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1. 发明授权

US06670167B1 Catalytic domain of the human effector cell cycle checkpoint protein kinase materials and methods for identification of inhibitors thereof 失效
标题翻译：人效应细胞周期检查点蛋白激酶材料的催化结构域及其抑制剂的鉴定方法
公开(公告)号：US06670167B1
公开(公告)日：2003-12-30
申请号：US09460421
申请日：1999-12-14
申请人： Ping Chen , Mark Anderson , Ya-Li Deng , Smita Gaur , Chen Chen Kan , Chun Luo , Karen Lundgren , Stephen Margosiak , Binh Nguyen , Patrick O'Connor , James Register , Anna Tempczyk Russell , Jay Sarup
发明人： Ping Chen , Mark Anderson , Ya-Li Deng , Smita Gaur , Chen Chen Kan , Chun Luo , Karen Lundgren , Stephen Margosiak , Binh Nguyen , Patrick O'Connor , James Register , Anna Tempczyk Russell , Jay Sarup
IPC分类号： C07H2104
CPC分类号： C12N9/1205 , C12Q1/34
摘要： The present invention relates to the identification, isolation and purification of the catalytic domain of the human effector checkpoint protein kinase (hChk1). A 1.7Å crystal structure of the hChk1 kinase domain in the active conformation is reported herein. The kinase domain of hChk1 and its associated crystal structure is described for use in the discovery, identification and characterization of inhibitors of hChk1. This structure provides a three-dimensional description of the binding site of the hChk1 for structure-based design of small molecule inhibitors thereof as therapeutic agents. Inhibitors of hChk1 find utility in the treatment of hyperproliferative disorders such as HIV and cancer.
摘要翻译：本发明涉及人类效应子检测点蛋白激酶（hChk1）的催化结构域的鉴定，分离和纯化。本文报道了活性构象中hChk1激酶结构域的1.7Å晶体结构。描述了hChk1的激酶结构域及其相关晶体结构，用于hChk1抑制剂的发现，鉴定和表征。该结构提供了hChk1的结合位点的三维描述，用于其作为治疗剂的小分子抑制剂的基于结构的设计。 hChk1的抑制剂可用于治疗过度增生性疾病如艾滋病毒和癌症。

2. 发明申请

US20050013573A1 Fiber optic articles, assemblies, and cables having optical waveguides 有权
标题翻译：具有光波导的光纤制品，组件和电缆
公开(公告)号：US20050013573A1
公开(公告)日：2005-01-20
申请号：US10623219
申请日：2003-07-18
申请人： Gregory Lochkovic , Sheila Cooper , Leigh Josey , James Register , Larry Self , Edward Fewkes , Michael Winningham , Huan-Hung Sheng , Michelle Fabian
发明人： Gregory Lochkovic , Sheila Cooper , Leigh Josey , James Register , Larry Self , Edward Fewkes , Michael Winningham , Huan-Hung Sheng , Michelle Fabian
IPC分类号： G02B6/44 , G02B6/22
CPC分类号： G02B6/4433 , G02B6/4402 , G02B6/4404 , G02B6/441 , G02B6/4422 , G02B6/4482
摘要： Fiber optic articles, assemblies, and cables preserve optical performance by using optical waveguides having a core, a cladding, and a coating system according to the present invention. Moreover, the optical articles, assemblies, and cables of the present invention may achieve performance levels that were previously unattainable, for instance, the present invention contemplates acceptable optical performance for wavelengths such as 1625 nm and higher. Additionally, articles, assemblies, and/or cables of the present invention advantageously preserve optical performance, i.e., have relatively low delta attenuation, when subjected to manufacturing processes and/or environmental conditions such as temperature cycling. In other words, the articles, assemblies, and cables can withstand increased stress/strain before having significant attenuation.
摘要翻译：光纤制品，组件和电缆通过使用根据本发明的具有芯，包层和涂层系统的光波导来保持光学性能。此外，本发明的光学制品，组件和电缆可以实现以前不可实现的性能水平，例如，本发明考虑了对于诸如1625nm和更高的波长的可接受的光学性能。另外，当经受制造工艺和/或诸如温度循环的环境条件时，本发明的制品，组件和/或电缆有利地保持光学性能，即具有相对低的Δ衰减。换句话说，物品，组件和电缆可以在有明显的衰减之前承受增加的应力/应变。

3. 发明申请

US20070230879A1 Armored fiber optic cable having a centering element and methods of making 审中-公开
标题翻译：具有定心元件的装甲光纤和制造方法
公开(公告)号：US20070230879A1
公开(公告)日：2007-10-04
申请号：US11395405
申请日：2006-03-31
申请人： Warren McAlpine , Scott McDowell , Rodney Burns , James Register
发明人： Warren McAlpine , Scott McDowell , Rodney Burns , James Register
IPC分类号： G02B6/44
CPC分类号： G02B6/4488
摘要： Armored fiber optic cables and methods for making are disclosed that include an armor layer generally surrounding a fiber optic cable that includes at least one optical waveguide and a cable jacket. The cable jacket has an outer diameter and armor layer has an inner surface, wherein a gap exists between the outer diameter of the cable jacket and the inner surface of the armor layer. The armored fiber optic cable further includes a centering element disposed in the gap between the fiber optic cable and the armor layer. The centering element generally inhibits the fiber optic cable from moving away from a middle of the armored fiber optic cable towards the inner surface of the armor layer during winding of the armored fiber optic cable, thereby inhibiting wavy armor and/or preserving the optical performance of the at least one optical waveguide.
摘要翻译：公开了装甲光纤电缆和制造方法，其包括通常围绕包括至少一个光波导和电缆护套的光纤电缆的铠装层。电缆护套具有外径，并且护甲层具有内表面，其中在电缆护套的外径和护甲层的内表面之间存在间隙。装甲光缆还包括设置在光纤电缆和铠装层之间的间隙中的定心元件。定心元件通常在缠绕铠装光纤电缆期间阻止光纤电缆从铠装光纤电缆的中间向着装甲层的内表面移动，由此抑制波浪装甲和/或保持光纤性能所述至少一个光波导。

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