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1. 发明授权

US5900636A Dual-mode gamma camera system utilizing single-photon transmission scanning for attenuation correction of PET data 失效
标题翻译：双模γ相机系统利用单光子传输扫描对PET数据进行衰减校正
公开(公告)号：US5900636A
公开(公告)日：1999-05-04
申请号：US865916
申请日：1997-05-30
申请人： Peter Nellemann , Hugo Bertelsen , Lingxiong Shao , Horace H. Hines
发明人： Peter Nellemann , Hugo Bertelsen , Lingxiong Shao , Horace H. Hines
IPC分类号： G01T1/161 , G01T1/164 , G01T1/29 , G21K5/10
CPC分类号： G01T1/1611 , A61B6/037 , G01T1/1642 , G01T1/1648
摘要： A nuclear camera system includes a pair of detectors orientated 180 degrees apart about an axis of rotation for detecting radiation emitted from an object, a pair of single-photon radiation point sources for transmitting radiation through the object, each to a different detector, and a gantry supporting the detectors and the radiation sources. The gantry provides rotation of the detectors and the radiation source about the axis of rotation, such that the angular positions of the radiation source about the axis of rotation remain fixed relative to the angular positions of the detectors. The camera system further includes a processing system coupled to control the dectors and the radiation sources and to selectably configure the detectors for either coincidence or single-photon emission imaging. The processing system controls the detectors to acquire coincidence emission data of the object and controls the single-photon point sources to acquire transmission data of the object, wherein the radiation from the point sources has a fanbeam illumination profile. The processing system corrects the acquired coincidence emission data for attenuation using the transmission data.
摘要翻译：核相机系统包括一对围绕旋转轴定向180度的检测器，用于检测从物体发射的辐射;一对单光子辐射点源，用于将辐射通过物体传送到不同的检测器;以及龙门架支持探测器和辐射源。台架提供检测器和辐射源围绕旋转轴的旋转，使得辐射源围绕旋转轴线的角位置相对于检测器的角位置保持固定。相机系统还包括耦合以控制分界器和辐射源的处理系统，并且可选地配置用于重合或单光子发射成像的检测器。处理系统控制检测器以获取对象的重合发射数据，并控制单光点点源以获取对象的传输数据，其中来自点源的辐射具有扇形照明轮廓。处理系统使用传输数据来校正获得的用于衰减的重合发射数据。

2. 发明授权

US5999588A Deadtime correction in a nuclear medicine imaging system 失效
标题翻译：核医学成像系统中的死时校正
公开(公告)号：US5999588A
公开(公告)日：1999-12-07
申请号：US62222
申请日：1998-04-17
申请人： Lingxiong Shao , Peter Nellemann , David Coles , Hugo Bertelsen , Jacobus Koster
发明人： Lingxiong Shao , Peter Nellemann , David Coles , Hugo Bertelsen , Jacobus Koster
IPC分类号： G01T1/164 , G01T20060101 , G01T1/161 , G01T1/20 , G06T5/00
CPC分类号： G01T1/1647 , G01T1/171
摘要： A method of correcting for deadtime in an attenuation map generated by a nuclear medicine imaging system is provided. The imaging system includes a gamma ray detector that is rotatable about an object to be imaged. A region is defined on the imaging surface of the detector, such as the edge of the field of view of the detector, such that during a transmission scan of the object, the radiation shadow of the object is substantially less likely to fall upon the defined region than upon other regions of the imaging surface. A blank transmission scan is then performed, including recording the radiation intensity level detected in the region as a reference intensity level. A transmission scan of the object is then performed to acquire an attenuation map of the object, including recording a radiation intensity level detected in the first region during the transmission scan. A correction value is then determined as the ratio of the reference intensity level to the intensity level detected in the region during the transmission scan. The attenuation map is then corrected for deadtime based on the correction value.
摘要翻译：提供了一种校正由核医学成像系统生成的衰减图中的死时间的方法。成像系统包括可围绕待成像对象旋转的伽马射线检测器。区域被定义在检测器的成像表面上，例如检测器视场的边缘，使得在物体的透射扫描期间，物体的辐射阴影实际上不太可能落在所定义的区域比成像表面的其他区域。然后执行空白传输扫描，包括将在该区域中检测到的辐射强度水平记录为参考强度水平。然后执行对象的传输扫描以获取对象的衰减图，包括记录在传输扫描期间在第一区域中检测到的辐射强度级别。然后将校正值确定为在透射扫描期间在该区域中检测到的基准亮度水平与强度水平的比率。然后根据校正值对衰减图进行死区校正。

3. 发明授权

US5834779A Method and apparatus for performing correction for random coincidences in a medical imaging system 失效
标题翻译：用于在医疗成像系统中进行随机重合的校正的方法和装置
公开(公告)号：US5834779A
公开(公告)日：1998-11-10
申请号：US866355
申请日：1997-05-30
申请人： Lingxiong Shao , Horace H. Hines
发明人： Lingxiong Shao , Horace H. Hines
IPC分类号： G01T1/164 , G01T1/29 , G01T1/20
CPC分类号： G01T1/1611 , G01T1/1603 , G01T1/1648 , G01T1/2985
摘要： A method of correcting coincidence data for random coincidences in a nuclear medicine imaging system is provided. The system includes a pair of detectors that are rotatable about an axis, with an object to be imaged disposed about the axis. During an imaging session, the detectors detect coincidence radiation emitted from the object at a plurality of angular stops relative to the axis. While rotating the detectors between stops, the detectors are reconfigured for single-photon data acquisition and are used to detect radiation in singles mode. The detected singles are rebinned into a plurality of randoms sinograms, which are used to correct the coincidence data.
摘要翻译：提供了一种在核医学成像系统中校正随机重合的符合数据的方法。该系统包括可绕轴线旋转的一对检测器，其中待成像的物体绕轴线布置。在成像会话期间，检测器检测从物体在相对于轴线的多个角度停止点处发射的重合辐射。当在停止之间旋转检测器时，检测器被重新配置用于单光子数据采集，并且用于以单一模式检测辐射。检测到的单词被重新组合成用于校正重合数据的多个随机正弦图。

4. 发明授权

US6008493A Method and apparatus for performing correction of emission contamination and deadtime loss in a medical imaging system 失效
标题翻译：用于执行医疗成像系统中的排放污染和死时间损失校正的方法和装置
公开(公告)号：US6008493A
公开(公告)日：1999-12-28
申请号：US865930
申请日：1997-05-30
申请人： Lingxiong Shao , Hugo Bertelsen , Peter Nelleman , Horace Hines
发明人： Lingxiong Shao , Hugo Bertelsen , Peter Nelleman , Horace Hines
IPC分类号： G01T1/161 , G01T1/17 , G01T1/29 , G01T1/166
CPC分类号： G01T1/1611 , G01T1/171 , G01T1/2985
摘要： A method of correcting for deadtime and for emission contamination of a transmission scan in a nuclear camera system is provided. The transmission scan is used to correct positron emission tomography (PET) images for attenuation. The camera system includes two detectors and two corresponding single-photon point sources that are collimated to produce fanbeam illumination profiles. A transmission detection window and an emission contamination detection window is defined on each detector. Radiation from each source is scanned axially across the field of view of the corresponding detector in synchronization with the corresponding transmission detection window to acquire transmission projection data. The emission contamination detection windows are also scanned axially concurrently with, but offset from, the transmission detection windows to acquire emission data. Events detected in the transmission detection windows are used to add counts from appropriate locations of the transmission projection on an event-by-event basis as those events are detected. Events detected in the emission contamination detection windows are used to subtract counts from appropriate locations of the transmission projection on an event-by-event basis as those events are detected. The number of counts by which a given location is incremented or decremented for each detected event is determined event-by-event from a look-up table based on the current singles rate.
摘要翻译：提供了一种校正核相机系统中的发射扫描的死区时间和发射污染的方法。透射扫描用于校正正电子发射断层摄影（PET）图像以进行衰减。相机系统包括两个检测器和两个对准的单光子点源，其被准直以产生扇形照明轮廓。在每个检测器上定义传输检测窗口和排放污染检测窗口。与对应的传输检测窗口同步地从相应检测器的视野轴向扫描来自每个源的辐射以获取传输投影数据。排放污染检测窗口也与传输检测窗口轴向同时扫描但偏移以获取发射数据。在发送检测窗口中检测到的事件用于在检测到事件时逐个事件的基础上从传输投影的适当位置添加计数。在发射污染检测窗口中检测到的事件用于在检测到事件时逐个事件基础上从传输投影的适当位置减去计数。基于当前单打率，从查找表中逐个事件确定给定位置对于每个检测到的事件递增或递减的计数次数。

5. 发明授权

US5990482A Method and apparatus for performing correction of transmission self-contamination in a medical imaging system 失效
标题翻译：用于执行医疗成像系统中的传输自身污染的校正的方法和装置
公开(公告)号：US5990482A
公开(公告)日：1999-11-23
申请号：US865918
申请日：1997-05-30
申请人： Hugo Bertelsen , Lingxiong Shao
发明人： Hugo Bertelsen , Lingxiong Shao
IPC分类号： G01T1/164 , G01T1/166
CPC分类号： G01T1/1648
摘要： A method of acquiring transmission self-contamination data for correcting transmission scan data in a nuclear camera system including two transmission radiation sources and two scintillation detectors. A first source is for transmitting radiation to only a first detector and a second source is for transmitting radiation to only a second detector during a transmission scan of an object to be imaged. To acquire the calibration data, radiation is transmitted from the second source to the second detector while the first source is maintained in a non-transmitting state. While the second source is transmitting, the first detector is used to detect the radiation transmitted from the second source. A set of self-contamination data is then generated based on the radiation from the second source detected with the first detector. The calibration data is used to correct a subsequent transmission scan of the object by subtracting the self-contamination data from the transmission scan data.
摘要翻译：一种获取用于校正包括两个发射辐射源和两个闪烁检测器的核相机系统中的传输扫描数据的传输自身污染数据的方法。第一来源是用于将辐射传输到仅第一检测器，并且第二源用于在待成像对象的透射扫描期间仅向第二检测器发射辐射。为了获取校准数据，辐射从第二源发送到第二检测器，同时第一源保持在非发射状态。当第二个信号源正在传输时，第一个检测器用于检测从第二个信号源发射的辐射。然后基于用第一检测器检测到的来自第二源的辐射产生一组自污染数据。校准数据用于通过从传输扫描数据中减去自身污染数据来校正对象的后续传输扫描。

6. 发明授权

US06410920B1 Method and apparatus for performing correction of emission contamination and deadtime loss in a medical imaging system 失效
标题翻译：用于执行医疗成像系统中的排放污染和死时间损失校正的方法和装置
公开(公告)号：US06410920B1
公开(公告)日：2002-06-25
申请号：US09400745
申请日：1999-09-21
申请人： Lingxiong Shao , Hugo Bertelsen , Peter Nelleman , Horace Hines
发明人： Lingxiong Shao , Hugo Bertelsen , Peter Nelleman , Horace Hines
IPC分类号： G01T1164
CPC分类号： G01T1/2985 , A61B6/00 , A61B6/037 , G01T1/1611 , G01T1/171
摘要： A method of correcting for deadtime and for emission contamination of a transmission scan in a nuclear camera system is provided. The transmission scan is used to correct positron emission tomography (PET) images for attenuation. The camera system includes two detectors and two corresponding single-photon point sources that are collimated to produce fanbeam illumination profiles. A transmission detection window and an emission contamination detection window is defined on each detector. Radiation from each source is scanned axially across the field of view of the corresponding detector in synchronization with the corresponding transmission detection window to acquire transmission projection data. The emission contamination detection windows are also scanned axially concurrently with, but offset from, the transmission detection windows to acquire emission data. Events detected in the transmission detection windows are used to add counts from appropriate locations of the transmission projection on an event-by-event basis in real-time. Events detected in the emission contamination detection windows are used to subtract counts from appropriate locations of the transmission projection on an event-by-event basis as those events are detected. The number of counts by which a given location is incremented or decremented for each detected event is determined event-by-event from a look-up table based on the current singles rate.
摘要翻译：提供了一种校正核相机系统中的发射扫描的死区时间和发射污染的方法。透射扫描用于校正正电子发射断层摄影（PET）图像以进行衰减。相机系统包括两个检测器和两个对准的单光子点源，其被准直以产生扇形照明轮廓。在每个检测器上定义传输检测窗口和排放污染检测窗口。与对应的传输检测窗口同步地从相应检测器的视野轴向扫描来自每个源的辐射以获取传输投影数据。排放污染检测窗口也与传输检测窗口轴向同时扫描但偏移以获取发射数据。在传输检测窗口中检测到的事件用于实时地逐个事件地从传输投影的适当位置添加计数。在发射污染检测窗口中检测到的事件用于在检测到事件时逐个事件基础上从传输投影的适当位置减去计数。基于当前单打率，从查找表中逐个事件确定给定位置对于每个检测到的事件递增或递减的计数次数。

7. 发明授权

US09492123B2 Molecular imaging apparatus and method 有权
标题翻译：分子成像装置及方法
公开(公告)号：US09492123B2
公开(公告)日：2016-11-15
申请号：US12302929
申请日：2007-05-24
申请人： Lingxiong Shao , Douglas B. McKnight
发明人： Lingxiong Shao , Douglas B. McKnight
IPC分类号： A61B6/03 , A61B5/00 , A61B6/00
CPC分类号： A61B6/03 , A61B5/0013 , A61B6/00
摘要： A nuclear imaging chain (100) includes a molecular agent (102), an acquisition system (104), a reconstruction system (106), a detection system (108), and a display system (110). The various components of the imaging chain are optimized according to desired optimization criteria. The optimized characteristics of the imaging chain (100) may include one or more an agent characteristic, an acquisition characteristic (127), a reconstruction characteristic (143), a detection characteristic (159), and a display characteristic.
摘要翻译：核成像链（100）包括分子试剂（102），采集系统（104），重建系统（106），检测系统（108）和显示系统（110）。成像链的各种组件根据期望的优化标准进行优化。成像链（100）的优化特征可以包括一个或多个代理特征，获取特征（127），重建特性（143），检测特性（159）和显示特性。

8. 发明申请

US20080226149A1 Motion Compensation in Functional Imaging 有权
标题翻译：功能成像中的运动补偿
公开(公告)号：US20080226149A1
公开(公告)日：2008-09-18
申请号：US11997410
申请日：2006-07-27
申请人： Hans-Aloys Wischmann , Lingxiong Shao , Angela Da Silva , Ingwer-Curt Carlsen , Carsten Meyer
发明人： Hans-Aloys Wischmann , Lingxiong Shao , Angela Da Silva , Ingwer-Curt Carlsen , Carsten Meyer
IPC分类号： G01T1/164 , A61B5/00
CPC分类号： A61B6/503 , A61B5/113 , A61B5/7289 , A61B6/037 , A61B6/5235 , A61B6/541 , A61B8/0883 , G06F19/00 , G06T7/20 , G06T11/005 , G06T2207/30004 , G06T2211/412
摘要： Medical images are collected in a plurality of cardiac and respiratory phases. The images are transformed into a series of respiratory compensated images with the plurality of cardiac phases, but all at a common respiration phase. The series of respiratory compensated images are transformed into one image at a selected cardiac phase and the common respiration phase. In some embodiments, a database of gated transform matrices is generated. The database may be based on specific patient information or on information generated from a pool of patients. The database may account for respiratory motion, cardiac contractile motion, other physiological motion, or combinations thereof. For a current image to be motion corrected, the transformation matrices collected in the database are used to estimate a current set of transformation matrices accounting for the motion in the current image, and a motion-compensated image is generated based on the current set of transform matrices.
摘要翻译：在多个心脏和呼吸相中收集医学图像。图像被转换成具有多个心脏相的一系列呼吸补偿图像，但都在共同的呼吸阶段。一系列呼吸补偿图像在选定的心脏相和共同的呼吸期转化为一个图像。在一些实施例中，生成门控变换矩阵的数据库。数据库可以基于具体的患者信息或从患者池产生的信息。数据库可以解释呼吸运动，心脏收缩运动，其他生理运动或其组合。对于要进行运动校正的当前图像，使用在数据库中收集的变换矩阵来估计当前图像中运动的当前转换矩阵，并且基于当前变换集合生成运动补偿图像矩阵。

9. 发明授权

US06403960B1 Correction for spatial variations of deadtime of a monolithic scintillator based detector in a medical imaging system 失效
标题翻译：校正基于单片闪烁体的检测器在医学成像系统中的死区时间的空间变化
公开(公告)号：US06403960B1
公开(公告)日：2002-06-11
申请号：US09302161
申请日：1999-04-29
申请人： Donald R. Wellnitz , Michael J. Petrillo , Lingxiong Shao
发明人： Donald R. Wellnitz , Michael J. Petrillo , Lingxiong Shao
IPC分类号： G01T1164
CPC分类号： G01T1/171
摘要： A nuclear medicine imaging system includes the capability to correct for the deadtime, including the capability to correct for spatial variations in deadtime across the imaging surface of a detector. The imaging system includes one or more radiation detectors, each using a large, monolithic scintillation crystal. Each detector has deadtime associated with it. A given detector is used to acquire an energy profile of a patient based on emission radiation. The detector includes a number of timing channels. The energy profile is used to select a zone influence map indicating the extent of spatial overlap in response between the various timing channels. Emission data of the patient is then acquired during an emission scan. During acquisition of the emission data, a rate meter assigned to each timing channel samples the number of counts associated with each timing channel to acquire deadtime data. A unique deadtime function is provided for each unique zone represented in the zone influence map, including each region of overlap. The deadtime data acquired from the rate meters are then applied to the deadtime functions to correct the emission data for deadtime on a pixel-by-pixel basis. An image is generated based on the deadtime-corrected data.
摘要翻译：核医学成像系统包括校正死时间的能力，包括校正跨越检测器的成像表面的死时间的空间变化的能力。成像系统包括一个或多个辐射检测器，每个使用大的单片闪烁晶体。每个检测器都有与之相关的死区。给定的检测器用于基于发射辐射来获取患者的能量分布。检测器包括多个定时通道。能量分布用于选择区域影响图，指示各种定时通道之间响应的空间重叠程度。然后在发射扫描期间获取患者的排放数据。在获取排放数据期间，分配给每个定时通道的速率计对与每个定时通道相关联的计数进行采样以获取死区数据。为区域影响图中表示的每个独特区域提供独特的死区功能，包括每个重叠区域。然后将从速率计获得的死区时间数据应用于死区时间功能，以逐个像素为基础校正死时间的发射数据。基于死时间校正数据生成图像。

10. 发明授权

US5998793A Method and apparatus for correcting for random coincidences in a nuclear medicine imaging system 失效
标题翻译：用于校正核医学成像系统中的随机巧合的方法和装置
公开(公告)号：US5998793A
公开(公告)日：1999-12-07
申请号：US62226
申请日：1998-04-17
申请人： Lingxiong Shao , David Coles
发明人： Lingxiong Shao , David Coles
IPC分类号： G01T1/164 , G01T1/20
CPC分类号： G01T1/1647
摘要： A method and apparatus for correcting for random coincidences in a gamma camera imaging system are provided, based on the distribution of the object to be imaged as well as the measured singles and coincidence rates. Gamma radiation emitted from the object is detected for multiple projection angles, including detection of a plurality of coincidence events, to generate an object profile. The singles rate and the coincidence rate are also measured for each of the projection angles. A randoms distribution representing random coincidences in the detected coincidence events is then determined, including computing a randoms profile as the convolution of the object profile and a Gaussian function. The determination of the randoms distribution further includes computing a randoms fraction for each of the projection angles based on the measured singles rate and the measured coincidence rate, and then computing the randoms distribution based on the randoms profile and the randoms fraction for each of the projection angles. The coincidence projection data are corrected based on the randoms distribution prior to generating emission images.
摘要翻译：基于待成像对象的分布以及测量的单个和一致率，提供了用于校正伽马相机成像系统中的随机重合的方法和装置。检测从对象发射的伽马辐射用于多个投影角度，包括检测多个重合事件，以产生对象轮廓。对于每个投影角度也测量单打速率和一致率。然后确定在检测到的重合事件中表示随机符合的随机分布，包括计算随机分布作为对象分布的卷积和高斯函数。随机分布的确定还包括基于所测量的单数率和测量的一致率来计算每个投影角度的随机分数，然后基于随机分布和每个投影的随机分数来计算随机分布角度。基于在产生发射图像之前的随机分布来校正重合投影数据。

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