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1. 发明授权

US08961947B2 Polymeric tissue sealant 有权
标题翻译：聚合物组织密封剂
公开(公告)号：US08961947B2
公开(公告)日：2015-02-24
申请号：US12102157
申请日：2008-04-14
申请人： Annemie Rehor , Simona Cerritelli
发明人： Annemie Rehor , Simona Cerritelli
IPC分类号： A61K31/74 , A61L31/06 , A61L24/04 , C08G65/332 , C08G65/333 , C08G65/334 , C08L71/02
CPC分类号： A61L24/046 , A61K47/34 , A61L24/0042 , A61L31/06 , A61L2400/04 , C08G63/00 , C08G65/3322 , C08G65/33306 , C08G65/3342 , C08G2650/58 , C08L71/02 , C08L2666/22
摘要： Methods for making biomaterials for use as a tissue sealant, kits containing precursors for forming the biomaterials, and the resulting biomaterials are described herein. The biomaterials are formed from a composition comprising at least a first and a second precursor molecule, wherein: i) the first precursor molecule is a poly(ethylene glycol) based polymer having x nucleophilic groups selected from the group consisting of thiol or amino groups, wherein x is greater than or equal to 2 ii) the second precursor molecule is of the general formula: A-[(C3H6O)n—(C2H4O)m—B]i wherein m and n are integers from 1 to 200 i is greater than 2 A is a branch point B is a conjugated unsaturated group The precursors are selected based on the desired properties of the biomaterial. Optionally, the biomaterials contain additives, such as thixotropic agents, radiopaque agents, or bioactive agents. In the preferred embodiment, the biomaterials are used to reduce, inhibit, or contain loss of a biological fluid or gas in a patient.
摘要翻译：用于制备用作组织密封剂的生物材料的方法，包含用于形成生物材料的前体的试剂盒以及所得生物材料在本文中描述。生物材料由包含至少第一和第二前体分子的组合物形成，其中：i）第一前体分子是具有选自硫醇或氨基的x个亲核基团的聚（乙二醇）基聚合物，其中x大于或等于2 ii）第二前体分子具有以下通式：A - [（C 3 H 6 O）n - （C 2 H 4 O）m -B] i，其中m和n是1至200i的整数更大优于2 A是分支点B是共轭不饱和基团根据生物材料的所需性质选择前体。任选地，生物材料含有添加剂，例如触变剂，不透射线剂或生物活性剂。在优选的实施方案中，生物材料用于减少，抑制或含有患者体内的生物流体或气体的损失。

2. 发明申请

US20080253987A1 POLYMERIC TISSUE SEALANT 有权
标题翻译：聚合组织密封剂
公开(公告)号：US20080253987A1
公开(公告)日：2008-10-16
申请号：US12102157
申请日：2008-04-14
申请人： Annemie Rehor , Simona Cerritelli
发明人： Annemie Rehor , Simona Cerritelli
IPC分类号： A61K31/765 , C08L71/00 , A61P41/00
CPC分类号： A61L24/046 , A61K47/34 , A61L24/0042 , A61L31/06 , A61L2400/04 , C08G63/00 , C08G65/3322 , C08G65/33306 , C08G65/3342 , C08G2650/58 , C08L71/02 , C08L2666/22
摘要： Methods for making biomaterials for use as a tissue sealant, kits containing precursors for forming the biomaterials, and the resulting biomaterials are described herein. The biomaterials are formed from a composition comprising at least a first and a second precursor molecule, wherein: i) the first precursor molecule is a poly(ethylene glycol) based polymer having x nucleophilic groups selected from the group consisting of thiol or amino groups, wherein x is greater than or equal to 2 ii) the second precursor molecule is of the general formula: A-[(C3H6O)n—(C2H4O)m—B]i wherein m and n are integers from 1 to 200 i is greater than 2 A is a branch point B is a conjugated unsaturated group The precursors are selected based on the desired properties of the biomaterial. Optionally, the biomaterials contain additives, such as thixotropic agents, radiopaque agents, or bioactive agents. In the preferred embodiment, the biomaterials are used to reduce, inhibit, or contain loss of a biological fluid or gas in a patient.
摘要翻译：用于制备用作组织密封剂的生物材料的方法，包含用于形成生物材料的前体的试剂盒以及所得生物材料在本文中描述。生物材料由包含至少第一和第二前体分子的组合物形成，其中：i）第一前体分子是具有选自硫醇或氨基的x个亲核基团的聚（乙二醇）基聚合物，其中x大于或等于2 ii）第二前体分子具有以下通式：<？in-line-formula description =“In-line formula”end =“lead”？> A - [（C

3. 发明申请

US20100034769A1 COMPOSITIONS FOR TISSUE AUGMENTATION 有权
标题翻译：组织补充组合物
公开(公告)号：US20100034769A1
公开(公告)日：2010-02-11
申请号：US12500843
申请日：2009-07-10
申请人： Aaldert Rens Molenberg , Enrico Zamparo , Laurent Rapillard , Simona Cerritelli
发明人： Aaldert Rens Molenberg , Enrico Zamparo , Laurent Rapillard , Simona Cerritelli
IPC分类号： A61K31/74
CPC分类号： A61L27/26 , A61L2400/06 , A61L2430/38
摘要： Methods for making biomaterials for augmentation of soft and hard tissues, kits containing precursors for forming the biomaterials, and the resulting biomaterials are described herein. The biomaterials are formed from at least a first and a second precursor component. The first precursor component contains at least two nucleophilic groups, and the second precursor component contains at least two electrophilic groups. The nucleophilic and electrophilic groups of the first and second precursor components form covalent linkages with each other at physiological temperatures. The precursors are selected based on the desired properties of the biomaterial. In the preferred embodiment, the first precursor is a siloxane. Optionally, the biomaterials contain additives, such as thixotropic agents, radiopaque agents, or bioactive agents. In the preferred embodiment, the biomaterials are used to augment at least one vertebra of the spine (vertebroplasty).
摘要翻译：制备用于增加软组织和硬组织的生物材料的方法，包含用于形成生物材料的前体的试剂盒以及所得的生物材料在本文中描述。生物材料由至少第一和第二前体成分形成。第一前体组分含有至少两个亲核基团，第二前体组分含有至少两个亲电子基团。第一和第二前体组分的亲核基团和亲电基团在生理温度下彼此形成共价键。基于生物材料的所需性质选择前体。在优选的实施方案中，第一前体是硅氧烷。任选地，生物材料含有添加剂，例如触变剂，不透射线剂或生物活性剂。在优选实施例中，生物材料用于增加脊柱的至少一个椎骨（椎体成形术）。

4. 发明授权

US08282912B2 Compositions for tissue augmentation 有权
标题翻译：用于组织增强的组合物
公开(公告)号：US08282912B2
公开(公告)日：2012-10-09
申请号：US12500843
申请日：2009-07-10
申请人： Aaldert Rens Molenberg , Enrico Zamparo , Laurent Rapillard , Simona Cerritelli
发明人： Aaldert Rens Molenberg , Enrico Zamparo , Laurent Rapillard , Simona Cerritelli
IPC分类号： A61K31/74 , A61F13/00 , A61F2/00
CPC分类号： A61L27/26 , A61L2400/06 , A61L2430/38
摘要： Methods for making biomaterials for augmentation of soft and hard tissues, kits containing precursors for forming the biomaterials, and the resulting biomaterials are described herein. The biomaterials are formed from at least a first and a second precursor component. The first precursor component contains at least two nucleophilic groups, and the second precursor component contains at least two electrophilic groups. The nucleophilic and electrophilic groups of the first and second precursor components form covalent linkages with each other at physiological temperatures. The precursors are selected based on the desired properties of the biomaterial. In the preferred embodiment, the first precursor is a siloxane. Optionally, the biomaterials contain additives, such as thixotropic agents, radiopaque agents, or bioactive agents. In the preferred embodiment, the biomaterials are used to augment at least one vertebra of the spine (vertebroplasty).
摘要翻译：制备用于增加软组织和硬组织的生物材料的方法，包含用于形成生物材料的前体的试剂盒以及所得的生物材料在本文中描述。生物材料由至少第一和第二前体成分形成。第一前体组分含有至少两个亲核基团，第二前体组分含有至少两个亲电子基团。第一和第二前体组分的亲核基团和亲电基团在生理温度下彼此形成共价键。基于生物材料的所需性质选择前体。在优选的实施方案中，第一前体是硅氧烷。任选地，生物材料含有添加剂，例如触变剂，不透射线剂或生物活性剂。在优选实施例中，生物材料用于增加脊柱的至少一个椎骨（椎体成形术）。

5. 发明申请

US20100284919A1 Injectable Radio-Opaque Compositions for Tissue Augmentation 审中-公开
标题翻译：用于组织增强的可注射无线电不透明组合物
公开(公告)号：US20100284919A1
公开(公告)日：2010-11-11
申请号：US12682758
申请日：2008-10-13
申请人： Enrico Zamparo , Laurent Rapillard , Simona Cerritelli , Sauro Bianchi
发明人： Enrico Zamparo , Laurent Rapillard , Simona Cerritelli , Sauro Bianchi
IPC分类号： A61K38/48 , A61K49/00 , A61P19/00
CPC分类号： A61K33/24 , A61K38/29 , A61K38/363 , A61K38/4833 , A61K45/06 , A61K49/0438 , A61K49/0447 , A61L27/02 , A61L27/225 , A61L27/227 , A61L2400/06 , A61K2300/00
摘要： Injectable radio-opaque compositions for tissue augmentation and in particular hard tissue augmentation, and kits and methods of using thereof are described herein. The injectable compositions form porous, biologically degradable, fibrin matrices. The compositions are formed from fibrinogen, thrombin or another agent that causes the fibrinogen to crosslink, and strontium salts. Optionally an iodinated contrast agent is further incorporated in the composition. In certain aspects, the compositions have substantially no exothermicity when forming the matrix and the resulting matrices exhibit mechanical properties typically seen in elastomers. Adequate radio-opacity is achieved through the incorporation of strontium salts in combination or not with iodinated contrast agents.
摘要翻译：本文描述了用于组织增加，特别是硬组织增加的注射不透射线组合物，以及其使用的试剂盒及其使用方法。可注射组合物形成多孔，生物可降解的纤维蛋白基质。组合物由纤维蛋白原，凝血酶或引起纤维蛋白原交联的其它试剂和锶盐形成。任选地，将碘化造影剂进一步掺入组合物中。在某些方面，组合物在形成基质时基本上不具有放热性，并且所得基体表现出通常在弹性体中看到的机械性能。通过将锶盐与碘化造影剂组合或不结合来实现充分的无线电透明度。

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