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1. 发明授权

US08473063B2 Method and apparatus for event-triggered reinforcement of a favorable brain state 有权
公开(公告)号：US08473063B2
公开(公告)日：2013-06-25
申请号：US13090672
申请日：2011-04-20
申请人： Rahul Gupta , Gabriela C. Molnar , Dwight E. Nelson
发明人： Rahul Gupta , Gabriela C. Molnar , Dwight E. Nelson
IPC分类号： A61N1/36021
CPC分类号： A61N1/3606 , A61B5/4064 , A61B5/4082 , A61B5/4094 , A61B5/6868 , A61N1/0529 , A61N1/36025 , A61N1/36064 , A61N1/36067 , A61N1/36071 , A61N1/36082 , A61N1/36139 , A61N1/36167
摘要： Methods and apparatuses are disclosed for potentiating a favorable brain state that is associated with relief in symptoms of a brain condition. Techniques include monitoring one or more brain signals and detecting an episode of a favorable brain state based on the one or more brain signals, the favorable brain state associated with a decrease in one or more symptoms of a brain condition of the patient. Then, in response to the detection of the favorable brain state episode, electrical stimulation that potentiates the favorable brain state is delivered to the brain of the patient, the electrical stimulation delivered within a window of time opened for detection of each favorable brain state episode.

2. 发明申请

US20120071947A1 METHOD AND APPARATUS FOR EVENT-TRIGGERED REINFORCEMENT OF A FAVORABLE BRAIN STATE 有权
标题翻译：一种有利于大脑的事件触发加强的方法和装置
公开(公告)号：US20120071947A1
公开(公告)日：2012-03-22
申请号：US13090672
申请日：2011-04-20
申请人： Rahul Gupta , Gabriela C. Molnar , Dwight E. Nelson
发明人： Rahul Gupta , Gabriela C. Molnar , Dwight E. Nelson
IPC分类号： A61N1/05
CPC分类号： A61N1/3606 , A61B5/4064 , A61B5/4082 , A61B5/4094 , A61B5/6868 , A61N1/0529 , A61N1/36025 , A61N1/36064 , A61N1/36067 , A61N1/36071 , A61N1/36082 , A61N1/36139 , A61N1/36167
摘要： Methods and apparatuses are disclosed for potentiating a favorable brain state that is associated with relief in symptoms of a brain condition. Techniques include monitoring one or more brain signals and detecting an episode of a favorable brain state based on the one or more brain signals, the favorable brain state associated with a decrease in one or more symptoms of a brain condition of the patient. Then, in response to the detection of the favorable brain state episode, electrical stimulation that potentiates the favorable brain state is delivered to the brain of the patient, the electrical stimulation delivered within a window of time opened for detection of each favorable brain state episode.
摘要翻译：公开了用于增强与大脑状况症状缓解相关的有利的脑状态的方法和装置。技术包括基于一个或多个脑信号监测一个或多个脑信号和检测有利的脑状态的发作，所述脑信号与患者的脑部状况的一个或多个症状的减少有关的有利的脑状态。然后，响应于有利的脑状态发作的检测，将有利的脑状态的电刺激递送到患者的大脑，在打开每个有利的脑状态发作的时间窗口内递送电刺激。

3. 发明授权

US08892207B2 Electrical therapy for facilitating inter-area brain synchronization 有权
标题翻译：电疗法促进区域间大脑同步
公开(公告)号：US08892207B2
公开(公告)日：2014-11-18
申请号：US13446678
申请日：2012-04-13
申请人： Dwight E. Nelson , Rahul Gupta
发明人： Dwight E. Nelson , Rahul Gupta
IPC分类号： A61N1/00 , A61N1/36 , A61N1/05 , A61B5/0484 , A61B5/0476
CPC分类号： A61N1/0534 , A61B5/0476 , A61B5/0484 , A61N1/36082 , A61N1/36139 , A61N1/36185
摘要： Methods and apparatuses are described for monitoring synchronization of two or more brain areas and delivering an electrical therapy to the brain to facilitate synchronization of the two or more brain areas. The electrical therapy can be titrated to improve synchronization between the two or more areas of the brain based on the one or more signals, the synchronization between the two or more areas of the brain occurring in response to the patient being exposed to external sensory stimulus, wherein the electrical therapy does not independently cause activation of either of the two or more areas of the brain.
摘要翻译：描述了用于监测两个或更多个脑区域的同步并且向大脑递送电疗法以促进两个或更多个脑区域的同步的方法和装置。基于一个或多个信号可以滴定电疗法以改善大脑两个或更多个区域之间的同步，响应于患者暴露于外部感觉刺激而发生的大脑的两个或更多个区域之间的同步，其中所述电疗法不独立地引起脑的两个或更多个区域中的任一个的激活。

4. 发明申请

US20110196446A1 ELECTRICAL BRAIN STIMULATION IN GAMMA BAND 有权
标题翻译：伽马带电脑刺激
公开(公告)号：US20110196446A1
公开(公告)日：2011-08-11
申请号：US12701099
申请日：2010-02-05
申请人： Jianping Wu , Dwight E. Nelson , Rahul Gupta
发明人： Jianping Wu , Dwight E. Nelson , Rahul Gupta
IPC分类号： A61N1/05
CPC分类号： A61N1/36067 , A61B5/048 , A61N1/0534 , A61N1/36171
摘要： This disclosure describes techniques for delivering electrical stimulation to the brain of a patient at a frequency greater than a selected frequency. The techniques may reestablish gamma frequency band activity within the brain of a patient, and thus improve the patient's movements and cognitive states. In one example, the disclosure is directed to a method that includes selecting a frequency within a gamma frequency band and delivering electrical stimulation at a frequency greater than the selected frequency.
摘要翻译：本公开描述了以大于所选频率的频率向患者的大脑递送电刺激的技术。这些技术可能会重新建立患者脑内的伽马频带活动，从而改善患者的运动和认知状态。在一个示例中，本公开涉及一种方法，其包括选择伽马频带内的频率并以大于所选频率的频率递送电刺激。

5. 发明授权

US08868173B2 Method and apparatus for assessing neural activation 有权
标题翻译：用于评估神经激活的方法和装置
公开(公告)号：US08868173B2
公开(公告)日：2014-10-21
申请号：US13446459
申请日：2012-04-13
申请人： Dwight E. Nelson , Rahul Agarwal , Steven L. Jensen , Rahul Gupta
发明人： Dwight E. Nelson , Rahul Agarwal , Steven L. Jensen , Rahul Gupta
IPC分类号： A61B5/04 , A61B5/0476 , A61N1/36 , A61N1/372 , A61B5/0496 , A61M5/142 , A61N1/05
CPC分类号： A61N1/36139 , A61B5/0476 , A61B5/0496 , A61M5/14276 , A61M2005/14208 , A61N1/0534 , A61N1/36067 , A61N1/36132 , A61N1/36153 , A61N1/36171 , A61N1/36175 , A61N1/36185 , A61N1/37247
摘要： Various embodiments concern sensing a LFP signal from one or more electrodes, measuring the amplitude of the signals over a period of time, and calculating a plurality of variance values from the amplitude, wherein each of the variance values correspond to the variance of the amplitude for a different interval of time of the period of time with respect to the other variance values. Such embodiments may further include assessing the relative level of neural activation of an area of the brain based on the variance values, wherein the area of the brain is assessed to have a relatively higher level of neural activation when the variance is relatively higher and the area of the brain is assessed to have a relatively lower level of neural activation when the variance is relatively lower.
摘要翻译：各种实施例涉及感测来自一个或多个电极的LFP信号，在一段时间内测量信号的幅度，以及从幅度计算多个方差值，其中每个方差值对应于幅度的方差相对于其他方差值的时间段的不同时间间隔。这样的实施方案可以进一步包括基于方差值评估脑区域的神经激活的相对水平，其中当方差相对较高时评估脑的面积具有相对较高水平的神经激活，当方差相对较低时，脑的评估具有相对较低水平的神经激活。

6. 发明申请

US20120271374A1 ELECTRICAL THERAPY FOR FACILITATING INTER-AREA BRAIN SYNCHRONIZATION 有权
标题翻译：用于促进区域内大脑同步的电疗法
公开(公告)号：US20120271374A1
公开(公告)日：2012-10-25
申请号：US13446678
申请日：2012-04-13
申请人： Dwight E. Nelson , Rahul Gupta
发明人： Dwight E. Nelson , Rahul Gupta
IPC分类号： A61N1/36
CPC分类号： A61N1/0534 , A61B5/0476 , A61B5/0484 , A61N1/36082 , A61N1/36139 , A61N1/36185
摘要： Methods and apparatuses are described for monitoring synchronization of two or more brain areas and delivering an electrical therapy to the brain to facilitate synchronization of the two or more brain areas. The electrical therapy can be titrated to improve synchronization between the two or more areas of the brain based on the one or more signals, the synchronization between the two or more areas of the brain occurring in response to the patient being exposed to external sensory stimulus, wherein the electrical therapy does not independently cause activation of either of the two or more areas of the brain.
摘要翻译：描述了用于监测两个或更多个脑区域的同步并且向大脑递送电疗法以促进两个或更多个脑区域的同步的方法和装置。基于一个或多个信号可以滴定电疗法以改善大脑两个或更多个区域之间的同步，响应于患者暴露于外部感觉刺激而发生的大脑的两个或更多个区域之间的同步，其中所述电疗法不独立地引起脑的两个或更多个区域中的任一个的激活。

7. 发明授权

US08886323B2 Electrical brain stimulation in gamma band 有权
标题翻译： γ波段电脑刺激
公开(公告)号：US08886323B2
公开(公告)日：2014-11-11
申请号：US12701099
申请日：2010-02-05
申请人： Jianping Wu , Dwight E. Nelson , Rahul Gupta
发明人： Jianping Wu , Dwight E. Nelson , Rahul Gupta
IPC分类号： A61N1/05 , A61N1/36 , A61B5/048
CPC分类号： A61N1/36067 , A61B5/048 , A61N1/0534 , A61N1/36171
摘要： This disclosure describes techniques for delivering electrical stimulation to the brain of a patient at a frequency greater than a selected frequency. The techniques may reestablish gamma frequency band activity within the brain of a patient, and thus improve the patient's movements and cognitive states. In one example, the disclosure is directed to a method that includes selecting a frequency within a gamma frequency band and delivering electrical stimulation at a frequency greater than the selected frequency.
摘要翻译：本公开描述了以大于所选频率的频率向患者的大脑递送电刺激的技术。这些技术可能会重新建立患者脑内的伽马频带活动，从而改善患者的运动和认知状态。在一个示例中，本公开涉及一种方法，其包括选择伽马频带内的频率并以大于所选频率的频率递送电刺激。

8. 发明申请

US20120271189A1 METHOD AND APPARATUS FOR ASSESSING NEURAL ACTIVATION 有权
标题翻译：评估神经激活的方法和装置
公开(公告)号：US20120271189A1
公开(公告)日：2012-10-25
申请号：US13446459
申请日：2012-04-13
申请人： Dwight E. Nelson , Rahul Agarwal , Steven L. Jensen , Rahul Gupta
发明人： Dwight E. Nelson , Rahul Agarwal , Steven L. Jensen , Rahul Gupta
IPC分类号： A61B5/0476
CPC分类号： A61N1/36139 , A61B5/0476 , A61B5/0496 , A61M5/14276 , A61M2005/14208 , A61N1/0534 , A61N1/36067 , A61N1/36132 , A61N1/36153 , A61N1/36171 , A61N1/36175 , A61N1/36185 , A61N1/37247
摘要： Various embodiments concern sensing a LFP signal from one or more electrodes, measuring the amplitude of the signals over a period of time, and calculating a plurality of variance values from the amplitude, wherein each of the variance values correspond to the variance of the amplitude for a different interval of time of the period of time with respect to the other variance values. Such embodiments may further include assessing the relative level of neural activation of an area of the brain based on the variance values, wherein the area of the brain is assessed to have a relatively higher level of neural activation when the variance is relatively higher and the area of the brain is assessed to have a relatively lower level of neural activation when the variance is relatively lower.
摘要翻译：各种实施例涉及感测来自一个或多个电极的LFP信号，在一段时间内测量信号的幅度，以及从幅度计算多个方差值，其中每个方差值对应于幅度的方差相对于其他方差值的时间段的不同时间间隔。这样的实施方案可以进一步包括基于方差值来评估脑区域的神经激活的相对水平，其中当方差相对较高时评估脑的面积具有相对较高水平的神经激活，当方差相对较低时，脑的评估具有相对较低水平的神经激活。

9. 发明授权

US09089699B2 Adaptive stimulation for treating urgency or incontinence 有权
标题翻译：适应性刺激治疗紧急性或失禁
公开(公告)号：US09089699B2
公开(公告)日：2015-07-28
申请号：US13701690
申请日：2011-06-06
申请人： Xin Su , Dwight E. Nelson
发明人： Xin Su , Dwight E. Nelson
IPC分类号： A61N1/36
CPC分类号： A61N1/36007
摘要： In one example, a system includes a therapy module and a processor. The processor detects a voiding event of a patient and controls the therapy module to deliver electrical stimulation to the patient at a first intensity level for a period of time in response to the detection of the voiding event. Immediately following the period of time, the processor controls the therapy module to increase intensity of the electrical stimulation from the first intensity level to a second intensity level before a subsequent voiding event of the patient by at least controlling the therapy module to deliver stimulation to the patient at a plurality of intermediate intensity levels between the first and second intensity levels prior to delivering stimulation to the patient at the second intensity level following the detection of the voiding event.
摘要翻译：在一个示例中，系统包括治疗模块和处理器。处理器检测患者的排尿事件并且控制治疗模块响应于检测到排泄事件而以第一强度水平向患者递送电刺激持续一段时间。在该时间段之后，处理器立即控制治疗模块，以通过至少控制治疗模块将刺激递送给患者，从而将电刺激的强度从第一强度水平增加到第二强度水平，直到患者随后的排尿事件发生在检测到排尿事件之后，以第二强度水平向患者递送刺激之前，在第一和第二强度水平之间的多个中等强度水平的患者。

10. 发明授权

US08706233B2 Stimulation therapy including substantially simultaneous bilateral stimulation 有权
标题翻译：刺激疗法包括基本上同步的双侧刺激
公开(公告)号：US08706233B2
公开(公告)日：2014-04-22
申请号：US13358165
申请日：2012-01-25
申请人： Xin Su , Dwight E. Nelson
发明人： Xin Su , Dwight E. Nelson
IPC分类号： A61N1/08
CPC分类号： A61N1/36167 , A61N1/0551 , A61N1/36007 , A61N1/36107 , A61N1/36139 , A61N1/3615 , A61N1/36178 , A61N1/36185
摘要： In some examples, a medical device delivers a first electrical stimulation therapy to a patient, and, upon detecting a trigger event, delivers a second electrical stimulation therapy to the patient. In some examples, the first stimulation therapy includes unilateral stimulation or stimulation delivered to both lateral sides of the patient at different times at a stimulation intensity lower than, equal to, or greater than a threshold intensity level for the patient, or bilateral stimulation delivered substantially simultaneously to both lateral sides of the patient, where one lateral side of the patient receives stimulation at an intensity level that is lower than the threshold intensity level and the other lateral side receives stimulation at an intensity level that is greater than or equal to the threshold intensity level. The second stimulation therapy may include substantially simultaneous bilateral stimulation therapy at an intensity level that at or above the threshold intensity level.
摘要翻译：在一些示例中，医疗装置向患者递送第一电刺激疗法，并且在检测到触发事件时向患者传送第二电刺激疗法。在一些实例中，第一刺激疗法包括在刺激强度低于等于或高于患者的阈值强度水平的不同时间递送至患者的两侧的单侧刺激或刺激，或基本上递送的双侧刺激同时到患者的两个侧面，其中患者的一个侧面以低于阈值强度水平的强度水平接收刺激，另一个侧面以大于或等于阈值的强度水平接收刺激强度水平第二刺激疗法可以包括在等于或高于阈值强度水平的强度水平的基本上同时的双侧刺激治疗。

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