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1. 发明申请

US20070118180A1 Cardiac resynchronization therapy for improved hemodynamics based on disordered breathing detection 审中-公开
标题翻译：基于无序呼吸检测改善血液动力学的心脏再同步治疗
公开(公告)号：US20070118180A1
公开(公告)日：2007-05-24
申请号：US11282963
申请日：2005-11-18
申请人： Quan Ni , Douglas Daum , Jeffrey E. Stahmann , Kent Lee , Jesse Hartley
发明人： Quan Ni , Douglas Daum , Jeffrey E. Stahmann , Kent Lee , Jesse Hartley
IPC分类号： A61N1/365
CPC分类号： A61B5/4836 , A61B5/02 , A61B5/0472 , A61B5/08 , A61B5/4818 , A61B5/6846 , A61N1/3627 , A61N1/36521
摘要： The presence of disordered breathing is detected using an implantable medical device. A cardiac condition is detected that is indicative of the patient's cardiac status. Based on the presence of disordered breathing and the cardiac condition, the patient is identified as suitable for a cardiac resynchronization therapy.
摘要翻译：使用可植入的医疗装置来检测无序呼吸的存在。检测到指示患者心脏状态的心脏状况。基于呼吸紊乱和心脏病情的存在，患者被认为适合于心脏再同步治疗。

2. 发明申请

US20050042589A1 Sleep quality data collection and evaluation 有权
标题翻译：睡眠质量数据收集和评估
公开(公告)号：US20050042589A1
公开(公告)日：2005-02-24
申请号：US10642998
申请日：2003-08-18
申请人： John Hatlestad , Quan Ni , Jeffrey Stahmann , Jesse Hartley , Qingsheng Zhu , Bruce Kenknight , Douglas Daum , Kent Lee
发明人： John Hatlestad , Quan Ni , Jeffrey Stahmann , Jesse Hartley , Qingsheng Zhu , Bruce Kenknight , Douglas Daum , Kent Lee
IPC分类号： A61B5/00 , A61B5/0205 , A61B5/0476 , A61B5/0488 , A61B5/0496 , A61B5/08 , A61B5/11 , A61N1/362 , G09B23/28
CPC分类号： A61B5/4815 , A61B5/0031 , A61B5/0205 , A61B5/0476 , A61B5/0488 , A61B5/0496 , A61B5/0809 , A61B5/11 , A61B5/4528 , A61B5/4818 , A61N1/3621 , G06F19/00
摘要： A sleep quality assessment approach involves collecting data based on detected physiological or non-physiological patient conditions. At least one of detecting patient conditions and collecting data is performed using an implantable device. Sleep quality may be evaluated using the collected data by an imlantable or patient-external sleep quality processor. One approach to sleep quality evaluation involves computing one or more summary metrics based on occurrences of movement disorders or breathing disorders during sleep.
摘要翻译：睡眠质量评估方法包括基于检测到的生理或非生理性患者状况收集数据。使用可植入装置执行检测患者状况和收集数据中的至少一个。睡眠质量可以使用收集的数据由不可变的或患者外部的睡眠质量处理器进行评估。睡眠质量评估的一种方法包括基于睡眠期间的运动障碍或呼吸障碍的发生来计算一个或多个总结度量。

3. 发明申请

US20050043772A1 Therapy triggered by prediction of disordered breathing 有权
标题翻译：通过预测无序呼吸引发的治疗
公开(公告)号：US20050043772A1
公开(公告)日：2005-02-24
申请号：US10643154
申请日：2003-08-18
申请人： Jeffrey Stahmann , John Hatlestad , Quan Ni , Jesse Hartley , Douglas Daum , Kent Lee
发明人： Jeffrey Stahmann , John Hatlestad , Quan Ni , Jesse Hartley , Douglas Daum , Kent Lee
IPC分类号： A61N1/08 , A61N1/362 , A61N1/365 , A61N1/18
CPC分类号： A61N1/36514 , A61N1/3621 , A61N1/3627 , A61N1/3702
摘要： An approach to providing disordered breathing therapy includes providing therapy based on a prediction of disordered breathing. One or more patient conditions are detected and used to predict disordered breathing. Therapy is delivered to mitigate the predicted disordered breathing. The disordered breathing therapy may be adapted to enhance therapy efficacy and/or to reduce the impact of the therapy to the patient.
摘要翻译：提供无序呼吸治疗的方法包括基于无序呼吸预测提供治疗。检测一个或多个患者状况并用于预测无序呼吸。提供治疗以减轻预期的无序呼吸。无序的呼吸治疗可以适应于增强治疗功效和/或减少治疗对患者的影响。

4. 发明申请

US20050043644A1 Prediction of disordered breathing 有权
标题翻译：预测无序呼吸
公开(公告)号：US20050043644A1
公开(公告)日：2005-02-24
申请号：US10643016
申请日：2003-08-18
申请人： Jeffrey Stahmann , John Hatlestad , Quan Ni , Jesse Hartley , Douglas Daum , Kent Lee
发明人： Jeffrey Stahmann , John Hatlestad , Quan Ni , Jesse Hartley , Douglas Daum , Kent Lee
IPC分类号： A61B5/00 , A61B5/08 , A61B5/11 , A61N1/362 , A61N1/365
CPC分类号： A61B5/02405 , A61B5/0031 , A61B5/08 , A61B5/0816 , A61B5/1116 , A61B5/1118 , A61B5/4812 , A61B5/4815 , A61B5/4818 , A61B2560/0242 , A61B2562/0219 , A61N1/362 , A61N1/36514
摘要： An approach for predicting disordered breathing involves detecting one or more conditions associated with disordered breathing. The detected conditions are compared to disordered breathing prediction criteria. A prediction of disordered breathing is performed based on the comparison of the detected conditions to the prediction criteria. At least one of comparing the detected conditions to the prediction criteria and predicting disordered breathing is performed at least in part implantably.
摘要翻译：预测无序呼吸的方法涉及检测与无序呼吸相关的一个或多个情况。将检测到的条件与无序呼吸预测标准进行比较。基于检测到的条件与预测标准的比较来执行无序呼吸的预测。将检测到的条件与预测标准进行比较以及预测无序呼吸的至少一个至少部分地可植入地进行。

5. 发明申请

US20050039745A1 Adaptive therapy for disordered breathing 有权
标题翻译：呼吸紊乱的自适应治疗
公开(公告)号：US20050039745A1
公开(公告)日：2005-02-24
申请号：US10643203
申请日：2003-08-18
申请人： Jeffrey Stahmann , John Hatlestad , Quan Ni , Jesse Hartley , Douglas Daum , Kent Lee
发明人： Jeffrey Stahmann , John Hatlestad , Quan Ni , Jesse Hartley , Douglas Daum , Kent Lee
IPC分类号： A61N1/36 , A61N1/362 , A62B7/00
CPC分类号： A61N1/362 , A61N1/3601
摘要： An approach to providing disordered breathing therapy includes detecting disordered breathing and adapting a therapy to mitigate the disordered breathing. The therapy may be adapted to enhance therapy effectiveness, to provide therapy that reduces an impact of the therapy on the patient, or to achieve other therapeutic goals. Cardiac electrical therapy to mitigate the disordered breathing may include various cardiac pacing regimens and/or delivery of non-excitatory electrical stimulation to the heart.
摘要翻译：提供无序呼吸治疗的方法包括检测无序呼吸并适应治疗以减轻无序呼吸。治疗可以适应于增强治疗有效性，提供减少治疗对患者的影响或实现其它治疗目标的治疗。减轻无序呼吸的心脏电疗可能包括各种心脏起搏方案和/或向心脏递送非兴奋性电刺激。

6. 发明申请

US20070161873A1 Sleep detection using an adjustable threshold 有权
公开(公告)号：US20070161873A1
公开(公告)日：2007-07-12
申请号：US11717561
申请日：2007-03-13
申请人： Quan Ni , Zoe Hajenga , Douglas Daum , Jeff Stahmann , John Hatlestad , Kent Lee
发明人： Quan Ni , Zoe Hajenga , Douglas Daum , Jeff Stahmann , John Hatlestad , Kent Lee
IPC分类号： A61B5/00 , A61B5/08
CPC分类号： A61B5/4815 , A61B5/0031 , A61B5/0205 , A61B5/021 , A61B5/085 , A61B5/1116 , A61B5/4809 , A61B5/686 , A61B5/7271 , A61B5/7282 , A61N1/362 , A61N1/365 , A61N1/36542 , G16H40/63 , G16H50/20
摘要： Devices and methods for sleep detection involve the use of an adjustable threshold for detecting sleep onset and termination. A method for detecting sleep includes adjusting a sleep threshold associated with a first sleep-related signal using a second sleep-related signal. The first sleep-related signal is compared to the adjusted threshold and sleep is detected based on the comparison. The sleep-related signals may be derived from implantable or external sensors. Additional sleep-related signals may be used to confirm the sleep condition. A sleep detector device implementing a sleep detection method may be a component of an implantable pulse generator such as a pacemaker or defibrillator.

7. 发明申请

US20080051672A1 WIRELESS ECG IN IMPLANTABLE DEVICES 有权
标题翻译：无线心电图在可植入的设备
公开(公告)号：US20080051672A1
公开(公告)日：2008-02-28
申请号：US11925657
申请日：2007-10-26
申请人： Aaron McCabe , Avram Scheiner , Geng Zhang , Quan Ni , Douglas Daum
发明人： Aaron McCabe , Avram Scheiner , Geng Zhang , Quan Ni , Douglas Daum
IPC分类号： A61B5/0402
CPC分类号： A61B5/0402 , A61N1/365 , A61N1/3756
摘要： An implantable medical device such as an implantable pacemaker or implantable cardioverter/defibrillator includes a programmable sensing circuit providing for sensing of a signal approximating a surface electrocardiogram (ECG) through implanted electrodes. With various electrode configurations, signals approximating various standard surface ECG signals are acquired without the need for attaching electrodes with cables onto the skin. The various electrode configurations include, but are not limited to, various combinations of intracardiac pacing electrodes, portions of the implantable medical device contacting tissue, and electrodes incorporated onto the surface of the implantable medical device.
摘要翻译：诸如可植入起搏器或植入式心律转复/除颤器的可植入医疗装置包括可编程感测电路，用于通过植入电极感测接近表面心电图（ECG）的信号。通过各种电极配置，获取近似各种标准表面ECG信号的信号，而不需要将电极与电缆连接在皮肤上。各种电极配置包括但不限于心脏内起搏电极，可植入医疗器械接触组织的部分和结合到可植入医疗装置的表面上的电极的各种组合。

8. 发明申请

US20060271119A1 Closed loop impedance-based cardiac resynchronization therapy systems, devices, and methods 有权
标题翻译：基于闭环阻抗的心脏再同步治疗系统，装置和方法
公开(公告)号：US20060271119A1
公开(公告)日：2006-11-30
申请号：US11264941
申请日：2005-11-02
申请人： Quan Ni , Jiang Ding , Yinghong Yu , Douglas Daum , Julio Spinelli , Jeffrey Stahmann
发明人： Quan Ni , Jiang Ding , Yinghong Yu , Douglas Daum , Julio Spinelli , Jeffrey Stahmann
IPC分类号： A61N1/362
CPC分类号： A61N1/3627 , A61B5/053 , A61N1/36521 , A61N1/3682 , A61N1/3684
摘要： This document discusses, among other things, systems, devices, and methods measure an impedance and, in response, adjust an atrioventricular (AV) delay or other cardiac resynchronization therapy (CRT) parameter that synchronizes left and right ventricular contractions. A first example uses parameterizes a first ventricular volume against a second ventricular volume during a cardiac cycle, using a loop area to create a synchronization fraction (SF). The CRT parameter is adjusted in closed-loop fashion to increase the SF. A second example measures a septal-freewall phase difference (PD), and adjusts a CRT parameter to decrease the PD. A third example measures a peak-to-peak volume or maximum rate of change in ventricular volume, and adjusts a CRT parameter to increase the peak-to-peak volume or maximum rate of change in the ventricular volume.
摘要翻译：本文件还讨论了系统，设备和方法测量阻抗，并作为响应调整房室（AV）延迟或同步左心室收缩和右心室收缩的其他心脏再同步治疗（CRT）参数。第一个例子是使用循环区域创建同步分数（SF），在心动周期中使用第一心室容积对第二心室容积进行参数化。 CRT参数以闭环方式调整以增加SF。第二个例子是测量隔层相位差（PD），并调整CRT参数以减少PD。第三个例子测量心室容积的峰 - 峰体积或最大变化率，并调整CRT参数以增加心室容积的峰 - 峰体积或最大变化率。

9. 发明申请

US20060200204A1 CALIBRATION OF ADAPTIVE-RATE PACING USING INTRINSIC CHRONOTROPIC RESPONSE 失效
标题翻译：使用内部反应的校正自适应速度
公开(公告)号：US20060200204A1
公开(公告)日：2006-09-07
申请号：US11276530
申请日：2006-03-03
申请人： Douglas Daum , Quan Ni
发明人： Douglas Daum , Quan Ni
IPC分类号： A61N1/365
CPC分类号： A61N1/365
摘要： Calibration of adaptive-rate pacing by a cardiac rhythm management system using an intrinsic chronotropic response. The cardiac rhythm management system may include an adaptive-rate pacing device. The adaptive-rate pacing device may include an adaptive-rate sensor module for measuring an activity level of the individual. A monitor module may be coupled to the adaptive-rate sensor module, the monitor module monitoring an intrinsic chronotropic response. A calculator module may be coupled to the monitor module, the calculator module calculating a calibrated parameter for the adaptive-rate pacing device based on the intrinsic chronotropic response. An adjuster module may be coupled to the calculator module, wherein the adjuster module adjusts the adaptive-rate pacing device based on the calibrated parameter. The parameters of the adaptive-rate pacing device adjusted by the adjuster module may include a sensor rate target, a maximum sensor rate, and a response factor.
摘要翻译：使用内在的时间延迟响应通过心律管理系统校准自适应起搏。心律管理系统可以包括自适应速率起搏装置。自适应速率起搏装置可以包括用于测量个人的活动水平的自适应速率传感器模块。监视器模块可以耦合到自适应速率传感器模块，监视器模块监视固有的时间变化响应。计算器模块可以耦合到监视器模块，计算器模块基于固有的时间变化响应来计算自适应速率起搏装置的校准参数。调节器模块可以耦合到计算器模块，其中调节器模块基于校准参数来调整自适应速率起搏装置。由调节器模块调整的自适应速率起搏装置的参数可以包括传感器速率目标，最大传感器速率和响应因子。

10. 发明申请

US20050288719A1 Far-field sensing channel for implantable cardiac device 有权
标题翻译：用于可植入心脏装置的远场感测通道
公开(公告)号：US20050288719A1
公开(公告)日：2005-12-29
申请号：US10858848
申请日：2004-06-02
申请人： Geng Zhang , Douglas Daum , James Gilkerson , Quan Ni
发明人： Geng Zhang , Douglas Daum , James Gilkerson , Quan Ni
IPC分类号： A61N1/362 , A61N1/37 , A61N1/375
CPC分类号： A61N1/371 , A61N1/3621 , A61N1/3756
摘要： An implantable pacemaker is provided with a far-field sensing channel which requires a reduced refractory period during the time when pacing pulses are delivered as compared with sensing channels using intra-cardiac electrodes. The far-field sensing channel may use the conductive housing of the implantable device or can and an indifferent electrode mounted on the device header as the electrodes for its differential inputs. Such a far-field sensing channel is able to sense activity occurring in either the atria or the ventricles for the purposes of arrhythmia detection and/or capture verification.
摘要翻译：植入式心脏起搏器设置有远场感测通道，与使用心脏内电极的感测通道相比，在进行起搏脉冲的时间期间需要减少的不应期。远场感测通道可以使用可植入装置的导电外壳或者可以将安装在设备头上的无关电极用作其差分输入的电极。为了心律失常检测和/或捕获验证的目的，这种远场感测通道能够感测在心房或心室中发生的活动。

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