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1. 发明申请

US20120095049A1 NOCICEPTIN ANALOGS 有权
公开(公告)号：US20120095049A1
公开(公告)日：2012-04-19
申请号：US13051629
申请日：2011-03-18
申请人： Qun SUN , R. Richard Goehring , Donald Kyle , Zhengming Chen , Sam Victory , John Whitehead
发明人： Qun SUN , R. Richard Goehring , Donald Kyle , Zhengming Chen , Sam Victory , John Whitehead
IPC分类号： A61K31/454 , A61P25/04 , C07D401/04
CPC分类号： C07D401/04 , C07D235/26 , C07D263/58 , C07D405/14 , C07D413/04 , C07D413/14 , C07D471/04
摘要： A compound of the formula (I), (II), (III) or (IV) wherein Z, A, B, C, R, R1, R2, Q, and n are as described herein.
摘要翻译：其中Z，A，B，C，R，R 1，R 2，Q和n如本文所述的式（I），（II），（III）或（IV）

2. 发明授权

US07414062B2 Triazaspiro compounds useful for treating or preventing pain 有权
标题翻译：可用于治疗或预防疼痛的三氮唑类化合物
公开(公告)号：US07414062B2
公开(公告)日：2008-08-19
申请号：US11155263
申请日：2005-06-16
申请人： Zhengming Chen , Sam Victory
发明人： Zhengming Chen , Sam Victory
IPC分类号： A61K31/438 , C07D401/04
CPC分类号： C07D471/10
摘要： Triazaspiro Compounds, compositions comprising a Triazaspiro Compound, methods for treating or preventing pain in an animal comprising administering to an animal in need thereof an effective amount of a Triazaspiro Compound and methods for stimulating opioid-receptor function in a cell comprising contacting a cell capable of expressing an opioid receptor with an effective amount of a Triazaspiro Compound are disclosed.
摘要翻译：三唑类化合物，包含三氮唑类化合物的组合物，用于治疗或预防动物疼痛的方法，包括向有需要的动物施用有效量的三氮嘧啶化合物和刺激细胞中阿片受体功能的方法，包括使能够公开了表达具有有效量的三氮唑螺化合物的阿片受体。

3. 发明授权

US06872733B2 Benzimidazolone compounds 有权
标题翻译：苯并咪唑酮化合物
公开(公告)号：US06872733B2
公开(公告)日：2005-03-29
申请号：US10126437
申请日：2002-04-18
申请人： R. Richard Goehring , Zhengming Chen , Sam Victory , Donald Kyle
发明人： R. Richard Goehring , Zhengming Chen , Sam Victory , Donald Kyle
IPC分类号： A61K31/435 , A61K31/454 , A61P3/04 , A61P7/08 , A61P7/10 , A61P9/12 , A61P11/06 , A61P11/14 , A61P13/12 , A61P21/02 , A61P23/00 , A61P25/04 , A61P25/08 , A61P25/22 , A61P25/24 , A61P25/28 , A61P25/32 , A61P25/36 , A61P27/16 , A61P29/00 , C07D401/04 , A61K31/445
CPC分类号： C07D401/04
摘要： Disclosed are compounds of the formula (I): wherein A, B, C, M1-M4, R, R1, R2 and n are as described herein.
摘要翻译：公开了式（I）的化合物：其中A，B，C，M1-M4，R，R1，R2和n如本文所述。

4. 发明授权

US08604037B2 Therapeutic agents useful for treating pain 有权
公开(公告)号：US08604037B2
公开(公告)日：2013-12-10
申请号：US13212941
申请日：2011-08-18
申请人： Qun Sun , Laykea Tafesse , Sam Victory
发明人： Qun Sun , Laykea Tafesse , Sam Victory
IPC分类号： A61K31/501 , A61K31/497 , C07D409/04 , C07D409/12 , C07D417/04 , C07D417/12
CPC分类号： C07D417/12 , A61K31/495 , C07D401/12 , C07D403/12 , C07D413/12
摘要： A compound of formula: wherein Ar1, A, R3, x, and m are as disclosed herein and Ar2 is a benzothiazolyl, benzooxazolyl, or benzoimidazolyl group or a pharmaceutically acceptable salt thereof (a “Benzoazolylpiperazine Compound”), compositions comprising a Benzoazolylpiperazine Compound, and methods for treating or preventing pain, UI, an ulcer, IBD, IBS, an addictive disorder, Parkinson's disease, parkinsonism, anxiety, epilepsy, stroke, a seizure, a pruritic condition, psychosis, a cognitive disorder, a memory deficit, restricted brain function, Huntington's chorea, amyotrophic lateral sclerosis, dementia, retinopathy, a muscle spasm, a migraine, vomiting, dyskinesia, or depression in an animal comprising administering to an animal in need thereof an effective amount of a Benzoazolylpiperazine Compound are disclosed.

5. 发明授权

US08252815B2 Nociceptin analogs 有权
标题翻译：伤害感受类似物
公开(公告)号：US08252815B2
公开(公告)日：2012-08-28
申请号：US13051629
申请日：2011-03-18
申请人： Qun Sun , R. Richard Goehring , Donald Kyle , Zhengming Chen , Sam Victory , John Whitehead
发明人： Qun Sun , R. Richard Goehring , Donald Kyle , Zhengming Chen , Sam Victory , John Whitehead
IPC分类号： A61K31/435 , C07D401/00
CPC分类号： C07D401/04 , C07D235/26 , C07D263/58 , C07D405/14 , C07D413/04 , C07D413/14 , C07D471/04
摘要： A compound of the formula (I), (II), (III) or (IV) wherein Z, A, B, C, R, R1, R2, Q, and n are as described herein.
摘要翻译：其中Z，A，B，C，R，R 1，R 2，Q和n如本文所述的式（I），（II），（III）或（IV）

6. 发明申请

US20120015954A1 THERAPEUTIC AGENTS USEFUL FOR TREATING PAIN 有权
公开(公告)号：US20120015954A1
公开(公告)日：2012-01-19
申请号：US13212941
申请日：2011-08-18
申请人： Qun Sun , Laykea Tafesse , Sam Victory
发明人： Qun Sun , Laykea Tafesse , Sam Victory
IPC分类号： A61K31/501 , A61K31/496 , C07D403/14 , A61P25/04 , A61P1/08 , A61P1/00 , A61P1/04 , A61P25/16 , A61P25/08 , A61P25/06 , C07D409/14 , A61P13/02
CPC分类号： C07D417/12 , A61K31/495 , C07D401/12 , C07D403/12 , C07D413/12
摘要： A compound of formula: wherein Ar1, A, R3, x, and m are as disclosed herein and Ar2 is a benzothiazolyl, benzooxazolyl, or benzoimidazolyl group or a pharmaceutically acceptable salt thereof (a “Benzoazolylpiperazine Compound”), compositions comprising a Benzoazolylpiperazine Compound, and methods for treating or preventing pain, UI, an ulcer, IBD, IBS, an addictive disorder, Parkinson's disease, parkinsonism, anxiety, epilepsy, stroke, a seizure, a pruritic condition, psychosis, a cognitive disorder, a memory deficit, restricted brain function, Huntington's chorea, amyotrophic lateral sclerosis, dementia, retinopathy, a muscle spasm, a migraine, vomiting, dyskinesia, or depression in an animal comprising administering to an animal in need thereof an effective amount of a Benzoazolylpiperazine Compound are disclosed.

7. 发明申请

US20120004217A1 THERAPEUTIC AGENTS USEFUL FOR TREATING PAIN 有权
标题翻译：治疗药物有用的治疗药物
公开(公告)号：US20120004217A1
公开(公告)日：2012-01-05
申请号：US13205323
申请日：2011-08-08
申请人： Qun SUN , Laykea TAFESSE , Sam VICTORY
发明人： Qun SUN , Laykea TAFESSE , Sam VICTORY
IPC分类号： A61K31/496 , A61K31/501 , A61K31/541 , A61P25/00 , A61P13/00 , A61P1/04 , A61P1/00 , A61P25/30 , A61P25/16 , A61P25/22 , A61P25/08 , A61P17/04 , A61P25/18 , A61P25/28 , A61P25/14 , A61P27/02 , A61P21/00 , A61P25/06 , A61P1/08 , A61P25/24 , C07D417/14
CPC分类号： C07D417/12 , A61K31/495 , C07D401/12 , C07D403/12 , C07D413/12
摘要： A compound of formula: wherein Ar1, A, R3, x, and m are as disclosed herein and Ar2 is a benzothiazolyl, benzooxazolyl, or benzoimidazolyl group or a pharmaceutically acceptable salt thereof (a “Benzoazolylpiperazine Compound”), compositions comprising a Benzoazolylpiperazine Compound, and methods for treating or preventing pain, UI, an ulcer, IBD, IBS, an addictive disorder, Parkinson's disease, parkinsonism, anxiety, epilepsy, stroke, a seizure, a pruritic condition, psychosis, a cognitive disorder, a memory deficit, restricted brain function, Huntington's chorea, amyotrophic lateral sclerosis, dementia, retinopathy, a muscle spasm, a migraine, vomiting, dyskinesia, or depression in an animal comprising administering to an animal in need thereof an effective amount of a Benzoazolylpiperazine Compound are disclosed.
摘要翻译：下式的化合物：其中Ar1，A，R3，x和m如本文所公开，Ar 2是苯并噻唑基，苯并恶唑基或苯并咪唑基或其药学上可接受的盐（“苯并恶唑基哌嗪化合物”），包含苯并恶唑基哌嗪化合物以及用于治疗或预防疼痛，UI，溃疡，IBD，IBS，成瘾性障碍，帕金森病，帕金森综合征，焦虑，癫痫，中风，癫痫发作，瘙痒症状，精神病，认知障碍，记忆缺陷，限制性脑功能，亨廷顿氏舞蹈病，肌萎缩性侧索硬化，痴呆，视网膜病变，肌肉痉挛，偏头痛，呕吐，运动障碍或抑郁症，其中包括向有需要的动物施用有效量的苯并恶唑基哌嗪化合物。

8. 发明授权

US07582635B2 Therapeutic agents useful for treating pain 有权
标题翻译：用于治疗疼痛的治疗剂
公开(公告)号：US07582635B2
公开(公告)日：2009-09-01
申请号：US10739190
申请日：2003-12-19
申请人： Qun Sun , Laykea Tafesse , Sam Victory
发明人： Qun Sun , Laykea Tafesse , Sam Victory
IPC分类号： A61K31/497
CPC分类号： C07D417/12 , A61K31/495 , C07D401/12 , C07D403/12 , C07D413/12
摘要： A compound of formula: wherein Ar1, A, R3, x, and m are as disclosed herein and Ar2 is a benzothiazolyl, benzooxazolyl, or benzoimidazolyl group or a pharmaceutically acceptable salt thereof (a “Benzoazolylpiperazine Compound”), compositions comprising a Benzoazolylpiperazine Compound, and methods for treating or preventing pain, UI, an ulcer, IBD, IBS, an addictive disorder, Parkinson's disease, parkinsonism, anxiety, epilepsy, stroke, a seizure, a pruritic condition, psychosis, a cognitive disorder, a memory deficit, restricted brain function, Huntington's chorea, amyotrophic lateral sclerosis, dementia, retinopathy, a muscle spasm, a migraine, vomiting, dyskinesia, or depression in an animal comprising administering to an animal in need thereof an effective amount of a Benzoazolylpiperazine Compound are disclosed.
摘要翻译：下式的化合物：其中Ar1，A，R3，x和m如本文所公开，Ar 2是苯并噻唑基，苯并恶唑基或苯并咪唑基或其药学上可接受的盐（“苯并恶唑基哌嗪化合物”），包含苯并恶唑基哌嗪化合物以及用于治疗或预防疼痛，UI，溃疡，IBD，IBS，成瘾性障碍，帕金森病，帕金森综合征，焦虑，癫痫，中风，癫痫发作，瘙痒症状，精神病，认知障碍，记忆缺陷，限制性脑功能，亨廷顿氏舞蹈病，肌萎缩性侧索硬化，痴呆，视网膜病变，肌肉痉挛，偏头痛，呕吐，运动障碍或抑郁症，其中包括向有需要的动物施用有效量的苯并恶唑基哌嗪化合物。

9. 发明授权

US06984664B2 Tertiary amino compounds having opioid receptor affinity 有权
标题翻译：具有阿片受体亲和力的三氨基化合物
公开(公告)号：US06984664B2
公开(公告)日：2006-01-10
申请号：US09730814
申请日：2000-12-06
申请人： Donald Kyle , R Richard Goehring , Sam Victory
发明人： Donald Kyle , R Richard Goehring , Sam Victory
IPC分类号： A61K31/135
CPC分类号： C07C233/40 , C07C211/27
摘要： Disclosed are compounds of the formula (I) wherein R1, R2 R3 R4 R5, R6 and N are as disclosed herein. The compounds are useful for the treatment of chronic and acute pain.
摘要翻译：公开了式（I）的化合物，其中R 1，R 2，R 3，R 4，R 3， R 5，R 6和N如本文所公开的。该化合物可用于治疗慢性和急性疼痛。

10. 发明申请

US20050192307A1 Benzimidazolone compounds 审中-公开
标题翻译：苯并咪唑酮化合物
公开(公告)号：US20050192307A1
公开(公告)日：2005-09-01
申请号：US11091229
申请日：2005-03-28
申请人： R. Goehring , Zhengming Chen , Sam Victory , Donald Kyle
发明人： R. Goehring , Zhengming Chen , Sam Victory , Donald Kyle
IPC分类号： A61K31/435 , A61K31/454 , A61P3/04 , A61P7/08 , A61P7/10 , A61P9/12 , A61P11/06 , A61P11/14 , A61P13/12 , A61P21/02 , A61P23/00 , A61P25/04 , A61P25/08 , A61P25/22 , A61P25/24 , A61P25/28 , A61P25/32 , A61P25/36 , A61P27/16 , A61P29/00 , C07D401/04 , A61K31/4747 , C07D43/02
CPC分类号： C07D401/04
摘要： Disclosed are compounds of the formula (I): wherein A, B, C, M1-M4, R, R1, R2 and n are as described herein.
摘要翻译：公开了式（I）的化合物：其中A，B，C，M 1-M 4，R 1，R 1，R 2，R ＆lt; 2＆gt;和n如本文所述。

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