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1. 发明授权

US06719791B1 Device for the axial transport of fluid media 有权
标题翻译：流体介质的轴向输送装置
公开(公告)号：US06719791B1
公开(公告)日：2004-04-13
申请号：US09959044
申请日：2001-12-31
申请人： Peter Nüsser , Johannes Müller , Hans-Erhard Peters , Norbert Buske , Werner Neumann , Kurt Graichen , Conrad Kauffeldt
发明人： Peter Nüsser , Johannes Müller , Hans-Erhard Peters , Norbert Buske , Werner Neumann , Kurt Graichen , Conrad Kauffeldt
IPC分类号： A61M110
CPC分类号： F16J15/43 , A61M1/101 , A61M1/1012 , A61M1/102 , A61M1/1029 , A61M1/1031 , A61M1/122 , Y10S415/90
摘要： The invention provides a device for the axial delivery of fluidal mediums, which outer diameter is not or only insignificantly larger than the diameter of the fluid carrying pipe, which reduces to a large extent a shearing and vortexing of the fluid. A device for the axial delivery of fluidal mediums, having a tubular hollow body arrangement, in which delivery area, an impeller (9) with a blading, which can be rotated, is arranged and also has a fluid directional means. A motor (2), at least one impeller (9) which can be rotated, and at least one motor mounting (14) are arranged in a tubular hollow body (1) of the hollow body arrangement. The impeller (9) is connected axially force-fittingly and/or form-fittingly to the motor (2).
摘要翻译：本发明提供了用于轴向输送流体介质的装置，其外径不是或仅显着大于流体输送管的直径，这在很大程度上减少了流体的剪切和涡流。用于轴向输送流体介质的装置，具有管状中空主体装置，其中输送区域具有可旋转的叶片的叶轮（9）并且还具有流体定向装置。电动机（2），至少一个可旋转的叶轮（9）和至少一个电动机安装件（14）布置在中空体装置的管状空心体（1）中。叶轮（9）轴向力与/或成形方式连接到电动机（2）上。

2. 发明授权

US6074365A Ferrofluid-supported electromagnetic drive for a blood pump for supporting the heart or partially or totally replacing the heart 失效
标题翻译：用于血泵的铁磁流体支持的电磁驱动器用于支撑心脏或部分或完全替代心脏
公开(公告)号：US6074365A
公开(公告)日：2000-06-13
申请号：US945780
申请日：1998-01-26
申请人： Thomas Hahndel , Hanns-Dietrich Stahlmann , Arnim Nethe , Johannes Muller , Norbert Buske , Armin Rehfeld
发明人： Thomas Hahndel , Hanns-Dietrich Stahlmann , Arnim Nethe , Johannes Muller , Norbert Buske , Armin Rehfeld
IPC分类号： F04B43/08 , A61M1/10 , H01F1/44 , A61M1/00
CPC分类号： H01F1/442 , A61M1/1053 , A61M1/1055 , A61M1/106
摘要： The invention relates to a magnetofluid-supported electromagnetic drive for a blood pump for supporting or partially to totally replacing the heart whereby the blood pump in its weight as well as its energy density nearly corresponds to the natural heart and is especially suitable for an implantation whereby a reduction of the total system in comparison with known systems is to be made possible and the efficiency is improved at the same time. This task is solved by the blood pump having a magnetofluid-supported electromagnetic drive consisting of one or several electromagnets and force-transforming facilities and with the space of at least one electromagnetic circuit being completely or partially filled with magnetofluid, whereby the poles show permanent-magnetic properties. Thereby, a magnetofluid with a saturation magnetization of 150 to 450 mT has been used with an initial permeability of 5 to 25.
摘要翻译： PCT No.PCT / DE97 / 00441 Sec。 371日期1998年1月26日 102（e）日期1998年1月26日PCT 1997年2月27日提交PCT公布。公开号WO97 / 31662 日期1997年9月4日本发明涉及一种用于血泵的磁流体支持的电磁驱动器，用于支撑或部分地完全替代心脏，由此血液泵的重量以及其能量密度几乎对应于天然心脏，特别是适于植入，与已知系统相比，总体系统的减少将成为可能，同时提高效率。这个任务由具有由一个或多个电磁体和力转换设备构成的磁流体支持的电磁驱动的血泵解决，并且至少一个电磁线圈的空间被完全或部分地填充有磁流体，由此，磁性能。因此，使用饱和磁化强度为150〜450mT的磁流体，初始磁导率为5〜25。

3. 发明申请

US20050087719A1 Magnetic nanodispersion with cyclodextrines and method for the production thereof 审中-公开
标题翻译：具有环糊精的磁性纳米分散体及其制备方法
公开(公告)号：US20050087719A1
公开(公告)日：2005-04-28
申请号：US10493954
申请日：2002-10-28
申请人： Christian Gansau , Norbert Buske , Thomas Gotze
发明人： Christian Gansau , Norbert Buske , Thomas Gotze
IPC分类号： B82B1/00 , A61K9/10 , A61K9/51 , A61K47/40 , A61K47/48 , A61K49/00 , A61K49/18 , B01F17/38 , B82B3/00 , C09C1/00 , H01F1/34 , H01F1/00 , B05D5/12 , B32B5/16
CPC分类号： B82Y5/00 , A61K47/6923 , A61K47/6951 , A61K49/1863 , A61K49/189 , Y10T428/2991
摘要： Substituted and non-substituted cyclodextrines are used as stabilizing agents for nanodispersions containing magnetic core particles M. The nanodispersions, which exhibit high saturation polarization with great biocompatibility, are suitable as transport vehicles for other pharmacologically and biologically active substances. The magnetic core particles of the nanodispersions are enveloped by compounds of the general formula (Ap, C, Bq), wherein A is reactive groups, B is bioactive groups and C is cyclodextrines.
摘要翻译：取代和未取代的环糊精用作含有磁芯颗粒M的纳米分散体的稳定剂。显示出高生物相容性的高饱和极化的纳米分散体适用于其它药理学和生物活性物质的运输载体。纳米分散体的磁芯颗粒被通式（A，B，C，B Q q）的化合物包围，其中A是反应性基团，B是生物活性基团， C是环糊精。

4. 发明授权

US06767635B1 Magnetic nanoparticles having biochemical activity, method for the production thereof and their use 失效
标题翻译：具有生化活性的磁性纳米颗粒，其生产方法及其用途
公开(公告)号：US06767635B1
公开(公告)日：2004-07-27
申请号：US10088437
申请日：2002-05-24
申请人： Michael Bahr , Dimitri Berkov , Norbert Buske , Joachim Clement , Peter Görnert , Klaus Höffken , Kay-Oliver Kliche , Thomas Kober , Matthias Schnabelrauch , Sebastian Vogt , Kerstin Wagner , Christian Gansau
发明人： Michael Bahr , Dimitri Berkov , Norbert Buske , Joachim Clement , Peter Görnert , Klaus Höffken , Kay-Oliver Kliche , Thomas Kober , Matthias Schnabelrauch , Sebastian Vogt , Kerstin Wagner , Christian Gansau
IPC分类号： B32B516
CPC分类号： B82Y5/00 , A61K47/6923 , Y10T428/2982 , Y10T428/2989 , Y10T428/2991 , Y10T428/2998
摘要： The invention relates to magnetic nanoparticles, their production, and their use. The object of the invention is to provide nanoparticles capable of specifically forming bonds to intracellular biomacromolecules even in the intracellular region of cells, so that separation is possible by exposure to an exterior magnetic field. This is accomplished by means of magnetic nanoparticles having biochemical activity, consisting of a magnetic core particle and an envelope layer fixed to the core particle, and including a compound of general formula M-S-L-Z (I), the linkage sites between S and L and L and Z having covalently bound functional groups, wherein M represents said magnetic core particle; S represents a biocompatible substrate fixed to M; L represents a linker group; and Z represents a group comprised of nucleic acids, peptides or proteins or derivatives thereof, which group has at least one structure capable of specifically binding to a binding domain of an intracellular biomacromolecule.
摘要翻译：本发明涉及磁性纳米颗粒及其制备及其用途。本发明的目的是提供即使在细胞的细胞内区域也能特异性地形成与细胞内生物大分子的结合的纳米粒子，从而可以通过暴露于外部磁性这是通过具有生物化学活性的磁性纳米颗粒来实现的，该磁性纳米颗粒由固定在核心颗粒上的磁芯颗粒和包膜层组成，并且包括通式MSLZ（I）的化合物，S和L之间的连接位点和 L和Z具有共价结合的官能团，其中M表示所述磁芯颗粒; S表示固定于M的生物相容性底物; L表示连接基团; Z表示由核酸，肽或蛋白质或其衍生物组成的组，该基团具有至少一种能够特异性结合细胞内生物大分子的结合结构域的结构。

5. 发明授权

US5957298A Process and device for separating non-magnetic materials and objects by using ferrohydrodynamic fluid 失效
标题翻译：通过使用铁水动力流体分离非磁性材料和物体的方法和装置
公开(公告)号：US5957298A
公开(公告)日：1999-09-28
申请号：US591668
申请日：1996-05-03
申请人： Norbert Buske , Dirk Gunther , Hendrik E. Bohme , Karsten Thiessen
发明人： Norbert Buske , Dirk Gunther , Hendrik E. Bohme , Karsten Thiessen
IPC分类号： B03C1/32 , H01F1/44 , B03C1/30
CPC分类号： B82Y30/00 , B03C1/32 , H01F1/445
摘要： The invention describes a process and an appliance for separating non-magnetic materials and objects with the use of magnetic fluids. With this invention a restoration of the magnetic fluid adhering to the separated material is made possible, by removing the magnetic liquid still adhering to the separated product both through magnets as well as through water. The magnetic fluid in the separating chambers is constantly monitored as regards volume and concentration via a monitoring installation. An appropriate area of use for the invention is the separation of fragmented materials, the separation of capacitors in capacitators containing polychlorinated biphenylenes (PCB) and PCB-free capacitors. The invention described, moreover, the composition, manufacture and use of environment-friendly diluted magneto-fluids, which can be especially suitable in employment in the separation of non-magnetic materials using the sink-float process in the magnetic field gradient.
摘要翻译： PCT No.PCT / EP94 / 02404 Sec。 371日期：1996年5月3日 102（e）日期1996年5月3日PCT 1994年7月21日PCT公布。 WO95 / 03128 PCT出版物日期1995年2月2日本发明描述了使用磁性流体分离非磁性材料和物体的方法和设备。通过本发明，通过除了通过磁体以及通过水除去仍然附着在分离的产物上的磁性液体，可以使附着在分离材料上的磁性流体的恢复成为可能。通过监控设备，不断监测分离室内的磁性流体体积和浓度。用于本发明的合适的使用领域是分离碎片材料，分离含有多氯联苯（PCB）和无PCB电容器的电容器中的电容器。此外，本发明还描述了环境友好的稀释磁流体的组成，制造和使用，其特别适合于在磁场梯度中使用凹陷浮动工艺分离非磁性材料。

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