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1. 发明授权

US08469233B2 Dispensing device, kit containing the device, and method of operating the device 有权
标题翻译：分配装置，包含装置的工具包和操作装置的方法
公开(公告)号：US08469233B2
公开(公告)日：2013-06-25
申请号：US12988472
申请日：2009-04-16
申请人： Peter Lutz , Annemie Rehor
发明人： Peter Lutz , Annemie Rehor
IPC分类号： B67B1/00
CPC分类号： A61M5/31501 , A61J1/201 , A61J1/2058 , A61J1/2096 , A61M5/19 , A61M5/284 , A61M5/3134 , A61M5/50 , A61M2005/31506 , A61M2005/31508
摘要： The application relates to a dispensing device (1) containing at least one chamber (5, 5′) for receiving a fluid (B, B′), a plunger unit (6) including at least one piston (7, 7′), locking mechanism and counter-locking mechanism as well as a catching mechanism and counter-catching mechanism. The locking mechanism and the counter-locking mechanism can be brought into a locking position (L), in which a movement of the plunger unit (6) in one or both directions is substantially prevented. The catching mechanism and the counter-catching mechanism can be brought into an engagement position (E), in which the locking mechanism and the counter-locking mechanism cannot be brought into the locking position (L). Furthermore, the application relates to a kit (19) containing the dispensing device (1) and to a method of operating the device (1) or kit (19).
摘要翻译：本申请涉及一种分配装置（1），其包含用于接收流体（B，B'）的至少一个腔室（5,5'），包括至少一个活塞（7,7'）的柱塞单元（6）锁定机构和反锁定机构以及捕捉机构和反捕获机构。锁定机构和反向锁定机构可以进入锁定位置（L），其中基本上防止了柱塞单元（6）在一个或两个方向上的移动。捕获机构和反扣机构可以进入接合位置（E），其中锁定机构和反向锁定机构不能进入锁定位置（L）。此外，本申请涉及包含分配装置（1）的套件（19）和操作装置（1）或套件（19）的方法。

2. 发明申请

US20110049181A1 DISPENSING DEVICE, KIT CONTAINING THE DEVICE, AND METHOD OF OPERATING THE DEVICE 有权
标题翻译：分配设备，包含设备的套件以及操作设备的方法
公开(公告)号：US20110049181A1
公开(公告)日：2011-03-03
申请号：US12988472
申请日：2009-04-16
申请人： Peter Lutz , Annemie Rehor
发明人： Peter Lutz , Annemie Rehor
IPC分类号： B67D7/06 , B67D7/74 , B67D7/00
CPC分类号： A61M5/31501 , A61J1/201 , A61J1/2058 , A61J1/2096 , A61M5/19 , A61M5/284 , A61M5/3134 , A61M5/50 , A61M2005/31506 , A61M2005/31508
摘要： The application relates to a dispensing device (1) containing at least one chamber (5, 5′) for receiving a fluid (B, B′), a plunger unit (6) comprising at least one piston (7, 7′), locking means and counter-locking means as well as catching means and counter-catching means. The locking means and the counter-locking means can be brought into a locking position (L), in which a movement of the plunger unit (6) in one or both directions is substantially prevented. The catching means and the counter-catching means can be brought into an engagement position (E), in which the locking means and the counter-locking means cannot be brought into the locking position (L). Furthermore, the application relates to a kit (19) containing the dispensing device (1) and to a method of operating the device (1) or kit (19).
摘要翻译：该应用涉及一种分配装置（1），其包含用于接收流体（B，B'）的至少一个腔室（5,5'），包括至少一个活塞（7,7'）的柱塞单元（6）锁定装置和反锁定装置以及捕捉装置和反扣装置。锁定装置和反向锁定装置可以进入锁定位置（L），其中基本上防止了柱塞单元（6）在一个或两个方向上的移动。捕捉装置和反扣装置可以进入接合位置（E），其中锁定装置和反向锁定装置不能进入锁定位置（L）。此外，本申请涉及包含分配装置（1）的套件（19）和操作装置（1）或套件（19）的方法。

3. 发明授权

US08961947B2 Polymeric tissue sealant 有权
标题翻译：聚合物组织密封剂
公开(公告)号：US08961947B2
公开(公告)日：2015-02-24
申请号：US12102157
申请日：2008-04-14
申请人： Annemie Rehor , Simona Cerritelli
发明人： Annemie Rehor , Simona Cerritelli
IPC分类号： A61K31/74 , A61L31/06 , A61L24/04 , C08G65/332 , C08G65/333 , C08G65/334 , C08L71/02
CPC分类号： A61L24/046 , A61K47/34 , A61L24/0042 , A61L31/06 , A61L2400/04 , C08G63/00 , C08G65/3322 , C08G65/33306 , C08G65/3342 , C08G2650/58 , C08L71/02 , C08L2666/22
摘要： Methods for making biomaterials for use as a tissue sealant, kits containing precursors for forming the biomaterials, and the resulting biomaterials are described herein. The biomaterials are formed from a composition comprising at least a first and a second precursor molecule, wherein: i) the first precursor molecule is a poly(ethylene glycol) based polymer having x nucleophilic groups selected from the group consisting of thiol or amino groups, wherein x is greater than or equal to 2 ii) the second precursor molecule is of the general formula: A-[(C3H6O)n—(C2H4O)m—B]i wherein m and n are integers from 1 to 200 i is greater than 2 A is a branch point B is a conjugated unsaturated group The precursors are selected based on the desired properties of the biomaterial. Optionally, the biomaterials contain additives, such as thixotropic agents, radiopaque agents, or bioactive agents. In the preferred embodiment, the biomaterials are used to reduce, inhibit, or contain loss of a biological fluid or gas in a patient.
摘要翻译：用于制备用作组织密封剂的生物材料的方法，包含用于形成生物材料的前体的试剂盒以及所得生物材料在本文中描述。生物材料由包含至少第一和第二前体分子的组合物形成，其中：i）第一前体分子是具有选自硫醇或氨基的x个亲核基团的聚（乙二醇）基聚合物，其中x大于或等于2 ii）第二前体分子具有以下通式：A - [（C 3 H 6 O）n - （C 2 H 4 O）m -B] i，其中m和n是1至200i的整数更大优于2 A是分支点B是共轭不饱和基团根据生物材料的所需性质选择前体。任选地，生物材料含有添加剂，例如触变剂，不透射线剂或生物活性剂。在优选的实施方案中，生物材料用于减少，抑制或含有患者体内的生物流体或气体的损失。

4. 发明申请

US20080253987A1 POLYMERIC TISSUE SEALANT 有权
标题翻译：聚合组织密封剂
公开(公告)号：US20080253987A1
公开(公告)日：2008-10-16
申请号：US12102157
申请日：2008-04-14
申请人： Annemie Rehor , Simona Cerritelli
发明人： Annemie Rehor , Simona Cerritelli
IPC分类号： A61K31/765 , C08L71/00 , A61P41/00
CPC分类号： A61L24/046 , A61K47/34 , A61L24/0042 , A61L31/06 , A61L2400/04 , C08G63/00 , C08G65/3322 , C08G65/33306 , C08G65/3342 , C08G2650/58 , C08L71/02 , C08L2666/22
摘要： Methods for making biomaterials for use as a tissue sealant, kits containing precursors for forming the biomaterials, and the resulting biomaterials are described herein. The biomaterials are formed from a composition comprising at least a first and a second precursor molecule, wherein: i) the first precursor molecule is a poly(ethylene glycol) based polymer having x nucleophilic groups selected from the group consisting of thiol or amino groups, wherein x is greater than or equal to 2 ii) the second precursor molecule is of the general formula: A-[(C3H6O)n—(C2H4O)m—B]i wherein m and n are integers from 1 to 200 i is greater than 2 A is a branch point B is a conjugated unsaturated group The precursors are selected based on the desired properties of the biomaterial. Optionally, the biomaterials contain additives, such as thixotropic agents, radiopaque agents, or bioactive agents. In the preferred embodiment, the biomaterials are used to reduce, inhibit, or contain loss of a biological fluid or gas in a patient.
摘要翻译：用于制备用作组织密封剂的生物材料的方法，包含用于形成生物材料的前体的试剂盒以及所得生物材料在本文中描述。生物材料由包含至少第一和第二前体分子的组合物形成，其中：i）第一前体分子是具有选自硫醇或氨基的x个亲核基团的聚（乙二醇）基聚合物，其中x大于或等于2 ii）第二前体分子具有以下通式：<？in-line-formula description =“In-line formula”end =“lead”？> A - [（C

5. 发明申请

US20060147443A1 Synthetic biomaterials having incorporated therein bioactive factors through enzymatically degradable linkages 审中-公开
标题翻译：合成生物材料通过酶可降解的键连接其中的生物活性因子
公开(公告)号：US20060147443A1
公开(公告)日：2006-07-06
申请号：US11317846
申请日：2005-12-22
申请人： Jason Schense , Didier Cowling , Matthias Lutolf , Annemie Rehor
发明人： Jason Schense , Didier Cowling , Matthias Lutolf , Annemie Rehor
IPC分类号： A61K38/37 , A61K38/48
CPC分类号： A61L27/58 , A61K38/1825 , A61K38/1841 , A61K38/1858 , A61K38/29 , A61K38/30 , A61L27/227 , A61L27/54 , A61L2300/252 , A61L2300/258 , A61L2300/414 , A61L2300/43
摘要： Synthetic biomaterials containing bioactive factors or modified bioactive factors that are covalently bound to the synthetic precursor components and/or biomaterials by an enzymatically degradable linkage are described herein. Further described are methods to covalently bind bioactive factors to synthetic biomaterials by means of enzymatic catalysis, the biomaterials produced therewith and the bioactive factors necessary for practicing these methods. The bioactive factors contain an amino acid sequence which can serve as a substrate domain for cross-linkable enzymes. The enzyme catalyzes the cross-linking reaction between the substrate domain of the bioactive factor and functional groups of the synthetic precursor components capable of forming the biomaterial and/or synthetic biomaterial susceptible to an enzymatically catalyzed cross-linking reaction. The biomaterials described herein may be used for localized delivery of the bioactive factors, for tissue repair and regeneration and in particular for regeneration of soft and hard tissue, such as skin, bone, tendons and cartilage.
摘要翻译：本文描述了含有生物活性因子或通过可酶促降解的键共价结合于合成前体组分和/或生物材料的修饰的生物活性因子的合成生物材料。进一步描述的是通过酶催化，由其产生的生物材料和实践这些方法所需的生物活性因子将生物活性因子共价结合到合成生物材料的方法。生物活性因子含有可用作可交联酶的底物结构域的氨基酸序列。酶催化生物活性因子的底物结构域和能够形成对酶催化的交联反应敏感的生物材料和/或合成生物材料的合成前体组分的官能团之间的交联反应。本文所述的生物材料可用于生物活性因子的局部递送，用于组织修复和再生，特别是用于软和硬组织如皮肤，骨骼，腱和软骨的再生。

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