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1. 发明申请

US20120322835A1 PHARMACEUTICAL COMPOSITIONS AND METHODS FOR PRODUCING LOW IMPURITY CONCENTRATIONS OF THE SAME 审中-公开
标题翻译：药物组合物及其生产低劣化浓度的方法
公开(公告)号：US20120322835A1
公开(公告)日：2012-12-20
申请号：US13600056
申请日：2012-08-30
申请人： Rajeshwar Motheram , Gopal Krishna , Min Ding , Keith Flood , Kornepati Ramakrishna
发明人： Rajeshwar Motheram , Gopal Krishna , Min Ding , Keith Flood , Kornepati Ramakrishna
IPC分类号： A61K31/4418 , C07D213/80 , G01N30/00 , A61P9/12
CPC分类号： A61K31/4422 , A61K31/519 , G01N30/02
摘要： A composition having clevidipine as an active ingredient is described. The composition includes clevidipine as an active ingredient and an amount of the impurity H168/79 that is no greater than about 1.5%, or where the ratio between clevidipine and H168/79 is equal or above 60 to 1.
摘要翻译：描述了具有氯维地平作为活性成分的组合物。组合物包括氯维西肽作为活性成分，杂质H168 / 79的量不大于约1.5％，或者氯维地平与H168 / 79之间的比例等于或大于60比1。

2. 发明申请

US20100113534A1 Pharmaceutical Compositions And Methods For Producing Low Impurity Concentrations Of The Same 审中-公开
标题翻译：用于生产低杂质浓度的药物组合物和方法
公开(公告)号：US20100113534A1
公开(公告)日：2010-05-06
申请号：US12511631
申请日：2009-07-29
申请人： Rajeshwar Motheram , Gopal Krishna , Min Ding , Keith Flood , Kornepati Ramakrishna
发明人： Rajeshwar Motheram , Gopal Krishna , Min Ding , Keith Flood , Kornepati Ramakrishna
IPC分类号： A61K31/4418 , G01N30/02
CPC分类号： A61K31/4422 , A61K31/519 , G01N30/02
摘要： A composition having clevidipine as an active ingredient is described. The composition includes clevidipine as an active ingredient and an amount of the impurity H168/79 that is no greater than about 1.5%, or where the ratio between clevidipine and H168/79 is equal or above 60 to 1.
摘要翻译：描述了具有氯维地平作为活性成分的组合物。组合物包括氯维西肽作为活性成分，杂质H168 / 79的量不大于约1.5％，或者氯维地平与H168 / 79之间的比例等于或大于60比1。

3. 发明申请

US20120322836A1 PHARMACEUTICAL COMPOSITIONS AND METHODS FOR STABILIZING THE SAME 审中-公开
标题翻译：药物组合物及其稳定化方法
公开(公告)号：US20120322836A1
公开(公告)日：2012-12-20
申请号：US13600083
申请日：2012-08-30
申请人： Gopal Krishna , Rajeshwar Motheram , Min Ding
发明人： Gopal Krishna , Rajeshwar Motheram , Min Ding
IPC分类号： A61K31/4418 , A61P9/12 , C07D213/80
CPC分类号： A61K31/519 , A61K9/0019 , A61K9/10 , A61K31/435 , A61K31/4418 , A61K2300/00
摘要： Pharmaceutical compositions, and a method of stabilizing pharmaceutical compositions having clevidipine, or any pharmaceutically acceptable salt thereof, as the active ingredient is described. The method includes the slowing down or inhibiting of the oxidation pathway of clevidipine. This can be accomplished by reducing the amount the pharmaceutical composition is exposed to oxygen and/or light during the manufacturing and storing processes. According to this method, oxygen must be removed or replaced, or light must be sufficiently blocked such that light energy cannot reach the active ingredient of the composition, or is reduced to a level that the light-induced oxidation reaction converting clevidipine to H324/78 is minimized, such that the total detectable level of H324/78 in a given composition sample does not exceed about 0.2% on a weight-by-weight basis, or the ratio of clevidipine to H324/78 is equal to or greater than about 450 to 1 on a weight-to-weight basis.
摘要翻译：描述了药物组合物和稳定具有氯维地平的药物组合物或其任何药学上可接受的盐作为活性成分的方法。该方法包括减缓或抑制氯维地平的氧化途径。这可以通过在制造和储存过程中减少药物组合物暴露于氧和/或光的量来实现。根据该方法，必须除去或更换氧气，或者必须充分阻挡光，使得光能不能达到组合物的活性成分，或者降低到光诱导的氧化反应将氯维地平转化为H324 / 78 被最小化，使得给定组合物样品中H324 / 78的总可检测水平以重量计不超过约0.2％，或者氯维地平与H324 / 78的比例等于或大于约450 至1，以重量为基准。

4. 发明申请

US20100105743A1 Pharmaceutical compositions and methods for stabilizing the same 审中-公开
标题翻译：药物组合物及其稳定方法
公开(公告)号：US20100105743A1
公开(公告)日：2010-04-29
申请号：US12462147
申请日：2009-07-30
申请人： Gopal Krishna , Rajeshwar Motheram , Min Ding
发明人： Gopal Krishna , Rajeshwar Motheram , Min Ding
IPC分类号： A61K31/44 , A61P9/12
CPC分类号： A61K31/519 , A61K9/0019 , A61K9/10 , A61K31/435 , A61K31/4418 , A61K2300/00
摘要： Pharmaceutical compositions, and a method of stabilizing pharmaceutical compositions having clevidipine, or any pharmaceutically acceptable salt thereof, as the active ingredient is described. The method includes the slowing down or inhibiting of the oxidation pathway of clevidipine. This can be accomplished by reducing the amount the pharmaceutical composition is exposed to oxygen and/or light during the manufacturing and storing processes. According to this method, oxygen must be removed or replaced, or light must be sufficiently blocked such that light energy cannot reach the active ingredient of the composition, or is reduced to a level that the light-induced oxidation reaction converting clevidipine to H324/78 is minimized, such that the total detectable level of H324/78 in a given composition sample does not exceed about 0.2% on a weight-by-weight basis, or the ratio of clevidipine to H324/78 is equal to or greater than about 450 to 1 on a weight-to-weight basis.
摘要翻译：描述了药物组合物和稳定具有氯维地平的药物组合物或其任何药学上可接受的盐作为活性成分的方法。该方法包括减缓或抑制氯维地平的氧化途径。这可以通过在制造和储存过程中减少药物组合物暴露于氧和/或光的量来实现。根据该方法，必须除去或更换氧气，或者必须充分阻挡光，使得光能不能达到组合物的活性成分，或者降低到光诱导的氧化反应将氯维地平转化为H324 / 78 被最小化，使得给定组合物样品中H324 / 78的总可检测水平以重量计不超过约0.2％，或者氯维地平与H324 / 78的比例等于或大于约450 至1，以重量为基准。

5. 发明申请

US20120149770A1 Antimicrobial Preservation of Propofol Emulsions 失效
标题翻译：丙泊酚乳液的抗菌保存
公开(公告)号：US20120149770A1
公开(公告)日：2012-06-14
申请号：US13252667
申请日：2011-10-04
申请人： Min Ding , Rajeshwar Motheram , Glenn Sblendorio
发明人： Min Ding , Rajeshwar Motheram , Glenn Sblendorio
IPC分类号： A61K31/235 , A61K31/05
CPC分类号： A61K9/0019 , A61K9/107 , A61K31/045 , A61K31/05 , A61K31/33
摘要： The invention provides intravenous formulations of propofol in an oil-in-water emulsion, having a combination of preservatives.
摘要翻译：本发明提供具有防腐剂组合的水包油乳剂中的异丙酚的静脉内制剂。

6. 发明授权

US08754125B2 Antimicrobial preservation of propofol emulsions 失效
标题翻译：异丙酚乳剂的抗微生物保存
公开(公告)号：US08754125B2
公开(公告)日：2014-06-17
申请号：US13252667
申请日：2011-10-04
申请人： Min Ding , Rajeshwar Motheram , Glenn Sblendorio
发明人： Min Ding , Rajeshwar Motheram , Glenn Sblendorio
IPC分类号： A61K31/235 , A61K31/05
CPC分类号： A61K9/0019 , A61K9/107 , A61K31/045 , A61K31/05 , A61K31/33
摘要： The invention provides intravenous formulations of propofol in an oil-in-water emulsion, having a combination of preservatives.
摘要翻译：本发明提供具有防腐剂组合的水包油乳剂中的异丙酚的静脉内制剂。

7. 发明授权

US08383094B2 Hepatitis C virus inhibitors 有权
公开(公告)号：US08383094B2
公开(公告)日：2013-02-26
申请号：US12569466
申请日：2009-09-29
申请人： Makonen Belema , Van N. Nguyen , Michael Serrano-Wu , Denis R. St. Laurent , Yuping Qiu , Min Ding , Nicholas A. Meanwell , Lawrence B. Snyder
发明人： Makonen Belema , Van N. Nguyen , Michael Serrano-Wu , Denis R. St. Laurent , Yuping Qiu , Min Ding , Nicholas A. Meanwell , Lawrence B. Snyder
IPC分类号： A61K38/20 , A61K38/21 , A61K38/47 , C07D413/04 , C07D217/00 , C07D215/00
CPC分类号： C07D207/16 , A61K31/401 , A61K31/4015 , A61K31/47 , A61K31/5377 , A61K31/70 , A61K31/7088 , C07C233/62 , C07D401/12 , C07D401/14 , C07D403/14 , C07D405/06 , C07D405/12 , C07D409/14 , C07D487/08
摘要： The present disclosure relates to compounds, compositions and methods for the treatment of hepatitis C virus (HCV) infection. Also disclosed are pharmaceutical compositions containing such compounds and methods for using these compounds in the treatment of HCV infection.

8. 发明申请

US20090280083A1 Compounds for the Treatment of Hepatitis C 有权
公开(公告)号：US20090280083A1
公开(公告)日：2009-11-12
申请号：US12434748
申请日：2009-05-04
申请人： Scott W. Martin , Carl P. Bergstrom , Min Ding , Xiaofan Zheng , Robert G. Gentles
发明人： Scott W. Martin , Carl P. Bergstrom , Min Ding , Xiaofan Zheng , Robert G. Gentles
IPC分类号： A61K31/55 , C07D405/14 , A61K38/20 , A61K38/21 , A61K38/13 , A61P31/14 , C07D417/14 , C07D405/04
CPC分类号： C07D487/04 , C07D471/08 , C07D487/08 , C07D498/08
摘要： The invention encompasses compounds of formula I as well as compositions and methods of using the compounds. The compounds have activity against hepatitis C virus (HCV) and are useful in treating those infected with HCV.

9. 发明申请

US20090162318A1 Cyclopropyl Fused Indolobenzazepine HCV NS5B Inhibitors 审中-公开
标题翻译：环丙基稠合吲哚扎嗪氮芥HCV NS5B抑制剂
公开(公告)号：US20090162318A1
公开(公告)日：2009-06-25
申请号：US12392620
申请日：2009-02-25
申请人： John A. Bender , Min Ding , Robert G. Gentles , Piyasena Hewawasam
发明人： John A. Bender , Min Ding , Robert G. Gentles , Piyasena Hewawasam
IPC分类号： A61K38/20 , A61K31/55 , A61K31/397 , A61P31/12 , A61K38/21
CPC分类号： C07D487/08 , A61K31/55 , A61K45/06 , C07D471/08 , C07D487/04 , C07D519/00
摘要： The invention encompasses compounds of formula I as well as compositions and methods of using the compounds. The compounds have activity against hepatitis C virus (HCV) and are useful in treating those infected with HCV.
摘要翻译：本发明包括式I化合物以及使用该化合物的组合物和方法。该化合物具有抗丙型肝炎病毒（HCV）的活性，可用于治疗HCV感染者。

10. 发明授权

US07547690B2 Compounds for the treatment of Hepatitis C 有权
标题翻译：用于治疗丙型肝炎的化合物
公开(公告)号：US07547690B2
公开(公告)日：2009-06-16
申请号：US12039239
申请日：2008-02-28
申请人： Robert G. Gentles , Xiaofan Zheng , Min Ding , Yong Tu , Ying Han , Piyasena Hewawasam , John F. Kadow , John A. Bender , Kap-Sun Yeung , Katharine A. Grant-Young , Thomas W. Hudyma
发明人： Robert G. Gentles , Xiaofan Zheng , Min Ding , Yong Tu , Ying Han , Piyasena Hewawasam , John F. Kadow , John A. Bender , Kap-Sun Yeung , Katharine A. Grant-Young , Thomas W. Hudyma
IPC分类号： A61P31/00 , A61K31/55 , C07D223/14
CPC分类号： C07D519/00 , C07D487/04
摘要： The invention encompasses compounds of formula I, including pharmaceutically acceptable salts, as well as compositions and methods of using these compounds. The compounds have activity against hepatitis C virus (HCV) and are useful in treating those infected with HCV.
摘要翻译：本发明包括式I化合物，包括药学上可接受的盐，以及使用这些化合物的组合物和方法。该化合物具有抗丙型肝炎病毒（HCV）的活性，可用于治疗HCV感染者。

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