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1. 发明授权

US08167139B2 Stem and progenitor cell compositions recovered from bone marrow or cord blood; system and method for preparation thereof 有权
标题翻译：从骨髓或脐带血中回收的干细胞和祖细胞组成; 系统及其制备方法
公开(公告)号：US08167139B2
公开(公告)日：2012-05-01
申请号：US11825542
申请日：2007-07-06
申请人： Philip H. Coelho , Bruce A. Baker , John R. Chapman , Junzhi Li , Prince Emmanuel , Robert S. Childers
发明人： Philip H. Coelho , Bruce A. Baker , John R. Chapman , Junzhi Li , Prince Emmanuel , Robert S. Childers
IPC分类号： B01D24/32 , B04B5/02 , A61M37/00 , B04B5/00
CPC分类号： A61M1/3693 , A61B5/15003 , A61B5/150038 , A61B5/150045 , A61B5/150366 , A61B5/150389 , A61B5/150503 , A61B5/153 , A61M1/0209 , A61M1/0231 , A61M1/029 , A61M2202/0462 , B01D21/262 , B01D21/34 , B01D2221/10 , B04B5/0428
摘要： The invention includes compositions of stem and progenitor cells recovered from bone marrow or cord blood containing most of the viable CD34+ cells and substantially depleted of red blood cells resident in the original sample, without any xenobiotic additives to aid cell separation. The invention also includes a system and method for preparing the compositions. The system includes a bag set and a processing device, which utilizes an optical sensor, microcontroller, servo motor, accelerometer, load cell, and battery. The system and method utilize centrifugation to stratify the cells into layers and then separate and transfer the stem cells into a stem cell bag. The processing device's microcontroller receives input from the device's accelerometer, load cell and optical sensor to direct the metering valve in the bag set to open and close to permit the transfer of as many stems cells as possible with as few red cells as possible.
摘要翻译：本发明包括从含有大多数活的CD34 +细胞的骨髓或脐血回收的干细胞和祖细胞的组合物，并且基本上不存在驻留在原始样品中的红细胞，而没有任何异生生物添加剂来辅助细胞分离。本发明还包括用于制备组合物的系统和方法。该系统包括一个采用光学传感器，微控制器，伺服电机，加速度计，称重传感器和电池的行李箱和处理装置。该系统和方法利用离心将细胞分层，然后分离并将干细胞转移到干细胞袋中。处理设备的微控制器接收来自设备的加速度计，称重传感器和光学传感器的输入，以将计量阀引导到袋组中打开和关闭，以允许尽可能少的红细胞转移尽可能多的茎细胞。

2. 发明授权

US09050422B2 Stem and progenitor cell compositions recovered from bone marrow or cord blood; system and method for preparation thereof 有权
标题翻译：从骨髓或脐带血中回收的干细胞和祖细胞组成; 系统及其制备方法
公开(公告)号：US09050422B2
公开(公告)日：2015-06-09
申请号：US13385951
申请日：2012-03-15
申请人： Philip H. Coelho , Bruce A. Baker , John R. Chapman , Junzhi Li , Prince Emmanuel , Robert S. Childers
发明人： Philip H. Coelho , Bruce A. Baker , John R. Chapman , Junzhi Li , Prince Emmanuel , Robert S. Childers
IPC分类号： A61M1/36 , B04B5/00 , A61M1/02 , B04B5/04 , B01D21/34 , B01D21/26
CPC分类号： A61M1/3693 , A61B5/15003 , A61B5/150038 , A61B5/150045 , A61B5/150366 , A61B5/150389 , A61B5/150503 , A61B5/153 , A61M1/0209 , A61M1/0231 , A61M1/029 , A61M2202/0462 , B01D21/262 , B01D21/34 , B01D2221/10 , B04B5/0428
摘要： The invention includes compositions of stem and progenitor cells recovered from bone marrow or cord blood containing most of the viable CD34+ cells and substantially depleted of red blood cells resident in the original sample, without any xenobiotic additives to aid cell separation. The invention also includes a system and method for preparing the compositions. The system includes a bag set and a processing device, which utilizes an optical sensor, microcontroller, servo motor, accelerometer, load cell, and battery. The system and method utilize centrifugation to stratify the cells into layers and then separate and transfer the stem cells into a stem cell bag. The processing device's microcontroller receives input from the device's accelerometer, load cell and optical sensor to direct the metering valve in the bag set to open and close to permit the transfer of as many stems cells as possible with as few red cells as possible.
摘要翻译：本发明包括从含有大多数活的CD34 +细胞的骨髓或脐血回收的干细胞和祖细胞的组合物，并且基本上不存在驻留在原始样品中的红细胞，而没有任何异生生物添加剂来辅助细胞分离。本发明还包括用于制备组合物的系统和方法。该系统包括一个采用光学传感器，微控制器，伺服电机，加速度计，称重传感器和电池的行李箱和处理装置。该系统和方法利用离心将细胞分层，然后分离并将干细胞转移到干细胞袋中。处理设备的微控制器接收来自设备的加速度计，称重传感器和光学传感器的输入，以将计量阀引导到袋组中打开和关闭，以允许尽可能少的红细胞转移尽可能多的茎细胞。

3. 发明申请

US20120171762A1 Stem and progenitor cell compositions recovered from bone marrow or cord blood; system and method for preparation thereof 有权
公开(公告)号：US20120171762A1
公开(公告)日：2012-07-05
申请号：US13385951
申请日：2012-03-15
申请人： Philip H. Coelho , Bruce A. Baker , John R. Chapman , Junzhi Li , Prince Emmanuel , Robert S. Childers
发明人： Philip H. Coelho , Bruce A. Baker , John R. Chapman , Junzhi Li , Prince Emmanuel , Robert S. Childers
IPC分类号： C12N5/0789
CPC分类号： A61M1/3693 , A61B5/15003 , A61B5/150038 , A61B5/150045 , A61B5/150366 , A61B5/150389 , A61B5/150503 , A61B5/153 , A61M1/0209 , A61M1/0231 , A61M1/029 , A61M2202/0462 , B01D21/262 , B01D21/34 , B01D2221/10 , B04B5/0428
摘要： The invention includes compositions of stem and progenitor cells recovered from bone marrow or cord blood containing most of the viable CD34+ cells and substantially depleted of red blood cells resident in the original sample, without any xenobiotic additives to aid cell separation. The invention also includes a system and method for preparing the compositions. The system includes a bag set and a processing device, which utilizes an optical sensor, microcontroller, servo motor, accelerometer, load cell, and battery. The system and method utilize centrifugation to stratify the cells into layers and then separate and transfer the stem cells into a stem cell bag. The processing device's microcontroller receives input from the device's accelerometer, load cell and optical sensor to direct the metering valve in the bag set to open and close to permit the transfer of as many stems cells as possible with as few red cells as possible.

4. 发明授权

US09101925B2 Centrifuge and separation vessel therefore 有权
标题翻译：因此离心和分离容器
公开(公告)号：US09101925B2
公开(公告)日：2015-08-11
申请号：US13199111
申请日：2011-08-19
申请人： John R. Chapman , Rodney Sparks , Philip H. Coelho
发明人： John R. Chapman , Rodney Sparks , Philip H. Coelho
IPC分类号： B01L3/00 , G01N33/49 , A61M1/36
CPC分类号： B04B5/0414 , A61M1/3693 , B01D21/262 , B01L3/5021 , B01L2300/0851 , B01L2400/0409 , B04B1/00 , B04B5/02 , G01N33/491
摘要： The centrifugation vessel includes an outer wall containing an interior space. A dam defines a barrier which divides the interior space into at least two regions including a catch basin defining a higher gee region and a reservoir defining a lower gee region. These regions are joined together over the dam. The dam includes a face which is preferably tapered to enable optimization of speed of separation of a sample placed within the vessel. The vessel is usable in a biological sample processing method by having the higher gee region of the vessel configured to have an elongate form and the volume optimized for collection of a higher density fraction of the sample. Supply and withdrawal tubes extend into the regions for reliable extraction and separate collection of differing density fractions after separation by centrifugation.
摘要翻译：离心容器包括包含内部空间的外壁。大坝定义了将内部空间分成至少两个区域的屏障，所述至少两个区域包括限定更高的gee区域的捕集池和限定较低的gee区域的储存器。这些地区通过大坝连接在一起。大坝包括一个优选为锥形的面，以便优化放置在容器内的样品的分离速度。容器可用于生物样品处理方法，其中容器的较高的gee区域被配置为具有细长形状，并且针对样品的较高密度部分收集而优化的体积。供应和取出管延伸到区域以进行可靠的提取，并通过离心分离后分离收集不同密度的馏分。

5. 发明授权

US09101926B2 Method for separating a sample into density specific fractions 有权
$Method for separating a sample into density specific fractions$
标题翻译：将样品分离成密度特异性馏分的方法
公开(公告)号：US09101926B2
公开(公告)日：2015-08-11
申请号：US13199119
申请日：2011-08-19
申请人： John R. Chapman , Rodney Sparks , Philip H. Coelho
发明人： John R. Chapman , Rodney Sparks , Philip H. Coelho
IPC分类号： B01L3/00 , G01N33/49 , A61M1/36
CPC分类号： B04B5/0414 , A61M1/3693 , B01D21/262 , B01L3/5021 , B01L2300/0851 , B01L2400/0409 , B04B1/00 , B04B5/02 , G01N33/491
摘要： The centrifugation vessel includes an outer wall containing an interior space. A dam defines a barrier which divides the interior space into at least two regions including a catch basin defining a higher gee region and a reservoir defining a lower gee region. These regions are joined together over the dam. The dam includes a face which is preferably tapered to enable optimization of speed of separation of a sample placed within the vessel. The vessel is usable in a biological sample processing method by having the higher gee region of the vessel configured to have an elongate form and the volume optimized for collection of a higher density fraction of the sample. Supply and withdrawal tubes extend into the regions for reliable extraction and separate collection of differing density fractions after separation by centrifugation.
摘要翻译：离心容器包括包含内部空间的外壁。大坝定义了将内部空间分成至少两个区域的障碍物，所述至少两个区域包括限定更高的gee区域的捕集池和限定较低的gee区域的储存器。这些地区通过大坝连接在一起。大坝包括一个优选为锥形的面，以便优化放置在容器内的样品的分离速度。该容器可用于生物样品处理方法，通过使容器的较高gee区域配置为具有细长形式，并且为了收集样品的较高密度部分而优化的体积。供应和取出管延伸到区域以进行可靠的提取，并通过离心分离后分离收集不同密度的馏分。

6. 发明申请

US20120065048A1 Method for separating a sample into density specific fractions 有权
$Method for separating a sample into density specific fractions$
标题翻译：将样品分离成密度特异性馏分的方法
公开(公告)号：US20120065048A1
公开(公告)日：2012-03-15
申请号：US13199119
申请日：2011-08-19
申请人： John R. Chapman , Rodney Sparks , Philip H. Coelho
发明人： John R. Chapman , Rodney Sparks , Philip H. Coelho
IPC分类号： B01D21/26
CPC分类号： B04B5/0414 , A61M1/3693 , B01D21/262 , B01L3/5021 , B01L2300/0851 , B01L2400/0409 , B04B1/00 , B04B5/02 , G01N33/491
摘要： The centrifugation vessel includes an outer wall containing an interior space. A dam defines a barrier which divides the interior space into at least two regions including a catch basin defining a higher gee region and a reservoir defining a lower gee region. These regions are joined together over the dam. The dam includes a face which is preferably tapered to enable optimization of speed of separation of a sample placed within the vessel. The vessel is usable in a biological sample processing method by having the higher gee region of the vessel configured to have an elongate form and the volume optimized for collection of a higher density fraction of the sample. Supply and withdrawal tubes extend into the regions for reliable extraction and separate collection of differing density fractions after separation by centrifugation.
摘要翻译：离心容器包括包含内部空间的外壁。大坝定义了将内部空间分成至少两个区域的障碍物，所述至少两个区域包括限定更高的gee区域的捕集池和限定较低的gee区域的储存器。这些地区通过大坝连接在一起。大坝包括一个优选为锥形的面，以便优化放置在容器内的样品的分离速度。容器可用于生物样品处理方法，其中容器的较高的gee区域被配置为具有细长形状，并且针对样品的较高密度部分收集而优化的体积。供应和取出管延伸到区域以进行可靠的提取，并通过离心分离后分离收集不同密度的馏分。

7. 发明申请

US20120065047A1 Centrifuge and separation vessel therefore 有权
标题翻译：因此离心和分离容器
公开(公告)号：US20120065047A1
公开(公告)日：2012-03-15
申请号：US13199111
申请日：2011-08-19
申请人： John R. Chapman , Rodney Sparks , Philip H. Coelho
发明人： John R. Chapman , Rodney Sparks , Philip H. Coelho
IPC分类号： B04B5/02 , B01L3/00
CPC分类号： B04B5/0414 , A61M1/3693 , B01D21/262 , B01L3/5021 , B01L2300/0851 , B01L2400/0409 , B04B1/00 , B04B5/02 , G01N33/491
摘要： The centrifugation vessel includes an outer wall containing an interior space. A dam defines a barrier which divides the interior space into at least two regions including a catch basin defining a higher gee region and a reservoir defining a lower gee region. These regions are joined together over the dam. The dam includes a face which is preferably tapered to enable optimization of speed of separation of a sample placed within the vessel. The vessel is usable in a biological sample processing method by having the higher gee region of the vessel configured to have an elongate form and the volume optimized for collection of a higher density fraction of the sample. Supply and withdrawal tubes extend into the regions for reliable extraction and separate collection of differing density fractions after separation by centrifugation.
摘要翻译：离心容器包括包含内部空间的外壁。大坝定义了将内部空间分成至少两个区域的障碍物，所述至少两个区域包括限定更高的gee区域的捕集池和限定较低的gee区域的储存器。这些地区通过大坝连接在一起。大坝包括一个优选为锥形的面，以便优化放置在容器内的样品的分离速度。容器可用于生物样品处理方法，其中容器的较高的gee区域被配置为具有细长形状，并且为了收集样品的较高密度部分而优化的体积。供应和取出管延伸到区域以进行可靠的提取，并通过离心分离后分离收集不同密度的馏分。

8. 发明申请

US20200072834A1 Methods for isolating target cells from blood 审中-公开
公开(公告)号：US20200072834A1
公开(公告)日：2020-03-05
申请号：US16556632
申请日：2019-08-30
申请人： William Busa , Philip H. Coelho , Jonathan Ellis , Dalip Sethi
发明人： William Busa , Philip H. Coelho , Jonathan Ellis , Dalip Sethi
IPC分类号： G01N33/569 , B01D21/26
摘要： Disclosed herein are methods for isolating target cells from blood, involving mixing in an open container an undiluted blood sample having a volume of 10 ml or less, and binding agents, wherein each binding agent comprises (A) a primary binding agent comprising an agent capable of binding to at least one cellular epitope on target cells in the undiluted blood sample, (B) a first linker bound to the primary binding agent, to generate binding agent-attached target cells in the undiluted blood sample; contacting the binding agent-attached target cells in the undiluted blood sample with a plurality of buoyant reagents that include a second linker capable of binding to the first linker to generate an undiluted buoyant reagent-attached target cell mixture; diluting the undiluted buoyant reagent-attached target cell mixture by at least 20% to produce a diluted buoyant reagent-attached target cell mixture; applying a vectorial force, such as centrifugal force, to the diluted buoyant reagent-attached target cell mixture to generate a stratified diluted buoyant reagent-attached target cell mixture; removing the buoyant reagent-attached target cells from the stratified diluted buoyant reagent-attached target cell mixture; and isolating the target cells from the buoyant reagent-attached target cells.

9. 发明申请

US20130029370A1 System for Purifying Certain Cell Populations in Blood or Bone Marrow by Depleting Others 有权
标题翻译：通过消耗其他血液或骨髓来净化某些细胞群体的系统
公开(公告)号：US20130029370A1
公开(公告)日：2013-01-31
申请号：US13634520
申请日：2011-03-17
申请人： Philip H. Coelho
发明人： Philip H. Coelho
IPC分类号： G01N1/34 , C12Q1/02
CPC分类号： G01N1/34 , A61M1/3693 , A61M1/3696 , A61M1/38 , A61M2202/08 , A61M2202/10 , B04B2013/006
摘要： An apparatus and method for purifying and harvesting certain cell populations in blood or bone marrow by depleting at least one of red blood cells, granulocytes, or platelets from a sample comprising blood, bone marrow, or stromal vascular fraction cells separated from adipose tissue is disclosed. The apparatus comprises a sterile, single use rigid, self-supporting cartridge within which the automated depletion, purification and harvesting of target cell populations occurs and all components may be distributed.
摘要翻译：公开了一种用于通过从包含从脂肪组织分离的血液，骨髓或基质血管部分细胞的样品中消耗红细胞，粒细胞或血小板中的至少一种来纯化和收获血液或骨髓中的某些细胞群的装置和方法。该装置包括无菌的单次使用刚性的自支撑筒，其中发生靶细胞群的自动消耗，纯化和收获，并且可以分布所有组分。

10. 发明授权

US06302327B1 Method and apparatus for cryogenic storage of thermolabile products 失效
标题翻译：用于低温储存的不耐热产品的方法和装置
公开(公告)号：US06302327B1
公开(公告)日：2001-10-16
申请号：US08876279
申请日：1997-06-16
申请人： Philip H. Coelho , Pablo Rubinstein , Mark Buckley , Kevin Pelletier
发明人： Philip H. Coelho , Pablo Rubinstein , Mark Buckley , Kevin Pelletier
IPC分类号： G06K1500
CPC分类号： F17C3/085 , F17C2201/0119 , F17C2201/032 , F17C2203/012 , F17C2203/0391 , F17C2203/0629 , F17C2205/052 , F17C2205/054 , F17C2209/228 , F17C2221/014 , F17C2223/0161 , F17C2250/032 , F17C2250/036 , F17C2250/0439 , F17C2270/0509 , F25D3/105 , F25D25/00 , G01N35/0099
摘要： A system and method for controlled rate freezing and storage of thermolabile substances. The system includes a storage unit for receiving product stored within a bag and an overlying protective canister associated with a robotic arm and reading device which places the canister in the preserving environment. A control system, driven by a computer monitors the ingress, egress and storage location and particularized profiles of the articles being placed in storage.
摘要翻译：控制速率冻结和储存不耐热物质的系统和方法。该系统包括用于接收存储在袋中的产品的存储单元和与机器人手臂相关联的上覆保护筒和将罐放置在保存环境中的读取装置。由计算机驱动的控制系统监视进入，出口和存储位置以及被放置在存储器中的物品的特定配置文件。

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