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1. 发明授权

US07199159B2 Use of biguanide derivatives for making a medicine having a wound healing effect 有权
标题翻译：使用双胍衍生物制造具有伤口愈合作用的药物
公开(公告)号：US07199159B2
公开(公告)日：2007-04-03
申请号：US10297003
申请日：2001-05-23
申请人： Pierre Jean-Paul Potier , Nobumichi-André Sasaki , Maria Conception Achab , Gisèle Franck , Claude Thal , Joanna Bakala
发明人： Pierre Jean-Paul Potier , Nobumichi-André Sasaki , Maria Conception Achab , Gisèle Franck , Claude Thal , Joanna Bakala
IPC分类号： A61K31/155
CPC分类号： A61K31/155 , Y10S514/969
摘要： The present invention relates to the use of biguanide derivatives of general formula I below: in which: the groups R1 and R2 represent, independently of each other, a hydrogen atom, a C1–C7, alkyl group, a cycloalkyl group, a heterocycle, a C2–C7 alkenyl group, an aryl group, an aralkyl group, an aryloxyalkyl group or a heteroaryl group, or R1 and R2, taken together, represent a C2–C7 alkylene which may contain one or more hetero atoms, and the group R3 represents a primary, secondary or tertiary amine, or pharmaceutically acceptable salts thereof, to manufacture a medicinal product with cicatrizing action, the said medicinal product being in a pharmaceutical form for topical use.
摘要翻译：本发明涉及以下通式I的双胍衍生物的用途：

2. 发明申请

US20120252866A1 Age Inhibitors 有权
标题翻译：年龄抑制剂
公开(公告)号：US20120252866A1
公开(公告)日：2012-10-04
申请号：US13437491
申请日：2012-04-02
申请人： Pierre Potier , Guy Jean Marie Potier , Marie Claude Denise Michele Zelveyan , Catherine Marie Germaine Magnan , Odette Drion , Nobumichi André Sasaki , Maria Concepcion Achab Garcia Alvarez , Qian Wang-Zhu , Lioudmila Ermolenko , Joanna Bakala , Gisèle Franck , Naïma Bakrim Nhiri
发明人： Pierre Potier , Guy Jean Marie Potier , Marie Claude Denise Michele Zelveyan , Catherine Marie Germaine Magnan , Odette Drion , Nobumichi André Sasaki , Maria Concepcion Achab Garcia Alvarez , Qian Wang-Zhu , Lioudmila Ermolenko , Joanna Bakala , Gisèle Franck , Naïma Bakrim Nhiri
IPC分类号： A61K8/36 , A61K8/49 , A61Q19/08 , A61K8/37
CPC分类号： C07K5/06086 , A61K38/00 , C07K5/0815
摘要： The invention relates to a compound having general formula I, wherein: X represents CH2, C═O, C═S or CHOH, R1 represents an amino acid optionally substituted by one or more halogen atoms, or by one or more CF3 groups and n=0.1 or 2, or R1 represents a peptide containing two amino acids, each amino acid being optionally substituted by one or more halogen atoms, or by one or more CF3 groups and n=0 or 1, or XR1 represent PO3H or SO3H and n=0.1 or 2; R2 represents H, XR1, an alkyl group at C1-C6, an aralkyl group at C1-C6 or an aryl group, whereby the alkyl, aralkyl and aryl groups can be substituted by an amine NH2, a carboxylic group COOH, one or more halogen atoms.
摘要翻译：本发明涉及具有通式I的化合物，其中：X表示CH 2，C = O，C = S或CHOH，R 1表示任选被一个或多个卤素原子取代或通过一个或多个CF 3基团和n = 0.1或2，或R1表示含有两个氨基酸的肽，每个氨基酸任选被一个或多个卤素原子取代，或被一个或多个CF 3基团取代，n = 0或1，或XR1表示PO3H或SO3H，n = 0.1或2; R 2表示H，XR1，C 1 -C 6的烷基，C 1 -C 6的芳烷基或芳基，其中烷基，芳烷基和芳基可以被胺NH 2，羧基COOH，一个或多个卤原子。

3. 发明申请

US20100129471A1 ISO CA-4 AND ANALOGUES THEREOF AS POTENT CYTOTOXIC AGENTS INHIBITING TUBULINE POLYMERIZATION 有权
标题翻译： ISO CA-4及其类似物作为细胞毒素代谢抑制管道聚合
公开(公告)号：US20100129471A1
公开(公告)日：2010-05-27
申请号：US12594495
申请日：2008-04-04
申请人： Mouâd Alami , Jean-Daniel Brion , Olivier Provot , Jean-François Peyrat , Samir Messaoudi , Abdallah Hamze , Anne Giraud , Jérôme Bignon , Joanna Bakala , Jian-Miao Liu
发明人： Mouâd Alami , Jean-Daniel Brion , Olivier Provot , Jean-François Peyrat , Samir Messaoudi , Abdallah Hamze , Anne Giraud , Jérôme Bignon , Joanna Bakala , Jian-Miao Liu
IPC分类号： A61K31/09 , C07C43/23 , C07C43/215 , C07D215/00 , C07C69/00 , C07C205/06 , C07F9/02 , C07C217/80 , C07H15/207 , C07D213/79 , A61K31/36 , A61K31/505 , A61K31/216 , A61K31/352 , A61K31/136 , A61K31/7034 , A61K31/66 , A61K31/44 , A61K31/52 , A61K31/7068 , A61K31/519 , A61K31/4545 , A61K31/7048 , A61K33/24 , A61K38/12
CPC分类号： C07H15/203 , C07C43/215 , C07C43/225 , C07C43/23 , C07C69/017 , C07C69/24 , C07C205/37 , C07C217/84 , C07C219/32 , C07C229/12 , C07C229/42 , C07C271/22 , C07C271/44 , C07C305/24 , C07C309/65 , C07C2603/18 , C07D215/14 , C07D317/54 , C07F9/12
摘要： The invention relates to a compound of the formula (I) in which: R1, R2 and R3 are independently a methoxy group optionally substituted by one or more fluorine atoms; R4 is a hydrogen atom; R5 and R6 are identical and each represent a hydrogen or fluorine atom; A is a cycle selected from the group including aryl and heteroaryl groups, wherein said groups can be substituted.
摘要翻译：本发明涉及式（I）化合物，其中：R 1，R 2和R 3独立地为任选被一个或多个氟原子取代的甲氧基; R4是氢原子; R5和R6相同，各自表示氢或氟原子; A是选自包括芳基和杂芳基的基团，其中所述基团可被取代。

4. 发明授权

US08697652B2 Cosmetic use of at least the natural tetrapeptide Ac-Ser-Asp-Lys-Pro or one of its analogs as a skin restructuring agent 有权
标题翻译：化妆品使用至少天然四肽Ac-Ser-Asp-Lys-Pro或其类似物之一作为皮肤重组剂
公开(公告)号：US08697652B2
公开(公告)日：2014-04-15
申请号：US11630264
申请日：2005-06-22
申请人： Joanna Bakala , Jean-Yves Lallemand , Jian-Miao Liu , Jérôme Bignon
发明人： Joanna Bakala , Jean-Yves Lallemand , Jian-Miao Liu , Jérôme Bignon
IPC分类号： A61K8/64 , A61K8/00 , A61P17/00 , A61K38/07 , A61K38/00 , A61K9/00 , A61Q19/00 , A61Q19/08
CPC分类号： A61K38/07 , A61K8/64 , A61K9/0014 , A61K38/00 , A61Q19/00 , A61Q19/08
摘要： This invention relates to the cosmetic use of at least one compound of formula (I) wherein A1 is the radical corresponding to D- or L-Ser A2 is the radical corresponding to D- or L-Asp or Glu, A3 is the radical corresponding to D- or L-Lys, Arg or Orn, A4 is the radical corresponding to D- or L-pro, R1, R2 and R3 are as defined in the claims as anti-aging and restructuring agents.
摘要翻译：本发明涉及至少一种式（I）化合物的化妆品用途，其中A1是对应于D-或L-Ser A2的基团是对应于D-或L-Asp或Glu的基团，A3是相应的基团对于D-或L-Lys，Arg或Orn，A4是对应于D-或L-pro的基团，R 1，R 2和R 3如权利要求中所定义，作为抗老化和重组剂。

5. 发明申请

US20070259819A1 Cosmetic Use of at Least Natural Tetrapeptide Ac-Ser-Asp-Lys-Pro or One of Its Analogs as a Skin Anti-Aging and Restructuring Agent 有权
标题翻译：至少天然四肽Ac-Ser-Asp-Lys-Pro或其类似物之一的化妆品使用作为皮肤抗衰老和重组剂
公开(公告)号：US20070259819A1
公开(公告)日：2007-11-08
申请号：US11630264
申请日：2005-06-22
申请人： Joanna Bakala , Jean-Yves Lallemand , Jian-Miao Liu , Jerome Bignon
发明人： Joanna Bakala , Jean-Yves Lallemand , Jian-Miao Liu , Jerome Bignon
IPC分类号： A61K38/07 , A61P17/00
CPC分类号： A61K38/07 , A61K8/64 , A61K9/0014 , A61K38/00 , A61Q19/00 , A61Q19/08
摘要： This invention relates to the cosmetic use of at least one compound of formula (I) wherein A1 is the radical corresponding to D- or L-Ser A2 is the radical corresponding to D- or L-Asp or Glu, A3 is the radical corresponding to D- or L-Lys, Arg or Orn, A4 is the radical corresponding to D- or L-pro, R1, R2 and R3 are as defined in the claims as anti-aging and restructuring agents.
摘要翻译：本发明涉及至少一种式（I）化合物的化妆品用途，其中A 1是对应于D-或L-Ser A 2 N 2的基团是自由基对应于D-或L-Asp或Glu，A 3是与D-或L-Lys，Arg或Orn相应的基团，A 4是对应于 D-或L-丙基，R 1，R 2和R 3如权利要求中所定义，作为抗老化和重组剂。

6. 发明授权

US08273768B2 Iso CA-4 and analogues thereof as potent cytotoxic agents inhibiting tubuline polymerization 有权
标题翻译： Iso CA-4及其类似物作为抑制微管蛋白聚合的有效细胞毒性剂
公开(公告)号：US08273768B2
公开(公告)日：2012-09-25
申请号：US12594495
申请日：2008-04-04
申请人： Mouâd Alami , Jean-Daniel Brion , Olivier Provot , Jean-François Peyrat , Samir Messaoudi , Abdallah Hamze , Anne Giraud , Jérôme Bignon , Joanna Bakala , Jian-Miao Liu
发明人： Mouâd Alami , Jean-Daniel Brion , Olivier Provot , Jean-François Peyrat , Samir Messaoudi , Abdallah Hamze , Anne Giraud , Jérôme Bignon , Joanna Bakala , Jian-Miao Liu
IPC分类号： A61K31/47 , C07D215/14
CPC分类号： C07H15/203 , C07C43/215 , C07C43/225 , C07C43/23 , C07C69/017 , C07C69/24 , C07C205/37 , C07C217/84 , C07C219/32 , C07C229/12 , C07C229/42 , C07C271/22 , C07C271/44 , C07C305/24 , C07C309/65 , C07C2603/18 , C07D215/14 , C07D317/54 , C07F9/12
摘要： The invention relates to a compound of the formula (I) in which: R1, R2 and R3 are independently a methoxy group optionally substituted by one or more fluorine atoms; R4 is a hydrogen atom; R5 and R6 are identical and each represent a hydrogen or fluorine atom; A is a cycle selected from the group including aryl and heteroaryl groups, wherein said groups can be substituted.
摘要翻译：本发明涉及式（I）化合物，其中：R 1，R 2和R 3独立地为任选被一个或多个氟原子取代的甲氧基; R4是氢原子; R5和R6相同，各自表示氢或氟原子; A是选自包括芳基和杂芳基的基团，其中所述基团可被取代。

7. 发明授权

US09512176B2 Age inhibitors 有权
标题翻译：年龄抑制剂
公开(公告)号：US09512176B2
公开(公告)日：2016-12-06
申请号：US13437491
申请日：2012-04-02
申请人： Pierre Potier , Guy Jean Marie Potier , Marie-Claude Denise Michele Zelveyan , Catherine Marie Germaine Magnan , Odette Drion , Nobumichi Andre Sasaki , Maria Concepcion Achab Garcia Alvarez , Qian Wang-Zhu , Lioudmila Ermolenko , Joanna Bakala , Gisele Franck , Naima Bakrim Nhiri
发明人： Pierre Potier , Nobumichi Andre Sasaki , Maria Concepcion Achab Garcia Alvarez , Qian Wang-Zhu , Lioudmila Ermolenko , Joanna Bakala , Gisele Franck , Naima Bakrim Nhiri
IPC分类号： C07K5/068 , A61K38/00 , C07K5/09
CPC分类号： C07K5/06086 , A61K38/00 , C07K5/0815
摘要： The invention relates to a compound having general formula I, wherein: X represents CH2, C═O, C═S or CHOH, R1 represents an amino acid optionally substituted by one or more halogen atoms, or by one or more CF3 groups and n=0.1 or 2, or R1 represents a peptide containing two amino acids, each amino acid being optionally substituted by one or more halogen atoms, or by one or more CF3 groups and n=0 or 1, or XR1 represent PO3H or SO3H and n=0.1 or 2; R2 represents H, XR1, an alkyl group at C1-C6, an aralkyl group at C1-C6 or an aryl group, whereby the alkyl, aralkyl and aryl groups can be substituted by an amine NH2, a carboxylic group COOH, one or more halogen atoms.

8. 发明申请

US20110160228A1 DIHYDRO-ISO-CA-4 AND ANALOGUES: POTENT CYTOTOXICS, INHIBITORS OF TUBULIN POLYMERIZATION 审中-公开
标题翻译： DIHYDRO-ISO-CA-4和模拟物：细胞毒素，管状体聚合酶抑制剂
公开(公告)号：US20110160228A1
公开(公告)日：2011-06-30
申请号：US12996488
申请日：2009-06-04
申请人： Mouâd Alami , Samir Messaoudi , Abdallah Hamze , Olivier Provot , Jean-Daniel Brion , Jian-Miao Liu , Jérôme Bignon , Joanna Bakala
发明人： Mouâd Alami , Samir Messaoudi , Abdallah Hamze , Olivier Provot , Jean-Daniel Brion , Jian-Miao Liu , Jérôme Bignon , Joanna Bakala
IPC分类号： A61K31/52 , C07C43/23 , A61K31/09 , A61P35/00 , A61P17/06 , A61K31/36 , C07D317/54 , C07C69/035 , A61K31/222 , A61K31/136 , C07C217/84 , C07C271/22 , A61K31/27 , C07D209/12 , A61K31/404 , A61K31/26 , C07C255/37 , C07D473/34
CPC分类号： C07D215/14 , C07C41/16 , C07C41/18 , C07C41/20 , C07C41/30 , C07C43/2055 , C07C43/225 , C07C43/23 , C07C69/013 , C07C217/80 , C07C217/84 , C07C217/90 , C07C217/92 , C07C229/12 , C07C233/25 , C07C255/37 , C07C271/22 , C07C271/44 , C07C2603/18 , C07D209/12 , C07D213/64 , C07D213/74 , C07D215/38 , C07D307/80 , C07D311/12 , C07D317/54 , C07D473/34 , C07F9/12 , C07C43/215
摘要： The present invention relates to compounds of formula (I) below in which: —R1 and R3 represent, independently of one another, a methoxy group optionally substituted by one or more fluorine atoms, —R2 and R4 represent, independently of one another, a hydrogen atom or a methoxy group optionally substituted by one or more fluorine atoms, —A represents a ring chosen from the group comprising aryl and heteroaryl groups, said ring possibly being substituted by or fused to a heterocycle, —X represents a nitrogen atom or a CH group, and —Z1 represents a hydrogen atom or a halogen atom, preferably fluorine, and —Z2 represents a hydrogen atom, a halogen atom, preferably fluorine, a C1 to C4 alkyl group, an aryl group or a —CN, —SO2NR12R13, —SO2R9, —COOR15 or —COR15 group, and also to the pharmaceutically acceptable salts thereof, the isomers thereof and the prodrugs thereof.
摘要翻译：本发明涉及以下式（I）化合物：其中：-R 1和R 3彼此独立地表示任选被一个或多个氟原子取代的甲氧基，-R 2和R 4彼此独立地表示：氢原子或任选被一个或多个氟原子取代的甲氧基，-A表示选自芳基和杂芳基的环，所述环可以被杂环取代或稠合，-X表示氮原子或 CH基，-Z1表示氢原子或卤素原子，优选氟，-Z2表示氢原子，卤素原子，优选氟，C1〜C4烷基，芳基或-CN，-SO2NR12R13 ，-SO 2 R 9，-COOR 15或-COR 15基团，以及其药学上可接受的盐，其异构体及其前药。

9. 发明申请

US20070167515A1 Pyranone derivatives useful for treating cancer 失效
标题翻译：用于治疗癌症的吡喃酮衍生物
公开(公告)号：US20070167515A1
公开(公告)日：2007-07-19
申请号：US10585974
申请日：2005-01-14
申请人： Joanna Bakala , Denyse Herlem , Emile Benechie , Jerome Bignon , Francoise Khuong-Huu , Pierre Potier
发明人： Joanna Bakala , Denyse Herlem , Emile Benechie , Jerome Bignon , Francoise Khuong-Huu , Pierre Potier
IPC分类号： A61K31/366 , C07D309/38
CPC分类号： C07D309/38 , C07C45/298 , C07C45/30 , C07C47/273
摘要： The invention relates to pyranone derivatives of general formula (I), wherein X is chlorine, bromine or iodine and R1 and R2 is independently a hydrogen atom, an alkyl, cycloalkyl or alkylene, linear or branched group containing 1-20 carbon atoms, optionally substituted by a hydroxyl, amino, ether or halogen group, or R1 and R2 form together a cycle of 5, 6, 7 or 8 members which is optionally substituted by a hydroxyl, amino, ether or halogen group including isomers, enantiomers, diastereoisomers and the mixtures thereof. A method for preparing the inventive derivatives and the therapeutic use thereof, in particular for treating cancer, are also disclosed.
摘要翻译：本发明涉及通式（I）的吡喃酮衍生物，其中X为氯，溴或碘，R 1和R 2独立地为氢原子，烷基，环烷基或亚烷基，任选被羟基，氨基，醚或卤素基团取代的1-20个碳原子的直链或支链基团，或者R 1和R 2共同形成任选被羟基，氨基，醚或卤素基团取代的5,6,7或8个成员的循环，包括异构体，对映异构体，非对映异构体及其混合物。还公开了制备本发明衍生物的方法及其治疗用途，特别是用于治疗癌症。

10. 发明授权

US07235532B2 Angiogenic agents and their uses 有权
标题翻译：血管生成剂及其用途
公开(公告)号：US07235532B2
公开(公告)日：2007-06-26
申请号：US10380983
申请日：2001-09-20
申请人： Joanna Bakala , Jean-Paul Pierre Potier , Françoise Lawrence , Nathalie Cheviron , Jérôme Bignon , Yves Fromes
发明人： Joanna Bakala , Jean-Paul Pierre Potier , Françoise Lawrence , Nathalie Cheviron , Jérôme Bignon , Yves Fromes
IPC分类号： A61K38/06 , A61K38/07
CPC分类号： A61K38/07 , A61K38/06
摘要： The present invention relates to the use of a compound of formula I: in which, A1 is the radical corresponding to D- or L-Ser, A2 is the radical corresponding to D- or L-Asp or Glu, A3 is the radical corresponding to D- or L-Lys, Arg or Gm, A4 is the radical corresponding to D- or L-Pro, R1 and R2 are chosen, independently, from H, C1–C12-alkyl which may or may not be substituted, C7–C20-arylalkyl which may or may not be substituted, R4CO or R4COO, R4 being C1–C12-alkyl which may or may not be substituted, or C7–C20-arylalkyl which may or may not be substituted; among the substitutions, mention should be made of OH, NH2 or COOH, X1 and X2 are peptide or pseudopeptide bonds, X3 is CO or CH2 and R3 is OH, NH2, C1–C1-alkoxy or NH-X4-CH2-Z, X4 is a normal or branched C1–C12 hydrocarbon, and Z is H, OH, CO2H or CONH2, or the corresponding tripeptides comprising the radicals A1, A2, A3, and also the pharmacautically acceptable salts, for the preparation of a medicament for treating pathologies which may benefit from stimulation of angiogenesis.
摘要翻译：本发明涉及式I化合物的用途：其中A 1是对应于D-或L-Ser的基团，A 2是基团对应于D-或L-Asp或Glu，A 3是与D-或L-Lys，Arg或Gm相应的基团，A 4是与 D或L-Pro，R 1和R 2独立地选自H，C 1 -C 12，可以被取代的或可以不被取代的C 1 -C 6烷基，可以被取代的也可以不被取代的C 7 -C 20 - 芳烷基，R 4 CO或R 4 COO，R 4为C 1 -C 12 - 烷基，其可以或不可以或可以被取代的C 7 -C 20 - 芳基烷基; 在这些取代中，应该提及OH，NH 2或COOH，X 1和X 2是肽或假肽键，X < SO 3是CO或CH 2，R 3是OH，NH 2，C 1 H 2 -C 1 - 烷氧基或NH-X 4 -CH 2 - Z，X 4是正常的或支链C 1 -C 12烃，Z是H，OH，CO 2 H或CONH 2 CO 2，，或包含基团A 1，A 2，A 3 N的相应的三肽以及药学上可接受的盐，用于制备用于治疗可能受益于血管生成刺激的病症的药物。

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