动并且基本上防止流体在第二方向流动。阀装置还包括至少部分地附接到柔性构件的可充气室。充气室适于接收充气介质并且适于接触身体容器。还提供了包括阀装置和输送装置的输送系统。输送装置包括适于用充气介质填充阀装置的室的构件。还提供了制造阀装置的相关方法。

6. 发明申请

US20090082851A1 VARIABLE STIFFNESS WIRE GUIDE 有权
标题翻译：可变硬线指南
公开(公告)号：US20090082851A1
公开(公告)日：2009-03-26
申请号：US11860837
申请日：2007-09-25
申请人： John A. Brumleve , Brian L. Bates
发明人： John A. Brumleve , Brian L. Bates
IPC分类号： A61F2/06
CPC分类号： A61M25/09025 , A61M2025/0915
摘要： The present invention provides a wire guide having a variable stiffness region that may be selectively adjusted to vary the stiffness along a portion of the wire guide. The wire guide generally comprises an outer core member and an inner core member, wherein the inner core member is disposed for longitudinal movement with respect to the outer core member. The outer core member is attached to a proximal end of a coiled member, while the inner core member is attached to the coiled member at an attachment region between proximal and distal ends of the coiled member. In operation, distal advancement of the outer core member with respect to the inner core member causes the coiled member to compress at a location between the proximal end of the coiled member and the attachment region, thereby selectively increasing the stiffness along a portion of the length of the wire guide.
摘要翻译：本发明提供了具有可变刚度区域的导线器，其可以被选择性地调节以沿着导线器的一部分改变刚度。线导向器通常包括外芯部件和内芯部件，其中内芯部件设置成相对于外芯部件纵向移动。外芯构件附接到线圈构件的近端，而内芯构件在线圈构件的近端和远端之间的附接区附接到线圈构件。在操作中，外芯构件相对于内芯构件的远端前进使得线圈构件在线圈构件的近端和附接区域之间的位置处被压缩，从而沿着长度的一部分选择性地增加刚度的导线。

7. 发明申请

US20090062838A1 SPIDER DEVICE WITH OCCLUSIVE BARRIER 审中-公开
标题翻译：带潜水障碍物的防空设备
公开(公告)号：US20090062838A1
公开(公告)日：2009-03-05
申请号：US11845452
申请日：2007-08-27
申请人： John A. Brumleve , Kurt J. Tekulve
发明人： John A. Brumleve , Kurt J. Tekulve
IPC分类号： A61B17/00
CPC分类号： A61B17/12022 , A61B17/12172 , A61B17/12177
摘要： An occlusion device for occluding a body vessel. The occlusion device includes a first hub extending from a proximal end to a distal end and a tubular wall defining a lumen having a central axis. A plurality of arcuate legs are attached to the first hub and extend distally to a distal portion. The legs extend radially away from the central axis in an open configuration and extend substantially along the central axis in a closed configuration. A biocompatible material is attached to the plurality of legs to form an occlusive barrier when deployed within the body vessel. The biocompatible material either extends along and between each of the plurality of legs or it forms a disk attached to at least one leg.
摘要翻译：一种用于封闭体血管的闭塞装置。闭塞装置包括从近端延伸到远端的第一轮毂和限定具有中心轴线的管腔的管状壁。多个弓形腿连接到第一轮毂并且向远端延伸到远侧部分。腿部以中心轴线径向延伸，处于打开构型，并且在闭合构型中基本上沿着中心轴线延伸。当部署在体内容器内时，生物相容性材料附接到多个腿以形成闭塞屏障。所述生物相容性材料沿着所述多个腿中的每一个延伸，或者形成附接到至少一个腿的盘。

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