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1. 发明申请

US20070129550A1 AMINO ACIDS WITH AFFINITY FOR THE ALPHA-2-DELTA-PROTEIN 失效
标题翻译：具有ALPHA-2-DELTA-PROTEIN的亲和力的氨基酸
公开(公告)号：US20070129550A1
公开(公告)日：2007-06-07
申请号：US11567878
申请日：2006-12-07
申请人： Peter Blazecka , Joseph Bozelak , Norman Colbry , Timothy Curran , Annise Goodman , Kevin Henegar , Garrett Hoge , Paul Johnson , Augustine Osuma , Mark Plummer , Jacob Schwarz , Derek Vrieze , Ji Zhang
发明人： Peter Blazecka , Joseph Bozelak , Norman Colbry , Timothy Curran , Annise Goodman , Kevin Henegar , Garrett Hoge , Paul Johnson , Augustine Osuma , Mark Plummer , Jacob Schwarz , Derek Vrieze , Ji Zhang
IPC分类号： A61K31/44 , C07D413/02 , C07D213/55 , C07C255/45 , C07C229/14
CPC分类号： C07C229/08 , C07B2200/07 , C07C227/32 , C07C229/28 , C07C229/34 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07D263/26 , Y02P20/582
摘要： Certain β-amino acids that bind to the alpha-2-delta (α2δ) subunit of a calcium channel are disclosed. These compounds and their pharmaceutically acceptable salts are useful in the treatment of a variety of psychiatric, pain and other disorders. Also disclosed are methods of making the β-amino acids.
摘要翻译：公开了结合钙通道的α-2-δ（α2delta）亚基的某些β-氨基酸。这些化合物及其药学上可接受的盐可用于治疗各种精神病，疼痛和其它疾病。还公开了制备β-氨基酸的方法。

2. 发明申请

US20050101643A1 Amino acids with affinity for the alpha2delta-protein 失效
标题翻译：对α2delta蛋白具有亲和力的氨基酸
公开(公告)号：US20050101643A1
公开(公告)日：2005-05-12
申请号：US10949907
申请日：2004-09-24
申请人： Peter Blazecka , Joseph Bozelak , Norman Colbry , Timothy Curran , Annise Goodman , Kevin Henegar , Garrett Hoge , Paul Johnson , Augustine Osuma , Mark Plummer , Jacob Schwarz , Derek Vrieze , Ji Zhang
发明人： Peter Blazecka , Joseph Bozelak , Norman Colbry , Timothy Curran , Annise Goodman , Kevin Henegar , Garrett Hoge , Paul Johnson , Augustine Osuma , Mark Plummer , Jacob Schwarz , Derek Vrieze , Ji Zhang
IPC分类号： A61P23/00 , C07C227/32 , C07C229/08 , C07C229/28 , C07C229/34 , C07D263/26 , A61K31/44 , A61K31/198 , C07C227/18
CPC分类号： C07C229/08 , C07B2200/07 , C07C227/32 , C07C229/28 , C07C229/34 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07D263/26 , Y02P20/582
摘要： Certain β-amino acids that bind to the alpha-2-delta (α2δ) subunit of a calcium channel are disclosed. These compounds and their pharmaceutically acceptable salts are useful in the treatment of a variety of psychiatric, pain and other disorders. Also disclosed are methods of making the β-amino acids.
摘要翻译：公开了结合钙通道的α-2-δ（α2delta）亚基的某些β-氨基酸。这些化合物及其药学上可接受的盐可用于治疗各种精神病，疼痛和其它疾病。还公开了制备β-氨基酸的方法。

3. 发明申请

US20060004211A1 Preparation of 4-substituted-2-buten-4-olides from mucohalic acids 审中-公开
标题翻译：从粘稠卤酸制备4-取代-2-丁烯-4-醇
公开(公告)号：US20060004211A1
公开(公告)日：2006-01-05
申请号：US11168795
申请日：2005-06-28
申请人： Paul Angell , Daniel Belmont , Timothy Curran , Ji Zhang
发明人： Paul Angell , Daniel Belmont , Timothy Curran , Ji Zhang
IPC分类号： C07D307/34
CPC分类号： C07D307/58
摘要： Methods and materials for preparing 4-substituted-2-buten-4-olides are disclosed. The method includes reacting a mucohalic acid with a silyl enol ether or a ketene silyl acetal in the presence of a Lewis acid.
摘要翻译：公开了制备4-取代-2-丁烯-4-醇的方法和材料。该方法包括在路易斯酸存在下使粘羟基酸与甲硅烷基烯醇醚或乙烯酮甲硅烷基缩醛反应。

4. 发明申请

US20060074240A1 Process for the synthesis of derivatives of 2,3-dihydro-1,4-dioxino-[2,3-f] quinoline 失效
标题翻译：合成2,3-二氢-1,4-二氧杂 - [2,3-f]喹啉衍生物的方法
公开(公告)号：US20060074240A1
公开(公告)日：2006-04-06
申请号：US11282202
申请日：2005-11-18
申请人： Anita Chan , Timothy Curran , Silvio Iera , Warren Chew , John Sellstedt , Galina Vid , Gregg Feigelson , Zhixian Ding
发明人： Anita Chan , Timothy Curran , Silvio Iera , Warren Chew , John Sellstedt , Galina Vid , Gregg Feigelson , Zhixian Ding
IPC分类号： C07D491/00
CPC分类号： C07D491/04
摘要： Methods of preparing compounds of Formula I are provided.
摘要翻译：提供制备式I化合物的方法。

5. 发明申请

US20070123705A1 Process for the Synthesis of Derivatives of 2,3-Dihydro-1,4-Dioxino-[2,3-f] Quinolines 失效
标题翻译： 2,3-二氢-1,4-二氧代 - [2,3-f]喹啉衍生物的合成方法
公开(公告)号：US20070123705A1
公开(公告)日：2007-05-31
申请号：US11566528
申请日：2006-12-04
申请人： Anita Chan , Timothy Curran , Silvio Iera , Warren Chew , John Sellstedt , Galina Vid , Gregg Feigelson , Zhixian Ding
发明人： Anita Chan , Timothy Curran , Silvio Iera , Warren Chew , John Sellstedt , Galina Vid , Gregg Feigelson , Zhixian Ding
IPC分类号： C07D237/26 , C07D215/16
CPC分类号： C07D491/04
摘要： Methods of preparing compounds of Formula I are provided.
摘要翻译：提供制备式I化合物的方法。

6. 发明授权

US6159157A Blood pressure measurement device with a sensor locator 失效
标题翻译：带有传感器定位器的血压测量装置
公开(公告)号：US6159157A
公开(公告)日：2000-12-12
申请号：US299222
申请日：1999-04-23
申请人： G. Kent Archibald , Timothy Curran , Orland H. Danielson , Marius O. Poliac , Roger C. Thede
发明人： G. Kent Archibald , Timothy Curran , Orland H. Danielson , Marius O. Poliac , Roger C. Thede
IPC分类号： A61B5/021 , A61B5/024 , A61B5/00
CPC分类号： A61B5/02116 , A61B5/02438 , A61B2562/0247
摘要： A blood pressure measurement device with a sensor locator for placing a non-invasive blood pressure measurement device over an underlying artery, the sensor locator having a plurality of extending fingers spaced from each other coupled to the non-invasive blood pressure measurement device.
摘要翻译：一种具有传感器定位器的血压测量装置，用于将非侵入性血压测量装置放置在下面的动脉上方，所述传感器定位器具有彼此间隔开的多个延伸的指状物，其联接到所述非侵入性血压测量装置。

7. 外观设计

USD894780S1 Bracelet 有权
公开(公告)号：USD894780S1
公开(公告)日：2020-09-01
申请号：US29647180
申请日：2018-05-10
申请人： Christine Canny , Timothy Curran
设计人： Christine Canny , Timothy Curran
摘要： FIG. 1 is a top, front and right side perspective view of a bracelet according to our new design;
FIG. 2 is a top view thereof;
FIG. 3 is a bottom view thereof;
FIG. 4 is a left side view thereof;
FIG. 5 is a right side view thereof;
FIG. 6 is a rear view thereof; and,
FIG. 7 is a front view thereof.
Broken lines in the Drawings illustrate portions of the bracelet that form no part of the claimed design. The other broken lines showing text or indicia represent environmental subject matter only and form no part of the claimed design.

8. 发明申请

US20090076495A2 Ablation catheter with sensor array and discrimination circuit to maximize variation in power density 有权
标题翻译：消融导管与传感器阵列和鉴别电路，以最大化功率密度变化
公开(公告)号：US20090076495A2
公开(公告)日：2009-03-19
申请号：US11617656
申请日：2006-12-28
申请人： Jeremy Dando , Timothy Curran , Todd Stangenes
发明人： Jeremy Dando , Timothy Curran , Todd Stangenes
IPC分类号： A61B18/14
CPC分类号： A61B18/1492 , A61B2018/00642 , A61B2018/00797 , A61B2018/00839 , A61B2018/1472
摘要： A catheter is designed with a virtual electrode structure for creating a linear lesion. The catheter includes a sensor array that measures temperatures of adjacent tissue along the length of the virtual electrode section. The sensors in the sensor array include a conductive material that is substantially coated with an electrically and thermally insulating material. An aperture is formed in the insulating coating to expose an area of the conductive material. Leads are coupled with each sensor and are connected at their opposite, proximal ends with a discrimination circuit. The circuit processes the signals induced in the sensors to output a single temperature measurement, for example, the highest temperature, the lowest temperature, or the average temperature. The sensors also measure cardiac electrical activity and the leads are further connected to an electrocardiograph monitor to determine the efficacy of treatment.
摘要翻译：导管设计有用于产生线性损伤的虚拟电极结构。导管包括传感器阵列，其测量沿着虚拟电极部分的长度的相邻组织的温度。传感器阵列中的传感器包括基本上涂覆有电绝热材料的导电材料。在绝缘涂层中形成孔以暴露导电材料的区域。引线与每个传感器耦合，并且在其相对的近端处与鉴别电路连接。电路处理在传感器中感应的信号，以输出单个温度测量，例如最高温度，最低温度或平均温度。传感器还测量心脏电活动，并且引线进一步连接到心电图仪监测器以确定治疗的功效。

9. 发明授权

US09182115B2 Fluid heating system 有权
标题翻译：流体加热系统
公开(公告)号：US09182115B2
公开(公告)日：2015-11-10
申请号：US12722067
申请日：2010-03-11
申请人： Kenneth A. Dongo , Timothy Curran
发明人： Kenneth A. Dongo , Timothy Curran
IPC分类号： F24H9/20 , F23B40/08 , F23N1/08 , F24B1/02 , F24D3/10 , F24D12/02 , F24D17/00 , F24D19/10 , F24H1/20 , F24H9/12 , F28D9/00 , F28D20/00
CPC分类号： F23B40/08 , F23K2203/202 , F23N1/082 , F23N2025/19 , F24B1/024 , F24D3/10 , F24D3/1083 , F24D12/02 , F24D17/0031 , F24D19/1051 , F24D2200/067 , F24D2200/08 , F24H1/202 , F24H1/205 , F24H9/122 , F24H9/124 , F24H9/2057 , F24H2230/00 , F28D9/005 , F28D20/0034 , Y02B30/14 , Y10T29/49826
摘要： A fluid heat exchange system with a fluid flow circuit having a heat exchange fluid flow loop, a heat absorption component (as in a domestic hot water tank inclusive of small commercial use tanks as in tanks of 20 to 120 gallons), a heat exchanger and preferably also a pump. A controlled and automated fuel supply source based heater (as in a pellet stove) is in heat passage communication with the said heat exchanger. A control unit triggers activation of the pump upon fluid in the heat absorption component reaching or dropping below a preset temperature, and the fluid flow circuit is arranged such that, during times of non-activation of the pump, fluid is free to flow in a unidirectional flow within the fluid circuit based on thermodynamic temperature differentials alone. A retrofitting of a domestic hot water tank is also featured preferably making use of preexisting drain and safety vent porting for in-feed and out-feed porting in the exchange loop side. Also, the flow circuit preferably is free of check valves and steam accommodation equipment.
摘要翻译：一种具有流体回路的流体热交换系统，其具有热交换流体流动回路，吸热部件（如在包括20至120加仑的罐中的小型商用罐的家用热水箱中），热交换器和优选也是泵。基于控制和自动化的基于燃料供应源的加热器（如颗粒炉）与所述热交换器进行热通道连通。控制单元在吸热组件中的流体达到或低于预设温度时触发泵的激活，并且流体流动回路被布置成使得在泵的非活化期间，流体可以自由流动基于单独的热力学温度差异，流体回路内的单向流动。家用热水箱的改装也优选利用预先存在的排水口和安全排气口进行交换回路侧的进料和出料口。此外，流动回路优选地没有止回阀和蒸汽容纳设备。

10. 发明申请

US20060116588A1 Method and apparatus for calculating blood pressure of an artery 审中-公开
公开(公告)号：US20060116588A1
公开(公告)日：2006-06-01
申请号：US11334287
申请日：2006-01-18
申请人： G. Archibald , Timothy Curran , Orland Danielson , Marius Poliac , Roger Thede
发明人： G. Archibald , Timothy Curran , Orland Danielson , Marius Poliac , Roger Thede
IPC分类号： A61B5/02
CPC分类号： A61B5/02233 , A61B5/021 , A61B5/02116 , A61B5/02141 , A61B5/02225 , A61B5/6843 , A61B2562/0247
摘要： The present invention is a method for calculating blood pressure of an artery having a pulse. The method includes applying a varying pressure to the artery. Pressure waveforms are sensed to produce pressure waveform data. Waveform parameters are derived from the sensed pressure waveform data. Blood pressure is then determined using the derived parameters.

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