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1. 发明授权

US11181105B2 Low elasticity films for microfluidic use 有权
公开(公告)号：US11181105B2
公开(公告)日：2021-11-23
申请号：US16679076
申请日：2019-11-08
申请人： PerkinElmer Health Sciences, Inc.
发明人： Isaac Sprague , Justin L. Kay , Matthew Scott Bragd , C. Frederick Battrell
IPC分类号： F04B43/04 , B01L3/00 , F16K99/00 , F04B19/00 , F04B43/00
摘要： Microfluidic circuit elements, such as a microvalve, micropump or microvent, formed of a microcavity divided by a diaphragm web into a first subcavity bounded by a first internal wall and a second subcavity bounded by a second internal wall, where the diaphragm web is characterized as a thin film having a first state contacting the first internal wall and a second state contacting the second internal wall and exhibiting essentially no elasticity in moving between the first state and the second state, the thin film web having been stretched beyond its yield point before or during use are provided. The disclosed elements enable faster and more efficient cycling of the diaphragm in the microcavity and increases the diaphragm surface area. In a preferred embodiment, the microfluidic circuit element is pneumatically driven and controls the motion of fluids in a microassay device.

2. 发明授权

US10518262B2 Low elasticity films for microfluidic use 有权
公开(公告)号：US10518262B2
公开(公告)日：2019-12-31
申请号：US14653737
申请日：2013-12-20
申请人： PerkinElmer Health Sciences, Inc.
发明人： Isaac Sprague , Justin L. Kay , Matthew Scott Bragd , C. Frederick Battrell
IPC分类号： B01L3/00 , F16K99/00
摘要： Microfluidic circuit elements, such as a microvalve, micropump or microvent, formed of a microcavity divided by a diaphragm web into a first subcavity bounded by a first internal wall and a second subcavity bounded by a second internal wall, where the diaphragm web is characterized as a thin film having a first state contacting the first internal wall and a second state contacting the second internal wall and exhibiting essentially no elasticity in moving between the first state and the second state, the thin film web having been stretched beyond its yield point before or during use are provided. The disclosed elements enable faster and more efficient cycling of the diaphragm in the microcavity and increases the diaphragm surface area. In a preferred embodiment, the microfluidic circuit element is pneumatically driven and controls the motion of fluids in a microassay device.

3. 发明授权

US11504681B2 Microfluidic mixing device and method 有权
公开(公告)号：US11504681B2
公开(公告)日：2022-11-22
申请号：US15999845
申请日：2017-02-17
申请人： PerkinElmer Health Sciences, Inc.
发明人： Andrew Kolb , Matthew Scott Bragd , C. Frederick Battrell
IPC分类号： B01F33/30 , B01F31/65
摘要： A microfluidic mixing device comprising two bellows pumps (105, 115), microfluidic cartridges comprising the same and methods for use of the same are provided. The disclosed device enables efficient mixing of samples at the microfluidic scale. More particularly, the microfluidic mixing device comprises: a first bellows pump (105); a second bellows pump (115); a first microchannel fluidly interconnecting the first bellows pump (105) with a sample inlet and a reagent reservoir, wherein the first microchannel comprises a valve (V10) interposed between the pump and the inlet, and a valve (V1) interposed between the pump and the reservoir; a second microchannel fluidly interconnecting the first bellows pump (105) with the second bellows pump (115), wherein the second micro channel comprises a valve (V11) interposed between the first and second pump; a third microchannel fluidly interconnecting the first bellows pump (105) with the second bellows pump, wherein the third micro channel comprises a valve (V11) interposed between the first and second pump; a first and second pneumatic member pneumatically connected to the first and second bellows pumps; wherein, the volume of the second bellows pump (115) is greater than the volume of the first bellows pump (105).

4. 发明授权

US11071526B2 Specimen collection and delivery apparatus 有权
公开(公告)号：US11071526B2
公开(公告)日：2021-07-27
申请号：US15569701
申请日：2016-04-29
申请人： PerkinElmer Health Sciences, Inc.
发明人： Andrew Kolb , Alan K. Lofquist , C. Frederick Battrell
IPC分类号： A61B10/00 , B01L3/00 , A61B10/02 , G01N1/00
摘要： A specimen collection and delivery apparatus for collecting clinical specimens and delivery of samples thereof to, e.g., microfluidic testing devices for diagnostic analysis is disclosed. The specimen collection and delivery apparatus includes a closure housing for coupling with a sample tube at one end, an open luer for coupling with a complementary luer on a microfluidic device at the other end, and a filter matrix disposed in the interior. The filter matrix is air permeable and liquid impermeable at atmospheric pressure and prevents sample from flowing through the open luer end when coupled to a sample tube containing a specimen. Under vacuum, the liquid sample fraction of the specimen can be drawn through the filter matrix and into the microfluidic testing device through the luer connection for diagnostic analysis.

5. 发明申请

US20210129097A1 MICROFLUIDIC MIXING DEVICE AND METHOD 有权
公开(公告)号：US20210129097A1
公开(公告)日：2021-05-06
申请号：US15999845
申请日：2017-02-17
申请人： PERKINELMER HEALTH SCIENCES, INC.
发明人： Andrew Kolb , Matthew Scott Bragd , C. Frederick Battrell
IPC分类号： B01F13/00 , B01F11/00
摘要： A microfluidic mixing device comprising two bellows pumps (105, 115), microfluidic cartridges comprising the same and methods for use of the same are provided. The disclosed device enables efficient mixing of samples at the microfluidic scale. More particularly, the microfluidic mixing device comprises: a first bellows pump (105); a second bellows pump (115); a first microchannel fluidly interconnecting the first bellows pump (105) with a sample inlet and a reagent reservoir, wherein the first microchannel comprises a valve (V10) interposed between the pump and the inlet, and a valve (V1) interposed between the pump and the reservoir; a second microchannel fluidly interconnecting the first bellows pump (105) with the second bellows pump (115), wherein the second micro channel comprises a valve (V11) interposed between the first and second pump; a third microchannel fluidly interconnecting the first bellows pump (105) with the second bellows pump, wherein the third micro channel comprises a valve (V11) interposed between the first and second pump; a first and second pneumatic member pneumatically connected to the first and second bellows pumps; wherein, the volume of the second bellows pump (115) is greater than the volume of the first bellows pump (105).

6. 发明申请

US20200070154A1 LOW ELASTICITY FILMS FOR MICROFLUIDIC USE 审中-公开
公开(公告)号：US20200070154A1
公开(公告)日：2020-03-05
申请号：US16679076
申请日：2019-11-08
申请人： PerkinElmer Health Sciences, Inc.
发明人： Isaac Sprague , Justin L. Kay , Matthew Scott Bragd , C. Frederick Battrell
IPC分类号： B01L3/00 , F16K99/00 , F04B43/04 , F04B19/00
摘要： Microfluidic circuit elements, such as a microvalve, micropump or microvent, formed of a microcavity divided by a diaphragm web into a first subcavity bounded by a first internal wall and a second subcavity bounded by a second internal wall, where the diaphragm web is characterized as a thin film having a first state contacting the first internal wall and a second state contacting the second internal wall and exhibiting essentially no elasticity in moving between the first state and the second state, the thin film web having been stretched beyond its yield point before or during use are provided. The disclosed elements enable faster and more efficient cycling of the diaphragm in the microcavity and increases the diaphragm surface area. In a preferred embodiment, the microfluidic circuit element is pneumatically driven and controls the motion of fluids in a microassay device.

7. 发明申请

US20210315550A1 SPECIMEN COLLECTION AND DELIVERY APPARATUS 有权
公开(公告)号：US20210315550A1
公开(公告)日：2021-10-14
申请号：US17357111
申请日：2021-06-24
申请人： PerkinElmer Health Sciences, Inc.
发明人： Andrew Kolb , Alan K. Lofquist , C. Frederick Battrell
IPC分类号： A61B10/00 , B01L3/00 , A61B10/02 , G01N1/00
摘要： A specimen collection and delivery apparatus for collecting clinical specimens and delivery of samples thereof to, e.g., microfluidic testing devices for diagnostic analysis is disclosed. The specimen collection and delivery apparatus includes a closure housing for coupling with a sample tube at one end, an open luer for coupling with a complementary luer on a microfluidic device at the other end, and a filter matrix disposed in the interior. The filter matrix is air permeable and liquid impermeable at atmospheric pressure and prevents sample from flowing through the open luer end when coupled to a sample tube containing a specimen. Under vacuum, the liquid sample fraction of the specimen can be drawn through the filter matrix and into the microfluidic testing device through the luer connection for diagnostic analysis.

8. 发明授权

US11016108B2 Microfluidic devices and methods for performing serum separation and blood cross-matching 有权
公开(公告)号：US11016108B2
公开(公告)日：2021-05-25
申请号：US16455454
申请日：2019-06-27
申请人： PerkinElmer Health Sciences, Inc.
发明人： Andrew W. Kolb , Carolina L. Elmufdi , C. Frederick Battrell
IPC分类号： B01L3/00 , G01N33/80 , G01N33/49
摘要： Microfluidic cartridges or devices for serum separation and blood cross-match analysis are provided. The devices may include a serum separation subcircuit alone or in combination with a solute mixing subcircuit. The serum separation subcircuit promotes on-cartridge clotting of a blood sample and manipulates the flow of the separated serum sample for subsequent cross-match analysis with a second blood sample, for example. The solute mixing subcircuit includes at least two intake channels, one for a whole blood sample from, for example, a blood donor and the other for the separated serum sample from, for example, a transfusion recipient. The solute mixing subcircuit further includes a serpentine mixing channel conjoined to a downstream channel. Under vacuum generated by a conjoined finger pump, the two input streams fill the serpentine mixing and downstream channels due to capillary action, enabling visualization of an agglutination reaction.

9. 发明申请

US20190324045A1 MICROFLUIDIC DEVICES AND METHODS FOR PERFORMING SERUM SEPARATION AND BLOOD CROSS-MATCHING 审中-公开
公开(公告)号：US20190324045A1
公开(公告)日：2019-10-24
申请号：US16455454
申请日：2019-06-27
申请人： PerkinElmer Health Sciences, Inc.
发明人： Andrew W. Kolb , Carolina L. Elmufdi , C. Frederick Battrell
IPC分类号： G01N33/80 , B01L3/00 , G01N33/49
摘要： Microfluidic cartridges or devices for serum separation and blood cross-match analysis are provided. The devices may include a serum separation subcircuit alone or in combination with a solute mixing subcircuit. The serum separation subcircuit promotes on-cartridge clotting of a blood sample and manipulates the flow of the separated serum sample for subsequent cross-match analysis with a second blood sample, for example. The solute mixing subcircuit includes at least two intake channels, one for a whole blood sample from, for example, a blood donor and the other for the separated serum sample from, for example, a transfusion recipient. The solute mixing subcircuit further includes a serpentine mixing channel conjoined to a downstream channel. Under vacuum generated by a conjoined finger pump, the two input streams fill the serpentine mixing and downstream channels due to capillary action, enabling visualization of an agglutination reaction.

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