专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US5728877A Process for the manufacturing of iodinated contrast agents 失效
标题翻译：碘化造影剂的制造方法
公开(公告)号：US5728877A
公开(公告)日：1998-03-17
申请号：US685034
申请日：1996-07-23
申请人： Pier Lucio Anelli , Marino Brocchetta , Ornella Gazzotti , Fulvio Uggeri
发明人： Pier Lucio Anelli , Marino Brocchetta , Ornella Gazzotti , Fulvio Uggeri
IPC分类号： C07C231/12 , C07C235/48 , C07C237/46 , C07C233/65
CPC分类号： C07C231/12
摘要： A process for the preparation of compounds of general formula (I) ##STR1## characterized in that the corresponding derivatives of general formula (II) ##STR2## are reacted with the compounds of general formula (III) ##STR3## wherein Z is halogen atom or a reactive residue of a sulfonic acid or a --N.sup.+ (R.sub.9).sub.3 cation wherein R.sub.9 is a (C.sub.1 -C.sub.6) alkyl group and R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5 R.sub.6 R.sub.7 and R.sub.8 are as herein defined.
摘要翻译：制备通式（I）化合物（I）的方法，其特征在于通式（II）的相应衍生物与式（III）的化合物反应：IMAGE （III）其中Z是卤素原子或磺酸或-N +（R9）3阳离子的反应性残基，其中R9是（C1-C6）烷基，R1，R2，R3，R4，R5 R6 R7和 R8如本文所定义。

2. 发明授权

US06461588B1 Use of bile acid conjugates, derivatives thereof with metal complexes as blood pool agents for nuclear magnetic resonance diagnostics 有权
标题翻译：使用胆汁酸共轭物，其衍生物与金属络合物作为核磁共振诊断的血液池剂
公开(公告)号：US06461588B1
公开(公告)日：2002-10-08
申请号：US09318618
申请日：1999-05-26
申请人： Pier Lucio Anelli , Marino Brocchetta , Christoph De Haen , Ornella Gazzotti , Luciano Lattuada , Giovanna Lux , Giuseppe Manfredi , Pierfrancesco Morosini , Daniela Palano , Michele Serleti , Fulvio Uggeri , Massimo Visigalli
发明人： Pier Lucio Anelli , Marino Brocchetta , Christoph De Haen , Ornella Gazzotti , Luciano Lattuada , Giovanna Lux , Giuseppe Manfredi , Pierfrancesco Morosini , Daniela Palano , Michele Serleti , Fulvio Uggeri , Massimo Visigalli
IPC分类号： A61B5055
CPC分类号： A61K49/10 , A61K49/085 , Y10S977/928 , Y10S977/929 , Y10S977/93
摘要： Blood pool imaging contrast agents containing paramagnetic bi- and tri-valent metal ion chelates of bile acid conjugates with molecules having chelating activity are used in magnetic resonance imaging of the vascular system and particularly the coronaries.
摘要翻译：血液成像造影剂含有胆酸偶联物与具有螯合活性的分子的顺磁性二价和三价金属离子螯合物用于血管系统特别是冠状动脉的磁共振成像。

3. 发明授权

US08835685B2 Process for the preparation of contrast agents 有权
标题翻译：造影剂的制备方法
公开(公告)号：US08835685B2
公开(公告)日：2014-09-16
申请号：US13805306
申请日：2011-07-14
申请人： Pier Lucio Anelli , Marino Brocchetta , Enrico Cappelletti , Ornella Gazzotti
发明人： Pier Lucio Anelli , Marino Brocchetta , Enrico Cappelletti , Ornella Gazzotti
IPC分类号： C07C233/65 , C07C231/12 , C07C231/10
CPC分类号： C07C231/12 , C07C231/10 , C07C237/46
摘要： The present invention relates to a process for the preparation of 5-[(2-hydroxyacyl)amino]-2,4,6-triiodo-1,3-benzendicarboxamidic derivatives comprising the Smiles rearrangement of a suitable precursor, by contact of an aqueous solution of this latter with an anion exchanger solid phase.
摘要翻译：本发明涉及一种制备5 - [（2-羟基酰基）氨基] -2,4,6-三碘-1,3-苯二甲酰胺衍生物的方法，其包括合适的前体的微升重排，该溶液用阴离子交换剂固相。

4. 发明申请

US20130131382A1 Process For The Preparation Of Contrast Agents 有权
标题翻译：制备造影剂的方法
公开(公告)号：US20130131382A1
公开(公告)日：2013-05-23
申请号：US13805306
申请日：2011-07-14
申请人： Pier Lucio Anelli , Marino Brocchetta , Enrico Cappelletti , Ornella Gazzotti
发明人： Pier Lucio Anelli , Marino Brocchetta , Enrico Cappelletti , Ornella Gazzotti
IPC分类号： C07C231/12
CPC分类号： C07C231/12 , C07C231/10 , C07C237/46
摘要： The present invention relates to a process for the preparation of 5-[(2-hydroxyacyl)amino]-2,4,6-triiodo-1,3-benzendicarboxamidic derivatives comprising the Smiles rearrangement of a suitable precursor, by contact of an aqueous solution of this latter with an anion exchanger solid phase.
摘要翻译：本发明涉及一种制备5 - [（2-羟基酰基）氨基] -2,4,6-三碘-1,3-苯二甲酰胺衍生物的方法，其包括合适的前体的微升重排，该溶液用阴离子交换剂固相。

5. 发明授权

US5708166A Macrocyclic chelants, their chelates and uses thereof in the diagnostic field 失效
标题翻译：大环螯合剂及其螯合物及其在诊断领域的应用
公开(公告)号：US5708166A
公开(公告)日：1998-01-13
申请号：US783609
申请日：1997-01-14
申请人： Fulvio Uggeri , Pier Lucio Anelli , Giuseppe Manfredi , Marino Brocchetta , Franco Fedeli
发明人： Fulvio Uggeri , Pier Lucio Anelli , Giuseppe Manfredi , Marino Brocchetta , Franco Fedeli
IPC分类号： A61K49/00 , A61K49/06 , C07D257/02 , A61K49/04
CPC分类号： C07D257/02 , A61K49/06
摘要： This invention relates to novel compounds able to chelate paramagnetic bi- or trivalent metal ions, their chelates with said metal ions and their use as contrast agents in magnetic resonance imaging (MRI).
摘要翻译：本发明涉及能够螯合顺磁性二价或三价金属离子的螯合物，它们与所述金属离子的螯合物以及它们在磁共振成像（MRI）中作为造影剂的用途。

6. 发明授权

US5663413A Biphenyl iodinated derivatives and their diagnostic use 失效
标题翻译：联苯碘化衍生物及其诊断用途
公开(公告)号：US5663413A
公开(公告)日：1997-09-02
申请号：US448750
申请日：1995-05-24
申请人： Fulvio Uggeri , Pier Lucio Anelli , Marino Brocchetta , Massimo Visigalli
发明人： Fulvio Uggeri , Pier Lucio Anelli , Marino Brocchetta , Massimo Visigalli
IPC分类号： A61K49/04 , C07C39/367 , C07C43/225 , C07C59/70 , C07C69/708 , C07C233/65 , C07C233/69 , C07C235/06 , C07C235/08 , C07C235/16 , C07C235/20 , C07C235/46 , C07C235/48 , C07C69/76 , C07C17/00 , C07C233/11
CPC分类号： C07C235/20 , A61K49/0433 , C07C233/65 , C07C233/69 , C07C235/06 , C07C235/16 , C07C235/46 , C07C235/48 , C07C43/225 , C07C59/70 , C07C69/708
摘要： The invention relates to novel contrast media particularly useful for X-ray diagnostic investigations of human and animal body.
摘要翻译：本发明涉及对人体和动物体的X射线诊断研究特别有用的新型造影剂。

7. 发明授权

US07034183B2 Process for the preparation of iopamidol and the new intermediated therein 有权
标题翻译：制备碘帕醇及其中间体的方法
公开(公告)号：US07034183B2
公开(公告)日：2006-04-25
申请号：US10433389
申请日：2001-11-29
申请人： Pier Lucio Anelli , Marino Brocchetta , Giovanna Lux , Enrico Cappelletti
发明人： Pier Lucio Anelli , Marino Brocchetta , Giovanna Lux , Enrico Cappelletti
IPC分类号： C07C233/65
CPC分类号： C07C231/02 , C07C237/46
摘要： A process for the preparation of (S)-N,N′-bis[2-hydroxy-1-(hydroxymethyl)ethyl]-5-[(2-hydroxy-1-oxo-propyl)amino]-2,4,6-triiodo-1,3-benzendicarboxamide (iopamidol) starting from 5-amino-N,N′-bis[2-hydroxy-1-(hydroxymethyl)ethyl]-2,4,6-triiodo-1,3-benzenedicarboxamide (II) which process comprises a) reacting the compound of formula (II) with a suitable protecting agent, to give a compound of formula (III) wherein R is a group of formula A or B wherein R1 is a hydrogen atom, a C1÷C4 straight or branched alkoxy group, R2 is hydrogen, a C1÷C4 straight or branched alkoxy group and R3 ?is a C1÷C4 straight or branched alkyl group, a trifuoromethyl or a trichloromethyl group; b) acylating the amino group in position 5 of the intermediate compound of formula (III), by reaction with a (S)-2-(acetyloxy)propanoyl chloride to give a compound of formula (IV) wherein R is as defined above; and c) removing all the acyl groups present in the compound of formula (IV) under basic conditions, with prior cleavage of the cyclic protections of the hydroxy groups in the carboxamido substituents under acidic conditions, when R is a group of formula A carboxamido hydroxy groups under acidic conditions. The invention also refers to the new intermediates of formula (III) and (IV) wherein —R is a group A.
摘要翻译：制备（S）-N，N'-双[2-羟基-1-（羟甲基）乙基] -5 - [（2-羟基-1-氧代 - 丙基）氨基] -2,4， 5-氨基-N，N'-双[2-羟基-1-（羟甲基）乙基] -2,4,6-三碘-1,3-苯二甲酰胺的6-三碘-1,3-苯二甲酰胺（碘帕醇）（II）所述方法包括a）使式（II）化合物与合适的保护剂反应，得到其中R为式A或B的基团的式（III）化合物，其中R 1 >是氢原子，C 1或C 4直链或支链烷氧基，R 2是氢，C 1 直链或支链烷氧基，R 3？是C / C 直链或支链烷基，三氟甲基或三氯甲基; b）通过与（S）-2-（乙酰氧基）丙酰氯反应，酰化式（III）中间体化合物的第5位的氨基，得到其中R如上定义的式（Ⅳ）化合物; 和c）在碱性条件下除去存在于式（Ⅳ）化合物中的所有酰基，在R是式A的基团时，先前在酸性条件下，在甲酰氨基取代基中羟基的环保保护被切割。在酸性条件下。本发明还涉及式（III）和（IV）的新中间体，其中-R是基团A.

8. 发明授权

US06652834B2 Amphipatic polycarboxylic chelates and complexes with paramagnetic metals as MRI contrast agents 失效
公开(公告)号：US06652834B2
公开(公告)日：2003-11-25
申请号：US10014358
申请日：2001-12-14
申请人： Pier Lucio Anelli , Luciano Lattuada , Fulvio Uggeri , Giovanna Lux , Michele Serleti , Milena Gabellini , Hervé Tournier
发明人： Pier Lucio Anelli , Luciano Lattuada , Fulvio Uggeri , Giovanna Lux , Michele Serleti , Milena Gabellini , Hervé Tournier
IPC分类号： C07C23307
CPC分类号： C07J41/0055 , A61K49/06 , A61K49/1812 , C07C229/16 , C07C229/76 , C07C233/47 , C07C237/08 , C07C237/10 , C07C237/12 , C07F9/091 , Y10S977/896 , Y10S977/927 , Y10S977/93
摘要： Substituted polycarboxylic ligand molecules and corresponding metal complexes of said ligands, preferably paramagnetic metals complexes for generating responses in the field of magnetic resonance imaging (MRI) The paramagnetic complexes of the polycarboxylic ligands possess advantageous tensioactive properties and are useful as MRI contrast media in formulations for investigating the blood pool.

9. 发明授权

US07244864B2 Process for the preparation of N,N-substituted 5-amino-1,3-benzenedicarboxamides 有权
标题翻译：制备N，N-取代的5-氨基-1,3-苯二甲酰胺的方法
公开(公告)号：US07244864B2
公开(公告)日：2007-07-17
申请号：US10433388
申请日：2001-11-28
申请人： Pier Lucio Anelli , Marino Brocchetta , Giovanna Lux , Enrico Cappelletti
发明人： Pier Lucio Anelli , Marino Brocchetta , Giovanna Lux , Enrico Cappelletti
IPC分类号： C07C231/02
CPC分类号： C07C231/02 , C07C227/04 , C07C227/18 , C07C231/12 , C07C231/14 , C07C237/32 , C07C237/42
摘要： The invention relates to a process for the preparation of a compound of formula (I), wherein R represents a 2,3-dihydroxy-1-propyl or a 1,3-dihydroxy-2-propyl radical, via direct amidation of a dialkyl ester of 5-amino-1,3-benzenedicarboxylic acid of formula (V), wherein R1 represents a straight or branched (C1-C4)-alkyl group, with at least the stoichiometric amount of an amine of formula H2NR.
摘要翻译：本发明涉及制备式（I）化合物的方法，其中R代表2,3-二羟基-1-丙基或1,3-二羟基-2-丙基，通过二烷基的式（V）的5-氨基-1,3-苯二甲酸的酯，其中R 1表示直链或支链（C 1 -C 4 - 至少具有化学计量量的式H 2 NR的胺。

10. 发明授权

US06458337B1 Diagnostic imaging contrast agent with improved in serum relaxivity 失效
标题翻译：诊断成像造影剂具有改善的血清舒张度
公开(公告)号：US06458337B1
公开(公告)日：2002-10-01
申请号：US09620594
申请日：2000-07-20
申请人： Pier Lucio Anelli , Marco Lolli , Franco Fedeli , Mario Virtuani , Marino Brocchetta , Pierfrancesco Morosini , Daniela Palano
发明人： Pier Lucio Anelli , Marco Lolli , Franco Fedeli , Mario Virtuani , Marino Brocchetta , Pierfrancesco Morosini , Daniela Palano
IPC分类号： A61B5055
CPC分类号： C07C229/26 , A61K49/06 , C07C229/36 , C07C233/48 , C07C233/51 , C07C237/06 , C07C2601/14 , C07D209/20 , C07D263/26 , Y10S977/928 , Y10S977/93
摘要： Compounds of the formula when chelated with metals exhibit improved serum relaxivity and are used in magnetic resonance imaging, particularly for imaging the blood pool.
摘要翻译：与金属螯合的化合物表现出改善的血清舒张性，并用于磁共振成像，特别是用于血液成像。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式