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1. 发明授权

US09885768B2 Method for generating a desired spatially variable temporal profile of the magnetization state in magnetic resonance 有权
公开(公告)号：US09885768B2
公开(公告)日：2018-02-06
申请号：US14009113
申请日：2012-04-18
申请人： Peter Ullmann , Johannes Schneider , Wolfgang Ruhm
发明人： Peter Ullmann , Johannes Schneider , Wolfgang Ruhm
IPC分类号： G01V3/00 , G01R33/44 , G01R33/561
CPC分类号： G01R33/443 , G01R33/5612 , G01R33/5614
摘要： A method for generating a desired temporal profile of the magnetization state in an object under examination (O) during an experiment involving magnetic resonance is characterized in that at least one spatially dependent change in the magnetization state inside the object under examination (O) is predefined and spatially selective radio-frequency pulses, which allow a simultaneous and independent change in the magnetization state at locations with different stipulations, are irradiated in order to implement the predefined spatially dependent change in the magnetization state. The method permits establishment of the same desired temporal profile of the magnetization state for different regions of the object under examination despite different given experimental parameters or deliberate generation of different desired profiles of the magnetization state at different locations.

2. 发明授权

US09958522B2 Method for determining the spatial distribution of magnetic resonance signals in subvolumes of an object under examination 有权
公开(公告)号：US09958522B2
公开(公告)日：2018-05-01
申请号：US14009116
申请日：2012-04-18
申请人： Wolfgang Ruhm , Johannes Schneider , Peter Ullmann
发明人： Wolfgang Ruhm , Johannes Schneider , Peter Ullmann
IPC分类号： G01R33/483 , A61B5/055 , G01R33/561 , G01R33/24 , G01R33/385
CPC分类号： G01R33/4833 , A61B5/055 , G01R33/246 , G01R33/385 , G01R33/4836 , G01R33/561 , G01R33/5612
摘要： A method for determining the spatial distribution of magnetic resonance signals from at least one of N subvolumes predefines a reception encoding scheme and determines unique spatial encoding for at least one of the subvolumes but not for the entire volume under examination (UV). A transmission encoding scheme is also defined, wherein encoding is effected via the amplitude and/or phase of the transverse magnetization. The temporal amplitude and phase profile of the RF pulses is then calculated and each reception encoding step is carried out I times with variations according to the I transmission encoding steps in the transmission encoding scheme. The method makes it possible to largely restrict the spatially resolving MR signal encoding and image reconstruction to subvolumes of the object under examination without the achievable image quality sensitively depending on imperfections in the MR apparatus.

3. 发明授权

US08508227B2 Method for position dependent change in the magnetization in an object in a magnetic resonance experiment 有权
标题翻译：磁共振实验中物体磁化位置相关变化的方法
公开(公告)号：US08508227B2
公开(公告)日：2013-08-13
申请号：US12897806
申请日：2010-10-05
申请人： Martin Haas , Peter Ullmann , Wolfgang Ruhm , Maxim Zaitsev , Jürgen Hennig
发明人： Martin Haas , Peter Ullmann , Wolfgang Ruhm , Maxim Zaitsev , Jürgen Hennig
IPC分类号： G01V3/00
CPC分类号： G01R33/4836 , G01R33/3415 , G01R33/385 , G01R33/4833 , G01R33/5612
摘要： A method for position dependent change in the magnetization in an object, according to a requirement in a magnetic resonance measurement, wherein radio-frequency pulses are irradiated in conjunction with supplementary magnetic fields that vary in space and over time and are superposed on the static and homogeneous basic field of a magnetic resonance measurement apparatus along a z-direction, is characterized in that non-linear supplementary magnetic fields are used, whose spatial gradient of the z-component is not constant at least at one instant of the irradiation, and that the radio-frequency pulses to be irradiated are calculated in advance, wherein progressions over time of the field strengths of the supplementary magnetic fields in the region of the object that are calculated and/or measured position-dependently are included in this calculation. This enables change in the magnetization with an at least locally spatially higher resolution and/or shorter irradiation duration of the RF pulses and supplementary magnetic fields than is feasible with linear supplementary magnetic fields produced by conventional gradient systems. In particular, this is possible under the technical and physiological conditions that currently constrain the performance of the known methods using linear supplementary fields.
摘要翻译：根据磁共振测量中的要求，对物体的磁化位置相关变化的方法，其中射频脉冲与空间和时间上变化并叠加在静态和磁共振测量装置沿z方向的均匀基本场的特征在于，使用非线性辅助磁场，其至少在照射一瞬间z分量的空间梯度不恒定，并且预先计算要照射的射频脉冲，其中在该计算中包括在计算和/或测量的对象的区域中的辅助磁场的场强随时间的逐渐增加。这使得能够利用由常规梯度系统产生的线性补充磁场可行的RF脉冲和辅助磁场的至少局部空间上更高的分辨率和/或更短的照射持续时间来改变磁化。特别地，这在目前限制使用线性补充领域的已知方法的性能的技术和生理条件下是可能的。

4. 发明申请

US20110080169A1 Method for position dependent change in the magnetization in an object in a magnetic resonance experiment 有权
标题翻译：磁共振实验中物体磁化位置相关变化的方法
公开(公告)号：US20110080169A1
公开(公告)日：2011-04-07
申请号：US12897806
申请日：2010-10-05
申请人： Martin Haas , Peter Ullmann , Wolfgang Ruhm , Maxim Zaitsev , Jürgen Hennig
发明人： Martin Haas , Peter Ullmann , Wolfgang Ruhm , Maxim Zaitsev , Jürgen Hennig
IPC分类号： G01R33/48
CPC分类号： G01R33/4836 , G01R33/3415 , G01R33/385 , G01R33/4833 , G01R33/5612
摘要： A method for position dependent change in the magnetization in an object, according to a requirement in a magnetic resonance measurement, wherein radio-frequency pulses are irradiated in conjunction with supplementary magnetic fields that vary in space and over time and are superposed on the static and homogeneous basic field of a magnetic resonance measurement apparatus along a z-direction, is characterized in that non-linear supplementary magnetic fields are used, whose spatial gradient of the z-component is not constant at least at one instant of the irradiation, and that the radio-frequency pulses to be irradiated are calculated in advance, wherein progressions over time of the field strengths of the supplementary magnetic fields in the region of the object that are calculated and/or measured position-dependently are included in this calculation. This enables change in the magnetization with an at least locally spatially higher resolution and/or shorter irradiation duration of the RF pulses and supplementary magnetic fields than is feasible with linear supplementary magnetic fields produced by conventional gradient systems. In particular, this is possible under the technical and physiological conditions that currently constrain the performance of the known methods using linear supplementary fields.
摘要翻译：根据磁共振测量中的要求，对物体的磁化位置相关变化的方法，其中射频脉冲与空间和时间上变化并叠加在静态和磁共振测量装置沿z方向的均匀基本场的特征在于，使用非线性辅助磁场，其至少在照射一瞬间z分量的空间梯度不恒定，并且预先计算要照射的射频脉冲，其中在该计算中包括在计算和/或测量的对象的区域中的辅助磁场的场强随时间的逐渐增加。这使得能够利用由常规梯度系统产生的线性补充磁场可行的RF脉冲和辅助磁场的至少局部空间上更高的分辨率和/或更短的照射持续时间来改变磁化。特别地，这在目前限制使用线性补充领域的已知方法的性能的技术和生理条件下是可能的。

5. 发明申请

US20090273345A1 Method for determining the spatial distribution of magnetic resonance signals with use of local spatially encoding magnetic fields 有权
标题翻译：使用局部空间编码磁场确定磁共振信号的空间分布的方法
公开(公告)号：US20090273345A1
公开(公告)日：2009-11-05
申请号：US12453025
申请日：2009-04-28
申请人： Wolfgang Ruhm
发明人： Wolfgang Ruhm
IPC分类号： G01R33/48
CPC分类号： G01R33/561 , G01R33/3415 , G01R33/4824 , G01R33/4833 , G01R33/4836 , G01R33/5611
摘要： A method for determining the spatial distribution of magnetic resonance (MR) signals from an imaging region within MSEM regions of a local gradient system, wherein, in a preparatory step, a spatial encoding scheme is defined; in an execution step, nuclear spins are repeatedly excited with RF pulses, and thereafter spatially encoded according to the spatial encoding scheme, in at least one dimension by means of the local gradient system, and MR signals are acquired, from which the spatial distribution is calculated, visualized and/or stored,characterized in that in the preparatory step, a phase encoding scheme with I phase encoding steps is defined, for each phase encoding step according to the phase encoding scheme, an excitation pattern of the transverse magnetization is defined and RF pulses to be irradiated to implement this pattern are calculated, wherein the same phase is defined at all spatial locations of the imaging region within a MSEM region and, in the execution step, according to the spatial encoding scheme each encoding step is repeated I times according to the phase encoding scheme, wherein selection of the imaging region, amplitude modulation, and phase encoding are performed with the calculated RF pulses during excitation of the nuclear spin. This results in unique determination of the spatial distribution of the magnetic resonance signals with a simple RF receiver configuration using local gradient systems.
摘要翻译：一种用于确定来自局部梯度系统的MSEM区域内的成像区域的磁共振（MR）信号的空间分布的方法，其中在准备步骤中定义空间编码方案; 在执行步骤中，核自旋被RF脉冲重复激励，然后根据空间编码方案在至少一个维度上借助于局部梯度系统进行空间编码，并且获取MR信号，空间分布是计算，可视化和/或存储，其特征在于，在准备步骤中，定义了具有I相编码步骤的相位编码方案，对于根据相位编码方案的每个相位编码步骤，定义横向磁化的激励图案，计算要照射的RF脉冲以实现该图案，其中在MSEM区域内的成像区域的所有空间位置处定义相同的相位，并且在执行步骤中，根据空间编码方案，每个编码步骤重复I次根据相位编码方案，其中使用计算来执行成像区域的选择，幅度调制和相位编码在核旋转激发期间发射RF脉冲。这使得使用局部梯度系统的简单RF接收器配置可以独特地确定磁共振信号的空间分布。

6. 发明授权

US08082127B2 Method for determining the spatial distribution of magnetic resonance signals through multi-dimensional RF excitation pulses 有权
标题翻译：通过多维RF激励脉冲确定磁共振信号的空间分布的方法
公开(公告)号：US08082127B2
公开(公告)日：2011-12-20
申请号：US12678292
申请日：2008-09-13
申请人： Wolfgang Ruhm
发明人： Wolfgang Ruhm
IPC分类号： G01R33/54 , G06F19/00
CPC分类号： G01R33/561 , G01R33/446 , G01R33/4824 , G01R33/4833 , G01R33/4836
摘要： A method for determining the spatial distribution of magnetic resonance signals from an imaging area, wherein nuclear spins are excited in a spatially encoded fashion through multi-dimensional RF pulses, is characterized in that in a definition step, a resolution grid with resolution grid cells is predetermined, and in accordance with a predetermined phase encoding scheme, an excitation pattern is defined for each phase encoding step, in which the amplitudes within the imaging area are set in accordance with a predetermined distribution identically for each phase encoding step. In a preparatory step, the amplitude and phase behavior of the RF pulses to be irradiated is calculated in accordance with a predetermined k-space trajectory for each defined complex excitation pattern.
摘要翻译：用于确定来自成像区域的磁共振信号的空间分布的方法，其中通过多维RF脉冲以空间编码的方式激发核自旋，其特征在于，在定义步骤中，具有分辨率网格单元的分辨率网格为并且根据预定相位编码方案，为每个相位编码步骤定义激励模式，其中根据每个相位编码步骤相同的预定分布来设置成像区域内的振幅。在准备步骤中，根据用于每个定义的复合激励图案的预定的k空间轨迹来计算要照射的RF脉冲的振幅和相位特性。

7. 发明授权

US07843195B2 Method for determining the spatial distribution of magnetic resonance signals with use of local spatially encoding magnetic fields 有权
标题翻译：使用局部空间编码磁场确定磁共振信号的空间分布的方法
公开(公告)号：US07843195B2
公开(公告)日：2010-11-30
申请号：US12453025
申请日：2009-04-28
申请人： Wolfgang Ruhm
发明人： Wolfgang Ruhm
IPC分类号： G01V3/00
CPC分类号： G01R33/561 , G01R33/3415 , G01R33/4824 , G01R33/4833 , G01R33/4836 , G01R33/5611
摘要： A method for determining the spatial distribution of magnetic resonance (MR) signals from an imaging region has a preparatory step in which an encoding scheme with I phase encoding steps is defined, for each phase encoding step according to the phase encoding scheme, an excitation pattern of the transverse magnetization is defined and RF pulses to be irradiated to implement this pattern are calculated, wherein the same phase is defined at all spatial locations of the imaging region within an MSEM region and, in the execution step, according to the spatial encoding scheme each encoding step is performed I times according to the phase encoding scheme, wherein selection of the imaging region, amplitude modulation, and phase encoding are performed with the calculated RF pulses during excitation of the nuclear spin. This results in unique determination of the spatial distribution of the magnetic resonance signals with a simple RF receiver configuration using local gradient systems.
摘要翻译：用于确定来自成像区域的磁共振（MR）信号的空间分布的方法具有准备步骤，其中针对根据相位编码方案的每个相位编码步骤，定义具有I相编码步骤的编码方案，激励模式并且计算要照射的RF脉冲以实现该图案，其中在MSEM区域内的成像区域的所有空间位置处定义相同的相位，并且在执行步骤中，根据空间编码方案每个编码步骤根据相位编码方案执行I次，其中在核旋转激励期间利用所计算的RF脉冲来执行成像区域的选择，幅度调制和相位编码。这使得使用局部梯度系统的简单RF接收器配置可以独特地确定磁共振信号的空间分布。

8. 发明申请

US20100286500A1 Method for determining the spatial distribution of magnetic resonance signals through multi-dimensional rf excitation pulses 有权
标题翻译：通过多维射频激发脉冲确定磁共振信号的空间分布的方法
公开(公告)号：US20100286500A1
公开(公告)日：2010-11-11
申请号：US12678292
申请日：2008-09-13
申请人： Wolfgang Ruhm
发明人： Wolfgang Ruhm
IPC分类号： A61B5/055
CPC分类号： G01R33/561 , G01R33/446 , G01R33/4824 , G01R33/4833 , G01R33/4836
摘要： A method for determining the spatial distribution of magnetic resonance signals from an imaging area, wherein nuclear spins are excited in a spatially encoded fashion through multi-dimensional RF pulses, is characterized in that in a definition step, a resolution grid with resolution grid cells is predetermined, and in accordance with a predetermined phase encoding scheme, an excitation pattern is defined for each phase encoding step, in which the amplitudes within the imaging area are set in accordance with a predetermined distribution identically for each phase encoding step, the amplitudes of the residual resolution grid cells are set to zero, and the phases of the resolution grid cells within the imaging area are set in accordance with the phase encoding scheme, in a preparatory step, the amplitude and phase behavior of the RF pulses to be irradiated is calculated in accordance with a predetermined k-space trajectory for each defined complex excitation pattern of the phase encoding steps and for each transmitting element, in an execution step, the nuclear spins are repeatedly excited and their signals are acquired, wherein for each phase encoding step, the calculated RF pulses are applied during passage of the k-space trajectory, such that spatial encoding is performed within the imaging area during excitation of the nuclear spins.
摘要翻译：用于确定来自成像区域的磁共振信号的空间分布的方法，其中通过多维RF脉冲以空间编码的方式激发核自旋，其特征在于，在定义步骤中，具有分辨率网格单元的分辨率网格为并且根据预定相位编码方案，为每个相位编码步骤定义激励模式，其中根据每个相位编码步骤相同的预定分布来设置成像区域内的振幅，剩余分辨率网格单元被设置为零，并且根据相位编码方案设置成像区域内的分辨率网格单元的相位，在准备步骤中，计算要照射的RF脉冲的幅度和相位行为根据用于相位编码的每个定义的复合激励模式的预定k空间轨迹步骤，并且对于每个发射元件，在执行步骤中，重新激励核自旋并获取它们的信号，其中对于每个相位编码步骤，在k空间轨迹通过期间施加所计算的RF脉冲，使得空间编码在核自旋的激发期间在成像区域内执行。

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