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    • 6. 发明授权
    • Electrotherapy circuit for producing therapeutic discharge waveform
based on high-current sensing pulse
    • 基于大电流感应脉冲产生治疗放电波形的电疗电路
    • US5800462A
    • 1998-09-01
    • US769045
    • 1996-12-18
    • Michael L. LopinShervin Ayati
    • Michael L. LopinShervin Ayati
    • A61N1/39A61N1/37
    • A61N1/3937A61N1/3906A61N1/3912
    • An electrotherapy circuit administers to a patient a current waveform. The electrotherapy circuit includes a charge storage device, at least two discharge electrodes connected by electrical circuitry to opposite poles of the charge storage device, a sensor that senses a patient-dependent electrical parameter (such as a patient impedance sensor), and a control circuit. The control circuit is connected to the sensor and the charge storage device and controls discharge of the charge storage device through the electrodes. The discharge of the charge storage device includes a current waveform having a sensing pulse portion, with insufficient energy for performing therapy, during which the sensor senses a patient-dependent electrical parameter (such as patient impedance), and a therapeutic discharge portion, with sufficient energy for performing therapy, having an initial discharge current controlled by the control circuit based on the patient-dependent electrical parameter (such as patient impedance) as sensed by the sensor. The sensing pulse portion has a discharge current that is at least about one-third of the initial discharge current of the therapeutic discharge portion.
    • 电疗电路向患者施加电流波形。 电疗电路包括电荷存储装置,通过电路连接到电荷存储装置的相对极的至少两个放电电极,感测依赖于患者的电参数(例如患者阻抗传感器)的传感器和控制电路 。 控制电路连接到传感器和电荷存储装置,并通过电极控制电荷存储装置的放电。 电荷存储装置的放电包括具有感测脉冲部分的电流波形,其中用于进行治疗的能量不足,在此期间传感器感测依赖于患者的电参数(例如患者阻抗)和治疗性放电部分,具有足够的 用于执行治疗的能量,具有由控制电路根据由传感器检测到的依赖于患者的电参数(例如患者阻抗)控制的初始放电电流。 感测脉冲部分具有至少约治疗放电部分的初始放电电流的三分之一的放电电流。
    • 7. 发明申请
    • Method and Apparatus for Guidance and Application of High Intensity Focused Ultrasound for Control of Bleeding Due to Severed Limbs
    • 高强度聚焦超声引导和应用的方法和装置,用于控制由于断肢引起的出血
    • US20080312562A1
    • 2008-12-18
    • US12096716
    • 2006-12-07
    • Helen RouthJohn FraserJohn PetruzzelloShervin Ayati
    • Helen RouthJohn FraserJohn PetruzzelloShervin Ayati
    • A61N7/00
    • A61B8/4227A61B8/06A61B8/4281A61B8/4483A61N7/02A61N2007/0065A61N2007/0078A61N2007/0095A61N2007/027
    • An ultrasonic diagnostic and therapy system is described for stopping the bleeding of severely damaged blood vessels or vessels severed in a limb amputation. A cuff is attached to the stump of the severed limb which contains a diagnostic transducer array and a HIFU transducer. The diagnostic transducer surveys the tissue of the severed limb, searching for a Doppler flow signal. When a Doppler flow signal is detected, the range to and coordinates of the sample volume where the flow was detected are determined, as well as the flow velocity. This information is supplied to a HIFU therapy transducer controller, which controls the HIFU transducer to transmit focused ultrasound to the sample volume of the flow locus, the center of the lumen of a blood vessel. The focused ultrasound heats and coagulates blood in the severed vessel to stem the bleeding. Heat dissipation due to the blood flow is reduced by tracking and continuously heating the same bolus of blood as it flows, or by heating a significant length of the blood vessel instead of a fixed spot in the vessel.
    • 描述了超声诊断和治疗系统,用于阻止严重损伤的血管或肢体截肢切断的血管的出血。 一个袖带连接到包含诊断换能器阵列和HIFU换能器的切断肢体的残端。 诊断传感器检测切断的肢体的组织,寻找多普勒血流信号。 当检测到多普勒流量信号时,确定检测流量的样品体积的范围和坐标以及流速。 该信息被提供给HIFU治疗传感器控制器,HIFU治疗传感器控制器控制HIFU换能器将聚焦的超声波传输到血管的管腔中心的流动轨迹的样本体积。 聚焦超声加热并凝结切断的血管中的血液以阻止出血。 通过跟踪并持续加热相同的血液,当流动时,或通过加热血管的相当长度的血管而不是血管中的固定点来减少由血流引起的散热。
    • 8. 发明申请
    • Method and Apparatus for Guidance and Application of High Intensity Focused Ultrasound for Control of Bleeding Due to Severed Limbs
    • 高强度聚焦超声引导和应用的方法和装置,用于控制由于断肢引起的出血
    • US20080306414A1
    • 2008-12-11
    • US12096752
    • 2006-12-07
    • John PetruzzelloHelen RouthJohn FraserShervin Ayati
    • John PetruzzelloHelen RouthJohn FraserShervin Ayati
    • A61N7/00
    • A61B8/06A61B5/6843A61B8/4227A61B8/4281A61B8/4483A61B17/1325A61B17/135A61B17/1355A61N7/02A61N2007/0065A61N2007/027
    • An ultrasonic diagnostic and therapy system is described for stopping the bleeding of severely damaged blood vessels or vessels severed in a limb amputation. A cuff (30) is attached to the stump of the severed limb which contains a diagnostic transducer array and a HIFU transducer (42, 44). The diagnostic transducer surveys the tissue of the severed limb, searching for a Doppler flow signal. When a Doppler flow signal is detected, the range to and coordinates of the sample volume where the flow was detected are determined, as well as the flow velocity. This information is supplied to a HIFU therapy transducer controller, which controls the HIFU transducer to transmit focused ultrasound to the sample volume of the flow locus, the center of the lumen of a blood vessel. The focused ultrasound heats and coagulates blood in the severed vessel to stem the bleeding. Heat dissipation due to the blood flow is reduced by tracking and continuously heating the same bolus of blood as it flows, or by heating a significant length of the blood vessel instead of a fixed spot in the vessel.
    • 描述了超声诊断和治疗系统,用于阻止严重损伤的血管或肢体截肢切断的血管的出血。 袖带(30)附接到包含诊断换能器阵列和HIFU换能器(42,44)的切断的肢体的残端。 诊断传感器检测切断的肢体的组织,寻找多普勒血流信号。 当检测到多普勒流量信号时,确定检测流量的样品体积的范围和坐标以及流速。 该信息被提供给HIFU治疗传感器控制器,HIFU治疗传感器控制器控制HIFU换能器将聚焦的超声波传输到血管的管腔中心的流动轨迹的样本体积。 聚焦超声加热并凝结切断的血管中的血液以阻止出血。 通过跟踪并持续加热相同的血液,当流动时,或通过加热血管的相当长度的血管而不是血管中的固定点来减少由血流引起的散热。
    • 9. 发明授权
    • Method and apparatus for producing electrotherapy current waveform with
ripple
    • 用于产生具有波纹的电疗电流波形的方法和装置
    • US5904706A
    • 1999-05-18
    • US910757
    • 1997-08-13
    • Shervin AyatiMichael L. Lopin
    • Shervin AyatiMichael L. Lopin
    • A61N1/39
    • A61N1/39A61N1/3906A61N1/3912
    • The invention provides a method and circuit for forming an electrotherapy current waveform. A charge storage device located externally of a patient's body is charged, and is discharged through the patient's body through at least two discharge electrodes connected by electrical circuitry to opposite poles of the charge storage device. A continuous discharge of the charge storage device through the electrodes is controlled so as to produce at least one phase of a current waveform that includes a ripple. The ripple has a height less than one-third of the height of the peak current of the phase, and the difference between the peak current of the phase and the lowest current of the phase is less than one third of the peak current of the phase. The current waveform has a sensing pulse portion that is integral with the therapeutic discharge portion of the current waveform.
    • 本发明提供了一种形成电疗电流波形的方法和电路。 位于患者身体外部的电荷存储装置被充电,并且通过由电路连接到电荷存储装置的相对极的至少两个放电电极通过患者身体排出。 控制通过电极的电荷存储装置的连续放电,以便产生包括纹波的电流波形的至少一个相位。 纹波的高度小于相位峰值电流高度的三分之一,相位峰值电流与相位最小电流之间的差值小于相位峰值电流的三分之一 。 电流波形具有与电流波形的治疗放电部分成一体的感测脉冲部分。