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    • 1. 发明申请
    • METHODS OF TREATMENT USING LIPID COMPOUNDS
    • 使用脂质化合物治疗方法
    • US20130345269A1
    • 2013-12-26
    • US13883405
    • 2011-11-03
    • Ragnar HovlandTore SkjæretDavid Fraser
    • Ragnar HovlandTore SkjæretDavid Fraser
    • C07C69/734C07D263/26C07C59/60
    • C07C69/734A61K31/19A61K31/355C07C59/60C07D263/26A61K2300/00
    • Methods are disclosed to treat or prevent at least one disease or condition in a subject in need thereof comprising administering a compound of Formula (I): or a pharmaceutically acceptable salt, or ester thereof, wherein R1 and R2 are independently chosen from a hydrogen atom or linear, branched, and/or cyclic C1-C6 alkyl groups, with the proviso that R1 and R2 are not both hydrogen or a pharmaceutically acceptable salt or ester thereof. Such diseases or conditions may relate to coronary heart disease (CHD), for example atherosclerosis; metabolic syndrome/insulin resistance; and/or a dyslipidemic condition such as hypertriglyceridemia (HTG), elevated LDL-cholesterol, elevated total-cholesterol, elevated Apo B and low HDL-cholesterol. The present disclosure further provides for a method of reducing atherosclerosis development. Pharmaceutical compositions comprising a compound of Formula (I) are also disclosed.
    • 公开了治疗或预防有需要的受试者中的至少一种疾病或病症的方法,包括施用式(I)化合物或其药学上可接受的盐或酯,其中R 1和R 2独立地选自氢原子 或直链,支链和/或环状C 1 -C 6烷基,条件是R 1和R 2不同时为氢或其药学上可接受的盐或酯。 这些疾病或病症可能涉及冠心病(CHD),例如动脉粥样硬化; 代谢综合征/胰岛素抵抗; 和/或血脂异常状况如高甘油三酯血症(HTG),升高的LDL-胆固醇,升高的总胆固醇,升高的Apo B和低HDL-胆固醇。 本公开进一步提供了减少动脉粥样硬化发展的方法。 还公开了包含式(I)化合物的药物组合物。
    • 2. 发明授权
    • Methods of treatment using lipid compounds
    • 使用脂质化合物治疗的方法
    • US09394228B2
    • 2016-07-19
    • US13883405
    • 2011-11-03
    • Ragnar HovlandTore SkjæretDavid Fraser
    • Ragnar HovlandTore SkjæretDavid Fraser
    • C07C69/734C07D263/26C07C59/60A61K31/19A61K31/355
    • C07C69/734A61K31/19A61K31/355C07C59/60C07D263/26A61K2300/00
    • Methods are disclosed to treat or prevent at least one disease or condition in a subject in need thereof comprising administering a compound of Formula (I): or a pharmaceutically acceptable salt, or ester thereof,wherein R1 and R2 are independently chosen from a hydrogen atom or linear, branched, and/or cyclic C1-C6 alkyl groups, with the proviso that R1 and R2 are not both hydrogen or a pharmaceutically acceptable salt or ester thereof. Such diseases or conditions may relate to coronary heart disease (CHD), for example atherosclerosis; metabolic syndrome/insulin resistance; and/or a dyslipidemic condition such as hypertriglyceridemia (HTG), elevated LDL-cholesterol, elevated total-cholesterol, elevated Apo B and low HDL-cholesterol.The present disclosure further provides for a method of reducing atherosclerosis development. Pharmaceutical compositions comprising a compound of Formula (I) are also disclosed.
    • 公开了治疗或预防有需要的受试者中的至少一种疾病或病症的方法,包括施用式(I)化合物或其药学上可接受的盐或酯,其中R 1和R 2独立地选自氢原子 或直链,支链和/或环状C 1 -C 6烷基,条件是R 1和R 2不同时为氢或其药学上可接受的盐或酯。 这些疾病或病症可能涉及冠心病(CHD),例如动脉粥样硬化; 代谢综合征/胰岛素抵抗; 和/或血脂异常状况如高甘油三酯血症(HTG),升高的LDL-胆固醇,升高的总胆固醇,升高的Apo B和低HDL-胆固醇。 本公开进一步提供了减少动脉粥样硬化发展的方法。 还公开了包含式(I)化合物的药物组合物。
    • 3. 发明授权
    • Systems and methods for wireless network selection
    • 无线网络选择的系统和方法
    • US08554830B2
    • 2013-10-08
    • US12240920
    • 2008-09-29
    • Simon WynnDavid Fraser
    • Simon WynnDavid Fraser
    • G06F15/16G06F15/173
    • H04W12/06H04L63/0428H04L63/08H04W84/12
    • Systems and methods for selecting a wireless network are disclosed. In some embodiments, a method comprises receiving a first network device identifier for a first network device and a second network device identifier for a second network device, obtaining a first network profile comprising a first attribute, the first network profile based on the first network device identifier, obtaining a second network profile comprising a second attribute, the second network profile based on the second network device identifier, and selecting either the first network device identifier or the second network device identifier based on an attribute analysis of the first attribute and the second attribute.
    • 公开了用于选择无线网络的系统和方法。 在一些实施例中,一种方法包括:接收用于第一网络设备的第一网络设备标识符和用于第二网络设备的第二网络设备标识符,获得包括第一属性的第一网络配置文件,所述第一网络配置文件基于所述第一网络设备 标识符,获得包括第二属性的第二网络配置文件,基于第二网络设备标识符的第二网络配置文件,以及基于第一属性和第二网络设备标识符的属性分析来选择第一网络设备标识符或第二网络设备标识符 属性。
    • 4. 发明申请
    • Systems and Methods for Wireless Network Selection
    • 无线网络选择的系统与方法
    • US20090024550A1
    • 2009-01-22
    • US12240920
    • 2008-09-29
    • Simon WynnDavid Fraser
    • Simon WynnDavid Fraser
    • G06N5/02H04L9/32G06F7/06G06F15/16G06F17/30
    • H04W12/06H04L63/0428H04L63/08H04W84/12
    • Systems and methods for selecting a wireless network are disclosed. In some embodiments, a method comprises receiving a first network device identifier for a first network device and a second network device identifier for a second network device, obtaining a first network profile comprising a first attribute, the first network profile based on the first network device identifier, obtaining a second network profile comprising a second attribute, the second network profile based on the second network device identifier, and selecting either the first network device identifier or the second network device identifier based on an attribute analysis of the first attribute and the second attribute.
    • 公开了用于选择无线网络的系统和方法。 在一些实施例中,一种方法包括:接收用于第一网络设备的第一网络设备标识符和用于第二网络设备的第二网络设备标识符,获得包括第一属性的第一网络配置文件,所述第一网络配置文件基于所述第一网络设备 标识符,获得包括第二属性的第二网络配置文件,基于第二网络设备标识符的第二网络配置文件,以及基于第一属性和第二网络设备标识符的属性分析来选择第一网络设备标识符或第二网络设备标识符 属性。
    • 5. 发明申请
    • Front-Loading Rack for Displaying and First-In, First-Out Dispensing of Products
    • 用于显示和先进先出产品的前装货架
    • US20090020550A1
    • 2009-01-22
    • US11778726
    • 2007-07-17
    • Rick FincherDavid FraserGary Norton
    • Rick FincherDavid FraserGary Norton
    • A47F1/08
    • A47F1/12
    • A rack includes a loading chute into which products are loaded in a generally horizontal face-down orientation, and a dispensing chute defining a dispensing aperture at the front side of the rack. A cam is disposed at the rear end of the loading chute to tilt a product into an upright orientation and to position the upright product with the front face facing forward. The cam also slopes downwardly in a lateral direction so as to move the upright product onto the rear end of the dispensing ramp with the front face still facing forward. The product slides down the dispensing ramp and is stopped by a stop positioned adjacent the dispensing aperture. By virtue of the rack's design, facilitated by the specially designed cam, the upright product is positioned with its front face facing forward such that a consumer can view any indica thereon.
    • 产品包括加载斜槽,产品以大致水平的面朝下方向装载在该装载槽中,以及分配槽,其在机架的前侧限定分配孔。 凸轮设置在装载滑槽的后端,以将产品倾斜成垂直的方向,并且将正面朝向前方定位。 凸轮还在横向方向上向下倾斜,以将直立产品移动到分配斜面的后端,而前面仍面向前方。 产品沿着分配斜坡滑下,并通过邻近分配孔定位的止动件停止。 凭借由专门设计的凸轮促进的机架设计,直立产品的前表面朝前,使得消费者可以看到其上的任何烙印。
    • 7. 发明申请
    • Systems and Methods for Wireless Network Selection Based on Attributes Stored in a Network Database
    • 基于存储在网络数据库中的属性进行无线网络选择的系统和方法
    • US20090028082A1
    • 2009-01-29
    • US12240969
    • 2008-09-29
    • Simon WynnDavid Fraser
    • Simon WynnDavid Fraser
    • H04W48/18H04B7/00
    • H04W12/06H04L63/0428H04L63/08H04L63/12
    • Systems and methods for wireless network selection based on attributes stored in a network database are disclosed. In some embodiments, a method comprises receiving a network identifier associated with a wireless network, determining if a network profile associated with the network identifier is stored within a network profile database comprising a plurality of network profiles, and if the network profile associated with the network identifier is stored within the network profile database, retrieving the network profile, or if the network profile associated with the network identifier is not stored within the network profile database, initiating the network profile, obtaining an attribute associated with the network device identifier, and storing the attribute within the network profile.
    • 公开了基于存储在网络数据库中的属性进行无线网络选择的系统和方法。 在一些实施例中,一种方法包括接收与无线网络相关联的网络标识符,确定与所述网络标识符相关联的网络配置文件是否存储在包括多个网络配置文件的网络配置文件数据库内,以及如果与所述网络相关联的网络配置文件 标识符存储在网络配置文件数据库中,检索网络配置文件,或者如果与网络标识符相关联的网络配置文件没有存储在网络配置文件数据库内,启动网络配置文件,获取与网络设备标识符相关联的属性,并存储 网络配置文件中的属性。