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1. 发明授权

US09134201B2 Fluid providing apparatus 有权
标题翻译：流体提供装置
公开(公告)号：US09134201B2
公开(公告)日：2015-09-15
申请号：US13000031
申请日：2009-06-22
申请人： Petrus Johannes Wilhelmus Van Lankvelt , Dominique Maria Bruls , Albert Hendrik Jan Immink
发明人： Petrus Johannes Wilhelmus Van Lankvelt , Dominique Maria Bruls , Albert Hendrik Jan Immink
IPC分类号： G01N35/10 , G01N1/02 , G01N35/00
CPC分类号： G01N1/02 , G01N35/00584 , G01N35/10 , G01N2001/028
摘要： The invention relates to a fluid providing apparatus (5; 34) for providing a fluid to an analyzing apparatus (17; 33) for analyzing the fluid and to the analyzing apparatus (17; 33). The fluid providing apparatus (34) comprises a casing (35), which has an introduction opening (7), through which a fluid transferring element (1) is introducible into the casing (35) for transferring the fluid to the fluid providing apparatus (34). The casing (35) comprises further a fluid releasing section (8) for releasing the fluid from the fluid transferring element (1) and a fluid transferring element detection section (36) for detecting whether the fluid transferring element (1) is introduced into the casing (35) by interacting with a fluid transferring element detection unit of the analyzing apparatus (17; 33).
摘要翻译：本发明涉及一种用于向用于分析流体和分析装置（17; 33）的分析装置（17; 33）提供流体的流体提供装置（5; 34）。流体提供装置（34）包括具有引入开口（7）的壳体（35），流体转移元件（1）可以通过该导入开口引入到壳体（35）中，用于将流体传送到流体提供装置 34）。壳体（35）还包括用于从流体传送元件（1）释放流体的流体释放部分（8）和用于检测流体传递元件（1）是否被引入到流体传输元件壳体（35）通过与分析装置（17; 33）的流体转移元件检测单元相互作用。

2. 发明申请

US20110093213A1 FLUID PROVIDING APPARATUS 有权
标题翻译：流体提供装置
公开(公告)号：US20110093213A1
公开(公告)日：2011-04-21
申请号：US13000031
申请日：2009-06-22
申请人： Petrus Johannes Wilhelmus Van Lankvelt , Dominique Maria Bruls , Albert Hendrik Jan Immink
发明人： Petrus Johannes Wilhelmus Van Lankvelt , Dominique Maria Bruls , Albert Hendrik Jan Immink
IPC分类号： G06F19/00 , G01N21/59 , G01N21/55
CPC分类号： G01N1/02 , G01N35/00584 , G01N35/10 , G01N2001/028
摘要： The invention relates to a fluid providing apparatus (5; 34) for providing a fluid to an analyzing apparatus (17; 33) for analyzing the fluid and to the analyzing apparatus (17; 33). The fluid providing apparatus (34) comprises a casing (35), which has an introduction opening (7), through which a fluid transferring element (1) is introducible into the casing (35) for transferring the fluid to the fluid providing apparatus (34). The casing (35) comprises further a fluid releasing section (8) for releasing the fluid from the fluid transferring element (1) and a fluid transferring element detection section (36) for detecting whether the fluid transferring element (1) is introduced into the casing (35) by interacting with a fluid transferring element detection unit of the analyzing apparatus (17; 33).
摘要翻译：本发明涉及一种用于向用于分析流体和分析装置（17; 33）的分析装置（17; 33）提供流体的流体提供装置（5; 34）。流体提供装置（34）包括具有引入开口（7）的壳体（35），流体转移元件（1）可以通过该导入开口引入到壳体（35）中，用于将流体传送到流体提供装置 34）。壳体（35）还包括用于从流体传送元件（1）释放流体的流体释放部分（8）和用于检测流体传递元件（1）是否被引入到流体传输元件壳体（35）通过与分析装置（17; 33）的流体转移元件检测单元相互作用。

3. 发明申请

US20110206560A1 BIOSENSOR WITH MULTI-CHAMBER CARTRIDGE 审中-公开
标题翻译：生物传感器与多个盒子
公开(公告)号：US20110206560A1
公开(公告)日：2011-08-25
申请号：US13126000
申请日：2009-10-27
申请人： Jacobus Hermanus Maria Neijzen , Reinhold Wimberger-Friedl , Joost Hubert Maas , Jeroen Hans Nieuwenhuis , Dominique Maria Bruls , Albert Hendrik Jan Immink , Mikhail M. Ovsyanko
发明人： Jacobus Hermanus Maria Neijzen , Reinhold Wimberger-Friedl , Joost Hubert Maas , Jeroen Hans Nieuwenhuis , Dominique Maria Bruls , Albert Hendrik Jan Immink , Mikhail M. Ovsyanko
IPC分类号： G01N30/00
CPC分类号： G01N33/54326 , B01L3/502761 , B82Y25/00 , G01N27/745 , G01R33/093 , G01R33/1269
摘要： The present invention provides a biosensor comprising a cartridge for accommodating a fluid sample, the cartridge comprising at least two chambers, wherein each chamber comprises a sensor surface with one or more binding sites. The biosensor further comprises means for generating a magnetic field at the binding sites of the sensor surfaces of the at least two chambers. The biosensor also comprises means for detecting particles accumulated at/and or proximate the binding sites of the sensor surfaces of the at least two chambers. Therein, the magnetic field at the binding sites has a sufficiently large gradient to actuate magnetic label particles towards the binding sites.
摘要翻译：本发明提供了一种生物传感器，其包括用于容纳流体样品的盒，所述盒包括至少两个室，其中每个室包括具有一个或多个结合位点的传感器表面。生物传感器还包括用于在至少两个室的传感器表面的结合位置处产生磁场的装置。生物传感器还包括用于检测在至少两个室的传感器表面的结合位点处和/或附近堆积的颗粒的装置。其中，结合位点处的磁场具有足够大的梯度以朝向结合位点致动磁性标记颗粒。

4. 发明申请

US20100092996A1 MICROELECTRONIC SENSOR DEVICE FOR DETECTING LABEL PARTICLES 有权
标题翻译：用于检测标签颗粒的微电子传感器装置
公开(公告)号：US20100092996A1
公开(公告)日：2010-04-15
申请号：US12518164
申请日：2007-12-10
申请人： Coen Adrianus Verschuren , Dominique Maria Bruls , Albert Hendrik Jan Immink , Femke Karina De Theije , Thea Van Der Wijk , Alexander Marc Van Der Lee , Johannes Joseph Hubertina Barbara Schleipen
发明人： Coen Adrianus Verschuren , Dominique Maria Bruls , Albert Hendrik Jan Immink , Femke Karina De Theije , Thea Van Der Wijk , Alexander Marc Van Der Lee , Johannes Joseph Hubertina Barbara Schleipen
IPC分类号： G01N33/53 , C12M1/34
CPC分类号： G01N33/543 , G01N21/552 , G01N21/553 , G01N21/6428 , G01N21/6452 , G01N21/648 , G01N27/745 , G01N33/54306 , G01N33/54386 , Y10S436/00
摘要： The invention relates to a microelectronic sensor device for the detection of target components that comprise label particles, for example magnetic particles (1). The sensor device comprises a carrier (11) with a binding surface (12) at which target components can collect and optionally bind to specific capture elements. An input light beam (L1) is transmitted into the carrier and totally internally reflected at the binding surface (12). The amount of light in the output light beam (L2) and optionally also of fluorescence light emitted by target components at the binding surface is then detected by a light detector (31). Evanescent light generated during the total internal reflection is affected (absorbed, scattered) by target components and/or label particles (1) at the binding surface (12) and will therefore be missing in the output light beam (L2). This can be used to determine the amount of target components at the binding surface (12) from the amount of light in the output light beam (L2, L2a, L2b). A magnetic field generator (41) is optionally used to generate a magnetic field (B) at the binding surface (12) by which magnetic label particles (1) can be manipulated, for example 15 attracted or repelled.
摘要翻译：本发明涉及用于检测包含标签颗粒（例如磁性颗粒（1））的目标组分的微电子传感器装置。传感器装置包括具有结合表面（12）的载体（11），靶组分可以收集并任选地结合到特定的捕获元件。输入光束（L1）被传输到载体中并在结合表面（12）处全反射。由光检测器（31）检测输出光束（L2）中的光量以及可选地由结合表面上的目标成分发出的荧光。在全内反射期间产生的渐消光在目标部件和/或粘合表面（12）处的标签颗粒（1）受到影响（吸收，散射），因此在输出光束（L2）中将被丢失。这可以用于根据输出光束（L2，L2a，L2b）中的光量来确定结合表面（12）处的目标成分的量。可选地使用磁场发生器（41）来在绑定表面（12）处产生磁场（B），通过该磁场可以操纵磁性标签颗粒（1），例如15被吸引或排斥。

5. 发明授权

US09658219B2 Microelectronic sensor device for detecting label particles 有权
公开(公告)号：US09658219B2
公开(公告)日：2017-05-23
申请号：US12518164
申请日：2007-12-10
申请人： Coen Adrianus Verschuren , Dominique Maria Bruls , Albert Hendrik Jan Immink , Femke Karina De Theije , Thea Van Der Wijk , Alexander Marc Van Der Lee , Johannes Joseph Hubertina Barbara Schleipen
发明人： Coen Adrianus Verschuren , Dominique Maria Bruls , Albert Hendrik Jan Immink , Femke Karina De Theije , Thea Van Der Wijk , Alexander Marc Van Der Lee , Johannes Joseph Hubertina Barbara Schleipen
IPC分类号： G01N21/552 , G01N21/64 , G01N33/543 , G01N27/74 , G01N21/39
CPC分类号： G01N33/543 , G01N21/552 , G01N21/553 , G01N21/6428 , G01N21/6452 , G01N21/648 , G01N27/745 , G01N33/54306 , G01N33/54386 , Y10S436/00
摘要： A microelectronic sensor device for the detection of target components with label or magnetic particles includes a carrier with a binding surface at which target components can collect and optionally bind to specific capture elements. An input light beam is transmitted into the carrier and totally internally reflected at the binding surface. The amount of light in the output light beam is detected by a light detector. Evanescent light generated during the total internal reflection is affected by target components and/or label particles at the binding surface and will be missing in the output light beam. This is used to determine the amount of target components at the binding surface from the amount of light in the output light beam. A magnetic field generator is optionally used to generate a magnetic field at the binding surface by which magnetic label particles can be manipulated, such as attracted or repelled.

6. 发明申请

US20100253323A1 MAGNETIC WASHING FOR BIOSENSOR 审中-公开
标题翻译：生物传感器的磁性清洗
公开(公告)号：US20100253323A1
公开(公告)日：2010-10-07
申请号：US12746182
申请日：2008-12-04
申请人： Femke Karina De Theije , Dominique Maria Bruls , Thea Van Der Wijk , Coen Adrianus Verschuren , Albert Hendrik Jan Immink
发明人： Femke Karina De Theije , Dominique Maria Bruls , Thea Van Der Wijk , Coen Adrianus Verschuren , Albert Hendrik Jan Immink
IPC分类号： G01N27/74
CPC分类号： G01N33/54326 , G01N21/552 , G01N21/648 , G01N27/745
摘要： Detecting magnetized or magnetizable target components in a fluid containing the magnetized or magnetizable target components amongst other magnetized or magnetizable components, uses a magnetic field generator (M1, 28) to attract the magnetized or magnetizable components towards a binding surface. A magnetic field controller (C1) applies the magnetic field to concentrate the magnetized or magnetizable components in columns on the binding surface, subsequently reduces the magnetic field to enable the columns to collapse, to allow more components to reach the binding surface, and reapplies the magnetic field so as to cause other components to be pulled off the binding surface to reform columns based on the bound target components. A surface sensitive sensor (S1, 26, 29) detects the bound magnetized or magnetizable target components. The reapplication of the magnetic field acts as a magnetic washing step to release unwanted aspecific adsorption binding, leaving the targets, to improve sensitivity with simplified hardware and a reduction in cost and size.
摘要翻译：检测包含磁化或可磁化的目标部件的流体中的磁化或可磁化的目标部件在其他磁化或可磁化部件之间，使用磁场发生器（M1,28）将磁化或可磁化的部件吸引到装订表面。磁场控制器（C1）施加磁场以将磁化的或可磁化的组件在列中集中在结合表面上，随后减小磁场以使柱能够塌陷，以允许更多的部件到达结合表面，并重新应用磁场，以便使其他组分从结合表面上拉出，以便根据结合的目标组分重新制备柱。表面敏感传感器（S1,26,29）检测结合的磁化或可磁化的目标部件。磁场的重新应用充当磁性洗涤步骤以释放不期望的特异性吸附结合，留下目标，以通过简化的硬件提高灵敏度并降低成本和尺寸。

7. 发明授权

US08390817B2 Evanescent field modulation in a biosensor 有权
标题翻译：生物传感器中的消逝场调制
公开(公告)号：US08390817B2
公开(公告)日：2013-03-05
申请号：US12810867
申请日：2008-12-18
申请人： Johannes Joseph Hubertina Barbara Schleipen , Dominique Maria Bruls , Josephus Arnoldus Hendricus Maria Kahlman
发明人： Johannes Joseph Hubertina Barbara Schleipen , Dominique Maria Bruls , Josephus Arnoldus Hendricus Maria Kahlman
IPC分类号： G01N21/55 , G01N21/00
CPC分类号： G01N21/552
摘要： The present invention provides an FTIR system comprising a first light source emitting light of a first wavelength, a sample volume with an adjacent sensor surface, a detector for detecting light reflected at said sensor surface. The sensor surface is illuminated by said first light source fulfilling the condition of total internal reflection and generating an evanescent field with a decay length within the sample volume. The system further comprises means for changing the decay length of the evanescent field and means for correlating the detected signals with the change of the decay length of the evanescent field.
摘要翻译：本发明提供了一种FTIR系统，包括发射第一波长的光的第一光源，具有相邻传感器表面的样品体积，用于检测在所述传感器表面反射的光的检测器。所述传感器表面由满足全内反射条件的所述第一光源照射，并产生具有在样品体积内的衰减长度的ev逝场。该系统还包括用于改变ev逝场的衰减长度的装置和用于使检测到的信号与ev逝场的衰减长度变化相关联的装置。

8. 发明申请

US20080232208A1 High Frequency Central Aperture Tracking 审中-公开
标题翻译：高频中心光圈跟踪
公开(公告)号：US20080232208A1
公开(公告)日：2008-09-25
申请号：US12064085
申请日：2006-08-16
申请人： Alexander Marc Van Der Lee , Dominique Maria Bruls
发明人： Alexander Marc Van Der Lee , Dominique Maria Bruls
IPC分类号： G11B7/09
CPC分类号： G11B7/0903
摘要： The present invention relates to an optical system for performing radial tracking on an associated optical record carrier. The optical system contains at least one radiation-emitting device capable of emitting at least three beams: a first beam for reading and/or recording information, and at least a second beam and a third beam for tracking. The optical system is adapted for radial tracking of the first spot from a tracking error signal generated based on the high-frequency component of the central-aperture signal of the second and third beams. The tracking error signal may be generated based on a difference signal of a DC-level of the power of the high-frequency components of the central-aperture signal.
摘要翻译：本发明涉及一种用于在相关联的光学记录载体上进行径向跟踪的光学系统。该光学系统包含至少一个能够发射至少三个光束的辐射发射装置：用于读取和/或记录信息的第一光束，以及用于跟踪的至少第二光束和第三光束。光学系统适于从基于第二和第三光束的中心孔径信号的高频分量产生的跟踪误差信号中径向跟踪第一光点。可以基于中心孔径信号的高频分量的功率的直流电平的差信号来生成跟踪误差信号。

9. 发明申请

US20120040475A1 SENSING DEVICE FOR DETECTING A TARGET SUBSTANCE 有权
标题翻译：用于检测目标物质的感应装置
公开(公告)号：US20120040475A1
公开(公告)日：2012-02-16
申请号：US13201927
申请日：2010-02-08
申请人： Dominique Maria Bruls , Toon Hendrik Evers , Johannes Joseph Hubertina Barbara Schleipen
发明人： Dominique Maria Bruls , Toon Hendrik Evers , Johannes Joseph Hubertina Barbara Schleipen
IPC分类号： G01N21/55
CPC分类号： G01N21/552 , G01N21/274 , G01N33/54373
摘要： The present invention relates to a sensing device (100) for detecting a target substance (2) in an investigation region (113). The sensing device (100) comprises a sensing surface (112) with an investigation region (113) and a reference region (120) thereon. The sensing device (100) further comprises a reference element (121) located at the reference region (120). The reference element (121) is adapted to shield the reference region (120) from the target substance (2) such that light reflected at the reference region (120) under total internal reflection conditions remains unaffected by the presence or absence of the target substance (2). This allows measuring a property, typically the intensity, of light reflected at the reference region (120) independent of the presence or absence of the target substance (2). This measured property of the reflected light can be used for performing an improved correction of light reflected at the investigation region (113).
摘要翻译：本发明涉及一种用于在调查区域（113）中检测目标物质（2）的感测装置（100）。感测装置（100）包括其上具有调查区域（113）和参考区域（120）的感测表面（112）。感测装置（100）还包括位于参考区域（120）处的参考元件（121）。参考元件（121）适于屏蔽参考区域（120）与目标物质（2），使得在全内反射条件下在参考区域（120）处反射的光线不会受到目标物质的存在或不存在的影响（2）。这允许独立于目标物质（2）的存在或不存在来测量在参考区域（120）处反射的光的特性（通常为强度）。反射光的测量特性可用于对在调查区域（113）反射的光进行改进的校正。

10. 发明申请

US20080314407A1 Method of Cleaning an Optical Face of a Refractive Element for a Near Field Optical Scanning Apparatus and a Cleaning Device for Cleaning an Optical Face of a Refractive Element for a Near Field Optical Scanning Apparatus 审中-公开
$Method of Cleaning an Optical Face of a Refractive Element for a Near Field Optical Scanning Apparatus and a Cleaning Device for Cleaning an Optical Face of a Refractive Element for a Near Field Optical Scanning Apparatus$
标题翻译：清洁近场光扫描装置的折射元件的光学面的方法和用于清洁近场光学扫描装置的折射元件的光学面的清洁装置
公开(公告)号：US20080314407A1
公开(公告)日：2008-12-25
申请号：US12097557
申请日：2006-12-06
申请人： Dominique Maria Bruls , Jacobus Maria Antonius Van Den Eerenbeemd , Franciscus Marinus Andrea Maria Van Gaal
发明人： Dominique Maria Bruls , Jacobus Maria Antonius Van Den Eerenbeemd , Franciscus Marinus Andrea Maria Van Gaal
IPC分类号： B08B1/00 , B08B13/00
CPC分类号： G11B7/1387
摘要： The invention provides a method and a device for cleaning of the optical face of a refractive element for a near field optical scanning apparatus. A magnetically susceptible cleaning material is used to facilitate effective cleaning of the refractive element without damage to the element. The method according to the invention can be combined with known cleaning methods if desired.
摘要翻译：本发明提供一种用于清洁近场光学扫描装置的折射元件的光学面的方法和装置。使用磁敏感的清洁材料来促进折射元件的有效清洁而不损坏元件。如果需要，根据本发明的方法可以与已知的清洁方法组合。

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