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1. 发明申请

US20090235746A1 Detecting And Measuring Live Pathogens Utilizing A Mass Detection Device 有权
标题翻译：利用质量检测装置检测和测量活体病原体
公开(公告)号：US20090235746A1
公开(公告)日：2009-09-24
申请号：US12361922
申请日：2009-01-29
申请人： Rajakkannu Mutharasan , Peter A. Nagy , Sen Xu
发明人： Rajakkannu Mutharasan , Peter A. Nagy , Sen Xu
IPC分类号： G01H13/00 , C12Q1/04 , G01N33/53
CPC分类号： G01N33/56911
摘要： Extremely minute amounts of live pathogens are rapidly detected using a piezoelectric cantilever sensor. A single pathogen is detectable in about 30 minutes. Pathogen-specific antibodies are immobilized on the sensor surface. The sensor is exposed to a medium that potentially contains the target pathogen. When target pathogens are contained in the medium, both dead and live pathogen cells bind to the immobilized antibody on the sensor surface. The attached target pathogen cells are exposed to a pathogen discriminator capable of discriminating between live cells and dead cells by increasing the mass of live cells. Example pathogens include Escherichia coli, Listeri monocytogene, and Salmonella enteritidis. Example antibodies include those that bind to the pathogenic bacteria designated as ATCC 43251, ATCC 700375, and ATCC 31194. Example pathogen discriminators include intracellular pH indicating molecules.
摘要翻译：使用压电悬臂传感器快速检测极微量的活病原体。在大约30分钟内可以检测到单个病原体。病原体特异性抗体固定在传感器表面上。传感器暴露于潜在含有目标病原体的介质中。当目标病原体包含在培养基中时，死亡和活的病原体细胞均与传感器表面上的固定化抗体结合。将附着的目标病原体细胞暴露于能够通过增加活细胞质量来区分活细胞和死细胞的病原体鉴别器。示例性病原体包括大肠杆菌，单核细胞增多性李斯特菌和肠炎沙门氏菌。示例性抗体包括结合命名为ATCC 43251，ATCC 700375和ATCC 31194的致病细菌的抗体。实例性病原体鉴别剂包括细胞内pH指示分子。

2. 发明授权

US08236508B2 Detecting and measuring live pathogens utilizing a mass detection device 有权
标题翻译：利用质量检测装置检测和测量活的病原体
公开(公告)号：US08236508B2
公开(公告)日：2012-08-07
申请号：US12361922
申请日：2009-01-29
申请人： Rajakkannu Mutharasan , Peter A. Nagy , Sen Xu
发明人： Rajakkannu Mutharasan , Peter A. Nagy , Sen Xu
IPC分类号： C12Q1/04 , G01N33/53
CPC分类号： G01N33/56911
摘要： Extremely minute amounts of live pathogens are rapidly detected using a piezoelectric cantilever sensor. A single pathogen is detectable in about 30 minutes. Pathogen-specific antibodies are immobilized on the sensor surface. The sensor is exposed to a medium that potentially contains the target pathogen. When target pathogens are contained in the medium, both dead and live pathogen cells bind to the immobilized antibody on the sensor surface. The attached target pathogen cells are exposed to a pathogen discriminator capable of discriminating between live cells and dead cells by increasing the mass of live cells. Example pathogens include Escherichia coli, Listeri monocytogene, and Salmonella enteritidis. Example antibodies include those that bind to the pathogenic bacteria designated as ATCC 43251, ATCC 700375, and ATCC 31194. Example pathogen discriminators include intracellular pH indicating molecules.
摘要翻译：使用压电悬臂传感器快速检测极微量的活病原体。在大约30分钟内可以检测到单个病原体。病原体特异性抗体固定在传感器表面上。传感器暴露于潜在含有目标病原体的介质中。当目标病原体包含在培养基中时，死亡和活的病原体细胞均与传感器表面上的固定化抗体结合。将附着的目标病原体细胞暴露于能够通过增加活细胞质量来区分活细胞和死细胞的病原体鉴别器。示例性病原体包括大肠杆菌，单核细胞增多性李斯特菌和肠炎沙门氏菌。示例性抗体包括结合命名为ATCC 43251，ATCC 700375和ATCC 31194的致病细菌的抗体。实例性病原体鉴别剂包括细胞内pH指示分子。

3. 发明申请

US20120094270A1 SELF-EXCITING, SELF-SENSING PIEZOELECTRIC CANTILEVER SENSOR FOR DETECTION OF AIRBORNE ANALYTES DIRECTLY IN AIR 失效
标题翻译：自动感应自感式压电式CANTILEVER传感器，用于空气直接检测空气分析仪
公开(公告)号：US20120094270A1
公开(公告)日：2012-04-19
申请号：US11747183
申请日：2007-05-10
申请人： Rajakkannu Mutharasan , David L. de Lesdernier , Gossett Augustus Campbell , David R. Maraldo , Peter A. Nagy
发明人： Rajakkannu Mutharasan , David L. de Lesdernier , Gossett Augustus Campbell , David R. Maraldo , Peter A. Nagy
IPC分类号： G01N21/75 , C12Q1/70 , C12M1/34 , C12Q1/04
CPC分类号： G01H11/08 , G01H13/00 , G01N29/022 , G01N29/036 , G01N33/54373 , G01N2291/0255 , G01N2291/0256 , G01N2291/0426 , G01N2291/0427 , G01N2333/32 , H01L41/1132
摘要： A method for detection of airborne biological agent using a piezoelectric cantilever sensor that includes a piezoelectric layer and a non-piezoelectric layer. A recognition entity is placed on one or both of the two layers. The antibody that recognizes and binds to the airborne species may be chemically immobilized on the cantilever sensor surface. In one embodiment, the cantilever sensor is attached to a base at only one end. In another embodiment, the sensor includes first and second bases and at least one of the piezoelectric layer and the non-piezoelectric layer is affixed to each of the first and second bases to form a piezoelectric cantilever beam sensor. In this embodiment, resonance is measured via stress on the piezoelectric layer and it has been demonstrated that such sensors are robust and exhibit excellent sensing characteristics in gaseous media with sufficient sensitivity to detect airborne species at relatively low concentrations.
摘要翻译：一种使用包括压电层和非压电层的压电悬臂传感器检测空气传播生物剂的方法。识别实体被放置在两个层中的一个或两个上。识别和结合空气传播物种的抗体可以化学固定在悬臂传感器表面上。在一个实施例中，悬臂传感器仅在一端附接到基座。在另一个实施例中，传感器包括第一和第二基底，并且压电层和非压电层中的至少一个固定到第一和第二基底中的每一个上以形成压电悬臂梁传感器。在该实施例中，通过压电层上的应力来测量共振，并且已经证明这种传感器是鲁棒的并且在气体介质中表现出优异的感测特性，具有足够的灵敏度以在相对低的浓度下检测空气传播物种。

4. 发明授权

US08171795B1 Self-exciting, self-sensing piezoelectric cantilever sensor for detection of airborne analytes directly in air 失效
标题翻译：自激式自感压电悬臂传感器，用于直接在空气中检测机载分析物
公开(公告)号：US08171795B1
公开(公告)日：2012-05-08
申请号：US11747183
申请日：2007-05-10
申请人： Rajakkannu Mutharasan , David L. deLesdernier , Gossett Augustus Campbell , David R. Maraldo , Peter A. Nagy
发明人： Rajakkannu Mutharasan , David L. deLesdernier , Gossett Augustus Campbell , David R. Maraldo , Peter A. Nagy
IPC分类号： G01H1/00
CPC分类号： G01H11/08 , G01H13/00 , G01N29/022 , G01N29/036 , G01N33/54373 , G01N2291/0255 , G01N2291/0256 , G01N2291/0426 , G01N2291/0427 , G01N2333/32 , H01L41/1132
摘要： A method for detection of airborne biological agent using a piezoelectric cantilever sensor that includes a piezoelectric layer and a non-piezoelectric layer. A recognition entity is placed on one or both of the two layers. The antibody that recognizes and binds to the airborne species may be chemically immobilized on the cantilever sensor surface. In one embodiment, the cantilever sensor is attached to a base at only one end. In another embodiment, the sensor includes first and second bases and at least one of the piezoelectric layer and the non-piezoelectric layer is affixed to each of the first and second bases to form a piezoelectric cantilever beam sensor. In this embodiment, resonance is measured via stress on the piezoelectric layer and it has been demonstrated that such sensors are robust and exhibit excellent sensing characteristics in gaseous media with sufficient sensitivity to detect airborne species at relatively low concentrations.
摘要翻译：一种使用包括压电层和非压电层的压电悬臂传感器检测空气传播生物剂的方法。识别实体被放置在两个层中的一个或两个上。识别和结合空气传播物种的抗体可以化学固定在悬臂传感器表面上。在一个实施例中，悬臂传感器仅在一端附接到基座。在另一个实施例中，传感器包括第一和第二基底，并且压电层和非压电层中的至少一个固定到第一和第二基底中的每一个上以形成压电悬臂梁传感器。在该实施例中，通过压电层上的应力来测量共振，并且已经证明这种传感器是鲁棒的并且在气体介质中表现出优异的感测特性，具有足够的灵敏度以在相对低的浓度下检测空气传播物种。

5. 发明授权

US08349611B2 Resonant sensors and methods of use thereof for the determination of analytes 失效
标题翻译：共振传感器及其用于确定分析物的方法
公开(公告)号：US08349611B2
公开(公告)日：2013-01-08
申请号：US12707254
申请日：2010-02-17
申请人： Jacob J. Loverich , Jeremy E. Frank , Peter A. Nagy
发明人： Jacob J. Loverich , Jeremy E. Frank , Peter A. Nagy
IPC分类号： G01N33/551
CPC分类号： G01N29/022 , G01N29/036 , G01N29/2437 , G01N2291/012 , G01N2291/0255 , G01N2291/0256 , G01N2291/0427 , Y10T436/143333 , Y10T436/255
摘要： Resonant sensors, preferably having floating bilayer symmetry, and their methods of use is determining the presence, amount or binding kinetics of an analyte of interest in a test sample are disclosed. The test sample may be a liquid or gas.
摘要翻译：公开了共振传感器，优选具有浮双层对称性及其使用方法是确定测试样品中感兴趣分析物的存在，量或结合动力学。测试样品可以是液体或气体。

6. 发明授权

US5941479A Vehicle having a ceramic radome affixed thereto by a complaint metallic "T"-flexure element 失效
标题翻译：车辆具有通过投诉金属“T”弹性元件固定在其上的陶瓷天线罩
公开(公告)号：US5941479A
公开(公告)日：1999-08-24
申请号：US121134
申请日：1998-07-22
申请人： Wayne L. Sunne , Peter A. Nagy , Edward B. Liguori
发明人： Wayne L. Sunne , Peter A. Nagy , Edward B. Liguori
IPC分类号： B64C1/36 , B64C1/00 , B64C1/38 , F42B10/46 , H01Q1/28 , H01Q1/42 , B64C1/10
CPC分类号： H01Q1/42 , H01Q1/28
摘要： A missile has a body with a substantially circular nose opening therein, and a ceramic radome sized to cover the nose opening. A compliant metallic circular "T"-flexure element is disposed structurally between the radome and the body and is integral with the body. A niobium-containing washer is disposed between the radome and the "T"-flexure element. The "T"-flexure element includes an elongated compliant arm region and a cross bar region positioned adjacent the radome such that the niobium-containing washer is situated between a lower margin surface of the radome and an upper side of the crossbar region. A first brazed butt joint is formed between the lower margin surface of the radome and an upper surface of the niobium-containing washer, while a second brazed butt joint is formed between a lower surface of the niobium-containing washer and the crossbar region of the "T"-flexure element. Two separate brazing materials are employed to be compatible with the respective materials (radome and niobium washer; niobium washer and "T"-flexure element), but have substantially the same brazing temperature to permit brazing the radome to the body in a single brazing operation.
摘要翻译：导弹具有其中具有大致圆形的鼻部开口的主体，以及尺寸适于覆盖鼻部开口的陶瓷天线罩。符合金属的圆形“T”弹簧元件结构地设置在天体罩和主体之间，并与身体成一体。含钕的洗涤器设置在天线罩和“T”型穿刺元件之间。 “T”弹簧元件包括细长的柔性臂区域和邻近天线罩定位的横杆区域，使得含铌垫圈位于天线罩的下边缘表面和横梁区域的上侧之间。第一钎焊对接接头形成在天线罩的下边缘表面和含铌垫圈的上表面之间，而第二钎焊对接接头形成在含铌垫圈的下表面和 “T”弹簧元件。使用两种单独的钎焊材料与各种材料（天线罩和铌垫圈;铌垫圈和“T” - 复合元件）相容，但是具有基本上相同的钎焊温度，以允许在单个钎焊操作中将天线罩钎焊到身体。

7. 发明申请

US20100207602A1 RESONANT SENSORS AND METHODS OF USE THEREOF FOR THE DETERMINATION OF ANALYTES 失效
标题翻译：共振传感器及其使用方法用于确定分析仪
公开(公告)号：US20100207602A1
公开(公告)日：2010-08-19
申请号：US12707254
申请日：2010-02-17
申请人： Jacob J. Loverich , Jeremy E. Frank , Peter A. Nagy
发明人： Jacob J. Loverich , Jeremy E. Frank , Peter A. Nagy
IPC分类号： G01R23/00
CPC分类号： G01N29/022 , G01N29/036 , G01N29/2437 , G01N2291/012 , G01N2291/0255 , G01N2291/0256 , G01N2291/0427 , Y10T436/143333 , Y10T436/255
摘要： Resonant sensors, preferably having floating bilayer symmetry, and their methods of use is determining the presence, amount or binding kinetics of an analyte of interest in a test sample are disclosed. The test sample may be a liquid or gas.
摘要翻译：公开了共振传感器，优选具有浮双层对称性及其使用方法是确定测试样品中感兴趣分析物的存在，量或结合动力学。测试样品可以是液体或气体。

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