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1. 发明授权

US08080800B2 Method and apparatus for image reconstruction for a synthetic aperture gamma ray imager 有权
标题翻译：用于合成孔径伽马射线成像仪的图像重建的方法和装置
公开(公告)号：US08080800B2
公开(公告)日：2011-12-20
申请号：US12332439
申请日：2008-12-11
申请人： Ralph Thomas Hoctor , Scott Stephen Zelakiewicz , Evren Asma
发明人： Ralph Thomas Hoctor , Scott Stephen Zelakiewicz , Evren Asma
IPC分类号： G06K9/40 , G01T1/164
CPC分类号： G03B42/02
摘要： An imaging system includes a platform having mounted thereon an imaging device. The imaging device includes a first detector and a second detector. The imaging system includes a mask having a first pattern of apertures therein, the mask positioned on a first side of the first detector, an anti-mask having a second pattern of apertures therein, wherein the second pattern is derived from the first pattern, the anti-mask positioned on a first side of the second detector, and a computer configured to acquire a plurality of mask datasets and anti-mask datasets of a gamma source, add one of the mask datasets and subtract its respective anti-mask dataset to create a far-field dataset, adjust the far-field image dataset, reconstruct a near-field image of the source using the far-field dataset, and apply an expectation maximization (EM) algorithm to one of the far-field image dataset and the near-field image to enhance contrast.
摘要翻译：成像系统包括其上安装有成像装置的平台。成像装置包括第一检测器和第二检测器。所述成像系统包括掩模，所述掩模具有其中的孔的第一图案，所述掩模位于所述第一检测器的第一侧上，所述掩模具有第二图案孔，其中所述第二图案是从所述第一图案得到的，反掩模位于第二检测器的第一侧，以及计算机，被配置为获取伽马源的多个掩模数据集和反掩模数据集，添加掩模数据集之一并减去其各自的防掩模数据集以创建远场数据集，调整远场图像数据集，使用远场数据集重建源的近场图像，并将期望最大化（EM）算法应用于远场图像数据集和近场图像增强对比度。

2. 发明申请

US20090296890A1 APPARATUS AND METHOD FOR IMAGE RECONSTRUCTION FOR A SYNTHETIC APERTURE GAMMA RAY IMAGER 有权
标题翻译：用于合成孔径伽马射线成像器的图像重建的装置和方法
公开(公告)号：US20090296890A1
公开(公告)日：2009-12-03
申请号：US12331936
申请日：2008-12-10
申请人： Ralph Thomas Hoctor , Scott Stephen Zelakiewicz , Evren Asma , Jeffrey Gordon , Floribertus P.M. Heukensfeldt Jansen
发明人： Ralph Thomas Hoctor , Scott Stephen Zelakiewicz , Evren Asma , Jeffrey Gordon , Floribertus P.M. Heukensfeldt Jansen
IPC分类号： G03B42/02
CPC分类号： G03B42/02
摘要： An imaging system includes a platform having mounted thereon a coded-aperture imaging device and positioned to receive radiation over a baseline. The imaging system includes a computer configured to acquire a plurality of far-field datasets over the baseline, the plurality of far-field datasets comprising data received via the coded-aperture imaging device. The computer is also configured to form a preliminary image based on the acquired plurality of far-field datasets, and apply an expectation maximization (EM) algorithm to the preliminary image; wherein the EM algorithm includes an ordered subset algorithm.
摘要翻译：成像系统包括其上安装有编码孔径成像装置并被定位成在基线上接收辐射的平台。成像系统包括被配置为在基线上获取多个远场数据集的计算机，所述多个远场数据集包括经由编码孔径成像装置接收的数据。计算机还被配置为基于所获取的多个远场数据集形成初步图像，并将预期最大化（EM）算法应用于初步图像; 其中所述EM算法包括有序子集算法。

3. 发明申请

US20090297058A1 METHOD AND APPARATUS FOR IMAGE RECONSTRUCTION FOR A SYNTHETIC APERTURE GAMMA RAY IMAGER 有权
标题翻译：用于合成孔径伽马射线成像器的图像重建的方法和装置
公开(公告)号：US20090297058A1
公开(公告)日：2009-12-03
申请号：US12332439
申请日：2008-12-11
申请人： Ralph Thomas Hoctor , Scott Stephen Zelakiewicz , Evren Asma
发明人： Ralph Thomas Hoctor , Scott Stephen Zelakiewicz , Evren Asma
IPC分类号： G06K9/40 , G01T1/164 , G06K9/20
CPC分类号： G03B42/02
摘要： An imaging system includes a platform having mounted thereon an imaging device. The imaging device includes a first detector and a second detector. The imaging system includes a mask having a first pattern of apertures therein, the mask positioned on a first side of the first detector, an anti-mask having a second pattern of apertures therein, wherein the second pattern is derived from the first pattern, the anti-mask positioned on a first side of the second detector, and a computer configured to acquire a plurality of mask datasets and anti-mask datasets of a gamma source, add one of the mask datasets and subtract its respective anti-mask dataset to create a far-field dataset, adjust the far-field image dataset, reconstruct a near-field image of the source using the far-field dataset, and apply an expectation maximization (EM) algorithm to one of the far-field image dataset and the near-field image to enhance contrast.
摘要翻译：成像系统包括其上安装有成像装置的平台。成像装置包括第一检测器和第二检测器。所述成像系统包括掩模，所述掩模具有其中的孔的第一图案，所述掩模位于所述第一检测器的第一侧上，所述掩模具有第二图案孔，其中所述第二图案是从所述第一图案得到的，反掩模位于第二检测器的第一侧，以及计算机，被配置为获取伽马源的多个掩模数据集和反掩模数据集，添加掩模数据集之一并减去其各自的防掩模数据集以创建远场数据集，调整远场图像数据集，使用远场数据集重建源的近场图像，并将期望最大化（EM）算法应用于远场图像数据集和近场图像增强对比度。

4. 发明授权

US07663105B2 Apparatus and method for image reconstruction for a synthetic aperture gamma ray imager 有权
标题翻译：用于合成孔径伽马射线成像仪的图像重建的装置和方法
公开(公告)号：US07663105B2
公开(公告)日：2010-02-16
申请号：US12331936
申请日：2008-12-10
申请人： Ralph Thomas Hoctor , Scott Stephen Zelakiewicz , Evren Asma , Jeffrey Gordon , Floribertus P. M. Heukensfeldt Jansen
发明人： Ralph Thomas Hoctor , Scott Stephen Zelakiewicz , Evren Asma , Jeffrey Gordon , Floribertus P. M. Heukensfeldt Jansen
IPC分类号： G01T1/00
CPC分类号： G03B42/02
摘要： An imaging system includes a platform having mounted thereon a coded-aperture imaging device and positioned to receive radiation over a baseline. The imaging system includes a computer configured to acquire a plurality of far-field datasets over the baseline, the plurality of far-field datasets comprising data received via the coded-aperture imaging device. The computer is also configured to form a preliminary image based on the acquired plurality of far-field datasets, and apply an expectation maximization (EM) algorithm to the preliminary image; wherein the EM algorithm includes an ordered subset algorithm.
摘要翻译：成像系统包括其上安装有编码孔径成像装置并被定位成在基线上接收辐射的平台。成像系统包括被配置为在基线上获取多个远场数据集的计算机，所述多个远场数据集包括经由编码孔径成像装置接收的数据。计算机还被配置为基于所获取的多个远场数据集形成初步图像，并将预期最大化（EM）算法应用于初步图像; 其中所述EM算法包括有序子集算法。

5. 发明授权

US08507869B2 Methods and systems for adaptive tomographic imaging 有权
标题翻译：自适应断层成像的方法和系统
公开(公告)号：US08507869B2
公开(公告)日：2013-08-13
申请号：US13282586
申请日：2011-10-27
申请人： Evren Asma , Ravindra Mohan Manjeshwar
发明人： Evren Asma , Ravindra Mohan Manjeshwar
IPC分类号： G01T1/166
CPC分类号： A61B6/037 , A61B6/469 , A61B6/488 , A61B6/545
摘要： Nuclear imaging systems, non-transitory computer readable media and methods for adaptive imaging are presented. Particularly, the present method includes acquiring preliminary projection data by scanning each of one or more views of a subject for a determined preliminary scan interval. Further, a region of interest of the subject is identified. The preliminary projection data is then used to perform a constrained optimization of a rapidly computable image quality metric for determining an acquisition protocol that improves the image quality metric at the identified region of interest. Particularly, the determined acquisition protocol is used to acquire target projection data corresponding to at least the identified region of interest. Further, an image of at least the identified region of interest is reconstructed using the target projection data, the preliminary projection data, or a combination thereof.
摘要翻译：介绍了核成像系统，非瞬态计算机可读介质和自适应成像方法。特别地，本方法包括通过扫描被确定的初步扫描间隔的一个或多个视图中的每一个来获取初步投影数据。此外，识别受试者的感兴趣区域。然后使用初步投影数据来执行快速可计算的图像质量度量的约束优化，以确定改善所识别的感兴趣区域的图像质量度量的采集协议。特别地，所确定的获取协议被用于获取对应于至少所识别的感兴趣区域的目标投影数据。此外，使用目标投影数据，初步投影数据或其组合来重建至少所识别的感兴趣区域的图像。

6. 发明申请

US20130105699A1 METHODS AND SYSTEMS FOR ADAPTIVE TOMOGRAPHIC IMAGING 有权
标题翻译：自适应图像成像的方法和系统
公开(公告)号：US20130105699A1
公开(公告)日：2013-05-02
申请号：US13282586
申请日：2011-10-27
申请人： Evren Asma , Ravindra Mohan Manjeshwar
发明人： Evren Asma , Ravindra Mohan Manjeshwar
IPC分类号： G01T1/164 , G06K9/00
CPC分类号： A61B6/037 , A61B6/469 , A61B6/488 , A61B6/545
摘要： Nuclear imaging systems, non-transitory computer readable media and methods for adaptive imaging are presented. Particularly, the present method includes acquiring preliminary projection data by scanning each of one or more views of a subject for a determined preliminary scan interval. Further, a region of interest of the subject is identified. The preliminary projection data is then used to perform a constrained optimization of a rapidly computable image quality metric for determining an acquisition protocol that improves the image quality metric at the identified region of interest. Particularly, the determined acquisition protocol is used to acquire target projection data corresponding to at least the identified region of interest. Further, an image of at least the identified region of interest is reconstructed using the target projection data, the preliminary projection data, or a combination thereof.
摘要翻译：介绍了核成像系统，非瞬态计算机可读介质和自适应成像方法。特别地，本方法包括通过扫描被确定的初步扫描间隔的一个或多个视图中的每一个来获取初步投影数据。此外，识别受试者的感兴趣区域。然后使用初步投影数据来执行快速可计算的图像质量度量的约束优化，以确定改善所识别的感兴趣区域的图像质量度量的采集协议。特别地，所确定的获取协议被用于获取对应于至少所识别的感兴趣区域的目标投影数据。此外，使用目标投影数据，初步投影数据或其组合来重建至少所识别的感兴趣区域的图像。

7. 发明申请

US20100220909A1 METHOD AND APPARATUS FOR REDUCING IMAGE ARTIFACTS 有权
标题翻译：用于减少图像的方法和装置
公开(公告)号：US20100220909A1
公开(公告)日：2010-09-02
申请号：US12394772
申请日：2009-02-27
申请人： Kris Filip Johan Jules Thielemans , Scott David Wollenweber , Alexander Ganin , Anja Brau , Floribertus P. M. Heukensfeldt Jansen , Evren Asma , Rakesh Mullick , Ravindra Mohan Manjeshwar , Ajit Shankaranarayanan
发明人： Kris Filip Johan Jules Thielemans , Scott David Wollenweber , Alexander Ganin , Anja Brau , Floribertus P. M. Heukensfeldt Jansen , Evren Asma , Rakesh Mullick , Ravindra Mohan Manjeshwar , Ajit Shankaranarayanan
IPC分类号： G06K9/00
CPC分类号： G06T11/005 , G06T2211/412
摘要： A method and apparatus are provided for reducing motion related imaging artifacts. The method includes determining an internal motion for of two regions of the object, each region having a different level of motion, scanning the first region using a first scan protocol based on the motion, scanning a second region using a second different scan protocol based on the motion, and generating an image of the object based on the first and second regions.
摘要翻译：提供了一种用于减少运动相关成像伪影的方法和装置。该方法包括确定对象的两个区域的内部运动，每个区域具有不同的运动水平，基于运动使用第一扫描协议扫描第一区域，使用基于第二扫描协议的第二不同扫描协议扫描第二区域运动，以及基于第一和第二区域生成对象的图像。

8. 发明授权

US08575555B2 Nuclear medicine imaging system and method using multiple types of imaging detectors 有权
标题翻译：核医学成像系统和使用多种成像检测器的方法
公开(公告)号：US08575555B2
公开(公告)日：2013-11-05
申请号：US13077540
申请日：2011-03-31
申请人： Kristen Ann Wangerin , Evren Asma , Jorge Uribe , Ravindra Manjeshwar
发明人： Kristen Ann Wangerin , Evren Asma , Jorge Uribe , Ravindra Manjeshwar
IPC分类号： G01T1/166
CPC分类号： G01T1/166 , A61B6/037 , G01T1/1603 , G01T1/1644 , G01T1/249
摘要： A Nuclear Medicine (NM) imaging system and method using multiple types of imaging detectors are provided. One NM imaging system includes a gantry, at least a first imaging detector coupled to the gantry, wherein the first imaging detector is a non-moving detector, and at least a second imaging detector coupled to the gantry, wherein the second imaging detector is a moving detector. The first imaging detector is larger than the second imaging detector and the first and second imaging detectors have different detector configurations. The NM imaging system further includes a controller configured to control the operation of the first and second imaging detectors during an imaging scan of an object to acquire Single Photon Emission Computed Tomography (SPECT) image information such that at least the first imaging detector remains stationary with respect to the gantry during image acquisition.
摘要翻译：提供了使用多种成像检测器的核医学（NM）成像系统和方法。一个NM成像系统包括台架，至少第一成像检测器，其耦合到台架，其中第一成像检测器是非移动检测器，以及耦合到台架的至少第二成像检测器，其中第二成像检测器是移动探测器。第一成像检测器大于第二成像检测器，并且第一和第二成像检测器具有不同的检测器配置。 NM成像系统还包括控制器，其被配置为在对象的成像扫描期间控制第一和第二成像检测器的操作，以获取单光子发射计算机断层扫描（SPECT）图像信息，使得至少第一成像检测器保持静止，在图像采集期间对台架的尊重。

9. 发明授权

US08472683B2 Motion correction in tomographic images 有权
标题翻译：断层图像中的运动校正
公开(公告)号：US08472683B2
公开(公告)日：2013-06-25
申请号：US12550773
申请日：2009-08-31
申请人： Ravindra Mohan Manjeshwar , Kris Filip Johan Jules Thielemans , Evren Asma
发明人： Ravindra Mohan Manjeshwar , Kris Filip Johan Jules Thielemans , Evren Asma
IPC分类号： G06K9/00
CPC分类号： A61B6/032 , A61B5/7285 , A61B6/037 , A61B6/5235 , A61B6/5247 , A61B6/541 , G06T5/003 , G06T7/30 , G06T7/33 , G06T11/005 , G06T11/008 , G06T2207/10081 , G06T2207/10084 , G06T2207/10104 , G06T2207/20201 , G06T2207/20221 , G06T2207/30004 , G06T2207/30048 , G06T2207/30061 , G06T2211/412
摘要： An imaging method comprises reconstructing gated emission tomography images for a region of interest, adjusting a mismatch between the gated emission tomography images and a computed tomography image of the region of interest, registering the gated emission tomography images, and combining the registered gated emission tomography images to generate motion corrected images.
摘要翻译：一种成像方法包括重建关注区域的门控发射断层摄影图像，调整门控发射断层摄影图像与感兴趣区域的计算机断层摄影图像之间的失配，登记门控发射断层摄影图像，以及组合登记的门控发射断层摄影图像以产生运动校正图像。

10. 发明授权

US08355551B2 Method and apparatus for reducing image artifacts 有权
标题翻译：减少图像伪影的方法和装置
公开(公告)号：US08355551B2
公开(公告)日：2013-01-15
申请号：US12394772
申请日：2009-02-27
申请人： Kris Filip Johan Jules Thielemans , Scott David Wollenweber , Alexander Ganin , Anja Brau , Floribertus P. M. Heukensfeldt Jansen , Evren Asma , Rakesh Mullick , Ravindra Mohan Manjeshwar , Ajit Shankaranarayanan
发明人： Kris Filip Johan Jules Thielemans , Scott David Wollenweber , Alexander Ganin , Anja Brau , Floribertus P. M. Heukensfeldt Jansen , Evren Asma , Rakesh Mullick , Ravindra Mohan Manjeshwar , Ajit Shankaranarayanan
IPC分类号： G06K9/00
CPC分类号： G06T11/005 , G06T2211/412
摘要： A method and apparatus are provided for reducing motion related imaging artifacts. The method includes determining an internal motion for of two regions of the object, each region having a different level of motion, scanning the first region using a first scan protocol based on the motion, scanning a second region using a second different scan protocol based on the motion, and generating an image of the object based on the first and second regions.
摘要翻译：提供了一种用于减少运动相关成像伪影的方法和装置。该方法包括确定对象的两个区域的内部运动，每个区域具有不同的运动水平，基于运动使用第一扫描协议扫描第一区域，使用基于第二扫描协议的第二不同扫描协议扫描第二区域运动，以及基于第一和第二区域生成对象的图像。

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