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1. 发明申请

US20050163744A1 Novel method for down-regulation of amyloid 审中-公开
标题翻译：用于下调淀粉样蛋白的新方法
公开(公告)号：US20050163744A1
公开(公告)日：2005-07-28
申请号：US10783317
申请日：2004-02-20
申请人： Peter Rasmussen , Martin Jensen , Klaus Nielsen , Peter Koefoed , Florence Degan
发明人： Peter Rasmussen , Martin Jensen , Klaus Nielsen , Peter Koefoed , Florence Degan
IPC分类号： C12N15/09 , A61K20060101 , A61K35/74 , A61K35/76 , A61K38/00 , A61K39/00 , A61K39/02 , A61K39/10 , A61K39/12 , A61K39/385 , A61K39/39 , A61K39/395 , A61K45/06 , A61K48/00 , A61P20060101 , A61P3/10 , A61P25/00 , A61P25/14 , A61P25/16 , A61P25/28 , C07K20060101 , C07K14/47 , C07K19/00 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12Q1/68 , G01N33/53 , A61K38/17 , A61K31/785 , C07K14/705
摘要： Disclosed are novel methods for combatting diseases characterized by deposition of amyloid. The methods generally rely on immunization against amyloid precursor protien (APP) or beta amyloid (Aβ). Immunization is preferably effected by administration of analogues of autologous APP or Aβ, said analogues being capable of inducing antibody production against the autologous amyloidogenic polypeptides. Especially preferred as an immunogen is autologous Aβ which has been modified by introduction of one single or a few foreign, immunodominant and promiscuous T-cell epitopes. Also disclosed are nucleic acid vaccination against APP or Aβ and vaccination using live vaccines as well as methods and means useful for the vaccination. Such methods and means include methods for the preparation of analogues and pharmaceutical formulations, as well as nucleic acid fragments, vectors, transformed cells, polypeptides and pharmaceutical formulations.
摘要翻译：公开了以淀粉样蛋白淀积为特征的疾病的新型方法。该方法通常依赖于针对淀粉样蛋白前体蛋白（APP）或β淀粉样蛋白（Abeta）的免疫。免疫优选通过施用自体APP或Abeta的类似物来实现，所述类似物能够针对自体淀粉样蛋白多肽诱导抗体产生。特别优选作为免疫原是通过引入一种或几种外来的免疫显性和混杂的T细胞表位而被修饰的自体Abeta。还公开了针对APP或Abeta的核酸接种和使用活疫苗的疫苗接种以及用于疫苗接种的方法和装置。这些方法和手段包括制备类似物和药物制剂以及核酸片段，载体，转化细胞，多肽和药物制剂的方法。

2. 发明申请

US20070041945A1 NOVEL METHOD FOR DOWN-REGULATION OF AMYLOID 审中-公开
标题翻译：用于下调AMYLOID的新方法
公开(公告)号：US20070041945A1
公开(公告)日：2007-02-22
申请号：US11537566
申请日：2006-09-29
申请人： Martin JENSEN , Peter Rasmussen , Klaus Nielsen
发明人： Martin JENSEN , Peter Rasmussen , Klaus Nielsen
IPC分类号： A61K48/00 , A61K39/395 , C07K16/18 , C12N1/20 , C12N1/18 , C12P21/08 , C12N15/86 , C12N5/06
CPC分类号： G01N33/6896 , A61K38/00 , A61K38/1709 , A61K38/19 , A61K39/00 , A61K39/0007 , A61K39/385 , A61K47/646 , A61K2039/53 , A61K2039/6037 , A61K2039/6087 , A61K2039/64 , C07K14/4711 , C07K2319/00 , G01N2333/4709 , G01N2500/04 , Y02A50/412 , A61K2300/00
摘要： A method for in vivo down-regulation of amyloid protein in an animal, including a human being, the method comprising effecting presentation to the animal's immune system of an immunogenically effective amount of at least one amyloidogenic polypeptide or subsequence thereof which has been formulated so that immunization of the animal with the amyloidgenic polypeptide or subsequence thereof induces production of antibodies against the amyloidogenic polypeptide, and/or at least one analogue of the amyloidogenic polypeptide wherein is introduced at least one modification in the amino acid sequence of the amyloidogenic polypeptide which has as a result the immunization of the animal with the analogue induces production of antibodies against the amyloidogenic polypeptide.
摘要翻译：一种用于动物体内下调淀粉样蛋白的方法，包括人，所述方法包括向动物的免疫系统呈递免疫有效量的至少一种淀粉样变性多肽或其子序列，其被配制成使得用淀粉样蛋白生成多肽或其子序列免疫动物诱导针对淀粉样变性多肽和/或淀粉样变性多肽的至少一种类似物的抗体的产生，其中引入淀粉样变性多肽的氨基酸序列中的至少一个修饰，其具有如结果，用该类似物的动物的免疫诱导产生针对淀粉样变性多肽的抗体。

3. 发明申请

US20060008465A1 Novel methods for therapeutic vaccination 有权
标题翻译：治疗性接种的新方法
公开(公告)号：US20060008465A1
公开(公告)日：2006-01-12
申请号：US11202516
申请日：2005-08-11
申请人： Lucilla Steinaa , Soren Mouritsen , Anand Gautam , Iben Dalum , Jesper Hanning , Dana Leach , Klaus Nielsen , Gunilla Karlsson , Peter Rasmussen
发明人： Lucilla Steinaa , Soren Mouritsen , Anand Gautam , Iben Dalum , Jesper Hanning , Dana Leach , Klaus Nielsen , Gunilla Karlsson , Peter Rasmussen
IPC分类号： C07H21/04 , A61K39/00 , C07K14/82 , C12N1/21 , C12N1/18
CPC分类号： C07K16/3069 , A61K39/0011 , C07K14/50 , C07K14/705 , C07K14/70539 , C07K14/71 , C07K2317/34 , C12N2799/021 , Y02A50/412
摘要： A method is disclosed for inducing cell-mediated immunity against cellular antigens. More specifically, the invention provides for a method for inducing cytotoxic T-lymphocyte immunity against weak antigens, notably self-proteins. The method entails that antigen presenting cells are induced to present at least one CTL epitope of the weak antigen and at the same time presenting at least one foreign T-helper lymphocyte epitope. In a preferred embodiment, the antigen is a cancer specific antigen, e.g. PSM, Her2, or FGF8b. The method can be exercised by using traditional polypeptide vaccination, but also by using live attenuated vaccines or nucleic acid vaccination. The invention furthermore provides immunogenic analogues of PSM, Her2 and FGF8b, as well as nucleic acid molecules encoding these analogues. Also vectors and transformed cells are disclosed. The invention also provides for a method for identification of immunogenic analogues of weak or non-immunogenic antigens.
摘要翻译：公开了一种用于诱导针对细胞抗原的细胞介导的免疫的方法。更具体地，本发明提供了一种诱导针对弱抗原，特别是自身蛋白的细胞毒性T淋巴细胞免疫的方法。该方法需要抗原呈递细胞被诱导以呈现弱抗原的至少一个CTL表位，并且同时呈现至少一种外来T辅助淋巴细胞表位。在优选的实施方案中，抗原是癌特异性抗原，例如 PSM，Her2或FGF8b。该方法可以通过使用传统的多肽疫苗接种，也可以通过使用活减毒疫苗或核酸接种来进行。本发明还提供了PSM，Her2和FGF8b的免疫原性类似物以及编码这些类似物的核酸分子。还公开了载体和转化的细胞。本发明还提供了用于鉴定弱或非免疫原性抗原的免疫原性类似物的方法。

4. 发明申请

US20070184023A1 Method for down-regulation of vegf 审中-公开
标题翻译： vegf下调方法
公开(公告)号：US20070184023A1
公开(公告)日：2007-08-09
申请号：US10577489
申请日：2004-10-28
申请人： Peter Rasmussen , Florence Dal Degan , Valery Renard , Steen Klysner , Birgitte Volck
发明人： Peter Rasmussen , Florence Dal Degan , Valery Renard , Steen Klysner , Birgitte Volck
IPC分类号： A61K39/385 , A61K38/21 , C07H21/04 , C07K14/475 , C12N1/15 , C12N1/21 , C12N15/63 , C12N15/74 , C12N15/79 , C12N5/04 , C12N5/06
CPC分类号： C07K14/52 , A61K38/00 , A61K39/00 , A61K47/61 , A61K47/6415 , A61K47/642 , Y02A50/412
摘要： The present invention provides for novel immunogenic variants of VEGF (vascular endothelial growth factor) which are useful in active specific immunotherapy against diseases that are characterized by overexpression of VEGF. The invention also relates to methods of treating such diseases (for instance cancer) as well as to various tools in molecular biology that assist in the provision of the immunogenic variants.
摘要翻译：本发明提供VEGF（血管内皮生长因子）的新型免疫原性变体，其可用于针对以VEGF过表达为特征的疾病的活性特异性免疫疗法。本发明还涉及治疗这些疾病（例如癌症）的方法以及有助于提供免疫原性变体的分子生物学中的各种工具。

5. 发明申请

US20130270953A1 MAGNET COVER PLATE MODULE FOR WIND TURBINE GENERATORS, ARRANGEMENT, MOUNTING AND DISMOUNTING METHOD THEREOF 审中-公开
标题翻译：风力发电机用磁铁板模块，安装方式及安装方法
公开(公告)号：US20130270953A1
公开(公告)日：2013-10-17
申请号：US13807161
申请日：2011-06-08
申请人： Peter Rasmussen
发明人： Peter Rasmussen
IPC分类号： H02K1/30 , H02K15/03
CPC分类号： H02K1/30 , H02K1/278 , H02K7/1838 , H02K15/03 , Y02E10/725 , Y10T29/49012
摘要： The present invention describes a magnet cover plate module for positioning and protecting permanent magnets individually on a rotor's yoke for wind turbine generators. Said magnet module comprising a magnet cover plate made of a soft magnetic material for covering said permanent magnets individually, a non-magnetic plate is permanently fixed to said magnet cover plate, said non-magnetic plate comprises means for fixing said magnet cover plate module to an outer surface of said rotor's yoke, said fixing means being removable so as to allow mounting and dismounting of said cover plate module individually. Additionally a magnetic extender configured for guiding magnetic flux and avoid flux leakage is arranged on an inner surface of the rotor's yoke. Related methods of mounting, dismounting and repairing permanent magnets are equally described.
摘要翻译：本发明描述了一种用于将永磁体分别定位和保护在用于风力涡轮发电机的转子轭上的磁体盖板模块。所述磁体模块包括由用于单独覆盖所述永久磁体的软磁材料制成的磁体盖板，非磁性板永久地固定到所述磁体盖板，所述非磁性板包括用于将所述磁体盖板模块固定到所述转子的轭的外表面，所述固定装置是可拆卸的，以允许单独地安装和拆卸所述盖板模块。此外，构造成用于引导磁通并避免漏磁的磁性扩展器设置在转子轭的内表面上。同样地描述了安装，拆卸和修理永磁体的相关方法。

6. 发明申请

US20070184073A1 TB diagnostic based on antigens from M. tuberculosis 审中-公开
标题翻译：基于结核分枝杆菌抗原的TB诊断
公开(公告)号：US20070184073A1
公开(公告)日：2007-08-09
申请号：US11196018
申请日：2005-08-02
申请人： Peter Andersen , Karin Weldingh , Christina Hansen , Walter Florio , Li Mei Okkels , Rikke Skjot , Peter Rasmussen
发明人： Peter Andersen , Karin Weldingh , Christina Hansen , Walter Florio , Li Mei Okkels , Rikke Skjot , Peter Rasmussen
IPC分类号： A61K39/04 , C12Q1/68 , C07H21/04 , C12N15/74 , C07K14/35
CPC分类号： C07K14/35 , A61K38/00 , A61K39/00 , A61K2039/51 , C07K2319/00
摘要： The present invention is based on the identification and characterization of a number of novel M. tuberculosis derived proteins and protein fragments. The invention is directed to the polypeptides and immunologically active fragments thereof, the genes encoding them, immunological compositions such as diagnostic reagents containing the polypeptides.
摘要翻译：本发明基于鉴定和表征许多新型结核分枝杆菌来源的蛋白质和蛋白质片段。本发明涉及其多肽及其免疫活性片段，编码它们的基因，免疫组合物如含有该多肽的诊断试剂。

7. 发明申请

US20050180947A1 Novel application of vaccination against TNF-alpha 审中-公开
标题翻译：针对TNF-α的新型应用
公开(公告)号：US20050180947A1
公开(公告)日：2005-08-18
申请号：US10939107
申请日：2004-09-10
申请人： Hans Pedersen , Bjarke Ebert , Louise Pedersen , Peter Rasmussen
发明人： Hans Pedersen , Bjarke Ebert , Louise Pedersen , Peter Rasmussen
IPC分类号： A61K38/19 , A61K39/00 , A61K48/00 , A61P25/00 , C07K16/24
CPC分类号： C07K16/241 , A61K38/191 , A61K39/0005 , A61K2039/505 , A61K2039/55577
摘要： The present invention relates to novel medical applications of down-regulation of tumour necrosis factor α (TNF-α) activity, especially novel applications of active immunization against TNF-a in order to reduce or alleviate pain. In particular, the present invention discloses novel methods for treating or ameliorating neuropathic pain.
摘要翻译：本发明涉及肿瘤坏死因子α（TNF-α）活性下调的新型医学应用，特别是针对TNF-α的主动免疫的新型应用以减轻或缓解疼痛。特别地，本发明公开了治疗或改善神经性疼痛的新方法。

8. 发明授权

US06781276B1 Generator for a windmill, stator module for use in such a generator and use of such a generator 有权
标题翻译：用于风车的发电机，用于这种发电机的定子模块和这种发电机的使用
公开(公告)号：US06781276B1
公开(公告)日：2004-08-24
申请号：US09937711
申请日：2001-10-01
申请人： Henrik Stiesdal , Peter Rasmussen
发明人： Henrik Stiesdal , Peter Rasmussen
IPC分类号： H02K112
CPC分类号： H02K7/1838 , F03D9/25 , F03D13/10 , F03D15/20 , F05B2220/7066 , F05B2230/60 , H02K1/148 , H02K5/10 , H02K15/0006 , H02K15/02 , H02K2201/03 , H02K2213/12 , Y02E10/725 , Y02P70/523
摘要： The invention concerns a generator for a windmill. The generator is of the kind being directly coupled to the main shaft of the wind rotor of the windmill. The generator is a stator consisting of a number of stator modules that are individual and which may be installed, repaired and dismantled individually and independently of each other. This implies that it is very easy and thereby cheaper to mount the mill, especially at sea, as the stator for the generator can be transported in smaller units, which also makes it easier to assemble the stator in the tower top section. By sequent repairs and other maintenance of the generator it is not necessary either to use large cranes, but it is sufficient to use smaller hoisting devices that may be handled by one or two persons.
摘要翻译：本发明涉及一种用于风车的发电机。发电机直接与风车风轮的主轴连接。发电机是由多个定子模块构成的定子，它们是单独的并且可以彼此独立且独立地安装，修理和拆卸。这意味着，由于用于发电机的定子可以以更小的单元运输，所以安装磨机非常容易，特别是在海上安装，这也使得更容易在塔顶部分中组装定子。通过对发电机进行后续修理和其他维护，无需使用大型起重机，但使用可由一个或两个人处理的较小起重装置就足够了。

9. 发明授权

US4746194A Method of mounting an end portion of an optical fibre in an optical fibre connector 失效
标题翻译：将光纤的端部安装在光纤连接器中的方法
公开(公告)号：US4746194A
公开(公告)日：1988-05-24
申请号：US751494
申请日：1985-07-03
申请人： Peter Rasmussen
发明人： Peter Rasmussen
IPC分类号： G02B6/36 , G02B6/38 , G02B6/00
CPC分类号： G02B6/3841 , G02B6/3861 , G02B6/3863
摘要： In a method for fixing an optical fibre in an optical fibre connector element the fibre is fixed therein by means of centering elements (22) and a curable material (28), for example an adhesive. The centering elements and the curable material are positioned between the envelope of an end portion of the optical fibre (6) and a surface portion (26) of the connector element surrounding said envelope. After the fixing of the fibre end portion in the connector element the end portion of the connector element including the centering elements (22) and the fibre end portion (6) are machined, for example ground, up to a plane (30) which is positioned inside the points of contact between the centering elements (22) and the fibre end portion (6) and between the centering elements (22) and the surface portion (26) of the connector element surrounding the fibre end portion.
摘要翻译：在将光纤固定在光纤连接器元件中的方法中，纤维通过定心元件（22）和可固化材料（28）例如粘合剂固定在其中。定心元件和可固化材料位于光纤（6）的端部的外壳和围绕所述外壳的连接器元件的表面部分（26）之间。在光纤端部固定在连接器元件中之后，包括对中元件（22）和光纤端部（6）的连接器元件的端部被加工成例如接地，直至平面（30）为止位于定心元件（22）和纤维端部（6）之间的接触点之间，以及围绕光纤端部的连接器元件的定心元件（22）和表面部分（26）之间。

10. 发明授权

US08540020B2 Converting organic matter from a subterranean formation into producible hydrocarbons by controlling production operations based on availability of one or more production resources 有权
标题翻译：通过基于一个或多个生产资源的可用性控制生产操作，将有机物质从地层转化为可生产的碳氢化合物
公开(公告)号：US08540020B2
公开(公告)日：2013-09-24
申请号：US12764624
申请日：2010-04-21
申请人： Matthew T. Stone , Ganesh Ghurye , Matthew T Shanley , Peter Rasmussen , Xianghui Huang , Robert D. Kaminsky
发明人： Matthew T. Stone , Ganesh Ghurye , Matthew T Shanley , Peter Rasmussen , Xianghui Huang , Robert D. Kaminsky
IPC分类号： E21B36/04
CPC分类号： E21B43/2401 , E21B43/2405 , E21B43/247
摘要： One or more methods, systems and computer readable mediums are utilized to provide treatment of a subterranean formation that contains solid organic matter, such as oil shale, tar sands, and/or coal formation. The treatment of the formation includes heating a treatment interval within the subterranean formation with one or more electrical in situ heaters. Available power, or other production resources, for the electrical heaters are determined at regular, predetermined intervals. Heating rates of the one or more electrical heaters are selectively controlled based on the determined available power at each regular, predetermined interval and based on an optimization model that outputs optimal heating rates for each of the electrical heaters at the determined available power.
摘要翻译：使用一种或多种方法，系统和计算机可读介质来提供含有固体有机物质的地层的处理，例如油页岩，焦油砂和/或煤的形成。地层的处理包括用一个或多个电气原位加热器加热地下地层内的处理间隔。以规定的预定间隔确定电加热器的可用功率或其他生产资源。基于在每个规则的预定间隔处确定的可用功率并且基于优化模型来选择性地控制一个或多个电加热器的加热速率，该优化模型以所确定的可用功率为每个电加热器输出最佳加热速率。

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