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1. 发明申请

US20090069290A1 Method for treating a demyelinating condition 失效
标题翻译：治疗脱髓鞘症状的方法
公开(公告)号：US20090069290A1
公开(公告)日：2009-03-12
申请号：US12290423
申请日：2008-10-30
申请人： Peter Werner , David Pitt , Elimor Brand-Schieber
发明人： Peter Werner , David Pitt , Elimor Brand-Schieber
IPC分类号： A61K31/554 , A61K31/435 , A61K31/495 , A61K31/4184 , A61P37/06 , A61K31/13 , A61K31/4439 , A61K31/40
CPC分类号： A61K31/4422 , A61K45/06
摘要： Methods for treating a demyelinating condition in a subject in need of treatment are provided. In some aspects the methods encompass administering to the subject an amount of a Ca2+-channel blocker effective to treat the demyelinating condition. In other aspects, the methods encompass administering to the subject an amount of a glutamate inhibitor effective to treat the demyelinating condition. In additional aspects, the methods encompass administering to the subject a Ca2+-channel blocker in combination with a glutamate inhibitor, in amounts effective to treat the demyelinating condition. In still other aspects, the methods encompass administering to the subject a Ca2+-channel blocker in combination with a hypertensive agent, in amounts effective to treat the demyelinating condition. Also provided are pharmaceutical compositions having a Ca2+-channel blocker, a glutamate inhibitor, and a pharmaceutically-acceptable carrier. Additionally, pharmaceutical compositions having a Ca2+-channel blocker, a hypertensive agent, and a pharmaceutically-acceptable carrier are provided.
摘要翻译：提供了治疗需要治疗的受试者的脱髓鞘状态的方法。在一些方面，所述方法包括对受试者施用有效治疗脱髓鞘状况的量的Ca 2+通道阻断剂。在其他方面，所述方法包括向受试者施用一定量的有效治疗脱髓鞘状态的谷氨酸盐抑制剂。在另外的方面，所述方法包括以有效治疗脱髓鞘状况的量向受试者施用与谷氨酸盐抑制剂组合的Ca 2+通道阻断剂。在另外的方面，所述方法包括以有效治疗脱髓鞘状况的量向受试者施用与高血压药物组合的Ca 2+通道阻断剂。还提供了具有Ca 2+通道阻断剂，谷氨酸抑制剂和药学上可接受的载体的药物组合物。另外，提供了具有Ca 2+通道阻滞剂，高血压药剂和药学上可接受的载体的药物组合物。

2. 发明授权

US07470718B2 Method for treating a demyelinating condition 失效
标题翻译：治疗脱髓鞘症状的方法
公开(公告)号：US07470718B2
公开(公告)日：2008-12-30
申请号：US10223068
申请日：2002-08-16
申请人： Peter Werner , David Pitt , Elimor Brand-Schieber
发明人： Peter Werner , David Pitt , Elimor Brand-Schieber
IPC分类号： A61K31/40
CPC分类号： A61K31/4422 , A61K45/06
摘要： Methods for treating a demyelinating condition in a subject in need of treatment are provided. In some aspects the methods encompass administering to the subject an amount of a Ca2+-channel blocker effective to treat the demyelinating condition. In other aspects, the methods encompass administering to the subject an amount of a glutamate inhibitor effective to treat the demyelinating condition. In additional aspects, the methods encompass administering to the subject a Ca2+-channel blocker in combination with a glutamate inhibitor, in amounts effective to treat the demyelinating condition. In still other aspects, the methods encompass administering to the subject a Ca2+-channel blocker in combination with a hypertensive agent, in amounts effective to treat the demyelinating condition. Also provided are pharmaceutical compositions having a Ca2+-channel blocker, a glutamate inhibitor, and a pharmaceutically-acceptable carrier. Additionally, pharmaceutical compositions having a Ca2+-channel blocker, a hypertensive agent, and a pharmaceutically-acceptable carrier are provided.
摘要翻译：提供了治疗需要治疗的受试者的脱髓鞘状态的方法。在一些方面，所述方法包括对受试者施用有效治疗脱髓鞘状况的量的Ca 2+通道阻断剂。在其他方面，所述方法包括向受试者施用一定量的有效治疗脱髓鞘状态的谷氨酸盐抑制剂。在另外的方面，所述方法包括以有效治疗脱髓鞘状况的量向受试者施用与谷氨酸盐抑制剂组合的Ca 2+通道阻断剂。在另外的方面，所述方法包括以有效治疗脱髓鞘状况的量向受试者施用与高血压药物组合的Ca 2+通道阻断剂。还提供了具有Ca 2+通道阻断剂，谷氨酸抑制剂和药学上可接受的载体的药物组合物。另外，提供了具有Ca 2+通道阻滞剂，高血压药剂和药学上可接受的载体的药物组合物。

3. 发明授权

US07816384B2 Method for treating a demyelinating condition 失效
标题翻译：治疗脱髓鞘症状的方法
公开(公告)号：US07816384B2
公开(公告)日：2010-10-19
申请号：US12290423
申请日：2008-10-30
申请人： Peter Werner , David Pitt , Elimor Brand-Schieber
发明人： Peter Werner , David Pitt , Elimor Brand-Schieber
IPC分类号： A61K31/44
CPC分类号： A61K31/4422 , A61K45/06
摘要： Methods for treating a demyelinating condition in a subject in need of treatment are provided. In some aspects the methods encompass administering to the subject an amount of a Ca2+-channel blocker effective to treat the demyelinating condition. In other aspects, the methods encompass administering to the subject an amount of a glutamate inhibitor effective to treat the demyelinating condition. In additional aspects, the methods encompass administering to the subject a Ca2+-channel blocker in combination with a glutamate inhibitor, in amounts effective to treat the demyelinating condition. In still other aspects, the methods encompass administering to the subject a Ca2+-channel blocker in combination with a hypertensive agent, in amounts effective to treat the demyelinating condition. Also provided are pharmaceutical compositions having a Ca2+-channel blocker, a glutamate inhibitor, and a pharmaceutically-acceptable carrier. Additionally, pharmaceutical compositions having a Ca2+-channel blocker, a hypertensive agent, and a pharmaceutically-acceptable carrier are provided.
摘要翻译：提供了治疗需要治疗的受试者的脱髓鞘状态的方法。在一些方面，所述方法包括对受试者施用有效治疗脱髓鞘状况的量的Ca 2+通道阻断剂。在其他方面，所述方法包括向受试者施用一定量的有效治疗脱髓鞘状态的谷氨酸盐抑制剂。在另外的方面，所述方法包括以有效治疗脱髓鞘状况的量向受试者施用与谷氨酸盐抑制剂组合的Ca 2+通道阻断剂。在另外的方面，所述方法包括以有效治疗脱髓鞘状况的量向受试者施用与高血压药物组合的Ca 2+通道阻断剂。还提供了具有Ca 2+通道阻断剂，谷氨酸抑制剂和药学上可接受的载体的药物组合物。另外，提供了具有Ca 2+通道阻滞剂，高血压药剂和药学上可接受的载体的药物组合物。

4. 发明授权

US06455553B1 Method for treating a demyelinating condition 失效
标题翻译：治疗脱髓鞘症状的方法
公开(公告)号：US06455553B1
公开(公告)日：2002-09-24
申请号：US09678686
申请日：2000-10-03
申请人： Peter Werner , David Pitt
发明人： Peter Werner , David Pitt
IPC分类号： A61K3144
CPC分类号： A61K45/06 , A61K31/4422 , Y10S514/903
摘要： The present invention provides a method for treating a demyelinating condition in a subject in need of treatment, by administering to the subject an amount of a Ca2+-channel blocker effective to treat the demyelinating condition. The present invention is also directed to a method for treating a demyelinating condition in a subject in need of treatment, by administering to the subject a Ca2+-channel blocker in combination with a glutamate inhibitor, in amounts effective to treat the demyelinating condition. Also disclosed is a pharmaceutical composition comprising a Ca2+-channel blocker, a glutamate inhibitor, and a pharmaceutically-acceptable carrier. Additionally, the present invention provides a method for treating a demyelinating condition in a subject in need of treatment, by administering to the subject a Ca2+-channel blocker in combination with a hypertensive agent, in amounts effective to treat the demyelinating condition. Finally, the present invention discloses a pharmaceutical composition comprising a Ca2+-channel blocker, a hypertensive agent, and a pharmaceutically-acceptable carrier.
摘要翻译：本发明提供了一种治疗需要治疗的受试者的脱髓鞘状态的方法，通过向受试者施用有效治疗脱髓鞘状态的量的Ca 2+通道阻断剂。本发明还涉及一种用于治疗需要治疗的受试者的脱髓鞘状态的方法，其以有效治疗脱髓鞘状况的量向受试者施用与谷氨酸抑制剂组合的Ca 2+通道阻断剂。还公开了包含Ca 2+通道阻断剂，谷氨酸抑制剂和药学上可接受的载体的药物组合物。此外，本发明提供了治疗需要治疗的受试者的脱髓鞘状态的方法，通过以有效治疗脱髓鞘状况的量向受试者施用与高血压药物组合的Ca 2+通道阻断剂。最后，本发明公开了包含Ca 2+通道阻断剂，高血压药剂和药学上可接受的载体的药物组合物。

5. 发明申请

US20110146810A1 SEWAGE FLUSHING 有权
公开(公告)号：US20110146810A1
公开(公告)日：2011-06-23
申请号：US12993891
申请日：2009-05-05
申请人： David Pitt
发明人： David Pitt
IPC分类号： E03F9/00
CPC分类号： E03F9/00 , E03F9/007 , Y10T137/7287 , Y10T137/7339 , Y10T137/7504
摘要： A sewer flushing device 20 for location in a sewage system. The device comprises a housing 21 adapted for location in a sewage flow path 14 and a gate 22 pivotally supported on the housing 21 and movable between open and closed positions. The gate is biased towards its closed position so as to inhibit the flow of sewage and thereby cause a build up of sewage. In this way, when the sewage upstream of the gate 22 reaches a predetermined level the gate is urged to its open position such that a flushing pulse of sewage flows downstream.There may also be provided a locating device 23 for holding the housing 21 in the required position within the sewage system. The locating device may comprise a sewer engaging portion 51,52 adapted to locate in a sewer channel 12,14, and a housing connector 54 adapted to connect to the housing 21.
摘要翻译：用于污水处理系统中的位置的下水道冲洗装置20。该装置包括适于位于污水流路14中的壳体21和枢转地支撑在壳体21上并可在打开和关闭位置之间移动的门22。门偏向其关闭位置，以便抑制污水的流动，从而导致污水的积聚。以这种方式，当门22上游的污水达到预定水平时，门被推动到其打开位置，使得污水的冲洗脉冲下游流动。也可以设置用于将壳体21保持在污水系统内所需位置的定位装置23。定位装置可以包括适于定位在下水道12,14中的下水道接合部分51,52和适于连接到壳体21的壳体连接器54。

6. 发明授权

US08763630B2 Sewage flushing 有权
标题翻译：污水冲洗
公开(公告)号：US08763630B2
公开(公告)日：2014-07-01
申请号：US12993891
申请日：2009-05-05
申请人： David Pitt
发明人： David Pitt
IPC分类号： E03F9/00
CPC分类号： E03F9/00 , E03F9/007 , Y10T137/7287 , Y10T137/7339 , Y10T137/7504
摘要： A sewer flushing device 20 for location in a sewage system. The device comprises a housing 21 adapted for location in a sewage flow path 14 and a gate 22 pivotally supported on the housing 21 and movable between open and closed positions. The gate is biased towards its closed position so as to inhibit the flow of sewage and thereby cause a build up of sewage. In this way, when the sewage upstream of the gate 22 reaches a predetermined level the gate is urged to its open position such that a flushing pulse of sewage flows downstream.There may also be provided a locating device 23 for holding the housing 21 in the required position within the sewage system. The locating device may comprise a sewer engaging portion 51,52 adapted to locate in a sewer channel 12,14, and a housing connector 54 adapted to connect to the housing 21.
摘要翻译：用于污水处理系统中的位置的下水道冲洗装置20。该装置包括适于位于污水流路14中的壳体21和枢转地支撑在壳体21上并可在打开和关闭位置之间移动的门22。门偏向其关闭位置，以便抑制污水的流动，从而导致污水的积聚。以这种方式，当门22上游的污水达到预定水平时，门被推动到其打开位置，使得污水的冲洗脉冲下游流动。也可以设置用于将壳体21保持在污水系统内所需位置的定位装置23。定位装置可以包括适于定位在下水道12,14中的下水道接合部分51,52和适于连接到壳体21的壳体连接器54。

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