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1. 发明申请

US20070278097A1 BIOSENSOR WITH LASER-SEALED CAPILLARY SPACE AND METHOD OF MAKING 有权
标题翻译：具有激光密封毛细管空间的生物传感器及其制造方法
公开(公告)号：US20070278097A1
公开(公告)日：2007-12-06
申请号：US11773057
申请日：2007-07-03
申请人： Raghbir Bhullar , Ali Razban
发明人： Raghbir Bhullar , Ali Razban
IPC分类号： C12M1/00 , B23K26/00
CPC分类号： B01L3/502715 , B01L3/502707 , B01L2200/027 , B01L2300/0645 , B01L2300/0825 , B01L2300/0887 , B01L2400/0406 , B23K26/24 , B23K2101/42 , B29C65/1606 , B29C65/1612 , B29C65/1635 , B29C65/1645 , B29C65/1664 , B29C65/1667 , B29C65/1677 , B29C65/1696 , B29C65/8253 , B29C66/1122 , B29C66/43 , B29C66/45 , B29C66/4722 , B29C66/53461 , B29C66/71 , B29C66/7352 , B29C66/73521 , B29C66/73921 , B29C66/7394 , B29C66/83413 , B29C66/83415 , B29C66/83417 , B29C66/932 , B29C66/93451 , B29C66/961 , B29C66/98 , B29C2035/0822 , B29C2035/0827 , B29C2035/0844 , B29K2067/00 , B29K2069/00 , B29K2995/0025 , B29K2995/0026 , B29K2995/0069 , B29L2031/756 , G01N27/3272 , G01N33/5438
摘要： A test strip or biosensor comprising a base substrate on which an electrode system is formed. One or more laminate layers overlie the base substrate to form a sample-receiving chamber in which a reagent is deposited. An opening is provided from the sample-receiving chamber to the exterior of the biosensor. The layers and the base substrate are laser welded to secure the biosensor. One of the layer and base substrate is light transmissive to allow laser welding at the interface therebetween. The biosensor may be formed from a series of continuous webs that are subsequently sliced to form individual biosensors.
摘要翻译：一种测试条或生物传感器，包括形成有电极系统的基底基板。一个或多个层压层覆盖在基底基底上以形成其中沉积试剂的样品接收室。从样品接收室向生物传感器的外部提供开口。激光焊接层和基底以固定生物传感器。层和基底中的一个是透光的，以允许在它们之间的界面处进行激光焊接。生物传感器可以由一系列连续的网形成，随后将其切片以形成单独的生物传感器。

2. 发明申请

US20060200981A1 Method of making a biosensor 审中-公开
标题翻译：制作生物传感器的方法
公开(公告)号：US20060200981A1
公开(公告)日：2006-09-14
申请号：US11416491
申请日：2006-05-01
申请人： Raghbir Bhullar , Eric Diebold , Brian Hill , Nigel Surridge , P. Walling
发明人： Raghbir Bhullar , Eric Diebold , Brian Hill , Nigel Surridge , P. Walling
IPC分类号： H05K3/02 , B23K26/00
CPC分类号： G01N33/5438 , C12Q1/001 , G01N27/3272 , H05K1/0393 , H05K3/027 , Y10T29/49007 , Y10T29/49117 , Y10T29/49155 , Y10T29/49156
摘要： A method of making a biosensor is provided. The biosensor includes an electrically conductive material on a base and electrode patterns formed on the base, the patterns having different feature sizes. The conductive material is partially removed from the base using broad field laser ablation so that less than 90% of the conductive material remains on the base and that the electrode pattern has an edge extending between two points. A standard deviation of the edge from a line extending between two points is less than about 6 μm
摘要翻译：提供制造生物传感器的方法。生物传感器包括在基底上的导电材料和形成在基底上的电极图案，图案具有不同的特征尺寸。使用宽场激光烧蚀部分地从基底去除导电材料，使得小于90％的导电材料保留在基底上，并且电极图案具有在两个点之间延伸的边缘。边缘与两点之间延伸的线的标准偏差小于约6um

3. 发明申请

US20050103624A1 Biosensor and method of making 审中-公开
标题翻译：生物传感器和制作方法
公开(公告)号：US20050103624A1
公开(公告)日：2005-05-19
申请号：US10871937
申请日：2004-06-18
申请人： Raghbir Bhullar , Eric Diebold , Brian Hill , Nigel Surridge , Paul Walling
发明人： Raghbir Bhullar , Eric Diebold , Brian Hill , Nigel Surridge , Paul Walling
IPC分类号： C12Q1/00 , G01N27/30 , G01N27/403 , G01N33/487 , G01N33/49 , G01N33/543 , H05K1/00 , H05K3/02 , G01N27/26
CPC分类号： C12Q1/001 , G01N27/3272 , G01N33/5438 , H05K1/0393 , H05K3/027 , Y10T29/49117 , Y10T29/49155 , Y10T29/49156
摘要： An electrochemical biosensor with electrode elements that possess smooth, high-quality edges. These smooth edges define gaps between electrodes, electrode traces and contact pads. Due to the remarkable edge smoothness achieved with the present invention, the gaps can be quite small, which provides marked advantages in terms of test accuracy, speed and the number of different functionalities that can be packed into a single biosensor. Further, the present invention provides a novel biosensor production method in which entire electrode patterns for the inventive biosensors can be formed all at one, in nanoseconds—without regard to the complexity of the electrode patterns or the amount of conductive material that must be ablated to form them.
摘要翻译：具有电极元件的电化学生物传感器具有光滑，高质量的边缘。这些光滑边缘限定电极，电极迹线和接触垫之间的间隙。由于本发明实现了显着的边缘平滑度，所以间隙可以相当小，这在测试精度，速度和可以包装到单个生物传感器中的不同功能的数量方面提供显着的优点。此外，本发明提供了一种新颖的生物传感器制造方法，其中可以以纳秒为单位形成本发明的生物传感器的整个电极图案，而不考虑电极图案的复杂性或必须烧蚀的导电材料的量形成它们

4. 发明申请

US20050023137A1 Biosensor with multiple electrical functionalities 有权
标题翻译：具有多种电气功能的生物传感器
公开(公告)号：US20050023137A1
公开(公告)日：2005-02-03
申请号：US10871843
申请日：2004-06-18
申请人： Raghbir Bhullar , Harvey Buck , Brian Hill , Paul Walling , Terry Beaty , David Burke , Eric Diebold
发明人： Raghbir Bhullar , Harvey Buck , Brian Hill , Paul Walling , Terry Beaty , David Burke , Eric Diebold
IPC分类号： B01L3/02 , C12Q1/00 , G01N1/00 , G01N27/00 , G01N27/30 , G01N33/487
CPC分类号： C12M1/00 , C12Q1/001 , G01N27/3272
摘要： A biosensor having multiple electrical functionalities located both within and outside of the measurement zone in which a fluid sample is interrogated. Incredibly small and complex electrical patterns with high quality edges provide electrical functionalities in the biosensor and also provide the electrical wiring for the various other electrical devices provided in the inventive biosensor. In addition to a measurement zone with multiple and various electrical functionalities, biosensors of the present invention may be provided with a user interface zone, a digital device zone and/or a power generation zone. The inventive biosensors offer improved ease of use and performance, and decrease the computational burden and associated cost of the instruments that read the biosensors by adding accurate yet cost-effective functionalities to the biosensors themselves.
摘要翻译：具有位于测量区域内和外部的多个电功能的生物传感器，其中询问流体样品。具有高质量边缘的难以置信的小且复杂的电气图案在生物传感器中提供电功能，并且还为本发明的生物传感器中提供的各种其它电气装置提供电线。除了具有多个和各种电功能的测量区域之外，本发明的生物传感器可以设置有用户界面区域，数字设备区域和/或发电区域。本发明的生物传感器提供了改进的易用性和性能，并且通过向生物传感器本身添加准确而成本有效的功能来降低读取生物传感器的仪器的计算负担和相关成本。

5. 发明授权

US08443516B2 Process for refurbishing cylinder rolls and bases for printing machines 失效
标题翻译：滚筒滚筒和印刷机底座的翻新工艺
公开(公告)号：US08443516B2
公开(公告)日：2013-05-21
申请号：US12839744
申请日：2010-07-20
申请人： Raghbir Bhullar , Nitin Padhye , David R. Campbell
发明人： Raghbir Bhullar , Nitin Padhye , David R. Campbell
IPC分类号： G03C5/00
CPC分类号： B41F13/11 , B41C1/18 , B41N1/20 , B41N3/003 , B41N7/005 , B41N2207/02 , B41N2207/04 , B41N2207/14 , Y10T29/49545 , Y10T29/4956 , Y10T29/49563
摘要： The present invention relates to a refurbished cylinder roller and a process for refurbishing cylinder rollers for use in printing machines. More particularly, the present invention also relates to a process for refurbishing metallic gravure cylinder rollers by replacing the worn outer plating layers with an extruded and thermally cured electrically conductive polymer material, and thereafter electroplating new outer plating layers thereon, the new plating layers including a new printing image formed therein. The present invention also relates to a refurbished gravure cylinder roller which includes a core member extending along an axial length, an image-carrying layer having a printing image formed therein and arranged circumferentially about the core member, and an electrically conductive intermediate polymer layer arranged between the core member and the image-carrying layer, where the intermediate polymer material has a conductivity selected to permit electro-plating of the image-carrying layer directly thereon.
摘要翻译：本发明涉及一种翻新的圆筒滚子和用于翻新用于印刷机的滚筒滚筒的方法。更具体地说，本发明还涉及一种通过用挤出和热固化的导电聚合物材料替换磨损的外镀层，然后在其上电镀新的外镀层来翻新金属凹版滚筒辊的方法，所述新镀层包括在其中形成新的印刷图像。本发明还涉及一种翻新的凹版滚筒辊，其包括沿轴向长度延伸的芯部件，具有形成在其中并且围绕芯部件周向布置的印刷图像的图像承载层，以及布置在核心部件和图像承载层，其中中间聚合物材料具有选择的电导率，以允许图像承载层直接在其上电镀。

6. 发明申请

US20050019212A1 Test strip with flared sample receiving chamber 有权
标题翻译：带有扩口样品接收室的测试条
公开(公告)号：US20050019212A1
公开(公告)日：2005-01-27
申请号：US10872027
申请日：2004-06-18
申请人： Raghbir Bhullar , Nigel Surridge , Tom Funke , Paul Walling , Randall Riggles
发明人： Raghbir Bhullar , Nigel Surridge , Tom Funke , Paul Walling , Randall Riggles
IPC分类号： G01N21/00
CPC分类号： G01N27/3272 , Y10T156/1052
摘要： A test strip with a sample receiving chamber having a novel flared portion that terminates in a sample receiving opening. The flared portion provides a reservoir from which sample fluid can be drawn into the capillary or sample receiving chamber. The wider opening provided by the present invention is easier to “target” with a sample fluid. In preferred embodiments, the hydrophilic reagent layer extends to the dosing end or side of the test strip and further promotes wicking of the sample into the sample receiving chamber and thus reduces dose hesitation. In other preferred embodiments, a tapered dosing end is provided on the test strip in combination with the flared portion, and this combination create a test strip that will draw sample fluid into the sample receiving chamber regardless of where along the dosing edge of the test strip the fluid sample makes contact.
摘要翻译：具有样品接收室的测试条具有终止于样品接收开口的新颖的扩口部分。扩口部分提供储存器，样品流体可从该储存器吸入毛细管或样品接收室。本发明提供的更宽的开口更容易用样品流体“目标”。在优选的实施方案中，亲水试剂层延伸到测试条的计量端或侧，并进一步促进样品的芯吸到样品接收室中，从而减少剂量犹豫。在其它优选实施例中，在测试条上与锥形部分结合地提供锥形剂量端，并且该组合产生测试条，其将样品流体吸入样品接收室，而不管沿着测试条的计量边缘的哪里流体样品接触。

7. 发明申请

US20060200982A1 Method of making a biosensor 有权
标题翻译：制作生物传感器的方法
公开(公告)号：US20060200982A1
公开(公告)日：2006-09-14
申请号：US11416497
申请日：2006-05-01
申请人： Raghbir Bhullar , Eric Diebold , Brian Hill , Nigel Surridge , P. Douglas Walling
发明人： Raghbir Bhullar , Eric Diebold , Brian Hill , Nigel Surridge , P. Douglas Walling
IPC分类号： H05K3/02 , B23K26/00
CPC分类号： G01N33/5438 , C12Q1/001 , G01N27/3272 , H05K1/0393 , H05K3/027 , Y10T29/49007 , Y10T29/49117 , Y10T29/49155 , Y10T29/49156
摘要： A method of making a biosensor is provided. The method includes providing an electrically conductive material on a base and partially removing the conductive material using laser ablation from the base so that less than 90% of the conductive material remains on the base and at least one electrode pattern is formed from the conductive material. The at least one electrode pattern has an edge extending between two points. A standard deviation of the edge from a line extending between two points is less than about 6 μm along the length of the edge.
摘要翻译：提供制造生物传感器的方法。该方法包括在基底上提供导电材料，并使用从基底的激光烧蚀部分地去除导电材料，使得小于90％的导电材料保留在基底上，并且由导电材料形成至少一个电极图案。所述至少一个电极图案具有在两点之间延伸的边缘。边缘与两点之间延伸的线的标准偏差沿着边缘的长度小于约6μm。

8. 发明申请

US20050136471A1 Biosensor 审中-公开
公开(公告)号：US20050136471A1
公开(公告)日：2005-06-23
申请号：US11050348
申请日：2005-02-03
申请人： Raghbir Bhullar , Brian Hill , John Austera
发明人： Raghbir Bhullar , Brian Hill , John Austera
IPC分类号： G01N27/403 , C12Q1/68 , C12M1/34
CPC分类号： G01N27/3272
摘要： A biosensor is provided in accordance with the present invention. The biosensor includes an electrode support substrate, electrodes positioned on the electrode support, each electrode including a meter-contact portion and a measurement portion, and a sensor support substrate. The sensor support substrate cooperates with the electrode support substrate to define channel in alignment with the measurement portion of the electrodes. Additionally, the sensor support substrate includes opposite ends and at least one window. The at least one window is spaced-apart from the ends and in alignment with the meter-contact portion of at least one of the electrodes.

9. 发明申请

US20110083570A1 PROCESS FOR REFURBISHING CYLINDER ROLLS AND BASES FOR PRINTING MACHINES 失效
标题翻译：翻新圆筒滚筒和打印机基座的工艺
公开(公告)号：US20110083570A1
公开(公告)日：2011-04-14
申请号：US12839744
申请日：2010-07-20
申请人： Raghbir Bhullar , Nitin Padhye , David R. Campbell
发明人： Raghbir Bhullar , Nitin Padhye , David R. Campbell
IPC分类号： B41F13/10 , B41C3/00
CPC分类号： B41F13/11 , B41C1/18 , B41N1/20 , B41N3/003 , B41N7/005 , B41N2207/02 , B41N2207/04 , B41N2207/14 , Y10T29/49545 , Y10T29/4956 , Y10T29/49563
摘要： The present invention relates to a refurbished cylinder roller and a process for refurbishing cylinder rollers for use in printing machines. More particularly, the present invention also relates to a process for refurbishing metallic gravure cylinder rollers by replacing the worn outer plating layers with an extruded and thermally cured electrically conductive polymer material, and thereafter electroplating new outer plating layers thereon, the new plating layers including a new printing image formed therein. The present invention also relates to a refurbished gravure cylinder roller which includes a core member extending along an axial length, an image-carrying layer having a printing image formed therein and arranged circumferentially about the core member, and an electrically conductive intermediate polymer layer arranged between the core member and the image-carrying layer, where the intermediate polymer material has a conductivity selected to permit electro-plating of the image-carrying layer directly thereon.
摘要翻译：本发明涉及一种翻新的圆筒滚子和用于翻新用于印刷机的滚筒滚筒的方法。更具体地说，本发明还涉及一种通过用挤出和热固化的导电聚合物材料替换磨损的外镀层，然后在其上电镀新的外镀层来翻新金属凹版滚筒辊的方法，所述新镀层包括在其中形成新的印刷图像。本发明还涉及一种翻新的凹版滚筒辊，其包括沿轴向长度延伸的芯部件，具有形成在其中并且围绕芯部件周向布置的印刷图像的图像承载层，以及布置在核心部件和图像承载层，其中中间聚合物材料具有选择的电导率，以允许图像承载层直接在其上电镀。

10. 发明申请

US20070264421A1 Method for Producing Multiple Layer Systems 审中-公开
标题翻译：多层系统的制作方法
公开(公告)号：US20070264421A1
公开(公告)日：2007-11-15
申请号：US10552681
申请日：2004-04-07
申请人： Dieter Meier , Raghbir Bhullar
发明人： Dieter Meier , Raghbir Bhullar
IPC分类号： B05D5/12
CPC分类号： H01L51/0016 , B23K26/40 , B23K2103/08 , B23K2103/10 , B23K2103/12 , B23K2103/172 , B23K2103/26 , B23K2103/42 , B23K2103/50 , C23C14/5813 , C23C14/5873 , C23C16/56 , H01L51/0002 , H01L51/001 , H01L51/0021
摘要： The invention relates to a method for producing multiple layer systems on a non-conductive substrate. According to said method, metallic layers and electrically non-conductive layers are alternately deposited respectively by means of PVD and PECVD and are modified in such a way that at least one layer can be optionally selectively structured. It was thus determined that selective structuring by means of laser energy is only possible by introducing sacrificial layers. In this way, for the first time, a miniaturisation of multiple layer systems can be achieved that is not possible with conventionally constructed multiple layer systems.
摘要翻译：本发明涉及一种用于在非导电衬底上制造多层系统的方法。根据所述方法，通过PVD和PECVD分别交替地沉积金属层和非导电层，并且可以任选地选择性地构造至少一层。因此，确定仅通过引入牺牲层才能通过激光能量进行选择性结构化。以这种方式，首次可以实现多层系统的小型化，这对于传统构造的多层系统是不可能的。

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