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1. 发明申请

US20110086377A1 Bead Manipulations on a Droplet Actuator 有权
标题翻译：水珠致动器上的珠粒操作
公开(公告)号：US20110086377A1
公开(公告)日：2011-04-14
申请号：US12673893
申请日：2008-08-25
申请人： Prasanna Thwar , Dwayne Allen , Philip Paik
发明人： Prasanna Thwar , Dwayne Allen , Philip Paik
IPC分类号： C12Q1/02 , C12N13/00 , C12N11/00 , C12N5/00 , C12M1/00 , C25B7/00
CPC分类号： B01L3/52 , B01L3/502761 , B01L3/502792 , B01L2200/0668 , B01L2300/0864 , B01L2300/089 , B01L2400/0415 , B01L2400/0424 , B01L2400/0427
摘要： A droplet actuator comprising: (a) a base substrate comprising electrodes configured for conducting droplet operations on a droplet operations surface thereof; (b) a droplet comprising one or more beads situated on the droplet operations surface; (c) a barrier arranged in relation to the droplet and the electrodes such that a droplet may be transported away from the beads using one or more droplet operations mediated by one or more of the electrodes while transport of the beads is restrained by a barrier. Related methods and kits are also provided.
摘要翻译：一种液滴致动器，包括：（a）基底基底，包括构造成用于在其液滴操作表面上进行液滴操作的电极; （b）包含位于所述液滴操作表面上的一个或多个珠粒的液滴; （c）相对于液滴和电极布置的屏障，使得可以使用由一个或多个电极介导的一个或多个液滴操作将液滴从珠流出，同时珠的传送被屏障限制。还提供了相关方法和试剂盒。

2. 发明申请

US20100143963A1 Modular Droplet Actuator Drive 有权
标题翻译：模块化滴液致动器驱动
公开(公告)号：US20100143963A1
公开(公告)日：2010-06-10
申请号：US12707081
申请日：2010-02-17
申请人： Michael G. Pollack , Philip Paik
发明人： Michael G. Pollack , Philip Paik
IPC分类号： C12Q1/02 , B05C11/00
CPC分类号： B01L3/502792 , B01L2200/025 , B01L2200/04 , B01L2300/089 , B01L2400/0427 , G01N21/59 , G01N2021/035 , G01N2035/1046
摘要： The invention provides a droplet actuator drive. In certain embodiments, the droplet actuator drive may include a detection apparatus for sensing a property of a droplet on a droplet actuator; circuitry for controlling the detection apparatus electronically coupled to the detection apparatus; a droplet actuator cartridge connector; circuitry for controlling a droplet actuator coupled to the droplet actuator connector; and/or a means for coupling the droplet actuator circuitry to a processor. Systems, kits and methods of conducting assays are also provided.
摘要翻译：本发明提供一种液滴致动器驱动装置。在某些实施例中，液滴致动器驱动器可以包括用于感测液滴致动器上的液滴的特性的检测装置; 用于控制检测装置的电路，电子耦合到检测装置; 液滴致动器盒连接器; 用于控制耦合到液滴致动器连接器的液滴致动器的电路; 和/或用于将液滴致动器电路耦合到处理器的装置。还提供了进行测定的系统，试剂盒和方法。

3. 发明授权

US08951732B2 Droplet-based nucleic acid amplification in a temperature gradient 有权
标题翻译：基于液滴的核酸扩增在温度梯度
公开(公告)号：US08951732B2
公开(公告)日：2015-02-10
申请号：US12665788
申请日：2008-06-23
申请人： Michael G. Pollack , Vamsee K. Pamula , Philip Paik , Allen Eckhardt
发明人： Michael G. Pollack , Vamsee K. Pamula , Philip Paik , Allen Eckhardt
IPC分类号： C12Q1/68 , C12P19/34
CPC分类号： C12Q1/6846 , C12Q2527/15 , C12Q2527/101
摘要： A method of amplifying a nucleic acid, the method comprising cycling an amplification-ready droplet through a temperature gradient to locations within the temperature gradient suitable for effecting steps in an amplification reaction.
摘要翻译：一种扩增核酸的方法，所述方法包括使扩增准备的液滴通过温度梯度循环到适于在扩增反应中进行步骤的温度梯度内的位置。

4. 发明申请

US20100025250A1 Droplet Actuator Structures 审中-公开
标题翻译：液滴致动器结构
公开(公告)号：US20100025250A1
公开(公告)日：2010-02-04
申请号：US12529041
申请日：2008-03-03
申请人： Vamsee K. Pamula , Michael G. Pollack , Vijay Srinivasan , Philip Paik
发明人： Vamsee K. Pamula , Michael G. Pollack , Vijay Srinivasan , Philip Paik
IPC分类号： B41J2/045 , B03C9/00
CPC分类号： B01L3/502792 , B01L3/0241 , B01L3/50273 , B01L2200/06 , B01L2300/06 , B01L2400/0427 , B41J2/14
摘要： The objective of this research is to model and design a microfluidic system that uses electrostatic fields to induce movement of discrete droplets of solution. Of particular interest is movement of droplets of H2O for use in biological testing with lab-on a-chip and μTAS systems. Using computer modeling, the electric-fields for planar electrode configurations positioned on an insulating substrate are calculated for a hemispherical drop of H2O on the substrate at various positions. From these electric-fields the force on the drop is calculated. These models show that electrostatic actuation of droplets of H2O is possible. However, as the complexity of the model increases the properties of the system become less desirable and actuation may not be possible. Using microfabrication techniques, the modeled microfluidic systems have been built for testing using a Kapton substrate with copper electrodes. Hexadecenyltrichlorosilane (HTS), a self-assembled monolayer, and its oxidant have been studied and found capable of providing hydrophobic and hydrophilic surface coatings for the systems.
摘要翻译：本研究的目的是建立和设计一个使用静电场诱导离散液滴移动的微流体系统。特别令人感兴趣的是使用实验室上的芯片和muTAS系统用于生物测试的H 2 O滴。使用计算机建模，计算位于绝缘基板上的平面电极配置的电场，用于在不同位置的衬底上的半球形H 2 O的下降。从这些电场计算出液滴上的力。这些模型显示H2O的液滴的静电驱动是可能的。然而，随着模型的复杂性增加，系统的性能变得不太可取，并且致动可能是不可能的。使用微细加工技术，已经建立了用于使用具有铜电极的Kapton衬底进行测试的建模的微流体系统。已经研究了十六碳烯三氯硅烷（HTS），一种自组装单层及其氧化剂，能够为系统提供疏水和亲水的表面涂层。

5. 发明申请

US20080038810A1 Droplet-based nucleic acid amplification device, system, and method 有权
标题翻译：基于液滴的核酸扩增装置，系统和方法
公开(公告)号：US20080038810A1
公开(公告)日：2008-02-14
申请号：US11639990
申请日：2006-12-15
申请人： Michael Pollack , Philip Paik , Vamsee Pamula
发明人： Michael Pollack , Philip Paik , Vamsee Pamula
IPC分类号： C12M1/00 , B23P17/00 , C12M1/34
CPC分类号： B01L3/502761 , B01L3/5025 , B01L3/502784 , B01L3/502792 , B01L7/52 , B01L7/525 , B01L2200/027 , B01L2200/0668 , B01L2200/0673 , B01L2200/147 , B01L2300/0819 , B01L2300/0861 , B01L2300/0864 , B01L2300/0867 , B01L2300/087 , B01L2300/089 , B01L2300/1827 , B01L2400/0406 , B01L2400/0415 , B01L2400/0427 , B01L2400/043 , B01L2400/0442 , B01L2400/0448 , B01L2400/0487 , G01N15/1484 , G01N2015/1006 , G01N2035/1046 , Y10T29/49002 , Y10T137/0318
摘要： The present invention relates to a droplet-based nucleic acid amplification device, system, and method. According to one embodiment, a droplet microactuator is provided and includes: (a) a substrate comprising electrodes for conducting droplet operations; and (b) one or more temperature control means arranged in proximity with one or more of the electrodes for heating and/or cooling a region of the droplet microactuator and arranged such that a droplet can be transported on the electrodes into the region for heating.
摘要翻译：本发明涉及一种基于液滴的核酸扩增装置，系统和方法。根据一个实施例，提供液滴微致动器，其包括：（a）包括用于进行液滴操作的电极的基板; 和（b）设置在一个或多个电极附近的一个或多个温度控制装置，用于加热和/或冷却液滴微致动器的区域，并且布置成使得液滴可以在电极上传送到加热区域中。

6. 发明申请

US20060054503A1 Methods for manipulating droplets by electrowetting-based techniques 有权
公开(公告)号：US20060054503A1
公开(公告)日：2006-03-16
申请号：US11077569
申请日：2005-03-10
申请人： Vamsee Pamula , Michael Pollack , Philip Paik , Hong Ren , Richard Fair
发明人： Vamsee Pamula , Michael Pollack , Philip Paik , Hong Ren , Richard Fair
IPC分类号： C07K1/26 , G01N27/447
CPC分类号： B01L3/50273 , B01F11/0071 , B01F13/0071 , B01F13/0076 , B01F13/0084 , B01L3/00 , B01L3/5027 , B01L3/502784 , B01L3/502792 , B01L2200/06 , B01L2200/0605 , B01L2200/10 , B01L2300/089 , B01L2300/161 , B01L2300/165 , B01L2400/0415 , B01L2400/0427 , B41J2002/14395 , C25B9/00 , G01N27/44791 , G02B26/005
摘要： Methods are provided for manipulating droplets. The methods include providing the droplet on a surface comprising an array of electrodes and a substantially co-planer array of reference elements, wherein the droplet is disposed on a first one of the electrodes, and the droplet at least partially overlaps a second one of the electrodes and an intervening one of the reference elements disposed between the first and second electrodes. The methods further include activating the first and second electrodes to spread at least a portion of the droplet across the second electrode and deactivating the first electrode to move the droplet from the first electrode to the second electrode.

7. 发明申请

US20130233712A1 Method of Manipulating a Droplet 审中-公开
标题翻译：操纵水滴的方法
公开(公告)号：US20130233712A1
公开(公告)日：2013-09-12
申请号：US13870709
申请日：2013-04-25
申请人： Vamsee K. Pamula , Michael G. Pollack , Vijay Srinivasan , Philip Paik
发明人： Vamsee K. Pamula , Michael G. Pollack , Vijay Srinivasan , Philip Paik
IPC分类号： B01L3/02
CPC分类号： B01L3/502792 , B01L3/0241 , B01L3/50273 , B01L2200/06 , B01L2300/06 , B01L2400/0427 , B41J2/14
摘要： A method of manipulating a droplet comprising providing a substrate comprising a surface; an elongated transport electrode disposed on the substrate surface, the elongated transport electrode having a first and a second end and configured to impart a gradient force to the droplet; and one or more wires for providing power to the transport electrode; and providing power to the one or more wires to effect the gradient force and thereby transport the droplet along the length of the elongated transport electrode from the first end to the second end.
摘要翻译：一种操纵液滴的方法，包括提供包括表面的基底; 设置在基板表面上的细长输送电极，细长输送电极具有第一和第二端并且被配置为向液滴施加梯度力; 以及用于向输送电极供电的一根或多根线; 并且向所述一个或多个电线提供电力以实现所述梯度力，从而将所述液滴沿着所述细长输送电极的长度从所述第一端输送到所述第二端。

8. 发明授权

US08041463B2 Modular droplet actuator drive 有权
标题翻译：模块化液滴致动器驱动
公开(公告)号：US08041463B2
公开(公告)日：2011-10-18
申请号：US12707081
申请日：2010-02-17
申请人： Michael G. Pollack , Philip Paik
发明人： Michael G. Pollack , Philip Paik
IPC分类号： G05D7/00 , G05D11/00 , G01N7/00 , B05C11/00
CPC分类号： B01L3/502792 , B01L2200/025 , B01L2200/04 , B01L2300/089 , B01L2400/0427 , G01N21/59 , G01N2021/035 , G01N2035/1046
摘要： A droplet actuator drive including a detection apparatus for sensing a property of a droplet on a droplet actuator; circuitry for controlling the detection apparatus electronically coupled to the detection apparatus; a droplet actuator cartridge connector arranged so that when a droplet actuator cartridge electronically is coupled thereto: the droplet actuator cartridge is aligned with the detection apparatus; and the detection apparatus can sense the property of the droplet on a droplet actuator; circuitry for controlling a droplet actuator coupled to the droplet actuator connector; and the droplet actuator circuitry may be coupled to a processor.
摘要翻译：液滴致动器驱动器，其包括用于感测液滴致动器上的液滴的特性的检测装置; 用于控制检测装置的电路，电子耦合到所述检测装置; 液滴致动器盒连接器布置成使得当液滴致动器盒电子地耦合到其上时：液滴致动器盒与检测装置对准; 并且检测装置可以感测液滴致动器上的液滴的特性; 用于控制耦合到液滴致动器连接器的液滴致动器的电路; 并且液滴致动器电路可以耦合到处理器。

9. 发明申请

US20100270156A1 Droplet Actuator Configurations and Methods of Conducting Droplet Operations 审中-公开
标题翻译：液滴执行器配置和执行液滴操作的方法
公开(公告)号：US20100270156A1
公开(公告)日：2010-10-28
申请号：US12682830
申请日：2008-12-23
申请人： Vijay Srinivasan , Michael G. Pollack , Vamsee K. Pamula , Zhishan Hua , Arjun Sudarsan , Philip Paik
发明人： Vijay Srinivasan , Michael G. Pollack , Vamsee K. Pamula , Zhishan Hua , Arjun Sudarsan , Philip Paik
IPC分类号： C07K1/26
CPC分类号： B01L3/52 , B01F13/0071 , B01F13/0076 , B01L3/0241 , B01L3/502792 , B01L2200/027 , B01L2200/0605 , B01L2200/143 , B01L2200/16 , B01L2300/0816 , B01L2300/0819 , B01L2300/089 , B01L2400/0427 , B01L2400/06 , B01L2400/0688 , F04B19/006
摘要： A droplet actuator with a droplet formation electrode configuration associated with a droplet operations surface, wherein the electrode configuration comprises one or more electrodes configured to control volume of a droplet during formation of a sub-droplet on the droplet operations surface. Methods of making and using the droplet actuator are also provided.
摘要翻译：具有与液滴操作表面相关联的液滴形成电极配置的液滴致动器，其中所述电极配置包括一个或多个电极，其被配置为在液滴操作表面上形成子液滴期间控制液滴的体积。还提供了制造和使用液滴致动器的方法。

10. 发明申请

US20080105549A1 Methods for performing microfluidic sampling 有权
标题翻译：执行微流体取样的方法
公开(公告)号：US20080105549A1
公开(公告)日：2008-05-08
申请号：US11936289
申请日：2007-11-07
申请人： Vamsee Pamela , Michael Pollack , Philip Paik , Hong Ren , Richard Fair
发明人： Vamsee Pamela , Michael Pollack , Philip Paik , Hong Ren , Richard Fair
IPC分类号： G01N27/26
CPC分类号： B01F13/0071 , B01F13/0076 , B01F13/0084 , B01J2219/00479 , B01J2219/00653 , B01L3/502792 , B01L2300/089 , B01L2300/165 , B01L2400/0415 , B01L2400/0427 , C40B60/14 , G01N15/14 , G01N2035/1046 , G02B26/005 , Y10T436/11 , Y10T436/113332 , Y10T436/117497 , Y10T436/118339 , Y10T436/25 , Y10T436/25625 , Y10T436/2575
摘要： Methods for sampling a liquid flow are provided. The method includes supplying a continuous liquid flow from a continuous flow fluid input source to a surface along a first flow path. The method additionally includes sampling the continuous liquid flow by performing an electric field-based technique to split off a sample droplet from a portion of the liquid flow, whereby the sample droplet is distinct from the liquid flow and controllable independently of the liquid flow, wherein the electric field-based technique is performed by providing a set of electrodes on the surface and selectively biasing the set of electrodes, whereby the sample droplet is formed on one of the set of electrodes.
摘要翻译：提供了液体取样方法。该方法包括将连续的液体流从连续流体流体输入源提供到沿着第一流动路径的表面。该方法另外包括通过执行基于电场的技术对液体流的一部分分离样品液滴来对连续液体流进行采样，由此样品液滴与液体流不同，并且可独立于液体流动而控制，其中通过在表面上设置一组电极并选择性地偏置该组电极来执行基于电场的技术，由此在一组电极中形成样品液滴。

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