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1. 发明授权

US06946664B2 Specimen slides and methods and uses thereof 失效
标题翻译：试样片及其方法和用途
公开(公告)号：US06946664B2
公开(公告)日：2005-09-20
申请号：US10349179
申请日：2003-01-22
申请人： Peter Westphal , Tobias Neumann , Martin Kuehner , Dieter Graefe
发明人： Peter Westphal , Tobias Neumann , Martin Kuehner , Dieter Graefe
IPC分类号： G02B21/16 , G02B21/34 , G01N21/64
CPC分类号： G02B21/16 , G02B21/34
摘要： Emboidments are presented to improve spatial resolution or sensitivity in measuring fluorescent layers, including an embodiment wherein a specimen slide is provided which is not fluorescent by itself, is plate-shaped and has at least one plate side provided with fluorescent light absorbing properties, or with an antireflection-coating for fluorescent radiation.
摘要翻译：提出了提供用于提高测量荧光层的空间分辨率或灵敏度的实例，包括其中提供其本身不是荧光的样品载玻片是板形的并且具有提供荧光吸收性能的至少一个板侧的实施例，或者用于荧光辐射的抗反射涂层。

2. 发明申请

US20070058246A1 Microscope arrangement 审中-公开
标题翻译：显微镜装置
公开(公告)号：US20070058246A1
公开(公告)日：2007-03-15
申请号：US10552557
申请日：2004-03-25
申请人： Peter Westphal , Martin Kuehner , Tobias Neumann
发明人： Peter Westphal , Martin Kuehner , Tobias Neumann
IPC分类号： G02B21/00
CPC分类号： G02B27/0927 , G02B21/082 , G02B27/09 , G02B27/0994
摘要： The invention relates to a microscope arrangement which comprises an illumination source (1), optical components for generating an illumination beam path, an objective [lens] (21) through which the illumination beam path is directed onto a sample (20) which is present in the object plane of the objective [lens] (21) or in the proximity thereof, and optical components for generating an imaging beam path directed onto the receiving surface of a camera (22). According to the invention, the microscope arrangement of the aforementioned type is provided with a homogenizing unit (5) for homogenizing the illumination light that is incident on the sample section to be examined. Said homogenizing unit (5) makes it possible to illuminate the object plane of the microscope arrangement and thus the subsection of a sample (20) present in the object plane or in the proximity thereof in a homogeneous manner, thereby improving the quality of reproduction of said sample section and resulting in a higher measuring accuracy and thus in a higher reproducibility.
摘要翻译：本发明涉及一种显微镜装置，其包括照明源（1），用于产生照明光束路径的光学部件，物镜[透镜]（21），照明光束路径通过该物镜被引导到存在的样品（20）上在物镜[透镜]（21）的物平面中或其附近，以及用于产生朝向相机（22）的接收表面的成像光束路径的光学部件。根据本发明，上述类型的显微镜装置设置有均匀化单元（5），用于使入射到要检查的样品部分上的照明光均匀化。所述均化单元（5）使得可以以均匀的方式照亮显微镜装置的物平面和因此存在于物平面中或其附近的样品（20）的子部分，从而提高再现质量所述样品部分产生更高的测量精度并因此具有更高的再现性。

3. 发明申请

US20070102620A1 Method and array for determining the focal position during imaging of a sample 有权
标题翻译：用于在样品成像期间确定焦点位置的方法和阵列
公开(公告)号：US20070102620A1
公开(公告)日：2007-05-10
申请号：US10554899
申请日：2004-04-27
申请人： Daniel Bublitz , Dieter Graefe , Peter Westphal
发明人： Daniel Bublitz , Dieter Graefe , Peter Westphal
IPC分类号： G02B27/40 , G02B27/64 , G02B7/04
CPC分类号： G02B21/244 , G02B7/32 , G02B21/245
摘要： The invention refers to a process for determining the focus position when imaging a specimen (4) with a field stop imaged onto the specimen detecting this image using a position-sensitive receiving-device inclined relative to the field stop defining the focus position by means of intensity distribution in the receiving device. The invention also refers to set-ups as regards implementation of the process according to the invention. According to the invention, in a process of the above-mentioned type, imaging of the field stop onto the specimen (4) is at least partially superposed by an optical lattice; the position-sensitive receiving device is used to determine intensity values for the light reflected by the specimen; these intensity values are assigned to positions in the receiving device; position-related contrast values are determined from the position-related intensity values; the position of the contrast focus in the receiving device as equivalent of the current focus position is determined using these contrast values.
摘要翻译：一种用于通过利用接收装置中的强度分布相对于通过强度分布定义聚焦位置的场停止而倾斜的位置敏感的接收装置对具有使用场停止成像的样本成像到检测该图像的样本上的确定焦点位置的处理。本发明还包括用于实施根据本发明的方法的装置。根据本发明，在上述类型的过程中，场停止物到样本上的成像至少部分地被光栅重叠; 位置敏感接收装置用于确定由样本反射的光的强度值; 这些强度值被分配给接收装置中的位置; 与位置相关的强度值确定位置相关的对比度值; 使用这些对比度值确定接收装置中的对比度聚焦的位置等同于当前焦点位置。

4. 发明授权

US07488924B2 Method for determining the focal position during imaging of a sample using an inclined position receiving device 有权
标题翻译：用于在样品成像期间确定焦点位置的方法和阵列
公开(公告)号：US07488924B2
公开(公告)日：2009-02-10
申请号：US10554899
申请日：2004-04-27
申请人： Daniel Bublitz , Dieter Graefe , Peter Westphal
发明人： Daniel Bublitz , Dieter Graefe , Peter Westphal
IPC分类号： G02B7/04 , G02B27/40 , G02B27/64
CPC分类号： G02B21/244 , G02B7/32 , G02B21/245
摘要： The invention refers to a process for determining the focus position when imaging a specimen (4) with a field stop imaged onto the specimen detecting this image using a position-sensitive receiving-device inclined relative to the field stop defining the focus position by means of intensity distribution in the receiving device. The invention also refers to set-ups as regards implementation of the process according to the invention.According to the invention, in a process of the above-mentioned type, imaging of the field stop onto the specimen (4) is at least partially superposed by an optical lattice; the position-sensitive receiving device is used to determine intensity values for the light reflected by the specimen; these intensity values are assigned to positions in the receiving device; position-related contrast values are determined from the position-related intensity values; the position of the contrast focus in the receiving device as equivalent of the current focus position is determined using these contrast values.
摘要翻译：一种用于通过利用接收装置中的强度分布相对于通过强度分布定义聚焦位置的场停止而倾斜的位置敏感的接收装置对具有使用场停止成像的样本成像到检测该图像的样本上的确定焦点位置的处理。本发明还包括用于实施根据本发明的方法的装置。根据本发明，在上述类型的过程中，场停止物到样本上的成像至少部分地被光栅重叠; 位置敏感接收装置用于确定由样本反射的光的强度值; 这些强度值被分配给接收装置中的位置; 与位置相关的强度值确定位置相关的对比度值; 使用这些对比度值确定接收装置中的对比度聚焦的位置等同于当前焦点位置。

5. 发明授权

US09007579B2 Device and method for measuring luminescence 有权
标题翻译：用于测量发光的装置和方法
公开(公告)号：US09007579B2
公开(公告)日：2015-04-14
申请号：US12937474
申请日：2009-04-04
申请人： Peter Westphal
发明人： Peter Westphal
IPC分类号： G01N21/64 , G01J1/30 , G02B21/00
CPC分类号： G01N21/6408 , G01N21/6458 , G02B21/0076
摘要： An optical device for measuring luminescence includes a pulse generator for generating a periodic modulation signal having rectangular pulses, a pulse duration of the pulse being variably adjustable, an illumination device and/or means for illuminating an object under investigation with excitation radiation modulated in a pulse-like manner depending on the modulation signal, and a time-of-flight camera for phase-sensitive detection of a luminescence response emitted by the object under investigation in response to the excitation radiation. The modulation signal is supplied as reference signal to the time-of-flight camera. A method of measuring luminescence includes generating the periodic modulation signal having rectangular pulses, generating the signal-dependent, pulse-modulated excitation radiation, illuminating the object with the radiation, providing the modulation signal as reference signal to the camera, and performing phase-sensitive detection with the camera of the luminescence response emitted by the object in response to the excitation radiation for different pulse durations.
摘要翻译：用于测量发光的光学装置包括用于产生具有矩形脉冲的周期性调制信号的脉冲发生器，脉冲的脉冲持续时间可变地调节，照明装置和/或用于以脉冲调制的激发辐射照亮被研究对象的装置和根据调制信号的类似方式的飞行时间相机，以及响应于激发辐射的被研究对象发射的发光响应的相敏检测的飞行时间相机。调制信号作为参考信号提供给飞行时间相机。测量发光的方法包括产生具有矩形脉冲的周期性调制信号，产生依赖于信号的脉冲调制激励辐射，用辐射照射物体，将调制信号作为参考信号提供给相机，以及执行相敏利用照相机检测物体响应于不同脉冲持续时间的激发辐射而发射的发光响应。

6. 发明授权

US08643946B2 Autofocus device for microscopy 有权
标题翻译：显微镜自动对焦装置
公开(公告)号：US08643946B2
公开(公告)日：2014-02-04
申请号：US12305183
申请日：2007-06-15
申请人： Peter Westphal , Daniel Bublitz , Reiner Mitzkus
发明人： Peter Westphal , Daniel Bublitz , Reiner Mitzkus
IPC分类号： G02B21/00
CPC分类号： G02B7/36 , G02B21/244
摘要： A microscope including an objective, which images a sample along a microscope beam path, and an autofocus device, which is coupled into the microscope beam path via a beam splitter at a location behind the objective. A light modulator for generating a two-dimensional, intensity-modulated modulation object, is located in the autofocus beam path in a plane conjugated to the focal plane of the objective or intersects the latter and is imaged into the focal plane of the objective. A camera records a two-dimensional image onto which the modulation object's image is imaged. The image plane of the camera intersects a plane that is conjugated to the modulation object or is located in the plane and the camera detecting the contrast of the modulation object's image located in the sample.
摘要翻译：显微镜，其包括沿着显微镜光束路径对样品进行成像的物镜和自动聚焦装置，该自动对焦装置经由目标背后的位置处的分束器耦合到显微镜光束路径中。用于产生二维强度调制调制对象的光调制器位于与物镜的焦平面共轭的平面中的自动聚焦光束路径中，或者与物镜的焦平面相交，并被成像到物镜的焦平面。照相机记录调制对象的图像成像到的二维图像。相机的图像平面与共轭于调制对象的平面相交，或位于平面中，相机检测位于样本中的调制对象的图像的对比度。

7. 发明授权

US08563912B2 Microscope having focus-holding unit 有权
标题翻译：显微镜具有聚焦保持单元
公开(公告)号：US08563912B2
公开(公告)日：2013-10-22
申请号：US12937970
申请日：2009-04-04
申请人： Reiner Mitzkus , Eugen Wehner , Stefan Steinborn , Gleb Milinovici , Steffen Leidenbach , Peter Westphal
发明人： Reiner Mitzkus , Eugen Wehner , Stefan Steinborn , Gleb Milinovici , Steffen Leidenbach , Peter Westphal
IPC分类号： G02B27/40
CPC分类号： G02B21/241
摘要： The invention relates to a microscope having a stage for supporting a sample to be examined, a recording sensor, an imaging optic for imaging the sample onto the recording sensor, a moving unit by means of which the distance between the stage and the imaging optic can be changed, a control unit for controlling an image recording of the sample and a focus-holding unit for maintaining a prescribed focal position for image recording of the sample at temporal intervals, wherein the focus-holding device comprises at least one hardware element and one software module, wherein the focus-holding unit is fully integrated in the control unit, on both the hardware and software sides.
摘要翻译：本发明涉及一种显微镜，其具有用于支撑待检查样本的台，记录传感器，用于将样本成像到记录传感器上的成像光学元件，移动单元，通过该移动单元，台与成像光学元件之间的距离改变控制单元，用于控制样本的图像记录;以及聚焦保持单元，用于维持用于以时间间隔对样本进行图像记录的规定焦点位置，其中聚焦保持装置包括至少一个硬件元件和一个软件模块，其中聚焦保持单元在硬件和软件两侧完全集成在控制单元中。

8. 发明授权

US08097865B2 Multispectral illuminaton device 有权
标题翻译：多光谱照明装置
公开(公告)号：US08097865B2
公开(公告)日：2012-01-17
申请号：US12083980
申请日：2006-11-09
申请人： Peter Westphal , Daniel Bublitz
发明人： Peter Westphal , Daniel Bublitz
IPC分类号： G01N33/48
CPC分类号： G01N21/64 , F21V9/08 , G01N21/6458 , G02B19/0028 , G02B19/0066 , G02B19/0095 , G02B21/06 , G02B21/16 , G02B27/1006 , G02B27/141 , G02B27/145
摘要： An illumination device includes at least four semiconductor radiation sources (18) for emitting optical radiation in respectively different emission wavelength ranges. At least one color splitter (22.1, 22.2, 22.3), which is reflective for optical radiation of the respective semiconductor radiation source (18), is assigned to each of at least three of the semiconductor radiation sources (18). The semiconductor radiation sources (18) and the color splitters (22.1, 22.2, 22.3) are arranged such that the optical radiation, which is emitted in each case from each of the semiconductor radiation sources (18), is coupled into a common illumination beam path section (24). In each case, one collimating unit (20.1, 20.2, 20.3, 20.4), which collimates the optical radiation emitted by the respective semiconductor radiation source (18), is arranged in the beam path sections from the semiconductor radiation sources (18) to the color splitters (22.1, 22.2, 22.3).
摘要翻译：照明装置包括用于分别发射不同发射波长范围内的光辐射的至少四个半导体辐射源（18）。对于半导体辐射源（18）中的至少三个中的每一个分配至少一个用于相应半导体辐射源（18）的光学辐射的颜色分离器（22.1,22.2,22.3）。半导体辐射源（18）和分色器（22.1,22.2,22.3）被布置成使得从每个半导体辐射源（18）在每种情况下发射的光辐射被耦合到公共照明光束路径部分（24）。在每种情况下，将从半导体辐射源（18）发射的光辐射准直的一个准直单元（20.1,20.2,20.3,20.4）设置在从半导体辐射源（18）到分色机（22.1,22.2,22.3）。

9. 发明申请

US20110043905A1 MICROSCOPE HAVING FOCUS-HOLDING UNIT 有权
标题翻译：具有聚焦控制单元的显微镜
公开(公告)号：US20110043905A1
公开(公告)日：2011-02-24
申请号：US12937970
申请日：2009-04-04
申请人： Reiner Mitzkus , Eugen Wehner , Stefan Steinborn , Gleb Milinovici , Steffen Leidenbach , Peter Westphal
发明人： Reiner Mitzkus , Eugen Wehner , Stefan Steinborn , Gleb Milinovici , Steffen Leidenbach , Peter Westphal
IPC分类号： G02B21/24
CPC分类号： G02B21/241
摘要： The invention relates to a microscope having a stage for supporting a sample to be examined, a recording sensor, an imaging optic for imaging the sample onto the recording sensor, a moving unit by means of which the distance between the stage and the imaging optic can be changed, a control unit for controlling an image recording of the sample and a focus-holding unit for maintaining a prescribed focal position for image recording of the sample at temporal intervals, wherein the focus-holding device comprises at least one hardware element and one software module, wherein the focus-holding unit is fully integrated in the control unit, on both the hardware and software sides.
摘要翻译：本发明涉及一种显微镜，其具有用于支撑待检查样本的台，记录传感器，用于将样本成像到记录传感器上的成像光学元件，移动单元，通过该移动单元，台与成像光学元件之间的距离改变控制单元，用于控制样本的图像记录;以及聚焦保持单元，用于维持用于以时间间隔对样本进行图像记录的规定焦点位置，其中聚焦保持装置包括至少一个硬件元件和一个软件模块，其中聚焦保持单元在硬件和软件两侧完全集成在控制单元中。

10. 发明申请

US20090153798A1 Device and method for monitoring, documenting and/or diagnosing the fundus 有权
标题翻译：用于监测，记录和/或诊断眼底的装置和方法
公开(公告)号：US20090153798A1
公开(公告)日：2009-06-18
申请号：US11988965
申请日：2006-07-19
申请人： Manfred Dick , Thomas Mohr , Daniel Bublitz , Peter Westphal
发明人： Manfred Dick , Thomas Mohr , Daniel Bublitz , Peter Westphal
IPC分类号： A61B3/12 , A61B3/14
CPC分类号： A61B3/14 , A61B5/0261 , A61B5/0285 , A61B5/14555 , A61B5/7257
摘要： The present invention is directed to a device and a method for the observation, documentation and/or diagnosis of the fundus in which the diagnosis is carried out by evaluating the documented images of the fundus. The device according to the invention comprises an ophthalmological examination device, a multi-spectral sequential illumination module, an image recording module, a control and safety module, and an evaluating unit. The illumination module which is connected to the ophthalmologic examination device has at least two individual light sources and which can be regulated individually with respect to intensity and duration and which emit monochromatic light of different wavelengths. The light coming from the illumination module is imaged on the image recording module from the ophthalmologic examination device by the eye being examined. The control and safety module controls the chronological sequence, duration and intensity of the individual light sources and monitors the light stress. An evaluating unit evaluates the recordings of the fundus transmitted by the image recording module. The inventive solution serves to record monochromatic images of the retina, for example, red, green, blue, or also infrared, and to record fluorescence images.
摘要翻译：本发明涉及一种用于观察，记录和/或诊断眼底的装置和方法，其中通过评估眼底记录的图像进行诊断。根据本发明的装置包括眼科检查装置，多光谱顺序照明模块，图像记录模块，控制和安全模块以及评估单元。连接到眼科检查装置的照明模块具有至少两个单独的光源，并且可以相对于强度和持续时间单独地调节并且发射不同波长的单色光。来自照明模块的光被眼睛检查从眼科检查装置成像在图像记录模块上。控制和安全模块控制各个光源的时间顺序，持续时间和强度，并监控光应力。评估单元评估由图像记录模块发送的眼底的记录。本发明的解决方案用于记录视网膜的单色图像，例如红色，绿色，蓝色或红外，并记录荧光图像。

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