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1. 发明申请

US20050161335A1 Capillary electrophoresis chip apparatus for detecting polymorphism of nucleotide and mononucleotide 有权
标题翻译：用于检测核苷酸和单核苷酸多态性的毛细管电泳切片装置
公开(公告)号：US20050161335A1
公开(公告)日：2005-07-28
申请号：US10500180
申请日：2002-11-29
申请人： Peng Liu , Wanli Xing , Dong Liang , Jing Cheng
发明人： Peng Liu , Wanli Xing , Dong Liang , Jing Cheng
IPC分类号： G01N27/447 , G01N27/453
CPC分类号： G01N27/44791
摘要： The present invention provides a capillary electrophoresis chip apparatus for detecting nucleotide polymorphism or single nucleotide polymorphism belonging to capillary electrophoresis apparatuses. The apparatus comprises an upper channel layer comprising a one-, two-, or multi-dimensional microfluid channel and an electrode aperture structure for loading sample, a middle electrode layer for sealing the microfluid channel to form an intact capillary and providing the needed voltage for electrophoresis; and a lower heating layer for providing a stable temperature gradient for electrophoresis. The upper, middle and lower layers are thermal conductive and adhesive to each other.
摘要翻译：本发明提供一种用于检测属于毛细管电泳装置的核苷酸多态性或单核苷酸多态性的毛细管电泳芯片装置。该装置包括上通道层，其包括一维，二维或多维微流体通道和用于装载样品的电极孔结构，用于密封微流体通道以形成完整毛细管的中间电极层，并提供所需电压电泳; 以及用于提供电泳的稳定温度梯度的较低加热层。上，中，下层相互导热，粘合。

2. 发明授权

US07527719B2 Capillary electrophoresis chip apparatus for detecting nucleotide polymorphism and single nucleotide polymorphism 有权
标题翻译：用于检测核苷酸多态性和单核苷酸多态性的毛细管电泳芯片装置
公开(公告)号：US07527719B2
公开(公告)日：2009-05-05
申请号：US10500180
申请日：2002-11-29
申请人： Peng Liu , Wanli Xing , Dong Liang , Jing Cheng
发明人： Peng Liu , Wanli Xing , Dong Liang , Jing Cheng
IPC分类号： G01N27/453
CPC分类号： G01N27/44791
摘要： The present invention provides a capillary electrophoresis chip apparatus for detecting nucleotide polymorphism or single nucleotide polymorphism belonging to capillary electrophoresis apparatuses. The apparatus comprises an upper channel layer comprising a one-, two-, or multi-dimensional microfluid channel and an electrode aperture structure for loading sample, a middle electrode layer for sealing the microfluid channel to form an intact capillary and providing the needed voltage for electrophoresis; and a lower heating layer for providing a stable temperature gradient for electrophoresis. The upper, middle and lower layers are thermal conductive and adhesive to each other.
摘要翻译：本发明提供一种用于检测属于毛细管电泳装置的核苷酸多态性或单核苷酸多态性的毛细管电泳芯片装置。该装置包括上通道层，其包括一维，二维或多维微流体通道和用于装载样品的电极孔结构，用于密封微流体通道以形成完整毛细管的中间电极层，并提供所需电压电泳; 以及用于提供电泳的稳定温度梯度的较低加热层。上，中，下层相互导热，粘合。

3. 发明申请

US20070054273A1 Microarray devices having controllable reaction volume 有权
标题翻译：具有可控反应体积的微阵列装置
公开(公告)号：US20070054273A1
公开(公告)日：2007-03-08
申请号：US10566329
申请日：2003-08-13
申请人： Feijun Xian , Wanli Xing , Jing Cheng , Dong Liang , Liang Zhang , Dong Wang
发明人： Feijun Xian , Wanli Xing , Jing Cheng , Dong Liang , Liang Zhang , Dong Wang
IPC分类号： C12Q1/68 , C12M1/34
CPC分类号： B01L3/50853 , B01J2219/00281 , B01J2219/00596 , B01J2219/00659 , B01L9/52 , B01L2200/0689 , B01L2300/0636 , B01L2300/0822 , C12Q1/6837 , C40B60/14 , G01N33/54366
摘要： This invention relates generally to the field of microarray chips and uses thereof. In particular, the invention provides a microarray reaction device that can be used in assaying the interaction between various moieties, e.g., nucleic acids, immunoreactions involving proteins, interactions between a protein and a nucleic acid, a ligand-receptor interaction, and small molecule and protein or nucleic acid interactions, etc. Articles of manufacture and kits comprising the microarray reaction device and assaying methods using the microarray reaction device are also provided.
摘要翻译：本发明一般涉及微阵列芯片领域及其用途。特别地，本发明提供一种微阵列反应装置，其可用于测定各种部分之间的相互作用，例如核酸，涉及蛋白质的免疫反应，蛋白质与核酸之间的相互作用，配体 - 受体相互作用和小分子，以及蛋白质或核酸相互作用等。还提供了包含微阵列反应装置的生产制品和试剂盒以及使用微阵列反应装置的测定方法。

4. 发明授权

US08293519B2 Microarray devices having controllable reaction volume 有权
标题翻译：具有可控反应体积的微阵列装置
公开(公告)号：US08293519B2
公开(公告)日：2012-10-23
申请号：US10566329
申请日：2003-08-13
申请人： Feijun Xian , Wanli Xing , Jing Cheng , Dong Liang , Liang Zhang , Dong Wang
发明人： Feijun Xian , Wanli Xing , Jing Cheng , Dong Liang , Liang Zhang , Dong Wang
IPC分类号： C12M1/36 , G01N15/06 , B01L3/00
CPC分类号： B01L3/50853 , B01J2219/00281 , B01J2219/00596 , B01J2219/00659 , B01L9/52 , B01L2200/0689 , B01L2300/0636 , B01L2300/0822 , C12Q1/6837 , C40B60/14 , G01N33/54366
摘要： This invention relates generally to the field of microarray chips and uses thereof. In particular, the invention provides a microarray reaction device that can be used in assaying the interaction between various moieties, e.g., nucleic acids, immunoreactions involving proteins, interactions between a protein and a nucleic acid, a ligand-receptor interaction, and small molecule and protein or nucleic acid interactions, etc. Articles of manufacture and kits comprising the microarray reaction device and assaying methods using the microarray reaction device are also provided.
摘要翻译：本发明一般涉及微阵列芯片领域及其用途。特别地，本发明提供一种微阵列反应装置，其可用于测定各种部分之间的相互作用，例如核酸，涉及蛋白质的免疫反应，蛋白质与核酸之间的相互作用，配体 - 受体相互作用和小分子，以及蛋白质或核酸相互作用等。还提供了包含微阵列反应装置的生产制品和试剂盒以及使用微阵列反应装置的测定方法。

5. 发明申请

US20060144237A1 Microminiature gas chromatograph column 审中-公开
标题翻译：微型气相色谱柱
公开(公告)号：US20060144237A1
公开(公告)日：2006-07-06
申请号：US10537533
申请日：2002-12-31
申请人： Dong Liang , Wanli Xing , Jing Cheng
发明人： Dong Liang , Wanli Xing , Jing Cheng
IPC分类号： B01D53/02 , B01D53/14
CPC分类号： G01N30/6095 , G01N30/6039 , G01N2030/025
摘要： This invention relates to the field of miniaturing gas chromatograph instruments using microfabrication technologies. In particular, the invention provides a gas chromatograph column, which column comprises at least two lid layers and a channel layer, wherein each of said layers comprises a compact material suitable for gas chromatograph, said channel layer comprises microfabricated channels on both sides, said microfabricated channels and a side of said lid layers form at least two capillaries, said at least two capillaries are connected to each other through a hole in said channel layer to form an integrated capillary, said integrated capillary is connected to outside atmosphere on both ends via holes on two outmost lid layers to serve as an inlet and an outlet.
摘要翻译：本发明涉及使用微细加工技术的微型气相色谱仪的领域。特别地，本发明提供了一种气相色谱柱，该色谱柱包括至少两个盖层和沟道层，其中每个所述层包括适合于气相色谱的致密材料，所述通道层包括两侧的微细加工通道，所述微制造通道和所述盖层的一侧形成至少两个毛细管，所述至少两个毛细管通过所述通道层中的孔彼此连接以形成集成毛细管，所述集成毛细管连接到两端的外部大气通孔在两个最外层的盖层上用作入口和出口。

6. 发明授权

US08784633B2 Automatic positioning and sensing microelectrode arrays 有权
标题翻译：自动定位和感应微电极阵列
公开(公告)号：US08784633B2
公开(公告)日：2014-07-22
申请号：US12667507
申请日：2007-07-04
申请人： Guangxin Xiang , Liangbin Pan , Wanli Xing , Lihua Huang , Zhongyao Yu , Jing Zhu , Yuxiang Zhou , Jing Cheng
发明人： Guangxin Xiang , Liangbin Pan , Wanli Xing , Lihua Huang , Zhongyao Yu , Jing Zhu , Yuxiang Zhou , Jing Cheng
IPC分类号： G01N27/447 , G01N27/453
CPC分类号： G01N33/4836 , B01J2219/00653 , B01J2219/00743 , B01L3/502707 , B01L2300/0645 , B01L2400/0421 , B01L2400/0424
摘要： A microelectrode sensing device includes a substrate and an array of microelectrode sensors. Each sensor includes a first conductive layer that at least partially conducts electricity. The first conductive layer is formed above the substrate and patterned to include a recording electrode that measures electrical activities of target cells. Each sensor also includes a second conductive layer that at least partially conducts electricity. The second conductive layer is elevated above the first layer and patterned to include multiple positioning electrodes arranged to define a sensing region above the recording electrode. The positioning electrodes are designed to generate an electric field pattern in the sensing region to move and confine the target cells to a sub-region of the sensing region that at least partially overlaps the recording electrode.
摘要翻译：微电极感测装置包括基板和微电极传感器阵列。每个传感器包括至少部分地导电的第一导电层。第一导电层形成在衬底上并被图案化以包括测量靶细胞的电活动的记录电极。每个传感器还包括至少部分地传导电的第二导电层。第二导电层在第一层之上被升高并且被图案化以包括布置成限定记录电极上方的感测区域的多个定位电极。定位电极被设计成在感测区域中产生电场图案以移动并将目标单元限制在至少部分地与记录电极重叠的感测区域的子区域上。

7. 发明授权

US07632674B2 Apparatus for stimulating an animal cell and recording its physiological signal and production and use methods thereof 有权
标题翻译：用于刺激动物细胞并记录其生理信号的装置及其生产和使用方法
公开(公告)号：US07632674B2
公开(公告)日：2009-12-15
申请号：US10499098
申请日：2002-11-29
申请人： Wanli Xing , Zhe Yu , Guangxin Xiang , Liangbin Pan , Jing Cheng
发明人： Wanli Xing , Zhe Yu , Guangxin Xiang , Liangbin Pan , Jing Cheng
IPC分类号： C12M3/00
CPC分类号： G01N33/5438 , C12M35/02 , G01N2333/46 , G01N2500/10
摘要： The present invention provides an apparatus for stimulating an animal cell and recording its physiological signal and methods of making and using thereof. The purpose of the present invention is to provide an apparatus for stimulating an animal cell and recording its physiological signal that is efficient, convenient, and accurate. The apparatus for stimulating an animal cell and recording its physiological signal of the present invention comprises a poor conductive substrate, wherein on at least one surface of the substrate is provided at least one unit conductive polymer layer and at least one good conductive microelectrode.
摘要翻译：本发明提供一种用于刺激动物细胞并记录其生理信号的装置及其制造和使用方法。本发明的目的是提供一种用于刺激动物细胞并记录其生理信号的装置，其有效，方便和准确。用于刺激动物细胞并记录其本发明的生理信号的装置包括差的导电基底，其中在基底的至少一个表面上提供至少一个单位导电聚合物层和至少一个良好的导电微电极。

8. 发明申请

US20090143245A1 MICROARRAYS FOR GENOTYPING AND METHODS OF USE 审中-公开
标题翻译：用于基因组的微阵列和使用方法
公开(公告)号：US20090143245A1
公开(公告)日：2009-06-04
申请号：US12093504
申请日：2006-02-20
申请人： Huafang Gao , Ze Li , Dong Wang , Yanhua Liu , Xiang Liu , Yangzhou Jiang , Chuanzan Zhao , Li Li , Gengxin Lan , Tao Guo , Bin Cai , Wanli Xing , Yuxiang Zhou , Jing Cheng
发明人： Huafang Gao , Ze Li , Dong Wang , Yanhua Liu , Xiang Liu , Yangzhou Jiang , Chuanzan Zhao , Li Li , Gengxin Lan , Tao Guo , Bin Cai , Wanli Xing , Yuxiang Zhou , Jing Cheng
IPC分类号： C40B30/10 , C40B40/08 , C40B50/06
CPC分类号： C12Q1/6881 , C12Q1/6837 , C12Q2600/156
摘要： The present invention provides a microarray for detecting a genotype at a polymorphic site in a plurality of nucleic acid samples, comprising a first set of nucleic acid fragments derived from the samples and a second set of nucleic acid fragments derived from a plurality of references immobilized thereon. The invention also provides a microarray comprising a set of nucleic acid fragments immobilized on the surface of the microarray, wherein the nucleic acid fragments are derived from the samples by amplifying a region in the sample containing the polymorphism through asymmetric PCR amplification. Methods of using and making the microarrays are also provided.
摘要翻译：本发明提供了用于检测多个核酸样品中多态性位点处的基因型的微阵列，其包含衍生自样品的第一组核酸片段和衍生自多个固定在其上的参考文献的第二组核酸片段。本发明还提供了一种微阵列，其包含固定在微阵列表面上的一组核酸片段，其中通过不对称PCR扩增扩增含有多态性的样品中的区域，来从样品衍生出核酸片段。还提供了使用和制造微阵列的方法。

9. 发明申请

US20080124251A1 Sample Preparation Device for Extracting Drug Residue 有权
标题翻译：用于提取药物残留物的样品制备装置
公开(公告)号：US20080124251A1
公开(公告)日：2008-05-29
申请号：US11661019
申请日：2004-11-22
申请人： Renyuan Chen , Guoqing Wang , Feijun Xian , Wanli Xing , Xianhua Wang , Jing Cheng
发明人： Renyuan Chen , Guoqing Wang , Feijun Xian , Wanli Xing , Xianhua Wang , Jing Cheng
IPC分类号： B01L9/06 , B01L11/00 , B01L7/02
CPC分类号： G01N1/40 , G01N2001/2866
摘要： The present invention provides a sample preparation device for extracting drug residue. It comprises a case, in which a water bath, a vortex mixer, and a homogenizer are integrated. The case also has on it an integrated control panel for controlling heating temperature of the water bath and homogenization time of the homogenizer.
摘要翻译：本发明提供了用于提取药物残留物的样品制备装置。它包括其中集成了水浴，涡流混合器和均化器的壳体。该情况还具有用于控制水浴的加热温度和均化器的均化时间的集成控制面板。

10. 发明申请

US20060124152A1 Method and apparatus for washing solid substrate with ultrasonic wave after hybridization reaction 审中-公开
标题翻译：杂交反应后用超声波洗涤固体底物的方法和装置
公开(公告)号：US20060124152A1
公开(公告)日：2006-06-15
申请号：US10524903
申请日：2002-12-10
申请人： Gang Li , Wanli Xing , Ruige Wu , Min Guo , Jing Cheng
发明人： Gang Li , Wanli Xing , Ruige Wu , Min Guo , Jing Cheng
IPC分类号： B08B3/10
CPC分类号： B08B3/12 , C12Q1/6813 , C12Q2523/301
摘要： A method and apparatus for washing solid substrate with ultrasonic wave after hybridization reaction are provided. The method includes (1) putting the solid substrate into a container having a washing solution, on which the hybridization reaction has been completed, (2) using an ultrasonic generator to produce a certain strength of ultrasonic wave and transmit it into the washing solution, (3) washing the substrate by means of the cavitation effect being produced in the washing solution by the ultrasonic wave. Since the cavitation bubbles in the washing solution can produce intensive efflux and local microslipstream against the solid surface, evidently reducing the liquid surface tension and friction and enhance the liquid flow, non-specific adsorbate and deposit bound weakly on the solid substrate can be washed down rapidly.
摘要翻译：提供了一种用于在杂交反应之后用超声波洗涤固体底物的方法和装置。该方法包括：（1）将固体基质置于具有杂交反应完成的洗涤液的容器中，（2）使用超声波发生器产生一定强度的超声波并将其输送到洗涤液中，（3）通过超声波在洗涤液中产生的空化作用洗涤基板。由于洗涤液中的气穴气泡能够对固体表面产生强烈的流出和局部微滑流，明显降低了液面张力和摩擦力，增强了液体流动，固体基质上弱结合的非特异性吸附物和沉积物可以被冲洗掉迅速

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