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1. 发明授权

US06245724B1 Preparation of sulfurized phenol additives intermediates and compositions 失效
标题翻译：硫化酚添加剂中间体和组合物的制备
公开(公告)号：US06245724B1
公开(公告)日：2001-06-12
申请号：US09122013
申请日：1998-07-24
申请人： Philip Skinner , Dennis J. Simpkin , David Robert Adams
发明人： Philip Skinner , Dennis J. Simpkin , David Robert Adams
IPC分类号： C10M13500
CPC分类号： C10M159/22 , C07C319/22 , C07C323/20 , C10M127/02 , C10M135/30 , C10M159/12 , C10M177/00 , C10M2203/02 , C10M2203/022 , C10M2203/024 , C10M2203/04 , C10M2219/087 , C10M2219/088 , C10M2219/089 , C10M2227/00
摘要： A process is described wherein olefins or acetylenic compounds are reacted with sulfurised intermediates to produce nitrile seal compatible additives. Olefin or acetylinic compound reaction with sulfurised compounds e.g. sulfurised phenols results in low chlorine additives. Also disclosed is a process for the production of low chlorine intermediates.
摘要翻译：描述了一种方法，其中烯烃或炔属化合物与硫化中间体反应以制备腈密封相容的添加剂。与硫化化合物的烯烃或乙炔化合物反应，例如硫化酚导致低氯添加剂。还公开了一种生产低氯中间体的方法。

2. 发明授权

US5827806A Preparation of sulfurized phenol additives intermediates and compositions 失效
标题翻译：硫化酚添加剂中间体和组合物的制备
公开(公告)号：US5827806A
公开(公告)日：1998-10-27
申请号：US750947
申请日：1997-01-30
申请人： Philip Skinner , Dennis John Simpkin , David Robert Adams
发明人： Philip Skinner , Dennis John Simpkin , David Robert Adams
IPC分类号： C10M135/02 , C07C319/22 , C07C323/20 , C10M101/02 , C10M135/30 , C10M151/00 , C10M151/04 , C10M159/12 , C10M159/22 , C10M169/04 , C10M177/00 , C10N10/02 , C10N10/04 , C10N30/00 , C10N70/00 , C10M135/00
CPC分类号： C10M159/22 , C07C319/22 , C07C323/20 , C10M135/30 , C10M159/12 , C10M177/00 , C10M2203/02 , C10M2203/022 , C10M2203/024 , C10M2203/04 , C10M2219/087 , C10M2219/088 , C10M2219/089 , C10M2227/00
摘要： A process is described wherein olefins or acetylenic compounds are reacted with sulfurised intermediates to produce nitrile seal compatible additives. Olefin or acetylinic compound reaction with sulfurised compounds e.g. sulfurised phenols results in low chlorine additives. Also disclosed is a process for the production of low chlorine intermediates.
摘要翻译： PCT No.PCT / EP95 / 03055 Sec。 371日期1997年1月30日 102（e）1997年1月30日PCT PCT 1995年7月31日PCT公布。出版物WO96 / 04356 日期1996年2月15日描述了一种方法，其中使烯烃或炔属化合物与硫化中间体反应以产生腈密封相容的添加剂。与硫化化合物的烯烃或乙炔化合物反应，例如硫化酚导致低氯添加剂。还公开了一种生产低氯中间体的方法。

3. 发明申请

US20080164739A1 AUTOMOTIVE VEHICLE SEAT SYSTEM 有权
标题翻译：汽车座椅系统
公开(公告)号：US20080164739A1
公开(公告)日：2008-07-10
申请号：US11620186
申请日：2007-01-05
申请人： Anthony Valasin , Radesh Vangipuram , Richard Squires , Philip Skinner , Joseph Talamonti
发明人： Anthony Valasin , Radesh Vangipuram , Richard Squires , Philip Skinner , Joseph Talamonti
IPC分类号： B60N2/02
CPC分类号： B60N2/01583 , B60N2205/20
摘要： A portion of a riser of a removable vehicle seat has a layered structure. The layered structure provides abrasion resistance and noise isolation.
摘要翻译：可拆卸式车辆座椅的立管的一部分具有分层结构。分层结构提供耐磨性和噪音隔离。

4. 发明申请

US20070032537A1 5-Substituted 2h-pyrazole-3-carboxylic acid derivatives as agonists for the acid receptor rup25 for the treatment of dyslipidemia and related diseases 审中-公开
标题翻译： 5-取代的2h-吡唑-3-羧酸衍生物作为用于治疗血脂异常和相关疾病的酸受体rup25的激动剂
公开(公告)号：US20070032537A1
公开(公告)日：2007-02-08
申请号：US10560332
申请日：2004-06-10
申请人： Graeme Semple , Tawfik Gharbaoui , Young-Jun Shin , Marc Decaire , Claudia Averbuj , Philip Skinner
发明人： Graeme Semple , Tawfik Gharbaoui , Young-Jun Shin , Marc Decaire , Claudia Averbuj , Philip Skinner
IPC分类号： A61K31/4152 , C07D231/02
CPC分类号： C07D231/14 , A61K31/415 , A61K45/06 , A61K2300/00
摘要： The present invention relates to certain pyrazole carboxylic acid and ester derivatives, and pharmaceutically acceptable salts thereof, which exhibit useful pharmaceutical properties, for example as agonists for the RUP25 receptor. (I) Also provided by the present invention are pharmaceutical compositions containing compounds of the invention, and methods of using the compounds and compositions of the invention in the prophylaxis or treatment of metabolic-related disorders, including dyslipidemia, atherosclerosis, coronary heart disease, insulin resistance, type 2 diabetes, Syndrome-X and the like. In addition, the present invention also provides for the use of the compounds of the invention in combination with other active agents such as those belonging to the class of α-glucosidase inhibitors, aldose reductase inhibitors, biguanides, HMG-CoA reductase inhibitors, squalene synthesis inhibitors, fibrates, LDL catabolism enhancers, angiotensin converting enzyme (ACE) inhibitors, insulin secretion enhancers and the like the substituents are defined in claim 1.
摘要翻译：本发明涉及表现出有用的药物性质的某些吡唑羧酸和酯衍生物及其药学上可接受的盐，例如作为RUP25受体的激动剂。（I）本发明还提供含有本发明化合物的药物组合物，以及使用本发明化合物和组合物预防或治疗代谢相关疾病包括血脂异常，动脉粥样硬化，冠心病，胰岛素抗性，2型糖尿病，综合征等。此外，本发明还提供本发明化合物与其它活性剂如属于α-葡糖苷酶抑制剂类，醛糖还原酶抑制剂，双胍类，HMG-CoA还原酶抑制剂，角鲨烯合成抑制剂，贝特类，LDL分解代谢增强剂，血管紧张素转换酶（ACE）抑制剂，胰岛素分泌增强剂等，取代基如权利要求1中所定义。

5. 发明申请

US20060217562A1 Tetrazole derivatives and methods of treatment of metabolic-related disorders thereof 失效
标题翻译：四唑衍生物及其代谢相关病症的治疗方法
公开(公告)号：US20060217562A1
公开(公告)日：2006-09-28
申请号：US10535345
申请日：2004-10-29
申请人： Graeme Semple , Thomas Schrader , Philip Skinner , Steven Colletti , Tawfik Gharbaoui , Jason Imbriglio , Jae-Kyu Jung , Rui Liang , Subharekha Raghavan , Darby Schmidt , James Tata
发明人： Graeme Semple , Thomas Schrader , Philip Skinner , Steven Colletti , Tawfik Gharbaoui , Jason Imbriglio , Jae-Kyu Jung , Rui Liang , Subharekha Raghavan , Darby Schmidt , James Tata
IPC分类号： A61K31/416 , C07D403/02
CPC分类号： C07D491/04 , C07D403/04 , C07D495/04
摘要： The present invention relates to certain tetrazole derivatives of Formula (I), and pharmaceutically acceptable salts thereof, which exhibit useful pharmacological properties, for example, as agonists for the RUP25 receptor. Also provided by the present invention are pharmaceutical compositions containing compounds of the invention, and methods of using the compounds and compositions of the invention in the treatment of metabolic-related disorders, including dyslipidemia, atherosclerosis, coronary heart disease, insulin resistance, type 2 diabetes, Syndrome-X and the like. In addition, the present invention also provides for the use of the compounds of the invention in combination with other active agents such as those belonging to the class of α-glucosidase inhibitors, aldose reductase inhibitors, biguanides, HMG-CoA reductase inhibitors, squalene synthesis inhibitors, fibrates, LDL catabolism enhancers, angiotensin converting enzyme (ACE) inhibitors, insulin secretion enhancers and the like.
摘要翻译：本发明涉及式（I）的某些四唑衍生物及其药学上可接受的盐，其表现出有用的药理学性质，例如作为RUP25受体的激动剂。本发明还提供含有本发明化合物的药物组合物，以及使用本发明化合物和组合物治疗代谢相关疾病包括血脂异常，动脉粥样硬化，冠心病，胰岛素抵抗，2型糖尿病的方法，综合征-X等。此外，本发明还提供本发明化合物与其它活性剂如属于α-葡糖苷酶抑制剂类，醛糖还原酶抑制剂，双胍类，HMG-CoA还原酶抑制剂，角鲨烯合成抑制剂，贝特类，LDL分解代谢增强剂，血管紧张素转换酶（ACE）抑制剂，胰岛素分泌增强剂等。

6. 发明申请

US20060122240A1 Benzotriazoles and methods of prophylaxis or treatment of metabolic-related disorders thereof 审中-公开
标题翻译：苯并三唑及其代谢相关疾病的预防或治疗方法
公开(公告)号：US20060122240A1
公开(公告)日：2006-06-08
申请号：US10533799
申请日：2003-11-04
申请人： Graeme Semple , Philip Skinner , Martin Cherrier , Peter Webb , Susan Tamura
发明人： Graeme Semple , Philip Skinner , Martin Cherrier , Peter Webb , Susan Tamura
IPC分类号： C07D249/16 , A61K31/4192
CPC分类号： C07D405/06 , A61K31/4192 , C07D249/18
摘要： The present invention relates to certain benzotriazole carboxylic acid or ester derivatives of Formula (I), pharmaceutically acceptable salts and solvates thereof, which exhibit useful pharmaceutical properties, for example, as agonists for the GPCR referred to as hRUP38. Also provided by the present invention are pharmaceutical compositions containing compounds of the invention, and methods of using the compounds and compositions of the invention in the prophylaxis or treatment of metabolic-related disorders, including dyslipidemia, atherosclerosis, coronary heart disease, insulin resistance, type 2 diabetes, Syndrome-X and the like. In addition, the present invention also provides for the use of the compounds of the invention in combination with other active agents such as those belonging to the class of -glucosidase inhibitors, aldose reductase inhibitors, biguanides, HMG-CoA reductase inhibitors, squalene synthesis inhibitors, fibrates, LDL catabolism enhancers, angiotensin converting enzyme (ACE) inhibitors, insulin secretion enhancers and the like.
摘要翻译：本发明涉及一些表现出有用的药物性质的式（I）的苯并三唑羧酸或酯衍生物，其药学上可接受的盐和溶剂化物，例如被称为hRUP38的GPCR的激动剂。本发明还提供含有本发明化合物的药物组合物，以及使用本发明化合物和组合物预防或治疗代谢相关疾病（包括血脂异常，动脉粥样硬化，冠心病，胰岛素抵抗，类型 2型糖尿病，综合征X等。此外，本发明还提供本发明化合物与其它活性剂如属于葡糖苷酶抑制剂类，醛糖还原酶抑制剂，双胍类，HMG-CoA还原酶抑制剂，角鲨烯合成抑制剂，贝特类，LDL分解代谢增强剂，血管紧张素转换酶（ACE）抑制剂，胰岛素分泌增强剂等。

7. 发明授权

US06429178B1 Calcium overbased metal-containing detergents 有权
标题翻译：钙高碱性金属洗涤剂
公开(公告)号：US06429178B1
公开(公告)日：2002-08-06
申请号：US09180435
申请日：1998-11-09
申请人： Philip Skinner , Alain Louis Pierre Lenack
发明人： Philip Skinner , Alain Louis Pierre Lenack
IPC分类号： C11D1700
CPC分类号： C07G17/00 , C10M159/22
摘要： Phenate/salicylate overbased detergents with high proportions of phenate and salicylate surfactants in the surfactant system and with TBN; % surfactant ratios of 11 or more are useful marine diesel lubricant additives.
摘要翻译：在表面活性剂体系和TBN中，苯甲酸盐/水杨酸盐高碱性洗涤剂中酚盐和水杨酸盐表面活性剂的比例高; 11％以上的表面活性剂比例是有用的船用柴油润滑剂添加剂。

8. 发明授权

US06281179B1 Process for preparing an overbased metal-containing detergents 有权
标题翻译：制备高碱性含金属洗涤剂的方法
公开(公告)号：US06281179B1
公开(公告)日：2001-08-28
申请号：US09180438
申请日：1998-11-09
申请人： Philip Skinner , Alain Louis Pierre Lenack
发明人： Philip Skinner , Alain Louis Pierre Lenack
IPC分类号： C11D1700
CPC分类号： C07G17/008 , C10M159/22
摘要： A method of manufacturing a calcium overbased detergent, of TBN at least 300, from at least two surfactants, at least one of which is a phenol surfactant or a salicylic acid surfactant. Overbasing is carried out in at least two steps, at a temperature of less than 100° C., at least one of the overbasing steps being followed by a heat-soaking step. The overbased detergents produced may be useful marine diesel lubricant additives.
摘要翻译：从至少两种表面活性剂制备至少300个TBN的钙高碱性洗涤剂的方法，其中至少一种是酚表面活性剂或水杨酸表面活性剂。在至少两个步骤中，在小于100℃的温度下进行过碱性化，其中至少一个高碱化步骤之后是热浸渍步骤。生产的高碱性洗涤剂可能是有用的船用柴油润滑剂添加剂。

9. 发明申请

US20120329692A1 Wet Friction Clutch - Lubricant Systems Providing High Dynamic Coefficients of Friction Through the Use of Sodium Detergents 审中-公开
标题翻译：湿摩擦离合器 - 润滑系统通过使用洗涤剂提供高动态摩擦系数
公开(公告)号：US20120329692A1
公开(公告)日：2012-12-27
申请号：US13579638
申请日：2010-02-19
申请人： Joe R. Noles, JR. , Hirokazu Saito , Philip Skinner , Raymond F. Watts , Keiji Hayashi , Atsushi Suzuki , Koji Saito
发明人： Joe R. Noles, JR. , Hirokazu Saito , Philip Skinner , Raymond F. Watts , Keiji Hayashi , Atsushi Suzuki , Koji Saito
IPC分类号： C10M141/10 , F16D13/74
CPC分类号： C10M141/10 , C10M141/12 , C10M2207/042 , C10M2207/126 , C10M2207/144 , C10M2207/289 , C10M2215/04 , C10M2215/042 , C10M2215/08 , C10M2215/224 , C10M2215/28 , C10M2219/022 , C10M2219/046 , C10M2223/04 , C10M2223/041 , C10M2223/043 , C10M2223/045 , C10M2223/047 , C10M2223/049 , C10N2230/06 , C10N2230/42 , C10N2230/44 , C10N2230/45 , C10N2240/04 , C10N2240/042 , C10N2240/044 , C10N2240/045 , C10N2240/08 , C10N2260/14 , C10N2260/12 , C10N2210/01 , C10N2210/02
摘要： A wet friction clutch-lubricant system wherein a wet friction clutch having a cellulose-based friction lining, or a device including such a clutch, is lubricated with a lubricant composition a major amount of oil of lubricating viscosity and minor effective amounts of performance enhancing additives including (a) one or more ashless dispersant; (b) one or more organic phosphorus compound and (c) one or more sodium salt of an organic acid; and optionally, (d) an auxiliary friction modifier.
摘要翻译：一种湿式摩擦离合器 - 润滑剂系统，其中具有纤维素基摩擦衬片的湿摩擦离合器或包括这种离合器的装置用润滑剂组合物润滑，润滑剂组合物具有大量润滑粘度的油和少量有效量的性能增强添加剂包括（a）一种或多种无灰分散剂; （b）一种或多种有机磷化合物和（c）一种或多种有机酸的钠盐; 和（d）辅助摩擦改性剂。

10. 发明申请

US20080164732A1 AUTOMOTIVE VEHICLE SEAT SYSTEM 审中-公开
标题翻译：汽车座椅系统
公开(公告)号：US20080164732A1
公开(公告)日：2008-07-10
申请号：US11620213
申请日：2007-01-05
申请人： Anthony Valasin , Radesh Vangipuram , Richard Squires , Philip Skinner , Joseph Talamonti
发明人： Anthony Valasin , Radesh Vangipuram , Richard Squires , Philip Skinner , Joseph Talamonti
IPC分类号： B60N2/42
CPC分类号： B60N2/688 , B60N2/01583 , B60N2/7047 , B60R22/023 , B60R22/26
摘要： A structural member for a removable vehicle seat provides integrated attachment features for a flex-mat, risers, and restraint system.
摘要翻译：用于可移动车辆座椅的结构构件提供用于柔性垫，立管和约束系统的集成附接特征。

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