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1. 发明申请

US20120122940A1 POLYUNSATURATED FATTY ACIDS FOR THE TREATMENT OF DISEASES RELATED TO CARDIOVASCULAR, METABOLIC AND INFLAMMATORY DISEASE AREAS 有权
标题翻译：用于治疗与心血管，代谢和炎症疾病相关的疾病的多重脂肪酸
公开(公告)号：US20120122940A1
公开(公告)日：2012-05-17
申请号：US13319101
申请日：2010-05-07
申请人： Ragnar Hovland , Anne Kristin Holmeide , Tore Skjæret , Morten Brændvang
发明人： Ragnar Hovland , Anne Kristin Holmeide , Tore Skjæret , Morten Brændvang
IPC分类号： A61K31/19 , C07C69/734 , A61K31/22 , C07D263/26 , A61K31/421 , A61P29/00 , A61P1/00 , A61P9/10 , A61P3/10 , A61P7/00 , A61P3/06 , A61P3/04 , C07C51/42 , C07C67/48 , C07C57/03
CPC分类号： C07D263/26 , A61K31/19 , A61K31/22 , A61K31/421 , A61K45/06 , C07B2200/07 , C07C51/367 , C07C59/60 , C07C67/31 , C07C69/675 , C07C69/68 , C07C69/708
摘要： The present disclosure relates to lipid compounds of the general formula (I): R1-O—C(R2)(R3)-X (I) wherein R1 is a C10-C22 alkyl group, a C10-C22 alkenyl group having 1-6 double bonds, or a C10-C22 alkynyl group having 1-6 triple bonds; R2 and R3 are the same or different and may be chosen from different substituents; and X is a carboxylic acid or a derivative thereof, such as a carboxylic ester, a carboxylic anhydride, a phospholipid, triglyceride, or a carboxamide; or a pharmaceutically acceptable salt, solvate, solvate of such salt or a prodrug thereof. The present disclosure also relates to pharmaceutical compositions and lipid compositions comprising at least one compound according to the present disclosure, and to such compounds for use as medicaments or for use in therapy, in particular for the treatment of diseases related to the cardiovascular, metabolic, and inflammatory disease area.
摘要翻译：本发明涉及通式（I）的脂类化合物：R1-O-C（R2）（R3）-X（Ⅰ）其中R1是C10-C22烷基，C10-C22烯基具有1- 6个双键或具有1-6个三键的C10-C22炔基; R2和R3相同或不同，可以选自不同的取代基; X是羧酸或其衍生物，例如羧酸酯，羧酸酐，磷脂，甘油三酸酯或羧酰胺; 或其药学上可接受的盐，溶剂合物，这种盐的溶剂合物或其前药。本公开还涉及包含至少一种根据本公开的化合物的药物组合物和脂质组合物，以及用作药物或用于治疗的这类化合物，特别是用于治疗与心血管，代谢，和炎症性疾病区域。

2. 发明授权

US08735436B2 Polyunsaturated fatty acids for the treatment of diseases related to cardiovascular, metabolic and inflammatory disease areas 有权
标题翻译：用于治疗与心血管，代谢和炎症疾病相关的疾病的多不饱和脂肪酸
公开(公告)号：US08735436B2
公开(公告)日：2014-05-27
申请号：US13319101
申请日：2010-05-07
申请人： Ragnar Hovland , Anne Kristin Holmeide , Tore Skjæret , Morten Brændvang
发明人： Ragnar Hovland , Anne Kristin Holmeide , Tore Skjæret , Morten Brændvang
IPC分类号： C07D263/20 , A61K31/23 , A61K31/19 , A61K31/20 , C07C69/732 , C07C67/08 , C07C59/01
CPC分类号： C07D263/26 , A61K31/19 , A61K31/22 , A61K31/421 , A61K45/06 , C07B2200/07 , C07C51/367 , C07C59/60 , C07C67/31 , C07C69/675 , C07C69/68 , C07C69/708
摘要： The present disclosure relates to lipid compounds of the general formula (I): R1-O—C(R2)(R3)-X (I) wherein R1 is a C10-C22 alkyl group, a C10-C22 alkenyl group having 1-6 double bonds, or a C10-C22 alkynyl group having 1-6 triple bonds; R2 and R3 are the same or different and may be chosen from different substituents; and X is a carboxylic acid or a derivative thereof, such as a carboxylic ester, a carboxylic anhydride, a phospholipid, triglyceride, or a carboxamide; or a pharmaceutically acceptable salt, solvate, solvate of such salt or a prodrug thereof. The present disclosure also relates to pharmaceutical compositions and lipid compositions comprising at least one compound according to the present disclosure, and to such compounds for use as medicaments or for use in therapy, in particular for the treatment of diseases related to the cardiovascular, metabolic, and inflammatory disease area.
摘要翻译：本发明涉及通式（I）的脂类化合物：R1-O-C（R2）（R3）-X（Ⅰ）其中R1是C10-C22烷基，C10-C22烯基具有1- 6个双键或具有1-6个三键的C10-C22炔基; R2和R3相同或不同，可以选自不同的取代基; X是羧酸或其衍生物，例如羧酸酯，羧酸酐，磷脂，甘油三酸酯或羧酰胺; 或其药学上可接受的盐，溶剂合物，这种盐的溶剂合物或其前药。本公开还涉及包含至少一种根据本公开的化合物的药物组合物和脂质组合物，以及用作药物或用于治疗的这类化合物，特别是用于治疗与心血管，代谢，和炎症性疾病区域。

3. 发明申请

US20130345269A1 METHODS OF TREATMENT USING LIPID COMPOUNDS 有权
标题翻译：使用脂质化合物治疗方法
公开(公告)号：US20130345269A1
公开(公告)日：2013-12-26
申请号：US13883405
申请日：2011-11-03
申请人： Ragnar Hovland , Tore Skjæret , David Fraser
发明人： Ragnar Hovland , Tore Skjæret , David Fraser
IPC分类号： C07C69/734 , C07D263/26 , C07C59/60
CPC分类号： C07C69/734 , A61K31/19 , A61K31/355 , C07C59/60 , C07D263/26 , A61K2300/00
摘要： Methods are disclosed to treat or prevent at least one disease or condition in a subject in need thereof comprising administering a compound of Formula (I): or a pharmaceutically acceptable salt, or ester thereof, wherein R1 and R2 are independently chosen from a hydrogen atom or linear, branched, and/or cyclic C1-C6 alkyl groups, with the proviso that R1 and R2 are not both hydrogen or a pharmaceutically acceptable salt or ester thereof. Such diseases or conditions may relate to coronary heart disease (CHD), for example atherosclerosis; metabolic syndrome/insulin resistance; and/or a dyslipidemic condition such as hypertriglyceridemia (HTG), elevated LDL-cholesterol, elevated total-cholesterol, elevated Apo B and low HDL-cholesterol. The present disclosure further provides for a method of reducing atherosclerosis development. Pharmaceutical compositions comprising a compound of Formula (I) are also disclosed.
摘要翻译：公开了治疗或预防有需要的受试者中的至少一种疾病或病症的方法，包括施用式（I）化合物或其药学上可接受的盐或酯，其中R 1和R 2独立地选自氢原子或直链，支链和/或环状C 1 -C 6烷基，条件是R 1和R 2不同时为氢或其药学上可接受的盐或酯。这些疾病或病症可能涉及冠心病（CHD），例如动脉粥样硬化; 代谢综合征/胰岛素抵抗; 和/或血脂异常状况如高甘油三酯血症（HTG），升高的LDL-胆固醇，升高的总胆固醇，升高的Apo B和低HDL-胆固醇。本公开进一步提供了减少动脉粥样硬化发展的方法。还公开了包含式（I）化合物的药物组合物。

4. 发明授权

US09394228B2 Methods of treatment using lipid compounds 有权
标题翻译：使用脂质化合物治疗的方法
公开(公告)号：US09394228B2
公开(公告)日：2016-07-19
申请号：US13883405
申请日：2011-11-03
申请人： Ragnar Hovland , Tore Skjæret , David Fraser
发明人： Ragnar Hovland , Tore Skjæret , David Fraser
IPC分类号： C07C69/734 , C07D263/26 , C07C59/60 , A61K31/19 , A61K31/355
CPC分类号： C07C69/734 , A61K31/19 , A61K31/355 , C07C59/60 , C07D263/26 , A61K2300/00
摘要： Methods are disclosed to treat or prevent at least one disease or condition in a subject in need thereof comprising administering a compound of Formula (I): or a pharmaceutically acceptable salt, or ester thereof,wherein R1 and R2 are independently chosen from a hydrogen atom or linear, branched, and/or cyclic C1-C6 alkyl groups, with the proviso that R1 and R2 are not both hydrogen or a pharmaceutically acceptable salt or ester thereof. Such diseases or conditions may relate to coronary heart disease (CHD), for example atherosclerosis; metabolic syndrome/insulin resistance; and/or a dyslipidemic condition such as hypertriglyceridemia (HTG), elevated LDL-cholesterol, elevated total-cholesterol, elevated Apo B and low HDL-cholesterol.The present disclosure further provides for a method of reducing atherosclerosis development. Pharmaceutical compositions comprising a compound of Formula (I) are also disclosed.
摘要翻译：公开了治疗或预防有需要的受试者中的至少一种疾病或病症的方法，包括施用式（I）化合物或其药学上可接受的盐或酯，其中R 1和R 2独立地选自氢原子或直链，支链和/或环状C 1 -C 6烷基，条件是R 1和R 2不同时为氢或其药学上可接受的盐或酯。这些疾病或病症可能涉及冠心病（CHD），例如动脉粥样硬化; 代谢综合征/胰岛素抵抗; 和/或血脂异常状况如高甘油三酯血症（HTG），升高的LDL-胆固醇，升高的总胆固醇，升高的Apo B和低HDL-胆固醇。本公开进一步提供了减少动脉粥样硬化发展的方法。还公开了包含式（I）化合物的药物组合物。

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