专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20120058986A1 DI-AZETIDINYL DIAMIDE AS MONOACYLGLYCEROL LIPASE INHIBITORS 审中-公开
标题翻译： DI亚氨基二异氰酸酯作为单糖胆碱酯酶抑制剂
公开(公告)号：US20120058986A1
公开(公告)日：2012-03-08
申请号：US13224654
申请日：2011-09-02
申请人： Peter J. Connolly , Mark J. Macielag , Bin Zhu
发明人： Peter J. Connolly , Mark J. Macielag , Bin Zhu
IPC分类号： A61K31/427 , A61K31/428 , C07D403/04 , A61K31/397 , C07D409/14 , C07D413/14 , A61K31/423 , C07D403/14 , A61K31/4035 , C07D401/14 , A61K31/454 , C07D513/04 , A61K31/429 , A61P29/00 , A61P1/00 , A61P25/06 , A61P19/02 , A61P21/00 , A61P17/00 , A61P1/02 , A61P17/02 , A61P13/10 , A61P31/00 , A61P11/02 , A61P17/04 , A61P11/00 , A61P1/18 , C07D417/14
CPC分类号： A61K31/397 , A61K31/4035 , A61K31/423 , A61K31/427 , A61K31/428 , A61K31/429 , A61K31/454 , C07D205/04 , C07D403/14 , C07D409/14 , C07D413/14 , C07D417/12 , C07D417/14 , C07D513/04
摘要： Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula (I) as follows: wherein Q and Z are defined herein.
摘要翻译：公开了用于治疗各种疾病，综合征，病症和障碍（包括疼痛）的化合物，组合物和方法。这样的化合物由式（I）表示如下：其中Q和Z在本文中定义。

2. 发明申请

US20120077797A1 OXOPIPERAZINE-AZETIDINE AMIDES AND OXODIAZEPINE-AZETIDINE AMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS 失效
标题翻译：作为单加性胆碱酯酶抑制剂的奥西维他嗪 - 阿魏酸和氧化吖嗪 - 阿魏酸
公开(公告)号：US20120077797A1
公开(公告)日：2012-03-29
申请号：US13246232
申请日：2011-09-27
申请人： Peter J. Connolly , Mark J. Macielag , Mark E. McDonnell , Bin Zhu
发明人： Peter J. Connolly , Mark J. Macielag , Mark E. McDonnell , Bin Zhu
IPC分类号： A61K31/506 , A61P25/00 , A61K31/496 , C07D417/14 , C07D409/14 , C07D403/04
CPC分类号： C07D403/14 , C07D403/04 , C07D409/14 , C07D417/14
摘要： Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds, and enantiomers, diastereomers, and pharmaceutically acceptable salts thereof, are represented by Formula (Ia) and Formula (Ib) as follows: wherein Y, Z, and n are defined herein; and wherein Yb and Zb are as defined herein.
摘要翻译：公开了用于治疗各种疾病，综合征，病症和障碍（包括疼痛）的化合物，组合物和方法。这样的化合物及其对映体，非对映体及其药学上可接受的盐由式（Ia）和式（Ib）表示如下：其中Y，Z和n如本文所定义; 并且其中Yb和Zb如本文所定义。

3. 发明授权

US08637498B2 Oxopiperazine-azetidine amides and oxodiazepine-azetidine amides as monoacylglycerol lipase inhibitors 失效
标题翻译：氧基哌嗪 - 氮杂环丁烷酰胺和氧代二氮杂吖啶啶酰胺作为单酰基甘油脂肪酶抑制剂
公开(公告)号：US08637498B2
公开(公告)日：2014-01-28
申请号：US13246232
申请日：2011-09-27
申请人： Peter J. Connolly , Mark J. Macielag , Mark E. McDonnell , Bin Zhu
发明人： Peter J. Connolly , Mark J. Macielag , Mark E. McDonnell , Bin Zhu
IPC分类号： A61K31/496 , A61K31/506 , A61K31/551 , C07D403/04 , C07D403/14 , C07D409/14 , C07D417/14
CPC分类号： C07D403/14 , C07D403/04 , C07D409/14 , C07D417/14
摘要： Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds, and enantiomers, diastereomers, and pharmaceutically acceptable salts thereof, are represented by Formula (Ia) and Formula (Ib) as follows: wherein Y, Z, and n are defined herein; and wherein Yb and Zb are as defined herein.
摘要翻译：公开了用于治疗各种疾病，综合征，病症和障碍（包括疼痛）的化合物，组合物和方法。这样的化合物和对映体，非对映异构体及其药学上可接受的盐由式（Ia）和式（Ib）表示如下：其中Y，Z和n如本文所定义; 并且其中Yb和Zb如本文所定义。

4. 发明授权

US08513271B2 Pyrimidine compounds as delta opioid receptor modulators 有权
标题翻译：嘧啶化合物作为δ阿片受体调节剂
公开(公告)号：US08513271B2
公开(公告)日：2013-08-20
申请号：US12913966
申请日：2010-10-28
申请人： Steven J. Coats , Haiyan Bian , Peter J. Connolly , Gilles Bignan , Chaozhong Cai , Scott L. Dax , Bart L. DeCorte , Shu-Chen Lin , Li Liu , Mark J. Macielag , Philip M. Pitis , Yue-Mei Zhang , Bin Zhu , Wei He
发明人： Steven J. Coats , Haiyan Bian , Peter J. Connolly , Gilles Bignan , Chaozhong Cai , Scott L. Dax , Bart L. DeCorte , Shu-Chen Lin , Li Liu , Mark J. Macielag , Philip M. Pitis , Yue-Mei Zhang , Bin Zhu , Wei He
IPC分类号： A01N43/54
CPC分类号： C07D239/47 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14
摘要： Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula I as follows: wherein R1, R2, R3, and L, A, and Ra are defined herein.
摘要翻译：公开了用于治疗各种疾病，综合征，病症和障碍（包括疼痛）的化合物，组合物和方法。这样的化合物由式I表示如下：其中R1，R2，R3和L，A和Ra在本文中定义。

5. 发明申请

US20090156577A1 7-AMINO ALKYLIDENYL-HETEROCYCLIC QUINOLONES AND NAPHTHYRIDONES 审中-公开
标题翻译： 7-氨基亚苄基 - 杂环喹啉和萘胺
公开(公告)号：US20090156577A1
公开(公告)日：2009-06-18
申请号：US12268529
申请日：2008-11-11
申请人： Benjamin Davis , Eugene B. Grant, III , Shu-Chen Lin , Mark J. Macielag , Michele Ann Weidner-Wells , Xiaoqing Xu , Xiaodong Xu , Bin Zhu
发明人： Benjamin Davis , Eugene B. Grant, III , Shu-Chen Lin , Mark J. Macielag , Michele Ann Weidner-Wells , Xiaoqing Xu , Xiaodong Xu , Bin Zhu
IPC分类号： A61K31/5365 , C07D471/04 , A61K31/4375 , C07D401/04 , A61K31/4709 , C07D498/16
CPC分类号： C07D471/04 , C07D401/04 , C07D401/14 , C07D498/04 , C07D498/14 , C07D519/00
摘要： The present invention relates to compounds having a structure according to Formula (I) wherein n, m, z, R, R2, R3, R4, R5, R6, A, E, X, Y, a and b are as defined above; or an optical isomer, diastereomer or enantiomer thereof; a pharmaceutically acceptable salt, hydrate, or prodrug thereof.
摘要翻译：本发明涉及具有式（I）结构的化合物，其中n，m，z，R，R 2，R 3，R 4，R 5，R 6，A，E，X，Y，a和b如上所定义; 或其光学异构体，非对映异构体或对映异构体; 其药学上可接受的盐，水合物或前药。

6. 发明申请

US20090270379A1 QUINOLONE DERIVATIVES USEFUL AS ANTIBACTERIAL AGENTS 审中-公开
标题翻译：喹诺酮衍生物作为抗菌药物有用
公开(公告)号：US20090270379A1
公开(公告)日：2009-10-29
申请号：US12426442
申请日：2009-04-20
申请人： Mark J. Macielag , Bin Zhu
发明人： Mark J. Macielag , Bin Zhu
IPC分类号： A61K31/5383 , C07D487/04 , A61K31/498 , C07D498/06 , A61P31/04
CPC分类号： C07D471/04 , C07D519/00
摘要： The present invention is directed to quinolone derivatives, useful as antimicrobial compounds, pharmaceutical compositions comprising said derivatives and the use of said derivatives and pharmaceutical compositions as antimicrobial agents against pathogenic microorganisms, particularly against resistant microbes
摘要翻译：本发明涉及用作抗微生物化合物的喹诺酮衍生物，包含所述衍生物的药物组合物以及所述衍生物和药物组合物作为抗病原微生物的抗微生物剂的用途，特别是针对抗性微生物

7. 发明授权

US06825172B2 3-descladinosyl-6-O-carbamoyl and 6-O-carbonoyl macrolide antibacterial agents 有权
标题翻译： 3-脱酰基脯氨酰基-6-O-氨基甲酰基和6-O-碳酰基大环内酯类抗菌剂
公开(公告)号：US06825172B2
公开(公告)日：2004-11-30
申请号：US10447058
申请日：2003-05-28
申请人： Todd C. Henninger , Mark J. Macielag , Brett A. Marinelli , Bin Zhu
发明人： Todd C. Henninger , Mark J. Macielag , Brett A. Marinelli , Bin Zhu
IPC分类号： A61K3170
CPC分类号： C07H17/08
摘要： 3-Descladinosyl-6-O-carbamoyl and 6-O-carbonoyl macrolide antibacterial agents of the formula: wherein R1, W, R3, R4, R5, R6, X, X′, and Z are as described herein and in which the substituents have the meaning indicated in the description. These compounds are useful as antibacterial agents.
摘要翻译： 3-脱氨基腺苷基-6-O-氨基甲酰基和6-O-碳酰基大环内酯抗菌剂，其结构式如下：其中R 1，W，R 3，R 4，R 5，R 6， X，X'和Z如本文所述，其中取代基具有在说明书中指出的含义。这些化合物可用作抗菌剂。

8. 发明授权

US11692418B2 Inflow control device, method and system 有权
公开(公告)号：US11692418B2
公开(公告)日：2023-07-04
申请号：US17351718
申请日：2021-06-18
申请人： Zhihui Zhang , Bin Zhu , Guijun Deng , Zhiyue Xu , Ronnie Russell
发明人： Zhihui Zhang , Bin Zhu , Guijun Deng , Zhiyue Xu , Ronnie Russell
IPC分类号： E21B43/12 , E21B43/38
CPC分类号： E21B43/12 , E21B43/38
摘要： A flow control device including a flow channel having a housing defining an inside surface, the inside surface having an irregular helical structure of constant orthogonal cross-sectional dimensions.

9. 发明申请

US20220307964A1 METHOD FOR DETERMINING HYDRAULIC PARAMETERS AND WATER INFLOW IN EROSION STAGE OF GRAVEL SOIL 有权
公开(公告)号：US20220307964A1
公开(公告)日：2022-09-29
申请号：US17458604
申请日：2021-08-27
申请人： Bin Zhu , Chuandai Lin , Jun Chen , Juyan Chen , Xianyu Deng , Bo Li
发明人： Bin Zhu , Chuandai Lin , Jun Chen , Juyan Chen , Xianyu Deng , Bo Li
IPC分类号： G01N15/08 , G01V9/00 , G01N33/24
摘要： The invention discloses method for determining hydraulic parameters and water inflow in the erosion stage of gravel soil, comprising: calculate the soil particle content P and the soil porosity n of each grade of particle size a, and draw the PSD curve of each grade of particle size and the soil particle content P of each grade of particle size and the PSD curve cluster of each grade of particle size and the soil particle content P of each grade of particle size in each erosion stage; calculate the equivalent diameter Dh of the soil particle, and calculate the minimum equivalent pore diameter d0 of the soil particle; calculate the critical hydraulic gradient icr of particle erosion at each stage; calculate the permeability coefficient kh; calculate the seepage flow velocity ν and the total seepage flow Q.

10. 发明授权

US08935767B2 Overlay human interactive proof system and techniques 有权
标题翻译：覆盖人类互动证明系统和技术
公开(公告)号：US08935767B2
公开(公告)日：2015-01-13
申请号：US12780013
申请日：2010-05-14
申请人： Weisheng Li , Bin Zhu , Ning Xu , Jia Liu
发明人： Weisheng Li , Bin Zhu , Ning Xu , Jia Liu
IPC分类号： H04L29/00 , G06F9/44 , G06F21/36 , H04L9/32
CPC分类号： G06F9/44 , G06F21/36 , G06F2221/2133 , H04L9/32
摘要： The overlay human interactive proof system (“OHIPS”) and techniques described herein operate in conjunction with any known or later developed computer-based applications or services to provide secure access to resources by reliably differentiating between human and non-human users. Humans have a generally superior ability to differentiate misaligned characters or objects from correctly aligned ones. As such, the OHIP splits an image including one or more visual objects into two or more partial images to form a HIP. The partial images may also be further split into groups of sub-partial images, and/or the partial images (or the sub-partial images) may be moved, so that at any given alignment position, a user can recognize only some visual objects. A user is instructed to reassemble the partial images at one or more predetermined alignment positions using a GUI, and the user is asked to identify information regarding one or more visible objects.
摘要翻译：覆盖人类交互式证明系统（“OHIPS”）和本文所描述的技术与任何已知或未来开发的基于计算机的应用或服务相结合，通过可靠地区分人和非人类用户来提供对资源的安全访问。人类具有一般优越的能力来区分不正确的字符或对象与正确对齐的字符或对象。因此，OHIP将包括一个或多个可视对象的图像分割成两个或更多个部分图像以形成HIP。部分图像还可以进一步分割成一组子部分图像，和/或部分图像（或子部分图像）可以被移动，使得在任何给定的对准位置，用户只能识别一些视觉对象。指示用户使用GUI重新组装在一个或多个预定对准位置处的部分图像，并且要求用户识别关于一个或多个可见对象的信息。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式