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1. 发明申请

US20050159452A1 Nociceptin analogs 失效
标题翻译：伤害感受类似物
公开(公告)号：US20050159452A1
公开(公告)日：2005-07-21
申请号：US11032955
申请日：2005-01-11
申请人： Qun Sun , R. Goehring , Donald Kyle , Zhengming Chen , Sam Victory , John Whitehead
发明人： Qun Sun , R. Goehring , Donald Kyle , Zhengming Chen , Sam Victory , John Whitehead
IPC分类号： A61K31/415 , A61K31/4184 , A61K31/44 , A61K31/445 , A61K31/454 , A61K31/48 , A61P3/04 , A61P7/10 , A61P9/00 , A61P9/12 , A61P11/06 , A61P11/10 , A61P11/14 , A61P13/02 , A61P21/02 , A61P23/00 , A61P25/00 , A61P25/02 , A61P25/04 , A61P25/08 , A61P25/14 , A61P25/22 , A61P25/28 , A61P25/32 , A61P25/36 , A61P27/16 , A61P29/00 , A61P43/00 , C07D209/34 , C07D211/04 , C07D211/06 , C07D235/24 , C07D235/26 , C07D263/58 , C07D401/04 , C07D401/06 , C07D403/04 , C07D403/06 , C07D405/14 , C07D413/04 , C07D413/14 , C07D471/04
CPC分类号： C07D401/04 , C07D235/26 , C07D263/58 , C07D405/14 , C07D413/04 , C07D413/14 , C07D471/04
摘要： A compound of the formula (I), (II), (III) or (IV) wherein Z, A, B, C, R, R1, R2, Q, and n are as described herein.
摘要翻译：式（I），（II），（III）或（IV）的化合物，其中Z，A，B，C，R，R 1，R 2，，Q和n如本文所述。

2. 发明授权

US08252815B2 Nociceptin analogs 有权
标题翻译：伤害感受类似物
公开(公告)号：US08252815B2
公开(公告)日：2012-08-28
申请号：US13051629
申请日：2011-03-18
申请人： Qun Sun , R. Richard Goehring , Donald Kyle , Zhengming Chen , Sam Victory , John Whitehead
发明人： Qun Sun , R. Richard Goehring , Donald Kyle , Zhengming Chen , Sam Victory , John Whitehead
IPC分类号： A61K31/435 , C07D401/00
CPC分类号： C07D401/04 , C07D235/26 , C07D263/58 , C07D405/14 , C07D413/04 , C07D413/14 , C07D471/04
摘要： A compound of the formula (I), (II), (III) or (IV) wherein Z, A, B, C, R, R1, R2, Q, and n are as described herein.
摘要翻译：其中Z，A，B，C，R，R 1，R 2，Q和n如本文所述的式（I），（II），（III）或（IV）

3. 发明授权

US06867222B2 Nociceptin analogs 有权
标题翻译：伤害感受类似物
公开(公告)号：US06867222B2
公开(公告)日：2005-03-15
申请号：US10126471
申请日：2002-04-18
申请人： Qun Sun , R. Richard Goehring , Donald Kyle , Zhengming Chen , Sam Victory , John Whitehead
发明人： Qun Sun , R. Richard Goehring , Donald Kyle , Zhengming Chen , Sam Victory , John Whitehead
IPC分类号： A61K31/415 , A61K31/4184 , A61K31/44 , A61K31/445 , A61K31/454 , A61K31/48 , A61P3/04 , A61P7/10 , A61P9/00 , A61P9/12 , A61P11/06 , A61P11/10 , A61P11/14 , A61P13/02 , A61P21/02 , A61P23/00 , A61P25/00 , A61P25/02 , A61P25/04 , A61P25/08 , A61P25/14 , A61P25/22 , A61P25/28 , A61P25/32 , A61P25/36 , A61P27/16 , A61P29/00 , A61P43/00 , C07D209/34 , C07D211/04 , C07D211/06 , C07D235/24 , C07D235/26 , C07D263/58 , C07D401/04 , C07D401/06 , C07D403/04 , C07D403/06 , C07D405/14 , C07D413/04 , C07D413/14 , C07D471/04 , A61K31/495
CPC分类号： C07D401/04 , C07D235/26 , C07D263/58 , C07D405/14 , C07D413/04 , C07D413/14 , C07D471/04
摘要： A compound of the formula (I), (II), (III) or (IV) wherein Z, A, B, C, R, R1, R2, Q, and n are as described herein.
摘要翻译：式（I），（II），（III）或（IV）的化合物其中Z，A，B，C，R，R 1，R 2，Q和n如本文所述。

4. 发明授权

US07939670B2 Nociceptin analogs 有权
标题翻译：伤害感受类似物
公开(公告)号：US07939670B2
公开(公告)日：2011-05-10
申请号：US12390683
申请日：2009-02-23
申请人： Qun Sun , R. Richard Goehring , Donald Kyle , Zhengming Chen , Sam Victory , John Whitehead
发明人： Qun Sun , R. Richard Goehring , Donald Kyle , Zhengming Chen , Sam Victory , John Whitehead
IPC分类号： C07D263/52 , C07D263/58
CPC分类号： C07D401/04 , C07D235/26 , C07D263/58 , C07D405/14 , C07D413/04 , C07D413/14 , C07D471/04
摘要： A compound of the formula (I), (II), (III) or (IV) wherein Z, A, B, C, R, R1, R2, Q, and n are as described herein.
摘要翻译：其中Z，A，B，C，R，R 1，R 2，Q和n如本文所述的式（I），（II），（III）或（IV）

5. 发明授权

US07495109B2 Nociceptin analogs 失效
标题翻译：伤害感受类似物
公开(公告)号：US07495109B2
公开(公告)日：2009-02-24
申请号：US11032955
申请日：2005-01-11
申请人： Qun Sun , R. Richard Goehring , Donald Kyle , Zhengming Chen , Sam Victory , John Whitehead
发明人： Qun Sun , R. Richard Goehring , Donald Kyle , Zhengming Chen , Sam Victory , John Whitehead
IPC分类号： C07D235/00 , C07D235/20 , C07D403/02 , A61K31/40
CPC分类号： C07D401/04 , C07D235/26 , C07D263/58 , C07D405/14 , C07D413/04 , C07D413/14 , C07D471/04
摘要： A compound of the formula (I), (II), (III) or (IV) wherein Z, A, B, C, R, R1, R2, Q, and n are as described herein.
摘要翻译：其中Z，A，B，C，R，R 1，R 2，Q和n如本文所述的式（I），（II），（III）或（IV）

6. 发明授权

US08604037B2 Therapeutic agents useful for treating pain 有权
公开(公告)号：US08604037B2
公开(公告)日：2013-12-10
申请号：US13212941
申请日：2011-08-18
申请人： Qun Sun , Laykea Tafesse , Sam Victory
发明人： Qun Sun , Laykea Tafesse , Sam Victory
IPC分类号： A61K31/501 , A61K31/497 , C07D409/04 , C07D409/12 , C07D417/04 , C07D417/12
CPC分类号： C07D417/12 , A61K31/495 , C07D401/12 , C07D403/12 , C07D413/12
摘要： A compound of formula: wherein Ar1, A, R3, x, and m are as disclosed herein and Ar2 is a benzothiazolyl, benzooxazolyl, or benzoimidazolyl group or a pharmaceutically acceptable salt thereof (a “Benzoazolylpiperazine Compound”), compositions comprising a Benzoazolylpiperazine Compound, and methods for treating or preventing pain, UI, an ulcer, IBD, IBS, an addictive disorder, Parkinson's disease, parkinsonism, anxiety, epilepsy, stroke, a seizure, a pruritic condition, psychosis, a cognitive disorder, a memory deficit, restricted brain function, Huntington's chorea, amyotrophic lateral sclerosis, dementia, retinopathy, a muscle spasm, a migraine, vomiting, dyskinesia, or depression in an animal comprising administering to an animal in need thereof an effective amount of a Benzoazolylpiperazine Compound are disclosed.

7. 发明申请

US20120015954A1 THERAPEUTIC AGENTS USEFUL FOR TREATING PAIN 有权
公开(公告)号：US20120015954A1
公开(公告)日：2012-01-19
申请号：US13212941
申请日：2011-08-18
申请人： Qun Sun , Laykea Tafesse , Sam Victory
发明人： Qun Sun , Laykea Tafesse , Sam Victory
IPC分类号： A61K31/501 , A61K31/496 , C07D403/14 , A61P25/04 , A61P1/08 , A61P1/00 , A61P1/04 , A61P25/16 , A61P25/08 , A61P25/06 , C07D409/14 , A61P13/02
CPC分类号： C07D417/12 , A61K31/495 , C07D401/12 , C07D403/12 , C07D413/12
摘要： A compound of formula: wherein Ar1, A, R3, x, and m are as disclosed herein and Ar2 is a benzothiazolyl, benzooxazolyl, or benzoimidazolyl group or a pharmaceutically acceptable salt thereof (a “Benzoazolylpiperazine Compound”), compositions comprising a Benzoazolylpiperazine Compound, and methods for treating or preventing pain, UI, an ulcer, IBD, IBS, an addictive disorder, Parkinson's disease, parkinsonism, anxiety, epilepsy, stroke, a seizure, a pruritic condition, psychosis, a cognitive disorder, a memory deficit, restricted brain function, Huntington's chorea, amyotrophic lateral sclerosis, dementia, retinopathy, a muscle spasm, a migraine, vomiting, dyskinesia, or depression in an animal comprising administering to an animal in need thereof an effective amount of a Benzoazolylpiperazine Compound are disclosed.

8. 发明授权

US07582635B2 Therapeutic agents useful for treating pain 有权
标题翻译：用于治疗疼痛的治疗剂
公开(公告)号：US07582635B2
公开(公告)日：2009-09-01
申请号：US10739190
申请日：2003-12-19
申请人： Qun Sun , Laykea Tafesse , Sam Victory
发明人： Qun Sun , Laykea Tafesse , Sam Victory
IPC分类号： A61K31/497
CPC分类号： C07D417/12 , A61K31/495 , C07D401/12 , C07D403/12 , C07D413/12
摘要： A compound of formula: wherein Ar1, A, R3, x, and m are as disclosed herein and Ar2 is a benzothiazolyl, benzooxazolyl, or benzoimidazolyl group or a pharmaceutically acceptable salt thereof (a “Benzoazolylpiperazine Compound”), compositions comprising a Benzoazolylpiperazine Compound, and methods for treating or preventing pain, UI, an ulcer, IBD, IBS, an addictive disorder, Parkinson's disease, parkinsonism, anxiety, epilepsy, stroke, a seizure, a pruritic condition, psychosis, a cognitive disorder, a memory deficit, restricted brain function, Huntington's chorea, amyotrophic lateral sclerosis, dementia, retinopathy, a muscle spasm, a migraine, vomiting, dyskinesia, or depression in an animal comprising administering to an animal in need thereof an effective amount of a Benzoazolylpiperazine Compound are disclosed.
摘要翻译：下式的化合物：其中Ar1，A，R3，x和m如本文所公开，Ar 2是苯并噻唑基，苯并恶唑基或苯并咪唑基或其药学上可接受的盐（“苯并恶唑基哌嗪化合物”），包含苯并恶唑基哌嗪化合物以及用于治疗或预防疼痛，UI，溃疡，IBD，IBS，成瘾性障碍，帕金森病，帕金森综合征，焦虑，癫痫，中风，癫痫发作，瘙痒症状，精神病，认知障碍，记忆缺陷，限制性脑功能，亨廷顿氏舞蹈病，肌萎缩性侧索硬化，痴呆，视网膜病变，肌肉痉挛，偏头痛，呕吐，运动障碍或抑郁症，其中包括向有需要的动物施用有效量的苯并恶唑基哌嗪化合物。

9. 发明申请

US20100004254A1 THERAPEUTIC AGENTS USEFUL FOR TREATING PAIN 有权
标题翻译：治疗药物有用的治疗药物
公开(公告)号：US20100004254A1
公开(公告)日：2010-01-07
申请号：US12499480
申请日：2009-07-08
申请人： Qun Sun , Laykea Tafesse , Sam Victory
发明人： Qun Sun , Laykea Tafesse , Sam Victory
IPC分类号： A61K31/501 , C07D415/00 , C07D403/04 , A61K31/497
CPC分类号： C07D417/12 , A61K31/495 , C07D401/12 , C07D403/12 , C07D413/12
摘要： A compound of formula: wherein Ar1, A, R3, x, and m are as disclosed herein and Ar2 is a benzothiazolyl, benzooxazolyl, or benzoimidazolyl group or a pharmaceutically acceptable salt thereof (a “Benzoazolylpiperazine Compound”), compositions comprising a Benzoazolylpiperazine Compound, and methods for treating or preventing pain, UI, an ulcer, IBD, IBS, an addictive disorder, Parkinson's disease, parkinsonism, anxiety, epilepsy, stroke, a seizure, a pruritic condition, psychosis, a cognitive disorder, a memory deficit, restricted brain function, Huntington's chorea, amyotrophic lateral sclerosis, dementia, retinopathy, a muscle spasm, a migraine, vomiting, dyskinesia, or depression in an animal comprising administering to an animal in need thereof an effective amount of a Benzoazolylpiperazine Compound are disclosed.
摘要翻译：下式的化合物：其中Ar1，A，R3，x和m如本文所公开，Ar 2是苯并噻唑基，苯并恶唑基或苯并咪唑基或其药学上可接受的盐（“苯并恶唑基哌嗪化合物”），包含苯并恶唑基哌嗪化合物以及用于治疗或预防疼痛，UI，溃疡，IBD，IBS，成瘾性障碍，帕金森病，帕金森综合征，焦虑，癫痫，中风，癫痫发作，瘙痒症状，精神病，认知障碍，记忆缺陷，限制性脑功能，亨廷顿氏舞蹈病，肌萎缩性侧索硬化，痴呆，视网膜病变，肌肉痉挛，偏头痛，呕吐，运动障碍或抑郁症，其中包括向有需要的动物施用有效量的苯并恶唑基哌嗪化合物。

10. 发明授权

US08536177B2 Therapeutic agents useful for treating pain 有权
公开(公告)号：US08536177B2
公开(公告)日：2013-09-17
申请号：US13205323
申请日：2011-08-08
申请人： Qun Sun , Laykea Tafesse , Sam Victory
发明人： Qun Sun , Laykea Tafesse , Sam Victory
IPC分类号： A61K31/497 , A61K31/435 , C07D279/10 , C07D401/14
CPC分类号： C07D417/12 , A61K31/495 , C07D401/12 , C07D403/12 , C07D413/12
摘要： A compound of formula: wherein Ar1, A, R3, x, and m are as disclosed herein and Ar2 is a benzothiazolyl, benzooxazolyl, or benzoimidazolyl group or a pharmaceutically acceptable salt thereof (a “Benzoazolylpiperazine Compound”), compositions comprising a Benzoazolylpiperazine Compound, and methods for treating or preventing pain, UI, an ulcer, IBD, IBS, an addictive disorder, Parkinson's disease, parkinsonism, anxiety, epilepsy, stroke, a seizure, a pruritic condition, psychosis, a cognitive disorder, a memory deficit, restricted brain function, Huntington's chorea, amyotrophic lateral sclerosis, dementia, retinopathy, a muscle spasm, a migraine, vomiting, dyskinesia, or depression in an animal comprising administering to an animal in need thereof an effective amount of a Benzoazolylpiperazine Compound are disclosed.

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