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1. 发明授权

US5869330A DNA encoding a novel serum protein produced exclusively in adipocytes 失效
标题翻译：编码仅在脂肪细胞产生的新型血清蛋白的DNA
公开(公告)号：US5869330A
公开(公告)日：1999-02-09
申请号：US463911
申请日：1995-06-05
申请人： Philipp E. Scherer , Harvey F. Lodish
发明人： Philipp E. Scherer , Harvey F. Lodish
IPC分类号： A61K38/00 , C07K14/47 , C07H21/04 , C12N15/63
CPC分类号： C07K14/4702 , A61K38/00
摘要： The present invention relates to DNA encoding Acrp30, of vertebrate (e.g., mammalian) origin, and particularly of human and rodent origin. The present invention further relates to isolated, recombinantly produced or synthetic DNA which hybridizes to the nucleotide sequences described herein and RNA transcribed from the nucleotides sequence described herein. In addition, the invention relates to expression vectors comprising DNA encoding Acrp30, which is expressed when the vector is present in an appropriate host cell. The invention further relates to isolated, recombinantly produced or synthetic mammalian Acrp30 of vertebrate (e.g., mammalian) origin, and particularly of human and rodent origin. Also encompassed by the present invention is an inhibitor or enhancer of Acrp30. The present invention further relates to a method of identifying inhibitors or enhancers of Acrp30. Isolation of Acrp30 makes it possible to detect Acrp30 or adipocytes in a sample (e.g., test sample). In addition, the present invention relates to a method of regulating the energy balance (e.g., nutritional status) of a mammal by administering to the mammal an inhibitor or enhancer of the Acrp30.
摘要翻译：本发明涉及编码Acrp30的脊椎动物（例如哺乳动物）来源，特别是人和啮齿动物来源的DNA。本发明还涉及与本文所述的核苷酸序列杂交的分离的，重组产生的或合成的DNA，以及从本文所述的核苷酸序列转录的RNA。此外，本发明涉及包含编码Acrp30的DNA的表达载体，其在载体存在于合适的宿主细胞中时表达。本发明还涉及脊椎动物（例如哺乳动物）来源，特别是人和啮齿动物来源的分离的重组产生或合成的哺乳动物Acrp30。本发明还包括Acrp30的抑制剂或增强剂。本发明还涉及鉴定Acrp30抑制剂或增强剂的方法。 Acrp30的分离使得可以检测样品中的Acrp30或脂肪细胞（例如测试样品）。此外，本发明涉及通过向哺乳动物施用Acrp30的抑制剂或增强剂来调节哺乳动物的能量平衡（例如营养状态）的方法。

2. 发明申请

US20090011438A1 Collagen VI and Cancer 失效
标题翻译：胶原六和癌症
公开(公告)号：US20090011438A1
公开(公告)日：2009-01-08
申请号：US11660181
申请日：2005-08-11
申请人： Philipp E. Scherer , Puneeth Iyengar
发明人： Philipp E. Scherer , Puneeth Iyengar
IPC分类号： G01N33/574 , C12Q1/02
CPC分类号： G01N33/57415 , G01N33/57419 , G01N33/57449 , G01N2333/78
摘要： Methods of determining whether a cancer is progressing by measuring surface-bound collagen VIα3 are provided. Also provided are methods of identifying hyperplasia in a tissue by measuring surface-bound collagen VIα3. Additionally, methods of identifying carcinoma in a tissue by measuring surface-bound collagen VIα3 are provided. Further provided are methods of imaging carcinoma in a tissue by staining the tissue with a specific binding partner to collagen VIα3. Methods of treating a cancer by preventing binding of collagen VIα3 onto cells of the cancer are additionally provided.
摘要翻译：提供了通过测量表面结合胶原VIalpha3来确定癌症是否进展的方法。还提供了通过测量表面结合的胶原VIalpha3来鉴定组织中的增生的方法。另外，提供了通过测量表面结合的胶原VIalpha3来鉴定组织中的癌症的方法。还提供了通过用特异性结合配偶体对胶原VIalpha3染色组织来对组织中的癌进行成像的方法。另外提供了通过防止胶原VIalpha3与癌细胞结合来治疗癌症的方法。

3. 发明授权

US07820401B2 Collagen VI and cancer 失效
标题翻译：胶原蛋白VI和癌症
公开(公告)号：US07820401B2
公开(公告)日：2010-10-26
申请号：US11660181
申请日：2005-08-11
申请人： Philipp E. Scherer , Puneeth Iyengar
发明人： Philipp E. Scherer , Puneeth Iyengar
IPC分类号： G01N33/574
CPC分类号： G01N33/57415 , G01N33/57419 , G01N33/57449 , G01N2333/78
摘要： Methods of determining whether a cancer is progressing by measuring surface-bound collagen VIα3 are provided. Also provided are methods of identifying hyperplasia in a tissue by measuring surface-bound collagen VIα3. Additionally, methods of identifying carcinoma in a tissue by measuring surface-bound collagen VIα3 are provided. Further provided are methods of imaging carcinoma in a tissue by staining the tissue with a specific binding partner to collagen VIα3. Methods of treating a cancer by preventing binding of collagen VIα3 onto cells of the cancer are additionally provided.
摘要翻译：提供了通过测量表面结合胶原VIα3来确定癌症是否正在进行的方法。还提供了通过测量表面结合的胶原VIα3来鉴定组织中增生的方法。另外，提供了通过测量表面结合的胶原VIα3来鉴定组织中的癌症的方法。还提供了通过用特异性结合配偶体将组织染色成胶原VIα3来对组织中的癌进行成像的方法。另外提供了通过防止胶原VIα3与癌细胞结合来治疗癌症的方法。

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