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1. 发明申请

US20120322835A1 PHARMACEUTICAL COMPOSITIONS AND METHODS FOR PRODUCING LOW IMPURITY CONCENTRATIONS OF THE SAME 审中-公开
标题翻译：药物组合物及其生产低劣化浓度的方法
公开(公告)号：US20120322835A1
公开(公告)日：2012-12-20
申请号：US13600056
申请日：2012-08-30
申请人： Rajeshwar Motheram , Gopal Krishna , Min Ding , Keith Flood , Kornepati Ramakrishna
发明人： Rajeshwar Motheram , Gopal Krishna , Min Ding , Keith Flood , Kornepati Ramakrishna
IPC分类号： A61K31/4418 , C07D213/80 , G01N30/00 , A61P9/12
CPC分类号： A61K31/4422 , A61K31/519 , G01N30/02
摘要： A composition having clevidipine as an active ingredient is described. The composition includes clevidipine as an active ingredient and an amount of the impurity H168/79 that is no greater than about 1.5%, or where the ratio between clevidipine and H168/79 is equal or above 60 to 1.
摘要翻译：描述了具有氯维地平作为活性成分的组合物。组合物包括氯维西肽作为活性成分，杂质H168 / 79的量不大于约1.5％，或者氯维地平与H168 / 79之间的比例等于或大于60比1。

2. 发明申请

US20100113534A1 Pharmaceutical Compositions And Methods For Producing Low Impurity Concentrations Of The Same 审中-公开
标题翻译：用于生产低杂质浓度的药物组合物和方法
公开(公告)号：US20100113534A1
公开(公告)日：2010-05-06
申请号：US12511631
申请日：2009-07-29
申请人： Rajeshwar Motheram , Gopal Krishna , Min Ding , Keith Flood , Kornepati Ramakrishna
发明人： Rajeshwar Motheram , Gopal Krishna , Min Ding , Keith Flood , Kornepati Ramakrishna
IPC分类号： A61K31/4418 , G01N30/02
CPC分类号： A61K31/4422 , A61K31/519 , G01N30/02
摘要： A composition having clevidipine as an active ingredient is described. The composition includes clevidipine as an active ingredient and an amount of the impurity H168/79 that is no greater than about 1.5%, or where the ratio between clevidipine and H168/79 is equal or above 60 to 1.
摘要翻译：描述了具有氯维地平作为活性成分的组合物。组合物包括氯维西肽作为活性成分，杂质H168 / 79的量不大于约1.5％，或者氯维地平与H168 / 79之间的比例等于或大于60比1。

3. 发明申请

US20120322836A1 PHARMACEUTICAL COMPOSITIONS AND METHODS FOR STABILIZING THE SAME 审中-公开
标题翻译：药物组合物及其稳定化方法
公开(公告)号：US20120322836A1
公开(公告)日：2012-12-20
申请号：US13600083
申请日：2012-08-30
申请人： Gopal Krishna , Rajeshwar Motheram , Min Ding
发明人： Gopal Krishna , Rajeshwar Motheram , Min Ding
IPC分类号： A61K31/4418 , A61P9/12 , C07D213/80
CPC分类号： A61K31/519 , A61K9/0019 , A61K9/10 , A61K31/435 , A61K31/4418 , A61K2300/00
摘要： Pharmaceutical compositions, and a method of stabilizing pharmaceutical compositions having clevidipine, or any pharmaceutically acceptable salt thereof, as the active ingredient is described. The method includes the slowing down or inhibiting of the oxidation pathway of clevidipine. This can be accomplished by reducing the amount the pharmaceutical composition is exposed to oxygen and/or light during the manufacturing and storing processes. According to this method, oxygen must be removed or replaced, or light must be sufficiently blocked such that light energy cannot reach the active ingredient of the composition, or is reduced to a level that the light-induced oxidation reaction converting clevidipine to H324/78 is minimized, such that the total detectable level of H324/78 in a given composition sample does not exceed about 0.2% on a weight-by-weight basis, or the ratio of clevidipine to H324/78 is equal to or greater than about 450 to 1 on a weight-to-weight basis.
摘要翻译：描述了药物组合物和稳定具有氯维地平的药物组合物或其任何药学上可接受的盐作为活性成分的方法。该方法包括减缓或抑制氯维地平的氧化途径。这可以通过在制造和储存过程中减少药物组合物暴露于氧和/或光的量来实现。根据该方法，必须除去或更换氧气，或者必须充分阻挡光，使得光能不能达到组合物的活性成分，或者降低到光诱导的氧化反应将氯维地平转化为H324 / 78 被最小化，使得给定组合物样品中H324 / 78的总可检测水平以重量计不超过约0.2％，或者氯维地平与H324 / 78的比例等于或大于约450 至1，以重量为基准。

4. 发明申请

US20100105743A1 Pharmaceutical compositions and methods for stabilizing the same 审中-公开
标题翻译：药物组合物及其稳定方法
公开(公告)号：US20100105743A1
公开(公告)日：2010-04-29
申请号：US12462147
申请日：2009-07-30
申请人： Gopal Krishna , Rajeshwar Motheram , Min Ding
发明人： Gopal Krishna , Rajeshwar Motheram , Min Ding
IPC分类号： A61K31/44 , A61P9/12
CPC分类号： A61K31/519 , A61K9/0019 , A61K9/10 , A61K31/435 , A61K31/4418 , A61K2300/00
摘要： Pharmaceutical compositions, and a method of stabilizing pharmaceutical compositions having clevidipine, or any pharmaceutically acceptable salt thereof, as the active ingredient is described. The method includes the slowing down or inhibiting of the oxidation pathway of clevidipine. This can be accomplished by reducing the amount the pharmaceutical composition is exposed to oxygen and/or light during the manufacturing and storing processes. According to this method, oxygen must be removed or replaced, or light must be sufficiently blocked such that light energy cannot reach the active ingredient of the composition, or is reduced to a level that the light-induced oxidation reaction converting clevidipine to H324/78 is minimized, such that the total detectable level of H324/78 in a given composition sample does not exceed about 0.2% on a weight-by-weight basis, or the ratio of clevidipine to H324/78 is equal to or greater than about 450 to 1 on a weight-to-weight basis.
摘要翻译：描述了药物组合物和稳定具有氯维地平的药物组合物或其任何药学上可接受的盐作为活性成分的方法。该方法包括减缓或抑制氯维地平的氧化途径。这可以通过在制造和储存过程中减少药物组合物暴露于氧和/或光的量来实现。根据该方法，必须除去或更换氧气，或者必须充分阻挡光，使得光能不能达到组合物的活性成分，或者降低到光诱导的氧化反应将氯维地平转化为H324 / 78 被最小化，使得给定组合物样品中H324 / 78的总可检测水平以重量计不超过约0.2％，或者氯维地平与H324 / 78的比例等于或大于约450 至1，以重量为基准。

5. 发明授权

US07803762B1 Ready-to-use bivalirudin compositions 有权
公开(公告)号：US07803762B1
公开(公告)日：2010-09-28
申请号：US12545036
申请日：2009-08-20
申请人： Nagesh Palepu , Rajeshwar Motheram , Praful Shah , Gopal Krishna
发明人： Nagesh Palepu , Rajeshwar Motheram , Praful Shah , Gopal Krishna
IPC分类号： A61K38/00
CPC分类号： A61K38/58
摘要： Ready-to-use bivalirudin compositions, methods of using the ready-to-use bivalirudin compositions, and methods of preparing the ready-to-use bivalirudin compositions. The ready-to-use bivalirudin compositions comprise bivalirudin and one or more stabilizing agents. The one or more stabilizing agents may be buffering agents having a pKa of about 2.5 to about 6.5, pH-adjusting agents, polymers, preservatives, antioxidants, sugars or polyols, or a combination thereof. The ready-to-use bivalirudin compositions may also comprise [9-10]-cycloimido bivalirudin, [11-12]-cycloimido bivalirudin, or a combination thereof. The method of using the ready-to-use bivalirudin compositions comprises administering the ready-to-use compositions to a patient in need thereof. Further, the method of preparing the ready-to-use bivalirudin compositions comprises mixing bivalirudin with one or more stabilizing agents.

6. 发明授权

US07713928B1 Ready-to-use bivalirudin compositions 有权
标题翻译：即用型比伐卢定组合物
公开(公告)号：US07713928B1
公开(公告)日：2010-05-11
申请号：US12563821
申请日：2009-09-21
申请人： Nagesh Palepu , Rajeshwar Motheram , Praful Shah , Gopal Krishna
发明人： Nagesh Palepu , Rajeshwar Motheram , Praful Shah , Gopal Krishna
IPC分类号： A61K38/00
CPC分类号： A61K38/58
摘要： Ready-to-use bivalirudin compositions, methods of using the ready-to-use bivalirudin compositions, and methods of preparing the ready-to-use bivalirudin compositions. The ready-to-use bivalirudin compositions comprise bivalirudin and one or more stabilizing agents. The one or more stabilizing agents may be buffering agents having a pKa of about 2.5 to about 6.5, pH-adjusting agents, polymers, preservatives, antioxidants, sugars or polyols, or a combination thereof. The ready-to-use bivalirudin compositions may also comprise [9-10]-cycloimido bivalirudin, [11-12]-cycloimido bivalirudin, or a combination thereof. The method of using the ready-to-use bivalirudin compositions comprises administering the ready-to-use compositions to a patient in need thereof. Further, the method of preparing the ready-to-use bivalirudin compositions comprises mixing bivalirudin with one or more stabilizing agents.
摘要翻译：即用比伐卢定组合物，使用即用比伐卢定组合物的方法，以及制备即用型比伐卢定组合物的方法。即用型比伐卢列组合物包含比伐卢定和一种或多种稳定剂。一种或多种稳定剂可以是pKa为约2.5至约6.5的缓冲剂，pH调节剂，聚合物，防腐剂，抗氧化剂，糖或多元醇或其组合。即用型比伐卢定组合物还可以包含[9-10] - 环亚氨基比伐卢定，[11-12] - 环亚氨基比伐卢定或其组合。使用即用比伐卢定组合物的方法包括将即用组合物给予有需要的组合物。此外，制备即用型比伐卢定组合物的方法包括将比伐卢定与一种或多种稳定剂混合。

7. 发明授权

US07293113B1 Data communication system with hardware protocol parser and method therefor 有权
标题翻译：具有硬件协议解析器的数据通信系统及其方法
公开(公告)号：US07293113B1
公开(公告)日：2007-11-06
申请号：US10447824
申请日：2003-05-28
申请人： Gopal Krishna , Mrudula Kanuri
发明人： Gopal Krishna , Mrudula Kanuri
IPC分类号： G06F15/16 , G06F1/32
CPC分类号： H04L69/16 , H04L69/12 , H04L69/161 , H04L69/167 , H04L69/22
摘要： A communication processor comprises a data link layer parser circuit (310) and a plurality of network layer parser circuits (322, 326). The data link layer parser circuit (310) receives a data link layer frame, and removes a data link layer header therefrom to provide a network layer frame as an output. Each network layer parser circuit corresponds to a different network layer protocol, and is selectively activated to receive the network layer frame and to process a network layer header therefrom to provide a transport layer frame as an output. The data link layer parser circuit (310) further examines a portion of the network layer frame to determine which of the plurality of network protocols is used. The data link layer parser circuit (310) activates a corresponding one of the plurality of network layer parser circuits (322, 326) in response, while keeping another one of the plurality of network layer parser circuits (322, 326) inactive.
摘要翻译：通信处理器包括数据链路层解析器电路（310）和多个网络层解析器电路（322,326）。数据链路层解析器电路（310）接收数据链路层帧，并从其中去除数据链路层报头，以提供网络层帧作为输出。每个网络层解析器电路对应于不同的网络层协议，并且被选择性地激活以接收网络层帧并处理其中的网络层报头以提供传输层帧作为输出。数据链路层解析器电路（310）进一步检查网络层帧的一部分以确定使用多个网络协议中的哪一个。数据链路层解析器电路（310）响应于激活多个网络层解析器电路（322,326）中的对应的一个，同时保持多个网络层解析器电路（322,326）中的另一个不起作用。

8. 发明授权

US5873121A Efficient memory management system for minimizing overhead in storage of data transmitted in a network 失效
标题翻译：高效的存储器管理系统，用于最小化在网络中传输的数据的存储中的开销
公开(公告)号：US5873121A
公开(公告)日：1999-02-16
申请号：US753025
申请日：1996-11-19
申请人： Shashank Merchant , Alok Singh , Gopal Krishna
发明人： Shashank Merchant , Alok Singh , Gopal Krishna
IPC分类号： H04L12/56 , H04L29/06 , G06F12/02
CPC分类号： H04L29/06 , H04L49/90
摘要： The present invention provides a method and apparatus for storing additional information, such as HOLE information, within a buffer while minimizing the overhead.A method according to the present invention for efficiently storing additional information in a memory, the memory including at least one address, the memory for storing at least a portion of a packet to be transferred by a network system, the method comprising the steps of determining whether the at least a portion of a packet ends at a boundary of the at least one address; encoding a portion of the packet to indicate that the packet ends at the address boundary if the packet ends at the address boundary; and encoding a portion of the at least one address to indicate that the packet does not end at the address boundary, if the packet does not end at the address boundary.
摘要翻译：本发明提供了一种用于在缓冲器内存储附加信息（诸如HOLE信息）同时最小化开销的方法和装置。根据本发明的用于将附加信息有效地存储在存储器中的方法，所述存储器包括至少一个地址，所述存储器用于存储要由网络系统传送的分组的至少一部分，所述方法包括以下步骤：确定分组的至少一部分是否在所述至少一个地址的边界处结束; 编码分组的一部分以指示分组在地址边界处结束，如果分组在地址边界处结束; 以及编码所述至少一个地址的一部分以指示所述分组不在所述地址边界处结束，如果所述分组未在所述地址边界处结束。

9. 发明授权

US5784375A Rotating priority arrangement in an ethernet network 失效
标题翻译：在以太网网络中转移优先级排列
公开(公告)号：US5784375A
公开(公告)日：1998-07-21
申请号：US662333
申请日：1996-06-12
申请人： Mohan Kalkunte , Jayant Kadambi , Jim Mangin , Gopal Krishna
发明人： Mohan Kalkunte , Jayant Kadambi , Jim Mangin , Gopal Krishna
IPC分类号： H04L12/413
CPC分类号： H04L12/40163 , H04L12/413 , H04L12/40013 , H04L12/40136
摘要： Delay times are modified in Ethernet network devices by adding an integer multiple of a delay interval to the minimum interpacket gap (IPG) interval, and decrementing the integer in each network station in response to detected activity on the media. Each station has a unique integer value from the range of zero to the number of stations (N) minus one. The unique integer value ensures that each station has a different delay interval in accessing the media after sensing deassertion of the receive carrier. The station having a zero integer value will have its integer counter reset to (N-1) after a station transmits a data packet on the network, and the stations having nonzero integer values decrement their respective integer counters. Each network station also includes a deferral timer that counts the maximum delay interval of (N-1) delay intervals plus the minimum IPG value, and thus establishes a bounded access latency for a half-duplex shared network.
摘要翻译：通过将延迟间隔的整数倍添加到最小分组间隙（IPG）间隔，在以太网网络设备中修改延迟时间，并且响应于媒体上检测到的活动而递减每个网络站中的整数。每个站具有从零到站数（N）减一的唯一整数值。唯一的整数值确保每个站在感测到接收载波的取消消息之后在访问媒体时具有不同的延迟时间间隔。在站点在网络上发送数据包之后，具有零整数值的站将其整数计数器重置为（N-1），并且具有非零整数值的站减少其相应的整数计数器。每个网络站还包括延迟定时器，其计数（N-1）个延迟间隔的最大延迟间隔加上最小IPG值，从而建立半双工共享网络的有界访问等待时间。

10. 发明申请

US20060160823A1 Particulate-stabilized injectable pharmaceutical compositions of Posaconazole 审中-公开
标题翻译：泊沙康唑的颗粒稳定的可注射药物组合物
公开(公告)号：US20060160823A1
公开(公告)日：2006-07-20
申请号：US11300677
申请日：2005-12-14
申请人： Leonore Witchey-Lakshmanan , Sydney Ugwu , Varda Sandweiss , Catherine Hardalo , Roberta Hare , Gopal Krishna , Zaiqi Wang , Marco Taglietti
发明人： Leonore Witchey-Lakshmanan , Sydney Ugwu , Varda Sandweiss , Catherine Hardalo , Roberta Hare , Gopal Krishna , Zaiqi Wang , Marco Taglietti
IPC分类号： A61K31/496
CPC分类号： A61K31/496 , A61K9/0019 , A61K31/137 , A61K31/513 , A61K31/7048 , A61K45/06 , A61K47/24 , A61K47/26 , Y02A50/409 , Y02A50/414 , A61K2300/00
摘要： The present invention provides formulations useful for treating infections, in particular, formulations that include the active pharmaceutical ingredient Posaconazole in an injectable suspension of particles that is stable when subjected to terminal sterilization. Preferred median particle sizes of between 1.5 and 3.0 microns are found to result in superior pharmacokinetic characteristics, such as those displayed below.
摘要翻译：本发明提供了可用于治疗感染的制剂，特别是包含活性药物成分泊沙康唑在经受终末灭菌时稳定的颗粒的可注射悬浮液中的制剂。发现优选的中值粒度在1.5和3.0微米之间导致优异的药代动力学特征，例如下面显示的那些。

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