专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20110206560A1 BIOSENSOR WITH MULTI-CHAMBER CARTRIDGE 审中-公开
标题翻译：生物传感器与多个盒子
公开(公告)号：US20110206560A1
公开(公告)日：2011-08-25
申请号：US13126000
申请日：2009-10-27
申请人： Jacobus Hermanus Maria Neijzen , Reinhold Wimberger-Friedl , Joost Hubert Maas , Jeroen Hans Nieuwenhuis , Dominique Maria Bruls , Albert Hendrik Jan Immink , Mikhail M. Ovsyanko
发明人： Jacobus Hermanus Maria Neijzen , Reinhold Wimberger-Friedl , Joost Hubert Maas , Jeroen Hans Nieuwenhuis , Dominique Maria Bruls , Albert Hendrik Jan Immink , Mikhail M. Ovsyanko
IPC分类号： G01N30/00
CPC分类号： G01N33/54326 , B01L3/502761 , B82Y25/00 , G01N27/745 , G01R33/093 , G01R33/1269
摘要： The present invention provides a biosensor comprising a cartridge for accommodating a fluid sample, the cartridge comprising at least two chambers, wherein each chamber comprises a sensor surface with one or more binding sites. The biosensor further comprises means for generating a magnetic field at the binding sites of the sensor surfaces of the at least two chambers. The biosensor also comprises means for detecting particles accumulated at/and or proximate the binding sites of the sensor surfaces of the at least two chambers. Therein, the magnetic field at the binding sites has a sufficiently large gradient to actuate magnetic label particles towards the binding sites.
摘要翻译：本发明提供了一种生物传感器，其包括用于容纳流体样品的盒，所述盒包括至少两个室，其中每个室包括具有一个或多个结合位点的传感器表面。生物传感器还包括用于在至少两个室的传感器表面的结合位置处产生磁场的装置。生物传感器还包括用于检测在至少两个室的传感器表面的结合位点处和/或附近堆积的颗粒的装置。其中，结合位点处的磁场具有足够大的梯度以朝向结合位点致动磁性标记颗粒。

2. 发明授权

US08520211B2 Carrier for optical detection in small sample volumes 有权
标题翻译：小样本量的光学检测载体
公开(公告)号：US08520211B2
公开(公告)日：2013-08-27
申请号：US12935947
申请日：2009-04-07
申请人： Johannes Joseph Hubertina Barbara Schleipen , Toon Hendrikus Evers , Jeroen Hans Nieuwenhuis , Wendy Uyen Dittmer , Dominique Maria Bruls , Menno Willem Jose Prins , Jacobus Hermanus Maria Neijzen , Yannyk Parulian Julian Bourquin
发明人： Johannes Joseph Hubertina Barbara Schleipen , Toon Hendrikus Evers , Jeroen Hans Nieuwenhuis , Wendy Uyen Dittmer , Dominique Maria Bruls , Menno Willem Jose Prins , Jacobus Hermanus Maria Neijzen , Yannyk Parulian Julian Bourquin
IPC分类号： G01N21/00
CPC分类号： G01N21/253 , G01N21/41 , G01N2021/0346 , G01N2021/435
摘要： A carrier and an apparatus for optical detection of a sample in a sample chamber includes en optical structure for refracting an input light beam into the adjacent sample chamber and for collecting an output light beam from light that originates in the sample chamber from the input light beam. The optical structure includes grooves in the surface of the carrier in which the Input light beam is transmitted Over a short distance through a sample. The optical structure can also be used for a wetting detection.
摘要翻译：用于样品室中的样品的光学检测的载体和设备包括用于将输入光束折射到相邻样品室中的光学结构，并且用于从输入光束收集来自样品室的光的输出光束。光学结构包括在载体的表面中的凹槽，其中输入光束在短距离内透射通过样品。光学结构也可用于润湿检测。

3. 发明申请

US20110026030A1 CARRIER FOR OPTICAL DETECTION IN SMALL SAMPLE VOLUMES 有权
标题翻译：用于小样品中光学检测的载体
公开(公告)号：US20110026030A1
公开(公告)日：2011-02-03
申请号：US12935947
申请日：2009-04-07
申请人： Johannes Joseph Hubertina Barbara Schleipen , Toon Hendrikus Evers , Jeroen Hans Nieuwenhuis , Wendy Uyen Dittmer , Dominique Maria Bruls , Menno Willem Jose Prins , Jacobus Hermanus Maria Neijzen , Yannyk Parulian Julian Bourquin
发明人： Johannes Joseph Hubertina Barbara Schleipen , Toon Hendrikus Evers , Jeroen Hans Nieuwenhuis , Wendy Uyen Dittmer , Dominique Maria Bruls , Menno Willem Jose Prins , Jacobus Hermanus Maria Neijzen , Yannyk Parulian Julian Bourquin
IPC分类号： G01N21/00
CPC分类号： G01N21/253 , G01N21/41 , G01N2021/0346 , G01N2021/435
摘要： The invention relates to a carrier (11) and an apparatus (100) for optical detection in a sample (1) in a sample chamber (2). The carrier (11) comprises an optical structure (50) for refracting an input light beam (L1) into the adjacent sample chamber (2) and for collecting an output light beam (L2) from light that originates in the sample chamber (2) from the input light beam. Preferably, the optical structure (50) comprises grooves in the surface (12) of the carrier (11) in which the input light beam is transmitted over a short distance through a sample. The optical structure (50) can also be used for a wetting detection.
摘要翻译：本发明涉及一种用于在样品室（2）中的样品（1）中进行光学检测的载体（11）和装置（100）。载体（11）包括用于将输入光束（L1）折射到相邻的样品室（2）中并用于从源于样品室（2）的光收集输出光束（L2）的光学结构（50）从输入光束。优选地，光学结构（50）包括在载体（11）的表面（12）中的凹槽，其中输入光束通过样品在短距离上传播。光学结构（50）也可用于润湿检测。

4. 发明授权

US09134201B2 Fluid providing apparatus 有权
标题翻译：流体提供装置
公开(公告)号：US09134201B2
公开(公告)日：2015-09-15
申请号：US13000031
申请日：2009-06-22
申请人： Petrus Johannes Wilhelmus Van Lankvelt , Dominique Maria Bruls , Albert Hendrik Jan Immink
发明人： Petrus Johannes Wilhelmus Van Lankvelt , Dominique Maria Bruls , Albert Hendrik Jan Immink
IPC分类号： G01N35/10 , G01N1/02 , G01N35/00
CPC分类号： G01N1/02 , G01N35/00584 , G01N35/10 , G01N2001/028
摘要： The invention relates to a fluid providing apparatus (5; 34) for providing a fluid to an analyzing apparatus (17; 33) for analyzing the fluid and to the analyzing apparatus (17; 33). The fluid providing apparatus (34) comprises a casing (35), which has an introduction opening (7), through which a fluid transferring element (1) is introducible into the casing (35) for transferring the fluid to the fluid providing apparatus (34). The casing (35) comprises further a fluid releasing section (8) for releasing the fluid from the fluid transferring element (1) and a fluid transferring element detection section (36) for detecting whether the fluid transferring element (1) is introduced into the casing (35) by interacting with a fluid transferring element detection unit of the analyzing apparatus (17; 33).
摘要翻译：本发明涉及一种用于向用于分析流体和分析装置（17; 33）的分析装置（17; 33）提供流体的流体提供装置（5; 34）。流体提供装置（34）包括具有引入开口（7）的壳体（35），流体转移元件（1）可以通过该导入开口引入到壳体（35）中，用于将流体传送到流体提供装置 34）。壳体（35）还包括用于从流体传送元件（1）释放流体的流体释放部分（8）和用于检测流体传递元件（1）是否被引入到流体传输元件壳体（35）通过与分析装置（17; 33）的流体转移元件检测单元相互作用。

5. 发明申请

US20110093213A1 FLUID PROVIDING APPARATUS 有权
标题翻译：流体提供装置
公开(公告)号：US20110093213A1
公开(公告)日：2011-04-21
申请号：US13000031
申请日：2009-06-22
申请人： Petrus Johannes Wilhelmus Van Lankvelt , Dominique Maria Bruls , Albert Hendrik Jan Immink
发明人： Petrus Johannes Wilhelmus Van Lankvelt , Dominique Maria Bruls , Albert Hendrik Jan Immink
IPC分类号： G06F19/00 , G01N21/59 , G01N21/55
CPC分类号： G01N1/02 , G01N35/00584 , G01N35/10 , G01N2001/028
摘要： The invention relates to a fluid providing apparatus (5; 34) for providing a fluid to an analyzing apparatus (17; 33) for analyzing the fluid and to the analyzing apparatus (17; 33). The fluid providing apparatus (34) comprises a casing (35), which has an introduction opening (7), through which a fluid transferring element (1) is introducible into the casing (35) for transferring the fluid to the fluid providing apparatus (34). The casing (35) comprises further a fluid releasing section (8) for releasing the fluid from the fluid transferring element (1) and a fluid transferring element detection section (36) for detecting whether the fluid transferring element (1) is introduced into the casing (35) by interacting with a fluid transferring element detection unit of the analyzing apparatus (17; 33).
摘要翻译：本发明涉及一种用于向用于分析流体和分析装置（17; 33）的分析装置（17; 33）提供流体的流体提供装置（5; 34）。流体提供装置（34）包括具有引入开口（7）的壳体（35），流体转移元件（1）可以通过该导入开口引入到壳体（35）中，用于将流体传送到流体提供装置 34）。壳体（35）还包括用于从流体传送元件（1）释放流体的流体释放部分（8）和用于检测流体传递元件（1）是否被引入到流体传输元件壳体（35）通过与分析装置（17; 33）的流体转移元件检测单元相互作用。

6. 发明申请

US20100092996A1 MICROELECTRONIC SENSOR DEVICE FOR DETECTING LABEL PARTICLES 有权
标题翻译：用于检测标签颗粒的微电子传感器装置
公开(公告)号：US20100092996A1
公开(公告)日：2010-04-15
申请号：US12518164
申请日：2007-12-10
申请人： Coen Adrianus Verschuren , Dominique Maria Bruls , Albert Hendrik Jan Immink , Femke Karina De Theije , Thea Van Der Wijk , Alexander Marc Van Der Lee , Johannes Joseph Hubertina Barbara Schleipen
发明人： Coen Adrianus Verschuren , Dominique Maria Bruls , Albert Hendrik Jan Immink , Femke Karina De Theije , Thea Van Der Wijk , Alexander Marc Van Der Lee , Johannes Joseph Hubertina Barbara Schleipen
IPC分类号： G01N33/53 , C12M1/34
CPC分类号： G01N33/543 , G01N21/552 , G01N21/553 , G01N21/6428 , G01N21/6452 , G01N21/648 , G01N27/745 , G01N33/54306 , G01N33/54386 , Y10S436/00
摘要： The invention relates to a microelectronic sensor device for the detection of target components that comprise label particles, for example magnetic particles (1). The sensor device comprises a carrier (11) with a binding surface (12) at which target components can collect and optionally bind to specific capture elements. An input light beam (L1) is transmitted into the carrier and totally internally reflected at the binding surface (12). The amount of light in the output light beam (L2) and optionally also of fluorescence light emitted by target components at the binding surface is then detected by a light detector (31). Evanescent light generated during the total internal reflection is affected (absorbed, scattered) by target components and/or label particles (1) at the binding surface (12) and will therefore be missing in the output light beam (L2). This can be used to determine the amount of target components at the binding surface (12) from the amount of light in the output light beam (L2, L2a, L2b). A magnetic field generator (41) is optionally used to generate a magnetic field (B) at the binding surface (12) by which magnetic label particles (1) can be manipulated, for example 15 attracted or repelled.
摘要翻译：本发明涉及用于检测包含标签颗粒（例如磁性颗粒（1））的目标组分的微电子传感器装置。传感器装置包括具有结合表面（12）的载体（11），靶组分可以收集并任选地结合到特定的捕获元件。输入光束（L1）被传输到载体中并在结合表面（12）处全反射。由光检测器（31）检测输出光束（L2）中的光量以及可选地由结合表面上的目标成分发出的荧光。在全内反射期间产生的渐消光在目标部件和/或粘合表面（12）处的标签颗粒（1）受到影响（吸收，散射），因此在输出光束（L2）中将被丢失。这可以用于根据输出光束（L2，L2a，L2b）中的光量来确定结合表面（12）处的目标成分的量。可选地使用磁场发生器（41）来在绑定表面（12）处产生磁场（B），通过该磁场可以操纵磁性标签颗粒（1），例如15被吸引或排斥。

7. 发明授权

US09658219B2 Microelectronic sensor device for detecting label particles 有权
公开(公告)号：US09658219B2
公开(公告)日：2017-05-23
申请号：US12518164
申请日：2007-12-10
申请人： Coen Adrianus Verschuren , Dominique Maria Bruls , Albert Hendrik Jan Immink , Femke Karina De Theije , Thea Van Der Wijk , Alexander Marc Van Der Lee , Johannes Joseph Hubertina Barbara Schleipen
发明人： Coen Adrianus Verschuren , Dominique Maria Bruls , Albert Hendrik Jan Immink , Femke Karina De Theije , Thea Van Der Wijk , Alexander Marc Van Der Lee , Johannes Joseph Hubertina Barbara Schleipen
IPC分类号： G01N21/552 , G01N21/64 , G01N33/543 , G01N27/74 , G01N21/39
CPC分类号： G01N33/543 , G01N21/552 , G01N21/553 , G01N21/6428 , G01N21/6452 , G01N21/648 , G01N27/745 , G01N33/54306 , G01N33/54386 , Y10S436/00
摘要： A microelectronic sensor device for the detection of target components with label or magnetic particles includes a carrier with a binding surface at which target components can collect and optionally bind to specific capture elements. An input light beam is transmitted into the carrier and totally internally reflected at the binding surface. The amount of light in the output light beam is detected by a light detector. Evanescent light generated during the total internal reflection is affected by target components and/or label particles at the binding surface and will be missing in the output light beam. This is used to determine the amount of target components at the binding surface from the amount of light in the output light beam. A magnetic field generator is optionally used to generate a magnetic field at the binding surface by which magnetic label particles can be manipulated, such as attracted or repelled.

8. 发明申请

US20100253323A1 MAGNETIC WASHING FOR BIOSENSOR 审中-公开
标题翻译：生物传感器的磁性清洗
公开(公告)号：US20100253323A1
公开(公告)日：2010-10-07
申请号：US12746182
申请日：2008-12-04
申请人： Femke Karina De Theije , Dominique Maria Bruls , Thea Van Der Wijk , Coen Adrianus Verschuren , Albert Hendrik Jan Immink
发明人： Femke Karina De Theije , Dominique Maria Bruls , Thea Van Der Wijk , Coen Adrianus Verschuren , Albert Hendrik Jan Immink
IPC分类号： G01N27/74
CPC分类号： G01N33/54326 , G01N21/552 , G01N21/648 , G01N27/745
摘要： Detecting magnetized or magnetizable target components in a fluid containing the magnetized or magnetizable target components amongst other magnetized or magnetizable components, uses a magnetic field generator (M1, 28) to attract the magnetized or magnetizable components towards a binding surface. A magnetic field controller (C1) applies the magnetic field to concentrate the magnetized or magnetizable components in columns on the binding surface, subsequently reduces the magnetic field to enable the columns to collapse, to allow more components to reach the binding surface, and reapplies the magnetic field so as to cause other components to be pulled off the binding surface to reform columns based on the bound target components. A surface sensitive sensor (S1, 26, 29) detects the bound magnetized or magnetizable target components. The reapplication of the magnetic field acts as a magnetic washing step to release unwanted aspecific adsorption binding, leaving the targets, to improve sensitivity with simplified hardware and a reduction in cost and size.
摘要翻译：检测包含磁化或可磁化的目标部件的流体中的磁化或可磁化的目标部件在其他磁化或可磁化部件之间，使用磁场发生器（M1,28）将磁化或可磁化的部件吸引到装订表面。磁场控制器（C1）施加磁场以将磁化的或可磁化的组件在列中集中在结合表面上，随后减小磁场以使柱能够塌陷，以允许更多的部件到达结合表面，并重新应用磁场，以便使其他组分从结合表面上拉出，以便根据结合的目标组分重新制备柱。表面敏感传感器（S1,26,29）检测结合的磁化或可磁化的目标部件。磁场的重新应用充当磁性洗涤步骤以释放不期望的特异性吸附结合，留下目标，以通过简化的硬件提高灵敏度并降低成本和尺寸。

9. 发明授权

US08390817B2 Evanescent field modulation in a biosensor 有权
标题翻译：生物传感器中的消逝场调制
公开(公告)号：US08390817B2
公开(公告)日：2013-03-05
申请号：US12810867
申请日：2008-12-18
申请人： Johannes Joseph Hubertina Barbara Schleipen , Dominique Maria Bruls , Josephus Arnoldus Hendricus Maria Kahlman
发明人： Johannes Joseph Hubertina Barbara Schleipen , Dominique Maria Bruls , Josephus Arnoldus Hendricus Maria Kahlman
IPC分类号： G01N21/55 , G01N21/00
CPC分类号： G01N21/552
摘要： The present invention provides an FTIR system comprising a first light source emitting light of a first wavelength, a sample volume with an adjacent sensor surface, a detector for detecting light reflected at said sensor surface. The sensor surface is illuminated by said first light source fulfilling the condition of total internal reflection and generating an evanescent field with a decay length within the sample volume. The system further comprises means for changing the decay length of the evanescent field and means for correlating the detected signals with the change of the decay length of the evanescent field.
摘要翻译：本发明提供了一种FTIR系统，包括发射第一波长的光的第一光源，具有相邻传感器表面的样品体积，用于检测在所述传感器表面反射的光的检测器。所述传感器表面由满足全内反射条件的所述第一光源照射，并产生具有在样品体积内的衰减长度的ev逝场。该系统还包括用于改变ev逝场的衰减长度的装置和用于使检测到的信号与ev逝场的衰减长度变化相关联的装置。

10. 发明申请

US20080232208A1 High Frequency Central Aperture Tracking 审中-公开
标题翻译：高频中心光圈跟踪
公开(公告)号：US20080232208A1
公开(公告)日：2008-09-25
申请号：US12064085
申请日：2006-08-16
申请人： Alexander Marc Van Der Lee , Dominique Maria Bruls
发明人： Alexander Marc Van Der Lee , Dominique Maria Bruls
IPC分类号： G11B7/09
CPC分类号： G11B7/0903
摘要： The present invention relates to an optical system for performing radial tracking on an associated optical record carrier. The optical system contains at least one radiation-emitting device capable of emitting at least three beams: a first beam for reading and/or recording information, and at least a second beam and a third beam for tracking. The optical system is adapted for radial tracking of the first spot from a tracking error signal generated based on the high-frequency component of the central-aperture signal of the second and third beams. The tracking error signal may be generated based on a difference signal of a DC-level of the power of the high-frequency components of the central-aperture signal.
摘要翻译：本发明涉及一种用于在相关联的光学记录载体上进行径向跟踪的光学系统。该光学系统包含至少一个能够发射至少三个光束的辐射发射装置：用于读取和/或记录信息的第一光束，以及用于跟踪的至少第二光束和第三光束。光学系统适于从基于第二和第三光束的中心孔径信号的高频分量产生的跟踪误差信号中径向跟踪第一光点。可以基于中心孔径信号的高频分量的功率的直流电平的差信号来生成跟踪误差信号。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式