基本信息:
- 专利标题： Novel method for down-regulation of amyloid
- 专利标题（中）：用于下调淀粉样蛋白的新方法
- 申请号：US10783317 申请日：2004-02-20
- 公开(公告)号：US20050163744A1 公开(公告)日：2005-07-28
- 发明人： Peter Rasmussen , Martin Jensen , Klaus Nielsen , Peter Koefoed , Florence Degan
- 申请人： Peter Rasmussen , Martin Jensen , Klaus Nielsen , Peter Koefoed , Florence Degan
- 优先权： DKPA200101231 20010820; DKPA200200558 20020416
- 主分类号： C12N15/09
- IPC分类号： C12N15/09 ; A61K20060101 ; A61K35/74 ; A61K35/76 ; A61K38/00 ; A61K39/00 ; A61K39/02 ; A61K39/10 ; A61K39/12 ; A61K39/385 ; A61K39/39 ; A61K39/395 ; A61K45/06 ; A61K48/00 ; A61P20060101 ; A61P3/10 ; A61P25/00 ; A61P25/14 ; A61P25/16 ; A61P25/28 ; C07K20060101 ; C07K14/47 ; C07K19/00 ; C12N1/15 ; C12N1/19 ; C12N1/21 ; C12N5/10 ; C12Q1/68 ; G01N33/53 ; A61K38/17 ; A61K31/785 ; C07K14/705
摘要：
Disclosed are novel methods for combatting diseases characterized by deposition of amyloid. The methods generally rely on immunization against amyloid precursor protien (APP) or beta amyloid (Aβ). Immunization is preferably effected by administration of analogues of autologous APP or Aβ, said analogues being capable of inducing antibody production against the autologous amyloidogenic polypeptides. Especially preferred as an immunogen is autologous Aβ which has been modified by introduction of one single or a few foreign, immunodominant and promiscuous T-cell epitopes. Also disclosed are nucleic acid vaccination against APP or Aβ and vaccination using live vaccines as well as methods and means useful for the vaccination. Such methods and means include methods for the preparation of analogues and pharmaceutical formulations, as well as nucleic acid fragments, vectors, transformed cells, polypeptides and pharmaceutical formulations.
摘要（中）：
公开了以淀粉样蛋白淀积为特征的疾病的新型方法。 该方法通常依赖于针对淀粉样蛋白前体蛋白（APP）或β淀粉样蛋白（Abeta）的免疫。 免疫优选通过施用自体APP或Abeta的类似物来实现，所述类似物能够针对自体淀粉样蛋白多肽诱导抗体产生。 特别优选作为免疫原是通过引入一种或几种外来的免疫显性和混杂的T细胞表位而被修饰的自体Abeta。 还公开了针对APP或Abeta的核酸接种和使用活疫苗的疫苗接种以及用于疫苗接种的方法和装置。 这些方法和手段包括制备类似物和药物制剂以及核酸片段，载体，转化细胞，多肽和药物制剂的方法。