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1. 发明申请

US20100105666A1 TRIAZABENZO (A)NAPHTHO(2,1,8-CDE) AZULENE COMPOUNDS. 审中-公开
标题翻译：三氮杂萘（A）萘（2,1,8-CDE）亚苄基化合物。
公开(公告)号：US20100105666A1
公开(公告)日：2010-04-29
申请号：US12448627
申请日：2008-01-04
申请人： Jean-Daniel Brion , Maud Hervet , Anne Moreau , Zafiarisoa Dolor Renko , Alain Le Ridant , Catherine Harpey
发明人： Jean-Daniel Brion , Maud Hervet , Anne Moreau , Zafiarisoa Dolor Renko , Alain Le Ridant , Catherine Harpey
IPC分类号： A61K31/551 , C07D487/22 , A61P25/22 , A61P25/16 , A61P25/24
CPC分类号： C07D471/22
摘要： Compounds of formula (I): wherein: R1 represents hydrogen, (C1-C6)alkyl, (C1-C6)aminoalkyl or (C1-C6)hydroxyalkyl, R2 represents hydrogen, or R1 and R2, together with the carbon atoms carrying them, form a carbon-carbon bond, R3 represents hydrogen, R4 represents hydrogen, methyl or (C3-C6)alkyl, (C1-C6)aminoalkyl, (C1-C6)hydroxyalkyl, aryl-(C1-C6)alkyl or heterocycloalkyl-(C1-C6)alkyl, or R3 and R4 together with the carbon atoms carrying them, form a carbon-carbon bond, R5, R6, R7 and R8 represent hydrogen, or a pair of geminal substituents (R5 and R6 and/or R7 and R8) form an oxo, thioxo or imino group, R9 represents hydrogen, halogen, (C1-C6)alkyl, (C1-C6)alkoxy, hydroxy, cyano, nitro, (C1-C6)polyhaloalkyl or optionally substituted amino, R10 and R11 represent hydrogen, halogen, (C1-C6)alkyl, (C1-C6)alkoxy, hydroxy, cyano, nitro, (C1-C6)polyhaloalkyl or optionally substituted amino, n represents an integer between 0 and 4 inclusive, m represents an integer between 0 and 2 inclusive, p represents an integer between 0 and 3 inclusive, X represents a group NR12, R12 represents hydrogen, (C1-C6)alkyl, (C2-C6)alkenyl, aryl-(C1-C6)alkyl or (C1-C6)polyhaloalkyl, their enantiomers, diastereoisomers and N-oxides, and also addition salts thereof with a pharmaceutically acceptable acid or base.
摘要翻译：式（I）化合物：其中：R1表示氢，（C1-C6）烷基，（C1-C6）氨基烷基或（C1-C6）羟基烷基，R2表示氢，或R1和R2以及携带它们的碳原子（C 1 -C 6）烷基，（C 1 -C 6）羟基烷基，芳基 - （C 1 -C 6）烷基或杂环烷基 - （C 1 -C 6）（C1-C6）烷基或R3和R4与携带它们的碳原子一起形成碳 - 碳键，R5，R6，R7和R8表示氢或一对偕取代基（R5和R6和/或R7 卤素，（C1-C6）烷基，（C1-C6）烷氧基，羟基，氰基，硝基，（C1-C6）多卤代烷基或任意取代的氨基，R10 并且R 11表示氢，卤素，（C 1 -C 6）烷基，（C 1 -C 6）烷氧基，羟基，氰基，硝基，（C 1 -C 6）多卤代烷基或任选取代的氨基，n表示0至4的整数， 0和2之间的整数，包括0和2， p表示0〜3的整数，X表示NR12，R12表示氢，（C1-C6）烷基，（C2-C6）烯基，芳基 - （C1-C6）烷基或（C1-C6）多卤代烷基，它们的对映异构体，非对映异构体和N-氧化物，以及其与药学上可接受的酸或碱的加成盐。

2. 发明申请

US20090258883A1 1H-Indole-Pyridinecarboxamide and 1H-Indole-Piperidinecarboxamide Compounds 审中-公开
标题翻译： 1H-吲哚 - 吡啶甲酰胺和1H-吲哚 - 哌啶甲酰胺化合物
公开(公告)号：US20090258883A1
公开(公告)日：2009-10-15
申请号：US11988424
申请日：2006-07-06
申请人： Jean-Daniel Brion , Fabrice Bintein , Rodolphe Razet , Patrick Razon , Zafiarisoa Dolor Renko , Eric Levoirier , Jean-Francois Pujol , Dinah Weissmann , Alain Le Ridant , Catherine Harpey
发明人： Jean-Daniel Brion , Fabrice Bintein , Rodolphe Razet , Patrick Razon , Zafiarisoa Dolor Renko , Eric Levoirier , Jean-Francois Pujol , Dinah Weissmann , Alain Le Ridant , Catherine Harpey
IPC分类号： A61K31/496 , C07D401/12 , A61K31/454 , A61P25/22 , A61P25/16 , A61P25/24 , A61P25/28 , A61K31/4439 , C07D401/14
CPC分类号： C07D401/12
摘要： Compounds of formula (I): wherein: A represents a divalent radical: wherein: Z represents an oxygen atom or a sulphur atom, R6 represents a hydrogen atom, an alkyl, alkenyl, arylalkyl or polyhaloalkyl group or a substituted, linear or branched alkyl chain, represents a single bond or a double bond, R1, R2, R3 and R4 represent a hydrogen or halogen atom, an alkyl, alkoxy, hydroxy, cyano, nitro, polyhaloalkyl or optionally substituted amino group, or a linear or branched alkyl chain substituted by one or more groups, R5 represents a hydrogen atom or an alkyl, aminoalkyl or hydroxyalkyl group, X and Y represent a hydrogen atom or an alkyl group, Ra, Rb, Rc and Rd represent a hydrogen or halogen atom, an alkyl, hydroxy, alkoxy, cyano, nitro, polyhaloalkyl, optionally substituted amino group, or a substituted, linear or branched alkyl chain, Re represents a hydrogen atom or an alkyl, arylalkyl or alkenyl group or a substituted, linear or branched alkyl chain, their enantiomers, diastereoisomers, and N-oxides, and also addition salts thereof with a pharmaceutically acceptable acid or base.
摘要翻译：式（I）化合物：其中：A表示二价基团：其中：Z表示氧原子或硫原子，R6表示氢原子，烷基，烯基，芳基烷基或多卤代烷基或取代的直链或支链烷基链接，表示单键或双键，R 1，R 2，R 3和R 4表示氢或卤素原子，烷基，烷氧基，羟基，氰基，硝基，多卤代烷基或任选取代的氨基，或直链或支链烷基链被一个或多个基团取代，R 5表示氢原子或烷基，氨基烷基或羟烷基，X和Y表示氢原子或烷基，R a，R b，R c和R d表示氢或卤素原子，烷基，羟基，烷氧基，氰基，硝基，多卤代烷基，任选取代的氨基或取代的直链或支链烷基链，表示氢原子或烷基，芳基烷基或烯基或取代的直链或支链烷基链，它们的对映异构体，非对映异构体和N-氧化物，以及其与药学上可接受的酸或碱的加成盐。

3. 发明授权

US5602131A EburnanE analogues 失效
标题翻译： EburnanE类似物
公开(公告)号：US5602131A
公开(公告)日：1997-02-11
申请号：US354660
申请日：1994-12-13
申请人： Jean-Daniel Brion , Claude Thal , Luc Demuynck , Jean-Gilles Parmentier , Jean Lepagnol , Pierre Lestage , Jean-Fran.cedilla.ois Pujol , Pascal Schmitt , Pierre Potier
发明人： Jean-Daniel Brion , Claude Thal , Luc Demuynck , Jean-Gilles Parmentier , Jean Lepagnol , Pierre Lestage , Jean-Fran.cedilla.ois Pujol , Pascal Schmitt , Pierre Potier
IPC分类号： C07D471/06 , A61K31/435 , A61P25/00 , A61P25/20 , A61P25/24 , A61P25/26 , A61P25/28 , A61P43/00 , C07D461/00 , C07D471/22 , C07D471/04 , A61K31/44 , A61K31/50 , C07D471/14
CPC分类号： C07D461/00
摘要： A compound selected from those of general formula (I): ##STR1## wherein A represents a bivalent radical selected from ##STR2## and R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.6, R.sub.7, R.sub.8, R.sub.9 and Z are as defined in the description,the isomers and pharmaceutically-acceptable acid or base addition salts thereof, and medicinal products containing the same which are useful in the treatment of depression and anxiety.
摘要翻译：选自通式（I）的化合物：其中A表示选自以下的二价基团：R 1，R 2，R 3，R 4，R 5，R 6，R 7，R 8，R 9和Z分别为如本说明书中所定义，其异构体和药学上可接受的酸或碱加成盐，以及含有它们的药物，可用于治疗抑郁和焦虑。

4. 发明授权

US5391569A New chromene compounds having a triene side chain 失效
标题翻译：具有三烯侧链的新的色烯化合物
公开(公告)号：US5391569A
公开(公告)日：1995-02-21
申请号：US127804
申请日：1993-09-28
申请人： Jean-Daniel Brion , Guillaume Le Baut , Guillaume Poissonnet , Lucy De Montarby , Larbi Belachmi , Jacqueline Bonnet , Massimo Sabatini , Charles Tordjman
发明人： Jean-Daniel Brion , Guillaume Le Baut , Guillaume Poissonnet , Lucy De Montarby , Larbi Belachmi , Jacqueline Bonnet , Massimo Sabatini , Charles Tordjman
IPC分类号： A61K31/35 , A61K31/352 , A61K31/66 , A61P3/00 , A61P19/10 , A61P29/00 , A61P43/00 , C07D311/12 , C07D311/14 , C07D311/16 , C07D311/18 , C07D311/58 , C07D311/64 , C07D311/70 , C07D311/72 , C07D405/04 , C07D409/04 , C07F9/655 , A61K31/40 , A61K31/445 , A61K31/47
CPC分类号： C07D405/04 , C07D311/58 , C07D311/64 , C07D311/70 , C07D409/04
摘要： A compound selected from those of formula (I): ##STR1## in which the groups R.sub.1 to R.sub.8 are as defined the description. Medicaments.
摘要翻译：选自式（I）的化合物：其中基团R1至R8如说明书所定义。药剂

5. 发明申请

US20130203718A1 PROGESTERONE RECEPTOR ANTAGONISTS AND USES THEREOF 审中-公开
标题翻译：孕激素受体拮抗剂及其用途
公开(公告)号：US20130203718A1
公开(公告)日：2013-08-08
申请号：US13696418
申请日：2011-05-09
申请人： Marie-Edith Rafestin-Oblin , Mouad Alami , Hugues Loosfelt , Abdallah Hamze , Ali Junaid Khan , Abdellatif Tikad , Marc Lombes , Jean-Daniel Brion
发明人： Marie-Edith Rafestin-Oblin , Mouad Alami , Hugues Loosfelt , Abdallah Hamze , Ali Junaid Khan , Abdellatif Tikad , Marc Lombes , Jean-Daniel Brion
IPC分类号： C07J63/00 , C07J9/00 , C07J3/00 , C07J7/00 , C07J1/00 , C07J11/00 , C07J21/00
CPC分类号： C07J63/008 , A61K31/56 , A61K31/567 , A61K31/568 , A61K31/5685 , A61K31/569 , A61K31/57 , A61K31/575 , C07J1/0011 , C07J1/0022 , C07J1/0025 , C07J3/00 , C07J7/0005 , C07J7/002 , C07J7/007 , C07J9/00 , C07J11/00 , C07J21/006
摘要： The present invention relates to a compound of formula (I): for its use as progesterone receptor antagonist, in particular for its use for the prevention and/or the treatment of cancer or uterine pathologies.
摘要翻译：本发明涉及式（I）化合物：其用作孕激素受体拮抗剂，特别是其用于预防和/或治疗癌症或子宫病变的用途。

6. 发明申请

US20100129471A1 ISO CA-4 AND ANALOGUES THEREOF AS POTENT CYTOTOXIC AGENTS INHIBITING TUBULINE POLYMERIZATION 有权
标题翻译： ISO CA-4及其类似物作为细胞毒素代谢抑制管道聚合
公开(公告)号：US20100129471A1
公开(公告)日：2010-05-27
申请号：US12594495
申请日：2008-04-04
申请人： Mouâd Alami , Jean-Daniel Brion , Olivier Provot , Jean-François Peyrat , Samir Messaoudi , Abdallah Hamze , Anne Giraud , Jérôme Bignon , Joanna Bakala , Jian-Miao Liu
发明人： Mouâd Alami , Jean-Daniel Brion , Olivier Provot , Jean-François Peyrat , Samir Messaoudi , Abdallah Hamze , Anne Giraud , Jérôme Bignon , Joanna Bakala , Jian-Miao Liu
IPC分类号： A61K31/09 , C07C43/23 , C07C43/215 , C07D215/00 , C07C69/00 , C07C205/06 , C07F9/02 , C07C217/80 , C07H15/207 , C07D213/79 , A61K31/36 , A61K31/505 , A61K31/216 , A61K31/352 , A61K31/136 , A61K31/7034 , A61K31/66 , A61K31/44 , A61K31/52 , A61K31/7068 , A61K31/519 , A61K31/4545 , A61K31/7048 , A61K33/24 , A61K38/12
CPC分类号： C07H15/203 , C07C43/215 , C07C43/225 , C07C43/23 , C07C69/017 , C07C69/24 , C07C205/37 , C07C217/84 , C07C219/32 , C07C229/12 , C07C229/42 , C07C271/22 , C07C271/44 , C07C305/24 , C07C309/65 , C07C2603/18 , C07D215/14 , C07D317/54 , C07F9/12
摘要： The invention relates to a compound of the formula (I) in which: R1, R2 and R3 are independently a methoxy group optionally substituted by one or more fluorine atoms; R4 is a hydrogen atom; R5 and R6 are identical and each represent a hydrogen or fluorine atom; A is a cycle selected from the group including aryl and heteroaryl groups, wherein said groups can be substituted.
摘要翻译：本发明涉及式（I）化合物，其中：R 1，R 2和R 3独立地为任选被一个或多个氟原子取代的甲氧基; R4是氢原子; R5和R6相同，各自表示氢或氟原子; A是选自包括芳基和杂芳基的基团，其中所述基团可被取代。

7. 发明申请

US20060063801A1 Novel 3-(4-oxo-4h-chromen-2-yl)-(1H)-quinolin-4-one derivatives, method for preparing same and pharmaceutical compositions containing same 失效
标题翻译：新的3-（4-氧代-4H-色烯-2-基） - （1H） - 喹啉-4-酮衍生物，其制备方法和含有它们的药物组合物
公开(公告)号：US20060063801A1
公开(公告)日：2006-03-23
申请号：US10519208
申请日：2003-06-18
申请人： Jean-Daniel Brion , Lucien Israel , Alain Le Ridant , Catherine Harpey , Cherif Rabhi , El Bachir Kaloun
发明人： Jean-Daniel Brion , Lucien Israel , Alain Le Ridant , Catherine Harpey , Cherif Rabhi , El Bachir Kaloun
IPC分类号： A61K31/4709 , C07D405/02
CPC分类号： C07D405/04 , C07D405/14
摘要： Compound of formula (I): wherein: R1, R2, R3, R4, R6, R8, R9 and R10, which may be the same or different, each represent a group selected from hydrogen, hydroxy, alkoxy, alkyl, arylalkoxy, alkoxycarbonylalkoxy and OR′ wherein R′ represents an ionised or ionisable group, R5 represents a group selected from alkyl, aryl and heteroaryl, R7 represents a group selected from hydrogen, hydroxy, alkoxy, alkyl and cycloalkyl, or R7 represents a nitrogen-containing or oxygen-containing heterocycle, its optical isomers, hydrates and solvates thereof and addition salts thereof, with a pharmaceutically acceptable acid or base. Medicinal products containing the same which are useful as anti-cancer agents.
摘要翻译：式（I）化合物：

8. 发明授权

US4975454A Triene compounds having a chromene structure 失效
标题翻译：具有色烯结构的三烯化合物
公开(公告)号：US4975454A
公开(公告)日：1990-12-04
申请号：US336225
申请日：1989-04-11
申请人： Jean-Daniel Brion , Guillaume Le Baut , Patrick Ducrey , Sylvie Piessard-Robert , Claude Cudennec , Genevieve Seurre
发明人： Jean-Daniel Brion , Guillaume Le Baut , Patrick Ducrey , Sylvie Piessard-Robert , Claude Cudennec , Genevieve Seurre
IPC分类号： A61K31/35 , A61K31/352 , A61P35/00 , C07D311/04 , C07D311/58
CPC分类号： C07D311/58
摘要： Compounds of general formula (I): ##STR1## in which: R.sub.1, R.sub.2, R.sub.3 and R.sub.4, which may be identical or different, denote a hydrogen atom, a halogen atom or a lower alkyl, lower alkenyl, lower alkyloxy or lower alkenyloxy group, optionally substituted with one or more halogen atoms,R.sub.5 denotes a carboxyl, (lower alkyloxy)carbonyl, (lower alkenyloxy)carbonyl or (lower alkynyloxy)-carbonyl,their isomers, stereoisomers and diastereoisomers, and also their addition salts with a pharmaceutically acceptable base.Medicinal products.
摘要翻译：通式（I）的化合物：其中：R1，R2，R3和R4可以相同或不同，表示氢原子，卤原子或低级烷基，低级烯基，低级烷氧基或低级烯氧基 R 5表示羧基，（低级烷氧基）羰基，（低级链烯氧基）羰基或（低级炔氧基） - 羰基，它们的异构体，立体异构体和非对映异构体，以及它们与药学上的加成盐可接受的基数。药用产品。

9. 发明授权

US06350757B1 Beta-carboline compounds 失效
标题翻译： β-咔啉化合物
公开(公告)号：US06350757B1
公开(公告)日：2002-02-26
申请号：US09621742
申请日：2000-07-21
申请人： Solo Goldstein , Guillaume Poissonnet , Jean-Gilles Parmentier , Jean-Daniel Brion , Mark Millan , Anne Dekeyne , Jean Boutin
发明人： Solo Goldstein , Guillaume Poissonnet , Jean-Gilles Parmentier , Jean-Daniel Brion , Mark Millan , Anne Dekeyne , Jean Boutin
IPC分类号： C07D47114
CPC分类号： C07D471/04
摘要： A compound selected from those of formula (I): wherein: represents single or double bond, R1 represents hydrogen, alkyl, —R6-aryl, —R6-cycloalkyl, —R6-heterocycle, —CO2R7—, —COR8, or —CONHR8, wherein R6, R7, and R8 are as defined in the description, R2 represents cyano, mono- or di-alkylaminoalkylaminocarbonyl, —CO2R8, —CONHR8, —NR8R9, —NHCO2R7, or —COR8 wherein R7, R8, and R9 are as defined in the description, R3 and R4 together form (C3-C10)cycloalkyl, R5 represents hydrogen, alkyl, or arylalkyl, Ra, Rb, Rc, Rd, which may be identical or different, represent a group as defined in the description, its isomers, and pharmaceutically-acceptable acid or base addition salts thereof, and medicinal products containing the same which are useful in the treatment of CNS disorders.
摘要翻译：选自式（I）的化合物：其中：CUSTOM-CHARACTER FILE =“US06350757-20020226-P00900.TIF”ID =“CUSTOM-CHARACTER-00001”>表示单键或双键，R1表示氢，烷基， -R6-芳基，-R6-环烷基，-R6-杂环，-CO2R7-，-COR8或-CONHR8，其中R6，R7和R8如说明书中所定义，R 2表示氰基，单或二烷基氨基烷基氨基羰基，-CO 2 R 8，-CONHR 8，-NR 8 R 9，-NHCO 2 R 7或-COR 8，其中R 7，R 8和R 9如说明书中所定义，R 3和R 4一起形成（C 3 -C 10）环烷基，R 5表示氢，烷基或芳烷基可以相同或不同的R a，R b，R c，R d表示本说明书中定义的基团，其异构体及其药学上可接受的酸或碱加成盐，以及含有该基团的药物，其可用于治疗中枢神经系统疾病。

10. 发明授权

US5622957A Benzopyrrolizinoquinolizinones 失效
标题翻译：苯并吡咯啉喹诺酮类
公开(公告)号：US5622957A
公开(公告)日：1997-04-22
申请号：US433163
申请日：1995-05-03
申请人： Jean-Daniel Brion , Claude Thal , Luc Demuynck , Jean-Gilles Parmentier , Jean Lepagnol , Pierre Lestage , Jean-Fran.cedilla.ois Pujol , Pascal Schmitt , Pierre Potier
发明人： Jean-Daniel Brion , Claude Thal , Luc Demuynck , Jean-Gilles Parmentier , Jean Lepagnol , Pierre Lestage , Jean-Fran.cedilla.ois Pujol , Pascal Schmitt , Pierre Potier
IPC分类号： C07D471/06 , A61K31/435 , A61P25/00 , A61P25/20 , A61P25/24 , A61P25/26 , A61P25/28 , A61P43/00 , C07D461/00 , C07D471/22 , A61K31/475
CPC分类号： C07D461/00
摘要： A compound selected from those of general formula (I): ##STR1## wherein A represents a bivalent radical ##STR2## and R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.6, R.sub.7, R.sub.8, R.sub.9 and Z are as defined in the description,the isomers and pharmaceutically-acceptable acid or base addition salts thereof, and medicinal products containing the same which are useful in the treatment of depression and anxiety.
摘要翻译：选自通式（I）的化合物：其中A表示二价基团，并且R 1，R 2，R 3，R 4，R 6，R 7，R 8，R 9和Z如描述，其异构体和药学上可接受的酸或碱加成盐，以及含有它们的药物，其可用于治疗抑郁和焦虑。

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