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1. 发明申请

US20050233963A1 Heat shock response and virus replication 审中-公开
标题翻译：热休克反应和病毒复制
公开(公告)号：US20050233963A1
公开(公告)日：2005-10-20
申请号：US11047063
申请日：2005-01-31
申请人： Pope Moseley , Matthew Cotten , Brian Hjelle , Antonito Panganiban , Peter Angeletti
发明人： Pope Moseley , Matthew Cotten , Brian Hjelle , Antonito Panganiban , Peter Angeletti
IPC分类号： A61K31/352 , A61K31/353 , A61K38/00 , C07K14/47 , A61K38/17 , A61K48/00
CPC分类号： A61K31/353 , A01K2217/05 , A61K31/352 , A61K38/00 , C07K14/47
摘要： The present invention discloses a method of inhibiting heat shock protein-dependent virus replication in cells and in animals. The present invention also discloses a method of identifying compounds which inhibit heat shock protein-dependent virus replication.
摘要翻译：本发明公开了一种抑制细胞和动物中热休克蛋白依赖型病毒复制的方法。本发明还公开了鉴定抑制热休克蛋白依赖病毒复制的化合物的方法。

2. 发明授权

US5981273A Composition comprising an endosomolytic agent for introducing nucleic acid complexes into higher eucaryotic cells 失效
标题翻译：组合物，其包含用于将核酸复合物引入高级真核细胞的内体分解剂
公开(公告)号：US5981273A
公开(公告)日：1999-11-09
申请号：US450417
申请日：1995-05-25
申请人： David T. Curiel , Max L. Birnstiel , Matthew Cotten , Ernst Wagner , Kurt Zatloukal , Christian Plank , Berndt Oberhauser , Walter G. M. Schmidt
发明人： David T. Curiel , Max L. Birnstiel , Matthew Cotten , Ernst Wagner , Kurt Zatloukal , Christian Plank , Berndt Oberhauser , Walter G. M. Schmidt
IPC分类号： A61K47/48 , A61K48/00 , C07K14/11 , C07K14/775 , C07K14/79 , C12N15/87 , C07H21/02 , C12N7/00
CPC分类号： A61K47/48776 , A61K48/00 , C07K14/005 , C07K14/775 , C07K14/79 , C12N15/87 , C07K2319/00 , C12N2740/16022
摘要： A composition for the transfection of higher eucaryotic cells, comprising complexes of nucleic acid, a substance having an affinity for nucleic acid and optionally an internalizing factor, contains an endosomolytic agent, e.g. a virus or virus component, which may be conjugated. The endosomolytic agent, which is optionally part of the nucleic acid complex, is internalized into the cells together with the complex and releases the contents of the endosomes into the cytoplasm, thereby increasing the gene transfer capacity. Pharmaceutical preparations, transfection kits and methods for introducing nucleic acid into higher eucaryotic cells by treating the cells with the composition are also disclosed.
摘要翻译：用于转染高等真核细胞的组合物，其包含核酸复合物，对核酸和任选的内在因子具有亲和力的物质，含有内体细胞溶解剂可以结合的病毒或病毒组分。任选地是核酸复合物的一部分的内体细胞溶解剂与复合物一起被内化到细胞中，并将内体的内容物释放到细胞质中，从而增加基因转移能力。还公开了药物制剂，转染试剂盒和通过用组合物处理细胞将核酸引入高级真核细胞的方法。

3. 发明授权

US06335016B1 Chicken embryo lethal orphan (CELO) virus 有权
标题翻译：鸡胚致死性孤儿（CELO）病毒
公开(公告)号：US06335016B1
公开(公告)日：2002-01-01
申请号：US09171461
申请日：1999-01-12
申请人： Adam Baker , Matthew Cotten , Susanna Chiocca , Robert Kurzbauer , Gotthold Schaffner
发明人： Adam Baker , Matthew Cotten , Susanna Chiocca , Robert Kurzbauer , Gotthold Schaffner
IPC分类号： A61K3912
CPC分类号： C12N7/00 , A61K39/00 , A61K2039/525 , C07K14/005 , C12N15/86 , C12N2710/10222 , C12N2710/10243
摘要： A CELO virus obtained by in vitro manipulation of a plasmid-cloned CELO virus DNA is suitable for the production of vectors for gene therapy and as a vaccine against infectious diseases in humans and animals, particularly birds.
摘要翻译：通过体外操纵质粒克隆的CELO病毒DNA获得的CELO病毒适用于生产用于基因治疗的载体和作为针对人和动物特别是鸟类中的感染性疾病的疫苗。

4. 发明授权

US5521291A Conjugates for introducing nucleic acid into higher eucaryotic cells 失效
标题翻译：用于将核酸引入高级真核细胞的缀合物
公开(公告)号：US5521291A
公开(公告)日：1996-05-28
申请号：US166899
申请日：1993-12-15
申请人： David T. Curiel , Ping-chuan Hu , Max L. Birnstiel , Matthew Cotten , Ernst Wagner
发明人： David T. Curiel , Ping-chuan Hu , Max L. Birnstiel , Matthew Cotten , Ernst Wagner
IPC分类号： A61K47/48 , C07K16/08 , C12N15/87 , A61K39/42 , C07H19/00 , C12N7/00
CPC分类号： C12N15/87 , A61K47/48692 , A61K47/48776 , C07K16/081
摘要： Conjugates in which a virus is bound via an antibody to a substance having an affinity for nucleic acid, for transporting gene constructs into higher eucaryotic cells. Complexes of the conjugates and nucleic acid are internalized in the cell, whilst the virus as part of the complex brings about the internalization and the release of the contents of the endosomes, in which the complexes are located after entering the cell. Pharmaceutical preparations in which the nucleic acid is a therapeutically active gene construct, particularly for use in gene therapy.
摘要翻译：通过抗体将病毒结合到对核酸具有亲和性的物质，用于将基因构建体转运到较高真核细胞中的缀合物。缀合物和核酸的复合物被内化在细胞中，而作为复合物的一部分的病毒导致内含体的内化和释放，其中复合物在进入细胞后位于其中。其中核酸是治疗活性基因构建体，特别是用于基因治疗的药物制剂。

5. 发明授权

US5693509A Adenovirus for delivering foreign DNA into higher eukaryotic cells 失效
标题翻译：腺病毒用于将外源DNA递送入高等真核细胞
公开(公告)号：US5693509A
公开(公告)日：1997-12-02
申请号：US530181
申请日：1995-09-29
申请人： Matthew Cotten , Ernst Wagner
发明人： Matthew Cotten , Ernst Wagner
IPC分类号： C12N15/09 , A61K35/14 , A61K35/76 , A61K48/00 , C12N7/00 , C12N7/01 , C12N7/04 , C12N15/861 , C12N15/87 , C12N5/00 , C07K3/08
CPC分类号： C12N7/00 , A61K48/00 , C12N15/86 , C12N15/87 , C12N2710/10323 , C12N2710/10343 , C12N2710/10345 , C12N2710/10362 , C12N2810/80
摘要： Viruses or cells are targeted for selective internalization into a target in vive. A molecule Specific for a receptor on the surface of the target cell is introduced onto the surface of the virus or cell. The modified virus or cell binds the receptor in vive and is internalized by the target cell. The method provides vectors for selective delivery of nucleic acids to specific cell types in vivo and a means to alter the tropism of an infectious agent.
摘要翻译： PCT No.PCT / EP94 / 01065 Sec。 371 1995年9月29日第 102（e）1995年9月29日PCT PCT 1994年4月6日PCT公布。第WO94 / 24299号公报日期1994年10月27日病毒或细胞的目标是选择性地内化到一个目标。将靶细胞表面上的受体特异性的分子引入病毒或细胞的表面。修饰的病毒或细胞在vive中结合受体，并被靶细胞内化。该方法提供用于在体内选择性递送核酸到特定细胞类型的载体，以及改变感染因子的向性的方法。

6. 发明授权

US06797506B1 Recombinant, replication defective CELO virus and CELO virus DNA 有权
标题翻译：重组，复制缺陷型CELO病毒和CELO病毒DNA
公开(公告)号：US06797506B1
公开(公告)日：2004-09-28
申请号：US09688371
申请日：2000-10-12
申请人： Matthew Cotten , Jolanta Glotzer , Anne-Isabelle Michou
发明人： Matthew Cotten , Jolanta Glotzer , Anne-Isabelle Michou
IPC分类号： C12N701
CPC分类号： C07K14/005 , C07K14/465 , C07K2319/20 , C12N7/00 , C12N15/86 , C12N2710/10221 , C12N2710/10222 , C12N2710/10243
摘要： Recombinant CELO virus or CELO virus DNA with a deletion or disruption of the Gam1 gene, optionally combined with deletions at the right or left end of the viral genome that allow insertion of large pieces of foreign DNA. The virus is useful as a vaccine for animals, in particular birds, and for gene therapy and vaccine applications in humans. The virus can also be used for recombinant protein production.
摘要翻译：具有缺失或破坏Gam1基因的重组CELO病毒或CELO病毒DNA，任选地与病毒基因组右侧或左侧的缺失组合，允许插入大量外来DNA。该病毒可用作动物，特别是鸟类的疫苗，以及用于人类的基因治疗和疫苗应用。该病毒也可用于重组蛋白质生产。

7. 发明授权

US06773709B2 Chicken embryo lethal (CELO) virus 有权
标题翻译：鸡胚胎致死（CELO）病毒
公开(公告)号：US06773709B2
公开(公告)日：2004-08-10
申请号：US09970711
申请日：2001-10-05
申请人： Adam Baker , Matthew Cotten , Susanna Chiocca , Robert Kurzbauer , Gotthold Schaffner
发明人： Adam Baker , Matthew Cotten , Susanna Chiocca , Robert Kurzbauer , Gotthold Schaffner
IPC分类号： A61K3912
CPC分类号： C12N7/00 , A61K39/00 , A61K2039/525 , C07K14/005 , C12N15/86 , C12N2710/10222 , C12N2710/10243
摘要： A CELO virus obtained by in vitro manipulation of a plasmid-cloned CELO virus DNA is suitable for the production of vectors for gene therapy and as a vaccine against infectious diseases in humans and animals, particularly birds.
摘要翻译：通过体外操纵质粒克隆的CELO病毒DNA获得的CELO病毒适用于生产用于基因治疗的载体和作为针对人和动物特别是鸟类中的感染性疾病的疫苗。

8. 发明授权

US06284880B1 Chicken embryo lethal orphan (CELO) virus GAM-1 失效
标题翻译：鸡胚致死性孤儿（CELO）病毒GAM-1
公开(公告)号：US06284880B1
公开(公告)日：2001-09-04
申请号：US08750180
申请日：1997-02-14
申请人： Matthew Cotten , Adam Baker , Susanna Chiocca
发明人： Matthew Cotten , Adam Baker , Susanna Chiocca
IPC分类号： C07H2104
CPC分类号： C07K14/005 , C07K14/4702 , C07K14/4747 , C07K14/5412 , C07K14/5421 , C12N15/79 , C12N15/87 , C12N2710/10222 , C12N2710/10322
摘要： The toxicity problems which occur when foreign material is introduced into higher eukaryotic cells, particularly during transfection with DNA, are countered by causing gene products to be expressed in the cell, which block the apoptosis triggered by the transfection process, and/or by treating the cells with anti-inflammatory substances. Preferably, Bcl-2, E1B 19K or an anti-apoptotically active gene of chicken adenovirus CELO is used as the anti-apoptosis gene whilst the inflammatory substance used is adenovirus VA1, which is introduced into the cell in the form of VA1-DNA. Using these methods, long-lasting gene expression can be achieved.
摘要翻译：外源物质被引入高等真核生物细胞时，特别是在用DNA转染时发生的毒性问题，是通过使细胞中表达基因产物，阻止由转染过程触发的细胞凋亡和/或通过细胞具有抗炎物质。优选地，使用Bcl-2，E1B19K或鸡腺病毒CELO的抗细胞凋亡活性基因作为抗凋亡基因，而使用的炎性物质是以VA1-DNA的形式引入细胞的腺病毒VA1。使用这些方法可以实现持久的基因表达。

9. 发明授权

US06274322B1 Composition for introducing nucleic acid complexes into higher eucaryotic cells 有权
标题翻译：用于将核酸复合物引入高级真核细胞的组合物
公开(公告)号：US06274322B1
公开(公告)日：2001-08-14
申请号：US09465646
申请日：1999-12-16
申请人： David T. Curiel , Max L. Birnstiel , Matthew Cotten , Ernst Wagner , Kurt Zatloukal , Christian Plank , Berndt Oberhauser , Walter G. M. Schmidt
发明人： David T. Curiel , Max L. Birnstiel , Matthew Cotten , Ernst Wagner , Kurt Zatloukal , Christian Plank , Berndt Oberhauser , Walter G. M. Schmidt
IPC分类号： C12Q168
CPC分类号： C12N15/87 , A61K38/00 , A61K47/50 , A61K47/6901 , A61K48/00 , C07K14/005 , C07K14/56 , C07K14/775 , C07K14/79 , C07K16/00 , C07K16/2803 , C07K2317/77 , C07K2319/00 , C12N7/00 , C12N2710/10251 , C12N2710/10261 , C12N2710/10322 , C12N2710/10351 , C12N2710/10361 , C12N2710/10363 , C12N2740/11022 , C12N2740/15022 , C12N2740/16022 , C12N2740/16122 , C12N2760/16122 , C12N2770/32722 , C12N2770/32761 , Y10T436/143333
摘要： A composition for the transfection of higher eucaryotic cells, comprising complexes of nucleic acid, a substance having an affinity for nucleic acid and optionally an internalizing factor, contains an endosomolytic agent, e.g. a virus or virus component, which may be conjugated. The endosomolytic agent, which is optionally part of the nucleic acid complex, is internalized into the cells together with the complex and releases the contents of the endosomes into the cytoplasm, thereby increasing the gene transfer capacity. Pharmaceutical preparations, transfection kits and methods for introducing nucleic acid into higher eucaryotic cells by treating the cells with the composition are also disclosed.
摘要翻译：用于转染高等真核细胞的组合物，其包含核酸复合物，对核酸和任选的内在因子具有亲和力的物质，含有内体细胞溶解剂可以结合的病毒或病毒组分。任选地是核酸复合物的一部分的内体细胞溶解剂与复合物一起被内化到细胞中，并将内体的内容物释放到细胞质中，从而增加基因转移能力。还公开了药物制剂，转染试剂盒和通过用组合物处理细胞将核酸引入高级真核细胞的方法。

10. 发明授权

US5922859A Complexes containing nucleic acid which can be taken-up by endocytosis into higher eukaryotic cells 失效
标题翻译：含有核酸的复合物，其可通过内吞作用摄入高等真核细胞
公开(公告)号：US5922859A
公开(公告)日：1999-07-13
申请号：US98265
申请日：1993-08-05
申请人： Max L. Birnstiel , Matthew Cotten , Ernst Wagner
发明人： Max L. Birnstiel , Matthew Cotten , Ernst Wagner
IPC分类号： A61K48/00 , C12N15/87 , C07H21/04
CPC分类号： A61K48/00 , C12N15/87
摘要： Complexes between internalizing factor-bonding factor conjugates and nucleic acid which can be taken up into higher eukaryotic cells by endocytosis containing, in non-covalently bound form, one or more substances having an affinity for nucleic acid, which are capable of increasing the efficiency of absorption of the complexes into the cells. The non-covalently bound substance having an affinity for nucleic acid may optionally be identical to the bonding factor, preferably a polycationic substance. The internalizing factor is preferably transferrin. Processes for preparing the complexes and processes for introducing nucleic acid into higher eukaryotic cells. Pharmaceutical preparations containing complexes with a therapeutically active nucleic acid.
摘要翻译： PCT No.PCT / EP92 / 00217 Sec。 371日期：1993年8月5日 102（e）日期1993年8月5日PCT提交1992年2月1日PCT公布。出版物WO92 / 13570 日期1992年8月20日内部化因子结合因子偶联物和核酸之间的复合物，其可以通过内吞作用吸收到较高真核细胞中，所述胞吞作用以非共价结合形式含有一种或多种对核酸具有亲和力的物质，其具有能力提高复合物吸收细胞的效率。对核酸具有亲和力的非共价结合物质可任选地与结合因子相同，优选聚阳离子物质。内在因子优选为转铁蛋白。用于制备复合物的方法和将核酸引入更高真核细胞的方法。含有与治疗活性核酸复合物的药物制剂。

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