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1. 发明授权

US5290560A Extrusion of an admixture of a meltable binder and a food or drug 失效
标题翻译：挤出可熔融粘合剂和食品或药物的混合物
公开(公告)号：US5290560A
公开(公告)日：1994-03-01
申请号：US719039
申请日：1991-06-21
申请人： Pierre Autant , Jacques Ruel , Stephen Weinhold , Charles A. McCombs , Ernest P. Smith , Stephen H. Wu , Louis P. Hoskins
发明人： Pierre Autant , Jacques Ruel , Stephen Weinhold , Charles A. McCombs , Ernest P. Smith , Stephen H. Wu , Louis P. Hoskins
IPC分类号： A23K1/18 , A23K1/00 , A61K9/16 , A61K31/195 , A61K47/44 , A61P3/00
CPC分类号： A61K9/1617 , A23K40/35 , Y10S426/807
摘要： The present invention relates to new granules, as well as the process for their preparation, obtained by extrusion of a mixture containing a meltable binder in an amount such that it permits the passage of the mixture through a die. The granules obtained are then coated with a polymer permitting their trans-rumen passage without degradation. After coating, these granules are used for animal feeding of ruminants.
摘要翻译：本发明涉及新的颗粒，以及它们的制备方法，其通过挤出包含可熔粘合剂的混合物获得，其量使其允许混合物通过模头。然后将所获得的颗粒用聚合物包被，其允许其经转运通道而不降解。涂布后，将这些颗粒用于反刍动物饲养。

2. 发明授权

US5386003A Oil absorbing polymers 失效
标题翻译：吸油聚合物
公开(公告)号：US5386003A
公开(公告)日：1995-01-31
申请号：US33198
申请日：1993-03-15
申请人： Carol J. Greene , Stephen H. Wu
发明人： Carol J. Greene , Stephen H. Wu
IPC分类号： C08G63/688 , C08J3/12 , C08G63/02 , C08G63/68 , C08L77/00
CPC分类号： C08J3/122 , A61K8/022 , A61K8/85 , A61Q1/12 , C08G63/6886 , A61K2800/412 , A61Q17/04 , A61Q19/00 , C08J2367/02 , C08J2377/12
摘要： Water dispersible polyester polymers, polyesteramides polymers and blends of these polymers are dispersed in water and spray dried to form fine powders. In the solid state, these powders can absorb oils and/or diffuse ambient light, thereby resulting in the production of significant reduction in gloss and tack of lipids in cosmetic and personal care products when applied to ordinarily oily skin.
摘要翻译：水分散性聚酯聚合物，聚酯酰胺聚合物和这些聚合物的共混物分散在水中并喷雾干燥以形成细粉末。在固体状态下，这些粉末可以吸收油和/或扩散环境光，因此当应用于通常油性皮肤时，导致化妆品和个人护理产品中脂质的光泽度和粘性显着降低。

3. 发明授权

US4717567A Rumen-stable pellets 失效
标题翻译：瘤胃稳定的颗粒
公开(公告)号：US4717567A
公开(公告)日：1988-01-05
申请号：US802102
申请日：1985-11-25
申请人： Stephen H. Wu , Edward G. Miller, Jr.
发明人： Stephen H. Wu , Edward G. Miller, Jr.
IPC分类号： A23K1/18 , A23K1/00 , A23K1/16 , A61K9/00 , A61K9/22 , A61K9/48 , A61K9/50 , A61K9/24
CPC分类号： A61K9/4808 , A23K40/35 , A61K9/5089
摘要： Disclosed are coatings for protecting pellet cores from environmental conditions of predetermined pH conditions. The coatings have a pH sensitive portion and a pH insensitive portion. The pH sensitive portion allows the cores to be protected by the coating under certain pH conditions and disintegrates under other pH conditions to allow exposure of the cores.
摘要翻译：公开了用于将丸粒核心保护在预定pH条件的环境条件下的涂层。涂层具有pH敏感部分和pH不敏感部分。 pH敏感部分允许核心在特定pH条件下被包衣保护，并在其它pH条件下分解以允许核心暴露。

4. 发明授权

US4808412A Rumen-stable compositions 失效
标题翻译：瘤胃稳定组合物
公开(公告)号：US4808412A
公开(公告)日：1989-02-28
申请号：US61755
申请日：1987-06-11
申请人： E. Phillip Smith , Stephen H. Wu
发明人： E. Phillip Smith , Stephen H. Wu
IPC分类号： A61K9/14 , A61K9/16 , A61K9/00
CPC分类号： A61K9/1617 , A61K9/146 , A61K9/1623 , A61K9/1635 , A61K9/1652 , A61K9/167
摘要： A post-rumen effective composition for oral administration to ruminants containing a bioactive substance molecularly dispersed with a basic polymer. The bioactive substance is miscible with the polymer and may be a vitamin, antibiotic, peptide or anti-inflammatory agent. The basic polymer contains from about 1 percent to about 25 percent by weight of nitrogen and is resistant to a pH of greater than about 5 and soluble or swellable at a pH of less than about 3.5.
摘要翻译：用于口服给予反刍动物的后瘤胃有效组合物，其含有与碱性聚合物分子分散的生物活性物质。生物活性物质可与聚合物混溶，并且可以是维生素，抗生素，肽或抗炎剂。碱性聚合物含有约1重量％至约25重量％的氮气，并且耐pH大于约5，并且在小于约3.5的pH下可溶或溶胀。

5. 发明申请

US20100055179A1 Composition of and Method for Preparing Orally Disintegrating Tablets Containing a High Dose of Pharmaceutically Active Ingredients 审中-公开
标题翻译：用于制备含有高剂量药物活性成分的口服崩解片的组合物和方法
公开(公告)号：US20100055179A1
公开(公告)日：2010-03-04
申请号：US12519927
申请日：2007-12-20
申请人： Jae Han Park , Stephen H. Wu , Kevin M. Holman , Glenn A. Bish , Donald G. Krieger , Daniel S. Ramlose
发明人： Jae Han Park , Stephen H. Wu , Kevin M. Holman , Glenn A. Bish , Donald G. Krieger , Daniel S. Ramlose
IPC分类号： A61K9/20
CPC分类号： A61K9/0056
摘要： The present invention is directed to improved compositions and methods for preparing orally disintegrating tablets (ODTs). In one aspect of the present invention, the ODT further contains at least one active pharmaceutical ingredient (API). In another aspect of the present invention, the ODT contains a high load of at least one API. Specifically, the ODTs described in this invention containing a high load of API can accommodate up to about 70% w/w of active pharmaceutical ingredient in a unit dosage, while exhibiting the desirable attributes of fast disintegration time, acceptable hardness and friability for push through blister and bottle packages, and acceptable mouth feel.
摘要翻译：本发明涉及用于制备口腔崩解片（ODT）的改进的组合物和方法。在本发明的一个方面，ODT还含有至少一种活性药物成分（API）。在本发明的另一方面，ODT包含至少一种API的高负荷。具体地说，本发明中描述的包含高负荷的API的ODT可以以单位剂量容纳高达约70％w / w的活性药物成分，同时具有快速崩解时间，可接受的硬度和易碎性推荐的理想特性水泡和瓶子包装，以及可接受的口感。

6. 发明授权

US5380790A Process for the preparation of acrylic polymers for pharmaceutical coatings 失效
标题翻译：制备用于药物涂料的丙烯酸聚合物的方法
公开(公告)号：US5380790A
公开(公告)日：1995-01-10
申请号：US118903
申请日：1993-09-09
申请人： Robert G. Chen , Stephen H. Wu
发明人： Robert G. Chen , Stephen H. Wu
IPC分类号： A61K9/28 , C08F220/06 , C08F220/18 , C08K5/41 , A61K9/32 , C08L33/00
CPC分类号： C08F220/18 , A61K9/2846 , C08F220/06
摘要： Provided is a process useful for preparing acrylic polymers of methacrylic acid and ethyl acrylate. The process provides polymers useful as enteric coatings for medicaments in solid form, said coatings having improved effectiveness, reproducibility and coating efficiency. Also provided are medicaments in solid form coated with such polymers.
摘要翻译：提供了用于制备甲基丙烯酸和丙烯酸乙酯的丙烯酸聚合物的方法。该方法提供可用作固体形式的药物的肠溶衣的聚合物，所述涂层具有改善的有效性，再现性和涂布效率。还提供了用这种聚合物涂覆的固体形式的药物。

7. 发明授权

US5356634A Controlled-release delivery system 失效
标题翻译：控释系统
公开(公告)号：US5356634A
公开(公告)日：1994-10-18
申请号：US975758
申请日：1992-11-13
申请人： Stephen H. Wu , Carol J. Greene , Shane K. Kirk , David S. Kashdan
发明人： Stephen H. Wu , Carol J. Greene , Shane K. Kirk , David S. Kashdan
IPC分类号： A23K1/00 , A61K9/22 , A61K9/28 , A61K9/32 , A61K9/50 , A61K9/20
CPC分类号： A61K9/5042 , A23K40/35 , A61K9/2866
摘要： Provided is a controlled-release system for delivery of bioactive materials such as medicaments, cosmetic ingredients and agrichemicals using cellulose acetate succinate or certain blends of cellulose acetate phthalate polymers as enteric coating materials. Also provided is a method for delivering active ingredients to animals utilizing the controlled-release system of the invention.
摘要翻译：提供了一种用于递送生物活性材料如药物，化妆品成分和农用化学品的控释系统，其使用醋酸琥珀酸乙酯或某些醋酸纤维素邻苯二甲酸酯聚合物的混合物作为肠溶衣材料。还提供了使用本发明的控制释放系统将活性成分递送到动物的方法。

8. 发明授权

US4687676A Rumen-stable pellets 失效
标题翻译：瘤胃稳定的颗粒
公开(公告)号：US4687676A
公开(公告)日：1987-08-18
申请号：US848439
申请日：1986-04-07
申请人： Stephen H. Wu , Mohammad A. Sandhu
发明人： Stephen H. Wu , Mohammad A. Sandhu
IPC分类号： A23K1/00 , A23K1/16 , A23K1/18 , A61K9/22 , A61K9/50 , B02C17/00
CPC分类号： A61K9/5015 , A23K20/147 , A23K40/35 , A23K50/10 , A61K9/501 , A61K9/5026 , Y10S524/904
摘要： Disclosed is a composition adapted for use in coating pellets orally administrable to ruminants which protects the core material in the rumen and releases it in the abomasum comprising a film-forming polymeric material, a hydrophobic material dispersed in said polymeric material, and a physiologically acceptable flake material dispersed in said polymeric material, the flake material having been treated by bringing the particles into rubbing contact with the hydrophobic material so that the surface of the particles of flake material become hydrophobic.
摘要翻译：公开了一种组合物，其适用于涂覆口服给予反刍动物的丸剂，其保护瘤胃中的核心材料并将其在皱胃中释放，其包含成膜聚合物材料，分散在所述聚合物材料中的疏水材料和生理上可接受的片分散在所述聚合材料中的材料，已经通过使颗粒与疏水材料摩擦接触来处理薄片材料，使得薄片材料颗粒的表面变得疏水。

9. 发明申请

US20100316585A1 Use of Magnesium Stearate Dihydrate for Lubrication of Solid Industrial or Consumer Products 审中-公开
标题翻译：使用硬脂酸镁二水合物润滑固体工业或消费品
公开(公告)号：US20100316585A1
公开(公告)日：2010-12-16
申请号：US12866261
申请日：2009-02-11
申请人： Stephen H. Wu , Brian K. Cheng , Gary A. Nichols , Jae H. Park
发明人： Stephen H. Wu , Brian K. Cheng , Gary A. Nichols , Jae H. Park
IPC分类号： A61K8/18 , A23L1/00 , A61K47/00 , A61Q1/02 , A61Q1/08 , A61Q1/10 , C09D201/00 , C08K5/09
CPC分类号： A61K9/2013 , A23P10/43 , C08K5/098
摘要： The invention provides lubricant compositions comprising magnesium stearate dihydrate. The lubricant compositions may be used to lubricate a variety of solid materials that are used in industrial or consumer products.
摘要翻译：本发明提供了包含硬脂酸镁二水合物的润滑剂组合物。润滑剂组合物可用于润滑用于工业或消费品的各种固体材料。

10. 发明授权

US4429113A Fractionation of polymers 失效
标题翻译：聚合物的分级
公开(公告)号：US4429113A
公开(公告)日：1984-01-31
申请号：US229032
申请日：1981-01-26
申请人： Stephen H. Wu , Clarence C. Dannelly
发明人： Stephen H. Wu , Clarence C. Dannelly
IPC分类号： C08F6/04 , C08F6/00
CPC分类号： C08F6/04
摘要： Process of obtaining a high molecular weight fraction from a polar polymer which comprises the steps of first, forming a solution of the polar polymer in a solvent which is also a solvent for a selected coacervating substance, then mixing with the solution a coacervating substance having at least two proton donating or proton receiving groups which are opposite the polarity of the polar polymer in an amount sufficient to crosslink molecules of said polar polymer of a molecular weight above a selected range at the solution temperature, thereby forming coacervated high molecular weight polymer solids, and then separating the high molecular weight solids from the solution. The coacervated polymer may then be dissolved and the coacervating substance removed by precipitation.
摘要翻译：从极性聚合物获得高分子量级分的方法，该方法包括以下步骤：首先在极性聚合物溶液中形成溶剂，该溶剂也是选择的凝聚物质的溶剂，然后与溶液混合，至少两个质子供体或质子接受基团，其极性与极性聚合物极性相反，其量足以使分子量分子的分子在溶液温度下高于所选范围，从而形成凝聚的高分子量聚合物固体，然后从溶液中分离高分子量固体。然后可以将凝聚的聚合物溶解，并通过沉淀除去凝聚物质。

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