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1. 发明授权

US09568724B2 Autofocus method for microscope and microscope comprising autofocus device 有权
标题翻译：包括自动对焦装置的显微镜和显微镜的自动对焦方法
公开(公告)号：US09568724B2
公开(公告)日：2017-02-14
申请号：US14123871
申请日：2012-06-05
申请人： Peter Westphal , Reiner Mitzkus
发明人： Peter Westphal , Reiner Mitzkus
IPC分类号： G02B21/36 , G02B21/24 , G02B7/28 , G02B21/02
CPC分类号： H04N5/23212 , G02B7/28 , G02B7/36 , G02B21/02 , G02B21/082 , G02B21/244 , G02B21/245 , G02B21/361 , G02B21/362 , G02B21/365
摘要： A microscope including an objective having a focal plane in a sample space, and an autofocus device comprising a light modulator for generating a luminous modulation object that is intensity-modulated periodically along one direction, an autofocus illumination optical unit that images the modulation object such that its image arises in the sample space, an autofocus camera, an autofocus imaging optical unit that images the image of the modulation object in the sample space onto the autofocus camera, a control device, which receives signals of the autofocus camera and determines an intensity distribution of the image of the modulation object and generates a focus control signal therefrom. The control device determines an intensity distribution of the image of a luminous comparison object imaged by the optical unit to correct the intensity distribution of the image of the modulation object with regard to reflectivity variations in the sample space.
摘要翻译：一种显微镜，包括在样本空间中具有焦平面的物镜，以及自动聚焦装置，包括用于产生沿着一个方向周期性强度调制的发光调制对象的光调制器;自动聚焦照明光学单元，其对所述调制对象进行成像，使得其图像出现在样本空间中，自动对焦照相机，自动对焦成像光学单元，其将样本空间中的调制对象的图像成像到自动对焦照相机上;控制装置，其接收自动聚焦照相机的信号并确定强度分布的调制对象的图像，并从其生成聚焦控制信号。控制装置确定由光学单元成像的发光比较对象的图像的强度分布，以校正调制对象的图像在样本空间中的反射率变化的强度分布。

2. 发明申请

US20100033811A1 AUTOFOCUS DEVICE FOR MICROSCOPY 有权
标题翻译：用于显微镜的自动装置
公开(公告)号：US20100033811A1
公开(公告)日：2010-02-11
申请号：US12305183
申请日：2007-06-15
申请人： Peter Westphal , Daniel Bublitz , Reiner Mitzkus
发明人： Peter Westphal , Daniel Bublitz , Reiner Mitzkus
IPC分类号： G02B21/00
CPC分类号： G02B7/36 , G02B21/244
摘要： A microscope including an objective which images a sample along a microscope beam path, and an autofocus device, which is coupled into the microscope beam path via a beam splitter at a location behind the objective direction, a A light modulator for generating a two-dimensional, intensity-modulated modulation object, is located in the autofocus beam path in a plane conjugated to the focal plane of the objective or intersects the latter and is imaged into the focal plane of the objective. A camera records a two-dimensional image onto which the modulation object's image is imaged. The image plane of the camera intersects a plane that is conjugated to the modulation object or is located in the plane and the camera detecting the contrast of the modulation object's image located in the sample.
摘要翻译：一种显微镜，其包括沿着显微镜光束路径对样本进行成像的目标，以及自动聚焦装置，其经由目标方向后方的位置处的分束器耦合到显微镜光束路径中; A光调制器，用于产生二维强度调制调制对象位于与物镜的焦平面共轭的平面中的自动聚焦光束路径中，或者与物镜的相交，并被成像到物镜的焦平面。照相机记录调制对象的图像成像到的二维图像。相机的图像平面与共轭于调制对象的平面相交，或位于平面中，相机检测位于样品中的调制对象的图像的对比度。

3. 发明授权

US08643946B2 Autofocus device for microscopy 有权
标题翻译：显微镜自动对焦装置
公开(公告)号：US08643946B2
公开(公告)日：2014-02-04
申请号：US12305183
申请日：2007-06-15
申请人： Peter Westphal , Daniel Bublitz , Reiner Mitzkus
发明人： Peter Westphal , Daniel Bublitz , Reiner Mitzkus
IPC分类号： G02B21/00
CPC分类号： G02B7/36 , G02B21/244
摘要： A microscope including an objective, which images a sample along a microscope beam path, and an autofocus device, which is coupled into the microscope beam path via a beam splitter at a location behind the objective. A light modulator for generating a two-dimensional, intensity-modulated modulation object, is located in the autofocus beam path in a plane conjugated to the focal plane of the objective or intersects the latter and is imaged into the focal plane of the objective. A camera records a two-dimensional image onto which the modulation object's image is imaged. The image plane of the camera intersects a plane that is conjugated to the modulation object or is located in the plane and the camera detecting the contrast of the modulation object's image located in the sample.
摘要翻译：显微镜，其包括沿着显微镜光束路径对样品进行成像的物镜和自动聚焦装置，该自动对焦装置经由目标背后的位置处的分束器耦合到显微镜光束路径中。用于产生二维强度调制调制对象的光调制器位于与物镜的焦平面共轭的平面中的自动聚焦光束路径中，或者与物镜的焦平面相交，并被成像到物镜的焦平面。照相机记录调制对象的图像成像到的二维图像。相机的图像平面与共轭于调制对象的平面相交，或位于平面中，相机检测位于样本中的调制对象的图像的对比度。

4. 发明授权

US08563912B2 Microscope having focus-holding unit 有权
标题翻译：显微镜具有聚焦保持单元
公开(公告)号：US08563912B2
公开(公告)日：2013-10-22
申请号：US12937970
申请日：2009-04-04
申请人： Reiner Mitzkus , Eugen Wehner , Stefan Steinborn , Gleb Milinovici , Steffen Leidenbach , Peter Westphal
发明人： Reiner Mitzkus , Eugen Wehner , Stefan Steinborn , Gleb Milinovici , Steffen Leidenbach , Peter Westphal
IPC分类号： G02B27/40
CPC分类号： G02B21/241
摘要： The invention relates to a microscope having a stage for supporting a sample to be examined, a recording sensor, an imaging optic for imaging the sample onto the recording sensor, a moving unit by means of which the distance between the stage and the imaging optic can be changed, a control unit for controlling an image recording of the sample and a focus-holding unit for maintaining a prescribed focal position for image recording of the sample at temporal intervals, wherein the focus-holding device comprises at least one hardware element and one software module, wherein the focus-holding unit is fully integrated in the control unit, on both the hardware and software sides.
摘要翻译：本发明涉及一种显微镜，其具有用于支撑待检查样本的台，记录传感器，用于将样本成像到记录传感器上的成像光学元件，移动单元，通过该移动单元，台与成像光学元件之间的距离改变控制单元，用于控制样本的图像记录;以及聚焦保持单元，用于维持用于以时间间隔对样本进行图像记录的规定焦点位置，其中聚焦保持装置包括至少一个硬件元件和一个软件模块，其中聚焦保持单元在硬件和软件两侧完全集成在控制单元中。

5. 发明申请

US20110043905A1 MICROSCOPE HAVING FOCUS-HOLDING UNIT 有权
标题翻译：具有聚焦控制单元的显微镜
公开(公告)号：US20110043905A1
公开(公告)日：2011-02-24
申请号：US12937970
申请日：2009-04-04
申请人： Reiner Mitzkus , Eugen Wehner , Stefan Steinborn , Gleb Milinovici , Steffen Leidenbach , Peter Westphal
发明人： Reiner Mitzkus , Eugen Wehner , Stefan Steinborn , Gleb Milinovici , Steffen Leidenbach , Peter Westphal
IPC分类号： G02B21/24
CPC分类号： G02B21/241
摘要： The invention relates to a microscope having a stage for supporting a sample to be examined, a recording sensor, an imaging optic for imaging the sample onto the recording sensor, a moving unit by means of which the distance between the stage and the imaging optic can be changed, a control unit for controlling an image recording of the sample and a focus-holding unit for maintaining a prescribed focal position for image recording of the sample at temporal intervals, wherein the focus-holding device comprises at least one hardware element and one software module, wherein the focus-holding unit is fully integrated in the control unit, on both the hardware and software sides.
摘要翻译：本发明涉及一种显微镜，其具有用于支撑待检查样本的台，记录传感器，用于将样本成像到记录传感器上的成像光学元件，移动单元，通过该移动单元，台与成像光学元件之间的距离改变控制单元，用于控制样本的图像记录;以及聚焦保持单元，用于维持用于以时间间隔对样本进行图像记录的规定焦点位置，其中聚焦保持装置包括至少一个硬件元件和一个软件模块，其中聚焦保持单元在硬件和软件两侧完全集成在控制单元中。

6. 发明授权

US09128296B2 Microscope with retain focus control 有权
标题翻译：显微镜保留对焦控制
公开(公告)号：US09128296B2
公开(公告)日：2015-09-08
申请号：US12937965
申请日：2009-04-04
申请人： Stefan Steinborn , Eugen Wehner , Reiner Mitzkus , Gleb Milinovici , Steffen Leidenbach , Peter Westphal
发明人： Stefan Steinborn , Eugen Wehner , Reiner Mitzkus , Gleb Milinovici , Steffen Leidenbach , Peter Westphal
IPC分类号： G02B27/64 , G02B21/24 , G03B13/34 , G01B11/22 , G03B13/32 , G01B11/28 , G06K9/00 , G05B11/12 , G05B11/06 , G05B11/10 , G03B13/36 , G02B21/36
CPC分类号： G02B21/241 , G01B11/22 , G01B11/28 , G01B11/285 , G02B21/367 , G03B13/32 , G03B13/34 , G03B13/36 , G05B11/06 , G05B11/10 , G05B11/12 , G06K9/00127
摘要： A microscope including an imaging optical unit, a sample stage for supporting a sample to be examined, a movement unit, by which the distance between sample stage and imaging optical unit can be altered, a focus measuring unit, which measures the present focus position and outputs a focus measurement signal, a control unit for maintaining a predetermined focus position for examinations of the sample that are separated from one another in time. The control unit receives the focus measurement signal and derives a deviation of the present focus position from the predetermined focus position. Dependent on the deviation derived the movement unit, changes the distance between sample stage and imaging optical unit so that the predetermined focus position is maintained. The control unit drives the movement unit (9) for maintaining the predetermined focus position only before and/or after at least one of the examinations, but never during the examinations.
摘要翻译：显微镜，包括成像光学单元，用于支撑待检测样品的样品台，可以改变样品台和成像光学单元之间的距离的移动单元，测量当前聚焦位置的聚焦测量单元，输出焦点测量信号，用于维持用于在时间上彼此分离的样本的检查的预定焦点位置的控制单元。控制单元接收聚焦测量信号并且导出当前聚焦位置与预定聚焦位置的偏差。取决于移动单元的偏差，改变样本台与成像光学单元之间的距离，从而保持预定的对焦位置。控制单元驱动运动单元（9），用于仅在检查中的至少一个之前和/或之后维持预定的对焦位置，但从不在检查期间。

7. 发明申请

US20110051232A1 MICROSCOPE WITH RETAIN FOCUS CONTROL 有权
标题翻译：具有保留焦点控制的MICROSCOPE
公开(公告)号：US20110051232A1
公开(公告)日：2011-03-03
申请号：US12937965
申请日：2009-04-04
申请人： Stefan Steinborn , Eugen Wehner , Reiner Mitzkus , Gleb Milinovici , Steffen Leidenbach , Peter Westphal
发明人： Stefan Steinborn , Eugen Wehner , Reiner Mitzkus , Gleb Milinovici , Steffen Leidenbach , Peter Westphal
IPC分类号： G02B21/26 , G02B21/00
CPC分类号： G02B21/241 , G01B11/22 , G01B11/28 , G01B11/285 , G02B21/367 , G03B13/32 , G03B13/34 , G03B13/36 , G05B11/06 , G05B11/10 , G05B11/12 , G06K9/00127
摘要： A microscope including an imaging optical unit, a sample stage for supporting a sample to be examined, a movement unit, by which the distance between sample stage and imaging optical unit can be altered, a focus measuring unit, which measures the present focus position and outputs a focus measurement signal, a control unit for maintaining a predetermined focus position for examinations of the sample that are separated from one another in time. The control unit receives the focus measurement signal and derives a deviation of the present focus position from the predetermined focus position. Dependent on the deviation derived the movement unit, changes the distance between sample stage and imaging optical unit so that the predetermined focus position is maintained. The control unit drives the movement unit (9) for maintaining the predetermined focus position only before and/or after at least one of the examinations, but never during the examinations.
摘要翻译：显微镜，包括成像光学单元，用于支撑待检测样品的样品台，可以改变样品台和成像光学单元之间的距离的移动单元，测量当前聚焦位置的聚焦测量单元，输出焦点测量信号，用于维持用于在时间上彼此分离的样本的检查的预定焦点位置的控制单元。控制单元接收聚焦测量信号并且导出当前聚焦位置与预定聚焦位置的偏差。取决于移动单元的偏差，改变样本台与成像光学单元之间的距离，从而保持预定的对焦位置。控制单元驱动运动单元（9），用于仅在检查中的至少一个之前和/或之后维持预定的对焦位置，但从不在检查期间。

8. 发明申请

US20070146872A1 Invertible light-optical microscope 审中-公开
标题翻译：可逆光学显微镜
公开(公告)号：US20070146872A1
公开(公告)日：2007-06-28
申请号：US10578287
申请日：2004-11-04
申请人： Thomas Bocher , Hans Tandler , Hubert Wahl , Hans Brinkmann , Reiner Mitzkus , Franz Muchel , Harald Schadwinkel , Peter Gretscher
发明人： Thomas Bocher , Hans Tandler , Hubert Wahl , Hans Brinkmann , Reiner Mitzkus , Franz Muchel , Harald Schadwinkel , Peter Gretscher
IPC分类号： G02B21/06
CPC分类号： G02B21/0088
摘要： An optical microscope can be converted by the user quickly with a few movements of the hand so that it can be used as an upright variant or as an inverted variant. The required optical elements are accommodated in components that can be mechanically separated from one another and variously combined. The optical system is calculated in such a way that an upright microscope with vertical illumination or transmitted illumination or an inverted microscope with vertical illumination or transmitted illumination results when the components are combined in the required manner by interfaces provided for this purpose.
摘要翻译：光学显微镜可以由用户快速转换，几只手的移动，使其可以用作直立的变体或倒置的变体。所需的光学元件容纳在可彼此机械分离并且各种组合的部件中。以这样一种方式计算光学系统，即当通过为此目的提供的接口以所需方式组合部件时，会产生具有垂直照明或透射照明的立式显微镜或具有垂直照明或透射照明的倒置显微镜。

9. 发明申请

US20100309573A1 Optics Changer 有权
标题翻译：光学变换器
公开(公告)号：US20100309573A1
公开(公告)日：2010-12-09
申请号：US12745457
申请日：2008-11-03
申请人： Reiner Mitzkus , Peter Schnuell , Frank Bauer , Uwe Wolf , Hubert Wahl
发明人： Reiner Mitzkus , Peter Schnuell , Frank Bauer , Uwe Wolf , Hubert Wahl
IPC分类号： G02B7/00
CPC分类号： G02B21/24 , G02B21/26
摘要： The invention relates to an optics changer for arranging an optical element in a target position in a changer chamber g of an optical device accessible from the outside via a insertion channel, comprising a base frame and the optical element that is pivotally fastened to the base frame via a swivel mechanism, wherein the swivel mechanism effects a pivoting movement of the optical element when the optics changer is inserted through the insertion channel in the changer chamber starting at o a predetermined insertion depth such that after inserting, the optical element is placed and pivoted in the target position.
摘要翻译：本发明涉及一种用于将光学元件布置在目标位置的光学元件，该光学元件位于可从外部经由插入通道接近的光学装置的更换器室g中，该插入通道包括基座框架和枢转地固定到基座框架的光学元件通过旋转机构，其中当光学变换器从预定插入深度开始插入变换器腔中的插入通道时，旋转机构实现光学元件的枢转运动，使得在插入之后，光学元件被放置并枢转目标位置。

10. 发明授权

US08194312B2 Optics changer 有权
标题翻译：光学变换器
公开(公告)号：US08194312B2
公开(公告)日：2012-06-05
申请号：US12745457
申请日：2008-11-03
申请人： Reiner Mitzkus , Peter Schnuell , Frank Bauer , Uwe Wolf , Hubert Wahl
发明人： Reiner Mitzkus , Peter Schnuell , Frank Bauer , Uwe Wolf , Hubert Wahl
IPC分类号： G02B21/00
CPC分类号： G02B21/24 , G02B21/26
摘要： The invention relates to an optics changer for arranging an optical element in a target position in a changer chamber of an optical device accessible from the outside via a insertion channel, including a base frame and the optical element that is pivotally fastened to the base frame via a swivel mechanism, wherein the swivel mechanism effects a pivoting movement of the optical element when the optics changer is inserted through the insertion channel in the changer chamber starting at a predetermined insertion depth such that after inserting, the optical element is placed and pivoted in the target position.
摘要翻译：本发明涉及一种用于将光学元件布置在光学装置的更换器室中的光学元件，该光学元件可从外部通过插入通道接近，该插入通道包括基座框架，以及通过枢转地固定到基座框架的光学元件旋转机构，其中当所述光学变换器从预定的插入深度开始插入所述更换器腔中的所述插入通道时，所述旋转机构实现所述光学元件的枢转运动，使得在插入之后，所述光学元件被放置并枢转目标位置。

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