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1. 发明授权

US07653437B2 Method and apparatus for determining optimal pacing therapy timing intervals 有权
标题翻译：用于确定最佳起搏治疗定时间隔的方法和装置
公开(公告)号：US07653437B2
公开(公告)日：2010-01-26
申请号：US11344471
申请日：2006-01-31
申请人： Rajan Prakash , Edward Chinchoy , Thomas J. Mullen
发明人： Rajan Prakash , Edward Chinchoy , Thomas J. Mullen
IPC分类号： A61N1/368
CPC分类号： A61N1/3627 , A61N1/36542 , A61N1/368 , A61N1/3682
摘要： A method for determining an optimal pacing timing control parameter setting is provided for use in an implantable medical device programmed to deliver a pacing pulse in response to the timing control parameter. The method includes storing a user-selected optimization metric, iteratively adjusting the timing control parameter setting, sensing a first signal that varies in response to left ventricular wall acceleration, measuring the user-selected optimization metric in response to the sensed first signal, and determining an optimal timing control parameter value in response to the measured user-selected optimization metric.
摘要翻译：用于确定最佳起搏定时控制参数设置的方法被提供用于被编程为响应于定时控制参数递送起搏脉冲的可植入医疗设备。该方法包括存储用户选择的优化度量，迭代地调整定时控制参数设置，感测响应于左心室壁加速度而变化的第一信号，响应于感测的第一信号测量用户选择的优化度量，以及确定响应于所测量的用户选择的优化度量的最佳定时控制参数值。

2. 发明授权

US07869876B2 Method and apparatus for monitoring and optimizing atrial function 有权
标题翻译：监测和优化心房功能的方法和装置
公开(公告)号：US07869876B2
公开(公告)日：2011-01-11
申请号：US11245623
申请日：2005-10-07
申请人： Rajan Prakash , Edward Chinchoy , Thomas J. Mullen
发明人： Rajan Prakash , Edward Chinchoy , Thomas J. Mullen
IPC分类号： A61N1/368
CPC分类号： A61N1/368 , A61B5/0452 , A61B5/1107 , A61B2562/0219 , A61N1/3627 , A61N1/36542 , A61N1/3682
摘要： A method for use in an implantable medical device, comprising: sensing a signal corresponding to ventricular wall acceleration; and determining a metric of atrial function using the ventricular wall acceleration signal. The method includes sensing the ventricular wall acceleration signal during at least during a sensing window corresponding to a ventricular filling phase.
摘要翻译：一种用于可植入医疗装置的方法，包括：感测对应于心室壁加速度的信号; 并使用心室壁加速度信号确定心房功能的度量。该方法包括在至少在对应于心室填充阶段的感测窗口期间感测心室壁加速度信号。

3. 发明授权

US07672715B2 Method and apparatus for determining excitation-physiologic response delays 有权
标题翻译：用于确定激发 - 生理反应延迟的方法和装置
公开(公告)号：US07672715B2
公开(公告)日：2010-03-02
申请号：US11343753
申请日：2006-01-31
申请人： Rajan Prakash , Edward Chinchoy , Thomas J. Mullen
发明人： Rajan Prakash , Edward Chinchoy , Thomas J. Mullen
IPC分类号： A61B5/04
CPC分类号： A61N1/368 , A61N1/3627 , A61N1/36542 , A61N1/3682
摘要： An implantable medical device system and associated method are provided for measuring an excitation-physiological response delay. The method includes sensing a first signal responsive to electrical activity in a first cardiac chamber, sensing a second signal responsive to a physiologic response to the electrical activity in the first cardiac chamber; and determining an excitation-physiologic response delay in response to the first signal and the second signal.
摘要翻译：提供了一种用于测量激发 - 生理反应延迟的可植入医疗装置系统和相关方法。所述方法包括响应于第一心室中的电活动来感测第一信号，感测响应于对第一心室中的电活动的生理反应的第二信号; 以及响应于所述第一信号和所述第二信号确定激发 - 生理响应延迟。

4. 发明授权

US07715917B2 Method and apparatus for determining an efficacious atrioventricular delay interval 有权
标题翻译：用于确定有效房室延迟间隔的方法和装置
公开(公告)号：US07715917B2
公开(公告)日：2010-05-11
申请号：US11004543
申请日：2004-12-03
申请人： Edward Chinchoy , Nirav V. Sheth , Kathryn E. Hilpisch , Thomas J. Mullen , John E. Burnes
发明人： Edward Chinchoy , Nirav V. Sheth , Kathryn E. Hilpisch , Thomas J. Mullen , John E. Burnes
IPC分类号： A61N1/00
CPC分类号： A61N1/368 , A61N1/3627 , A61N1/3682 , A61N1/3684
摘要： Determining an optimal atrioventricular interval is of interest for proper delivery of cardiac resynchronization therapy. Although device optimization is gradually and more frequently being performed through a referral process with which the patient undergoes an echocardiographic optimization, the decision of whether to optimize or not is still generally reserved for the implanting physician. Recent abstracts have suggested a formulaic approach for setting A-V interval based on intrinsic electrical sensing, that may possess considerable appeal to clinicians versus a patient average nominal A-V setting of 100 ms. The present invention presents a methods of setting nominal device settings based on entering patient cardiac demographics to determine what A-V setting may be appropriate. The data is based on retrospective analysis of the MIRACLE trial to determine what major factors determined baseline A-V settings.
摘要翻译：确定最佳房室间隔对于正确递送心脏再同步治疗是有意义的。尽管通过与患者经历超声心动图优化的转诊过程逐渐且更频繁地进行装置优化，但仍然通常为植入医生保留是否优化的决定。最近的摘要提出了一种基于固有电学感测设置A-V间隔的公式化方法，这可能对临床医生具有相当大的吸引力，而患者平均标称A-V设置为100 ms。本发明提供了一种基于输入患者心脏人口统计学来设定标称装置设置以确定什么A-V设置可能适合的方法。数据基于MIRACLE试验的回顾性分析，以确定确定基线A-V设置的主要因素。

5. 发明申请

US20100023081A1 Comprehensive System for Detection of Coronary Syndrome, Cardiac Ischemia and Myocardial Infarction 审中-公开
标题翻译：冠状动脉综合征，心脏缺血和心肌梗死综合检测系统
公开(公告)号：US20100023081A1
公开(公告)日：2010-01-28
申请号：US12181247
申请日：2008-07-28
申请人： Sarah Anne Audet , James Kevin Carney , William J. Combs , Eduardo N. Warman , Edward Chinchoy , Thomas J. Mullen , Brian Bruce Lee , Qingshan (Sam) Ye
发明人： Sarah Anne Audet , James Kevin Carney , William J. Combs , Eduardo N. Warman , Edward Chinchoy , Thomas J. Mullen , Brian Bruce Lee , Qingshan (Sam) Ye
IPC分类号： A61N1/365
CPC分类号： A61B5/0452 , A61B5/0031 , A61B5/02028 , A61B5/02055 , A61B5/02405 , A61B5/08 , A61B5/11 , A61B5/14532 , A61B5/14539 , A61B5/7275 , A61B7/00 , A61N1/3627 , A61N1/36514
摘要： Heart-monitoring systems, apparatus, and methods adapted to detect CS, CI and/or MI. In one embodiment, a system comprising at least two first-tier sensors capable of measuring and converting into signals at least two aspects related to cardiac function, at least one second-tier sensor that is also a first-tier sensor, at least one signal processor capable of transmitting a first-tier and second-tier trigger signal when coronary syndrome, cardiac ischemia or myocardial infarction has been detected, at least one communication device capable of communicating, at least one control element adapted to produce a first-tier and second-tier trigger signal when at least one first-tier sensor exceeds its threshold signal level, to exclude the signal from the first-tier sensor that exceeded its threshold and lower at least one threshold of the at least one first-tier sensor is provided.
摘要翻译：适用于检测CS，CI和/或MI的心脏监测系统，装置和方法。在一个实施例中，一种系统包括至少两个第一层传感器，能够测量和转换成与心脏功能相关的至少两个方面的信号，至少一个第二层传感器，其也是第一层传感器，至少一个信号处理器能够在冠状动脉综合征，心脏缺血或心肌梗塞已经被检测时发送第一层和第二层触发信号，至少一个能够通信的通信设备，至少一个适于产生第一层和第二层的控制元件当至少一个第一层传感器超过其阈值信号电平时，将第一层传感器的信号排除超过其阈值并降低至少一个第一层传感器的至少一个阈值。

6. 发明申请

US20090024045A1 MECHANICAL FUNCTION MARKER CHANNEL FOR CARDIAC MONITORING AND THERAPY CONTROL 有权
标题翻译：机械功能标记通道用于心脏监测和治疗控制
公开(公告)号：US20090024045A1
公开(公告)日：2009-01-22
申请号：US11780140
申请日：2007-07-19
申请人： Rajan Prakash , Sameh Sowelam , Thomas J. Mullen
发明人： Rajan Prakash , Sameh Sowelam , Thomas J. Mullen
IPC分类号： A61B5/0432 , A61B5/00
CPC分类号： A61B5/0031 , A61B5/0215 , A61B5/042 , A61B5/11 , A61B5/14546 , A61B5/1455 , A61B5/7239 , A61N1/36514 , A61N1/36564 , A61N1/36578
摘要： The implantable medical device (IMD) system disclosed here utilizes one or more cardiac sensors that measure mechanical characteristics of the heart, such as left ventricular acceleration or right ventricular pressure. The raw sensor data is collected and processed by the IMD, which derives one or more mechanical event marker signals from features, traits, and characteristics of the sensor data waveforms. The mechanical event marker signals are wirelessly transmitted to an external monitor device for display.
摘要翻译：这里公开的可植入医疗装置（IMD）系统利用测量心脏的机械特征的一个或多个心脏传感器，例如左心室加速度或右心室压力。原始传感器数据由IMD收集和处理，IMD从特征，特征和传感器数据波形的特性中导出一个或多个机械事件标记信号。机械事件标记信号被无线传输到外部监视器装置进行显示。

7. 发明授权

US08340750B2 Mechanical function marker channel for cardiac monitoring and therapy control 有权
标题翻译：用于心脏监测和治疗控制的机械功能标记通道
公开(公告)号：US08340750B2
公开(公告)日：2012-12-25
申请号：US11780140
申请日：2007-07-19
申请人： Rajan Prakash , Sameh Sowelam , Thomas J. Mullen
发明人： Rajan Prakash , Sameh Sowelam , Thomas J. Mullen
IPC分类号： A61B5/00
CPC分类号： A61B5/0031 , A61B5/0215 , A61B5/042 , A61B5/11 , A61B5/14546 , A61B5/1455 , A61B5/7239 , A61N1/36514 , A61N1/36564 , A61N1/36578
摘要： The implantable medical device (IMD) system disclosed here utilizes one or more cardiac sensors that measure mechanical characteristics of the heart, such as left ventricular acceleration or right ventricular pressure. The raw sensor data is collected and processed by the IMD, which derives one or more mechanical event marker signals from features, traits, and characteristics of the sensor data waveforms. The mechanical event marker signals are wirelessly transmitted to an external monitor device for display.
摘要翻译：这里公开的可植入医疗装置（IMD）系统利用测量心脏的机械特征的一个或多个心脏传感器，例如左心室加速度或右心室压力。原始传感器数据由IMD收集和处理，IMD从特征，特征和传感器数据波形的特性中导出一个或多个机械事件标记信号。机械事件标记信号被无线传输到外部监视器装置进行显示。

8. 发明授权

US08876727B2 Phrenic nerve stimulation detection using heart sounds 有权
标题翻译：使用心脏声音进行膈神经刺激检测
公开(公告)号：US08876727B2
公开(公告)日：2014-11-04
申请号：US13474041
申请日：2012-05-17
申请人： Xusheng Zhang , Jeffrey M. Gillberg , Thomas J. Mullen , Paul J. DeGroot
发明人： Xusheng Zhang , Jeffrey M. Gillberg , Thomas J. Mullen , Paul J. DeGroot
IPC分类号： A61B5/04 , A61B5/08 , A61N1/36 , A61B7/04 , A61B5/00 , A61B7/00 , A61B5/0205 , A61N1/365 , A61B5/024
CPC分类号： A61N1/3611 , A61B5/0031 , A61B5/0205 , A61B5/024 , A61B5/0826 , A61B5/4029 , A61B5/7217 , A61B7/005 , A61B7/006 , A61B7/04 , A61N1/36114 , A61N1/36135 , A61N1/36535 , A61N1/36578
摘要： A method and system of detecting phrenic nerve stimulation in a patient that includes detecting an activation event, obtaining a heart sound signal of a patient from an implanted heart sound sensor, determining that an electrical stimulation has been applied to the patient, in response to detecting the activation event, monitoring a portion of the heart sound signal, the portion defined by a predetermined window after the application of the electrical stimulation, and determining whether phrenic nerve stimulation occurred based on the portion of the heart sound signal.
摘要翻译：一种检测患者膈神经刺激的方法和系统，包括检测激活事件，响应于检测，从植入的心音传感器获得患者的心音信号，确定电刺激已经施加到患者激活事件，监测心音信号的一部分，在施加电刺激之后由预定窗口定义的部分，以及基于心音信号的部分来确定是否发生膈神经刺激。

9. 发明申请

US20100198291A1 FUSION PACING INTERVAL DETERMINATION 有权
标题翻译： FUSION PACING INTERVAL确定
公开(公告)号：US20100198291A1
公开(公告)日：2010-08-05
申请号：US12363025
申请日：2009-01-30
申请人： Aleksandre T. Sambelashvili , Thomas J. Mullen , Berthold Stegemann
发明人： Aleksandre T. Sambelashvili , Thomas J. Mullen , Berthold Stegemann
IPC分类号： A61N1/365
CPC分类号： A61N1/3627 , A61N1/36514 , A61N1/3684 , A61N1/3688
摘要： Delivery of fusion pacing therapy to a later depolarizing ventricle (V2) of a heart of a patient may be timed based on the depolarization of the V2 during at least one prior cardiac cycle. In some examples, a V2 pacing pulse is delivered upon the expiration of a pacing interval that begins at detection of an atrial sense or pace event (AP/S). The pacing interval may be substantially equal to the duration of time between an AP/S and a V2 sensing event of at least one prior cardiac cycle decremented by an adjusted pre-excitation interval (PEI). In another example, the V2 pacing pulse is delivered at the expiration of a pacing interval that begins upon detection of a V2 sensing event of a prior cardiac cycle. The pacing interval may be substantially equal to a duration of time at least two subsequent V2 sensing events decremented by the adjusted PEI.
摘要翻译：将融合起搏治疗递送到患者心脏的后期去极化心室（V2）可以基于在至少一个在先的心动周期期间的V2的去极化来计时。在一些示例中，在起搏间隔期满后，在起搏时间间隔期间，起搏脉搏是在心房感觉或步速事件（AP / S）的检测开始时发送的。所述起搏间隔可以基本上等于在调整的预激励间隔（PEI）减小的至少一个先前心动周期的AP / S和V2感测事件之间的持续时间。在另一示例中，V2起搏脉冲在起搏间隔的期满时被递送，起搏间隔开始于检测到先前的心动周期的V2感测事件。起搏间隔可以基本上等于由调整后的PEI递减的至少两个后续V2感测事件的持续时间。

10. 发明授权

US07706879B2 Apparatus and methods for automatic determination of a fusion pacing pre-excitation interval 有权
标题翻译：用于自动确定融合起搏预激间隔的装置和方法
公开(公告)号：US07706879B2
公开(公告)日：2010-04-27
申请号：US11742230
申请日：2007-04-30
申请人： John E. Burnes , Thomas J. Mullen , Aleksandra T. Sambelashvili
发明人： John E. Burnes , Thomas J. Mullen , Aleksandra T. Sambelashvili
IPC分类号： A61N1/00
CPC分类号： A61N1/3627 , A61N1/36542 , A61N1/36585 , A61N1/3682 , A61N1/3684
摘要： Automated adjustment of a pre-excitation interval (PEI) used to deliver hemodynamically efficient fusion pacing therapy.
摘要翻译：用于提供血液动力学有效的融合起搏治疗的预激发间隔（PEI）的自动调整。

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