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    • 5. 发明授权
    • Process for the co-production of aliphatic diols and cyclic ethers
    • 共同生产脂族二醇和环醚的方法
    • US06844452B2
    • 2005-01-18
    • US10149199
    • 2000-12-12
    • Michael Anthony WoodPaul WillettRobert WildStephen William Colley
    • Michael Anthony WoodPaul WillettRobert WildStephen William Colley
    • C07B61/00C07C29/149C07C29/17C07C31/20C07D307/08C07D307/20C07D307/33C07D315/00C07D307/07
    • C07D315/00C07C29/177C07D307/08C07D307/20C07C31/207
    • A process for the co-production of a diol product (e.g. butane-1,4-diol) and a cyclic ether (e.g. tetrahydrofuran) by hydrogenation of an aliphatic diester or lactone feedstock (e.g. dimethyl or diethyl maleate), which contains a minor amount of acidic material, such as the corresponding monoester. The process utilizes a plurality of hydrogenation zones connected in series, each containing a charge of a granular ester hydrogenation catalyst. The catalyst in the first hydrogenation zone is tolerant of a minor amount of acidic material, while the catalyst in the second hydrogenation zone provides enhanced yields of cyclic ethers compared to the catalyst of the first hydrogenation zone. The catalyst in a third hydrogenation zone exhibits low selectivity towards conversion of the diester to at least one by product (e.g. 2-4′-hydroxybutoxy-tetrahydrofuran). The feedstock is supplied to the first hydrogenation zone as a vaporous stream comprising hydrogen and there is recovered a final product stream from the third hydrogenation zone which is substantially free of the hydrogenatable material and contains the diol, cyclic ether and other by products, the selectivity to the cyclic ether being greater in the final product stream than in the first intermediate product stream.
    • 通过氢化脂族二酯或内酯原料(例如二甲基或二乙基马来酸酯)共同生产二醇产物(例如丁烷-1,4-二醇)和环醚(例如四氢呋喃)的方法,其包含未成熟的 酸性物质的量,如相应的单酯。 该方法利用串联连接的多个氢化区,每个加氢区含有粒状酯加氢催化剂。 第一加氢区中的催化剂耐受少量酸性物质,而与第一氢化区的催化剂相比,第二加氢区中的催化剂提供了更高的环醚产率。 在第三加氢区中的催化剂对于将二酯转化为至少一种副产物(例如2-4'-羟基丁氧基 - 四氢呋喃)表现出低的选择性。 原料作为包含氢气的气流被供应到第一氢化区,并且从第三氢化区回收最终产物流,其基本上不含可氢化材料并含有二醇,环醚和其它产物,选择性 在最终产物流中环醚比在第一中间产物流中更大。