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1. 发明申请

US20120022162A1 Mixed Amino Acid/Mineral Compounds Having Improved Solubility 有权
标题翻译：具有改善溶解性的混合氨基酸/矿物化合物
公开(公告)号：US20120022162A1
公开(公告)日：2012-01-26
申请号：US13189893
申请日：2011-07-25
申请人： R. Charles Thompson , Clayton Ericson , Stephen Ashmead , Jonathan Bortz
发明人： R. Charles Thompson , Clayton Ericson , Stephen Ashmead , Jonathan Bortz
IPC分类号： A61K31/198 , A23L1/304 , A23L2/52 , A23L1/05 , C07F15/00 , C07F9/00 , C07F13/00 , C07F11/00 , C07F1/00 , C07F3/00 , A23L1/305 , C07C229/24
CPC分类号： A23L33/175 , A23L33/16 , A23L33/165 , A23V2002/00 , A23V2250/1592 , A23V2250/1628 , A23V2250/044 , A23V2250/061 , A23V2250/0622
摘要： Mixed amino acid/mineral compounds can include at least two amino acids bound to a central mineral atom. The combination of amino acids can be tailored to provide improved solubility, absorption, and/or bioavailability of the mineral. Optionally, organic acids can be bound to the mineral or combined with the chelate in order to further improve solubility, absorption, and/or bioavailability. Compositions including one or more mixed amino acid/mineral compounds can be included in therapeutic regimens for indications in which the mineral may treat and/or prevent a condition or symptom.
摘要翻译：混合的氨基酸/矿物化合物可包括与中心矿物原子结合的至少两个氨基酸。可以调整氨基酸的组合以提供矿物质的改善的溶解度，吸收和/或生物利用度。任选地，有机酸可以与矿物结合或与螯合物结合，以进一步改善溶解度，吸收和/或生物利用度。包括一种或多种混合氨基酸/矿物化合物的组合物可以包括在用于矿物可以治疗和/或预防病症或症状的适应症的治疗方案中。

2. 发明授权

US08425956B2 Mixed amino acid/mineral compounds having improved solubility 有权
标题翻译：具有改善溶解性的混合氨基酸/矿物化合物
公开(公告)号：US08425956B2
公开(公告)日：2013-04-23
申请号：US13189893
申请日：2011-07-25
申请人： R. Charles Thompson , Clayton Ericson , Stephen Ashmead , Jonathan Bortz
发明人： R. Charles Thompson , Clayton Ericson , Stephen Ashmead , Jonathan Bortz
IPC分类号： A23L1/305
CPC分类号： A23L33/175 , A23L33/16 , A23L33/165 , A23V2002/00 , A23V2250/1592 , A23V2250/1628 , A23V2250/044 , A23V2250/061 , A23V2250/0622
摘要： Mixed amino acid/mineral compounds can include at least two amino acids bound to a central mineral atom. The combination of amino acids can be tailored to provide improved solubility, absorption, and/or bioavailability of the mineral. Optionally, organic acids can be bound to the mineral or combined with the chelate in order to further improve solubility, absorption, and/or bioavailability. Compositions including one or more mixed amino acid/mineral compounds can be included in therapeutic regimens for indications in which the mineral may treat and/or prevent a condition or symptom.
摘要翻译：混合的氨基酸/矿物化合物可包括与中心矿物原子结合的至少两个氨基酸。可以调整氨基酸的组合以提供矿物质的改善的溶解度，吸收和/或生物利用度。任选地，有机酸可以与矿物结合或与螯合物结合，以进一步改善溶解度，吸收和/或生物利用度。包括一种或多种混合氨基酸/矿物化合物的组合物可以包括在用于矿物可以治疗和/或预防病症或症状的适应症的治疗方案中。

3. 发明授权

US08007846B2 Mixed amino acid/mineral compounds having improved solubility 有权
标题翻译：具有改善溶解性的混合氨基酸/矿物化合物
公开(公告)号：US08007846B2
公开(公告)日：2011-08-30
申请号：US11623476
申请日：2007-01-16
申请人： R. Charles Thompson , Clayton Ericson , Stephen Ashmead , Jonathan Bortz
发明人： R. Charles Thompson , Clayton Ericson , Stephen Ashmead , Jonathan Bortz
IPC分类号： A23L1/304
CPC分类号： A23L33/175 , A23L33/16 , A23L33/165 , A23V2002/00 , A23V2250/1592 , A23V2250/1628 , A23V2250/044 , A23V2250/061 , A23V2250/0622
摘要： Mixed amino acid/mineral compounds can include at least two amino acids bound to a central mineral atom. The combination of amino acids can be tailored to provide improved solubility, absorption, and/or bioavailability of the mineral. Optionally, organic acids can be bound to the mineral or combined with the chelate in order to further improve solubility, absorption, and/or bioavailability. Compositions including one or more mixed amino acid/mineral compounds can be included in therapeutic regimens for indications in which the mineral may treat and/or prevent a condition or symptom.
摘要翻译：混合的氨基酸/矿物化合物可包括与中心矿物原子结合的至少两个氨基酸。可以调整氨基酸的组合以提供矿物质的改善的溶解度，吸收和/或生物利用度。任选地，有机酸可以与矿物结合或与螯合物结合，以进一步改善溶解度，吸收和/或生物利用度。包括一种或多种混合氨基酸/矿物化合物的组合物可以包括在用于矿物可以治疗和/或预防病症或症状的适应症的治疗方案中。

4. 发明申请

US20070172551A1 MIXED AMINO ACID/MINERAL COMPOUNDS HAVING IMPROVED SOLUBILITY 有权
标题翻译：具有改善溶解性的混合氨基酸/矿物化合物
公开(公告)号：US20070172551A1
公开(公告)日：2007-07-26
申请号：US11623476
申请日：2007-01-16
申请人： R. Thompson , Clayton Ericson , Stephen Ashmead , Jonathan Bortz
发明人： R. Thompson , Clayton Ericson , Stephen Ashmead , Jonathan Bortz
IPC分类号： A23L1/30
CPC分类号： A23L33/175 , A23L33/16 , A23L33/165 , A23V2002/00 , A23V2250/1592 , A23V2250/1628 , A23V2250/044 , A23V2250/061 , A23V2250/0622
摘要： Mixed amino acid/mineral compounds can include at least two amino acids bound to a central mineral atom. The combination of amino acids can be tailored to provide improved solubility, absorption, and/or bioavailability of the mineral. Optionally, organic acids can be bound to the mineral or combined with the chelate in order to further improve solubility, absorption, and/or bioavailability. Compositions including one or more mixed amino acid/mineral compounds can be included in therapeutic regimens for indications in which the mineral may treat and/or prevent a condition or symptom.
摘要翻译：混合的氨基酸/矿物化合物可包括与中心矿物原子结合的至少两个氨基酸。可以调整氨基酸的组合以提供矿物质的改善的溶解度，吸收和/或生物利用度。任选地，有机酸可以与矿物结合或与螯合物结合，以进一步改善溶解度，吸收和/或生物利用度。包括一种或多种混合氨基酸/矿物化合物的组合物可以包括在用于矿物可以治疗和/或预防病症或症状的适应症的治疗方案中。

5. 发明申请

US20070049553A1 Amino Sugar Chelates 有权
标题翻译：氨基糖螯合物
公开(公告)号：US20070049553A1
公开(公告)日：2007-03-01
申请号：US11466701
申请日：2006-08-23
申请人： Clayton Ericson , DeWayne Ashmead , Stephen Ashmead , Amanda Rees
发明人： Clayton Ericson , DeWayne Ashmead , Stephen Ashmead , Amanda Rees
IPC分类号： A61K31/7008 , C07H5/04
CPC分类号： C07H5/04
摘要： The present invention includes amino sugar chelates and methods for preparing amino sugar chelates of the formula given below, where M is a metal; R2 and R3 are independently selected from H, OH and hydroxyl substituted C1-C8 alkyl; R4 is selected from H, CO2H, OH, and hydroxyl substituted C1-C8 alkyl; each R5 is independently selected from H, OH, and hydroxyl substituted C1-C8 alkyl; A is selected from CH and O; a is from 0-6; b is from 0-6; n is from 1 to 8. The amino sugar chelates may include matrix stabilizing salts. The compounds and compositions disclosed can be used as nutritional supplements to impart health benefits.
摘要翻译：本发明包括氨基糖螯合物和下式给出的氨基糖螯合物的方法，其中M是金属; R 2和R 3独立地选自H，OH和羟基取代的C 1 -C 8烷基; R 4选自H，CO 2 H，OH和羟基取代的C 1 -C 8烷基 ; 每个R 5独立地选自H，OH和羟基取代的C 1 -C 8烷基; A选自CH和O; a是0-6; b为0-6; n为1至8.氨基糖螯合物可包括基质稳定盐。所公开的化合物和组合物可用作营养补充剂以赋予健康益处。

6. 发明申请

US20080248583A1 Quantitative and Qualitative Chelation Measuring Methods and Materials 审中-公开
标题翻译：定量和定性螯合测量方法和材料
公开(公告)号：US20080248583A1
公开(公告)日：2008-10-09
申请号：US11575465
申请日：2005-09-16
申请人： Clayton Ericson , Stephen Ashmead
发明人： Clayton Ericson , Stephen Ashmead
IPC分类号： G01N23/00 , C07F1/08
CPC分类号： G01N21/78 , G01N21/25 , G01N21/6428 , G01N33/20 , G01N2021/7783 , G01N2021/7786
摘要： The present invention is directed to a method of assaying for the presence or absence of a metal-ligand chelate in a sample containing either a metal-ligand chelate or a free ligand. The method includes (a) reacting the sample with a luminophore to obtain either a metal-ligand-luminophore chelate and/or a ligand-luminophore adduct; (b) detecting the electromagnetic spectrum of the reaction product; (c) matching the electromagnetic spectrum of the reaction product with an electromagnetic spectrum metal-ligand chelate luminophore chelate or the electromagnetic spectrum of a ligandluminophore adduct; (d) correlating a match of the electromagnetic spectrum of the reaction product and the electromagnetic spectrum of the metalligand-luminophore chelate with the presence of a metal-ligand chelate, or correlating a match of the electromagnetic spectrum of the reaction product and the electromagnetic spectrum of the ligand-luminophore adduct with the absence of a metal-ligand chelate.
摘要翻译：本发明涉及在含有金属 - 配体螯合物或游离配体的样品中测定金属 - 配体螯合物的存在或不存在的方法。该方法包括（a）使样品与发光体反应以获得金属 - 配体 - 发光体螯合物和/或配体 - 发光体加合物; （b）检测反应产物的电磁光谱; （c）使反应产物的电磁光谱与电磁光谱金属 - 配体螯合发光体螯合物或配体荧光团加合物的电磁光谱匹配; （d）将反应产物的电磁光谱与金属配偶 - 发光体螯合物的电磁光谱与金属 - 配体螯合物的存在相关联，或将反应产物的电磁光谱与电磁光谱的匹配相关联的配体 - 发光体加合物与不存在金属 - 配体螯合物。

7. 发明授权

US07776842B2 Amino sugar chelates 有权
标题翻译：氨基糖螯合物
公开(公告)号：US07776842B2
公开(公告)日：2010-08-17
申请号：US11466701
申请日：2006-08-23
申请人： Clayton Ericson , DeWayne Ashmead , Stephen D. Ashmead , Amanda Rees
发明人： Clayton Ericson , DeWayne Ashmead , Stephen D. Ashmead , Amanda Rees
IPC分类号： A61K31/7008 , A61K31/7012 , A61K31/70 , A61K31/715
CPC分类号： C07H5/04
摘要： The present invention includes amino sugar chelates and methods for preparing amino sugar chelates of the formula given below, where M is a metal; R2 and R3 are independently selected from H, OH and hydroxyl substituted C1-C8 alkyl; R4 is selected from H, CO2H, OH, and hydroxyl substituted C1-C8 alkyl; each R5 is independently selected from H, OH, and hydroxyl substituted C1-C8 alkyl; A is selected from CH and O; a is from 0-6; b is from 0-6; n is from 1 to 8. The amino sugar chelates may include matrix stabilizing salts. The compounds and compositions disclosed can be used as nutritional supplements to impart health benefits.
摘要翻译：本发明包括氨基糖螯合物和下式给出的氨基糖螯合物的方法，其中M是金属; R2和R3独立地选自H，OH和羟基取代的C1-C8烷基; R 4选自H，CO 2 H，OH和羟基取代的C 1 -C 8烷基; 每个R 5独立地选自H，OH和羟基取代的C 1 -C 8烷基; A选自CH和O; a是0-6; b为0-6; n为1至8.氨基糖螯合物可包括基质稳定盐。所公开的化合物和组合物可用作营养补充剂以赋予健康益处。

8. 发明授权

US06710079B1 Composition and method for preparing amino acid chelates and complexes free of interfering complex ions 有权
标题翻译：制备氨基酸螯合物和没有干扰复合离子的配合物的组成和方法
公开(公告)号：US06710079B1
公开(公告)日：2004-03-23
申请号：US09686683
申请日：2000-10-11
申请人： H. DeWayne Ashmead , Stephen D. Ashmead , David C. Wheelwright , Clayton Ericson , Mark Pedersen
发明人： H. DeWayne Ashmead , Stephen D. Ashmead , David C. Wheelwright , Clayton Ericson , Mark Pedersen
IPC分类号： A61K3128
CPC分类号： C07D233/64 , C07C227/16 , C07C319/20 , C07C323/58 , C07C229/76
摘要： A composition and method of preparing amino acid chelates and complexes free of interfering ions by blending an amino acid ligand, a calcium oxide and/or hydroxide, and a hydrated metal sulfate salt, placing the blend in a closed environment, heating the blend, and allowing the blend to react is disclosed and described. By heating at low to moderate temperatures in an enclosed environment, the waters of hydration of the metal salt are retained in the enclosed environment and serve to provide the moisture necessary to enable a bonding reaction to take place between the electron rich functional groups of the ligand and the metal ion of the hydrated metal sulfate salt. Additionally, calcium sulfate is formed which can be maintained in the final product.
摘要翻译：通过混合氨基酸配体，氧化钙和/或氢氧化物和水合金属硫酸盐制备不含干扰离子的氨基酸螯合物和配合物的组合物和方法，将共混物置于封闭环境中，加热共混物，和公开和描述允许共混物反应的方法。通过在封闭的环境中在低至中等温度下加热，金属盐的水合水被保留在封闭的环境中，并用于提供所需的水分，使配位反应发生在配体的富含电子的官能团之间和水合金属硫酸盐的金属离子。此外，形成硫酸钙，其可以保持在最终产品中。

9. 发明授权

US07144737B2 Process for determining the percent of chelation in a dry mixture 有权
公开(公告)号：US07144737B2
公开(公告)日：2006-12-05
申请号：US10245826
申请日：2002-09-17
申请人： Jennifer Hartle , Clayton Ericson , Stephen D. Ashmead
发明人： Jennifer Hartle , Clayton Ericson , Stephen D. Ashmead
IPC分类号： G01N33/00
CPC分类号： G01N21/3563 , G01N2021/3595 , Y10T436/24
摘要： A method for determining the amount of metal amino acid chelate present in various chelate compositions. FT-IR is used to determine the amount of free amino acid present. The bound amino acids may be in the form of an amino acid complex or an amino acid chelate. A total metal analysis and measurement of ligand quantity is then performed, from which the percent of metal amino acid chelate in the sample is calculated.

10. 发明授权

US06458981B1 Composition and method for preparing amino acid chelate hydroxides free of interfering ions 有权
标题翻译：制备不含干扰离子的氨基酸螯合氢氧化物的组成和方法
公开(公告)号：US06458981B1
公开(公告)日：2002-10-01
申请号：US09686046
申请日：2000-10-11
申请人： Stephen D. Ashmead , David C. Wheelwright , Clayton Ericson , Mark Pedersen
发明人： Stephen D. Ashmead , David C. Wheelwright , Clayton Ericson , Mark Pedersen
IPC分类号： C07F300
CPC分类号： C07C227/16 , C07C229/76
摘要： The present invention relates to compositions and methods of preparing amino acid chelates that are essentially free of interfering ions. The composition is prepared by reacting in an aqueous solution, a calcium oxide and/or hydroxide, an amino acid, and a soluble metal sulfate salt at a ratio sufficient to allow substantially all of the ions present in solution to react forming a positively charged metal amino acid chelate having a hydroxide counter-ion, and calcium sulfate, and wherein the metal amino acid chelate has a ligand to metal molar ratio from 1:1 to 2:1.
摘要翻译：本发明涉及制备基本上不含干扰离子的氨基酸螯合物的组合物和方法。该组合物通过使水溶液，氧化钙和/或氢氧化物，氨基酸和可溶性金属硫酸盐以足以使溶液中存在的基本上所有离子反应形成带正电荷的金属的比例反应来制备具有氢氧化物抗衡离子的氨基酸螯合物和硫酸钙，其中金属氨基酸螯合物的配体与金属的摩尔比为1:1至2:1。

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