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1. 发明申请

US20150052271A1 METHOD OF OPTIMIZING THE WIDTH OF TRANSACTION ID FOR AN INTERCONNECTING BUS 有权
标题翻译：优化互连总线的交易ID宽度的方法
公开(公告)号：US20150052271A1
公开(公告)日：2015-02-19
申请号：US13965226
申请日：2013-08-13
申请人： Ying-Ze Liao , Pei Yu , Yung-Sheng Fang
发明人： Ying-Ze Liao , Pei Yu , Yung-Sheng Fang
IPC分类号： G06F13/368
CPC分类号： G06F13/368
摘要： The present invention discloses a method of to generate transaction ID(s) in a bus interconnection design. An encoding table for each slave can be derived by calculating all possible transactions from all the masters to the slave so as to determine the minimum width of the transaction ID received by the slave in the interconnecting bus design, thereby avoiding the routing congestion in the interconnecting bus.
摘要翻译：本发明公开了一种在总线互连设计中产生交易ID的方法。可以通过计算从所有主机到从机的所有可能的事务来导出每个从机的编码表，以便确定从机在互连总线设计中接收到的事务ID的最小宽度，从而避免互连中的路由拥塞总线。

2. 发明申请

US20120115874A1 PYRAZINE DERIVATIVES, PROCESS FOR MANUFACTURE AND USE THEREOF 有权
标题翻译：吡嗪衍生物，其制备方法及其用途
公开(公告)号：US20120115874A1
公开(公告)日：2012-05-10
申请号：US13254653
申请日：2011-07-01
申请人： Yuqiang Wang , Yewei Sun , Pei Yu , Jing Du , Gaoxiao Zhang
发明人： Yuqiang Wang , Yewei Sun , Pei Yu , Jing Du , Gaoxiao Zhang
IPC分类号： A61K31/498 , A61K31/4965 , C07D241/42 , C07D403/12 , A61K31/497 , C07D495/04 , A61P25/00 , A61P9/00 , A61P29/00 , A61P27/02 , A61P35/00 , A61P25/08 , A61P25/16 , A61P25/28 , A61P9/10 , A61P1/00 , A61P3/10 , A61P11/06 , A61P1/16 , A61P37/06 , A61P1/18 , A61P13/12 , A61P3/04 , A61P27/06 , C07D241/12
CPC分类号： C07D241/12 , C07D241/24 , C07D241/42 , C07D495/04
摘要： The present invention provides pyrazine derivatives of formula I and pharmaceutically acceptable salts thereof, wherein the designation of R1, R2, R3 and R4 is provided herein. The invention also provides syntheses for preparation of such compounds. The invention further provides methods of use of these compounds and pharmaceutical compositions containing them for treatment and/or prevention of diseases and for manufacture of medicaments. These compounds and pharmaceutical compositions have antioxidative and thrombolytic effects, and thus can be used for the treatment and/or prevention of cerebral stroke caused by ischemia, and used for manufacture of medicaments for the treatment and/or prevention of nervous system diseases caused by excessive amount of radicals and/or thrombosis, infectious diseases, metabolic system diseases, cardiovascular and cerebrovascular diseases, and age-related degenerative diseases.
摘要翻译：本发明提供式I的吡嗪衍生物及其药学上可接受的盐，其中R1，R2，R3和R4的名称在本文中提供。本发明还提供了用于制备这些化合物的合成。本发明还提供了使用这些化合物和含有它们的药物组合物用于治疗和/或预防疾病和制备药物的方法。这些化合物和药物组合物具有抗氧化和溶栓作用，因此可用于治疗和/或预防由局部缺血引起的脑卒中，并用于制备用于治疗和/或预防由过度引起的神经系统疾病的药物自由基和/或血栓形成的数量，传染病，代谢系统疾病，心血管和脑血管疾病以及年龄相关的退行性疾病。

3. 发明授权

US08796281B2 Lighting device having at least one heat sink 有权
标题翻译：吡嗪衍生物，其制备方法和用途
公开(公告)号：US08796281B2
公开(公告)日：2014-08-05
申请号：US13254653
申请日：2011-07-01
申请人： Yuqiang Wang , Yewei Sun , Pei Yu , Jing Du , Gaoxiao Zhang
发明人： Yuqiang Wang , Yewei Sun , Pei Yu , Jing Du , Gaoxiao Zhang
IPC分类号： A61K31/4965 , C07D241/26
CPC分类号： C07D241/12 , C07D241/24 , C07D241/42 , C07D495/04
摘要： The present invention provides pyrazine derivatives of formula I and pharmaceutically acceptable salts thereof, wherein the designation of R1, R2, R3 and R4 is provided herein. The invention also provides syntheses for preparation of such compounds. The invention further provides methods of use of these compounds and pharmaceutical compositions containing them for treatment and/or prevention of diseases and for manufacture of medicaments. These compounds and pharmaceutical compositions have antioxidative and thrombolytic effects, and thus can be used for the treatment and/or prevention of cerebral stroke caused by ischemia, and used for manufacture of medicaments for the treatment and/or prevention of nervous system diseases caused by excessive amount of radicals and/or thrombosis, infectious diseases, metabolic system diseases, cardiovascular and cerebrovascular diseases, and age-related degenerative diseases.
摘要翻译：本发明提供式I的吡嗪衍生物及其药学上可接受的盐，其中R1，R2，R3和R4的名称在本文中提供。本发明还提供了用于制备这些化合物的合成。本发明还提供了使用这些化合物和含有它们的药物组合物用于治疗和/或预防疾病和制备药物的方法。这些化合物和药物组合物具有抗氧化和溶栓作用，因此可用于治疗和/或预防由局部缺血引起的脑卒中，并用于制备用于治疗和/或预防由过度引起的神经系统疾病的药物自由基和/或血栓形成的数量，传染病，代谢系统疾病，心血管和脑血管疾病以及年龄相关的退行性疾病。

4. 发明授权

US08404688B2 Nitrone compounds, process of preparation thereof, and use thereof in medicament manufacture 有权
标题翻译：硝基化合物，其制备方法及其在药物制备中的应用
公开(公告)号：US08404688B2
公开(公告)日：2013-03-26
申请号：US12937405
申请日：2009-04-16
申请人： Yuqiang Wang , Jie Jiang , Pei Yu , Yewei Sun , Linda Wang , Zaijun Zhang
发明人： Yuqiang Wang , Jie Jiang , Pei Yu , Yewei Sun , Linda Wang , Zaijun Zhang
IPC分类号： A61K31/4965
CPC分类号： C07D241/12
摘要： The present invention provides novel nitrones, their preparation and use. The novel compounds have the following formula: I The compounds of the present invention have strong antioxidative activity, and are thrombolytic. These compounds can be used to treat and/or prevent diseases caused by overproduction of free radicals and/or formation of thrombus.
摘要翻译：本发明提供新的硝酮，其制备和用途。该化合物具有以下结构式：I本发明化合物具有较强的抗氧化活性，且具有血栓溶解作用。这些化合物可用于治疗和/或预防由过度产生自由基和/或形成血栓引起的疾病。

5. 发明申请

US20110077295A1 ANDROGRAPHOLIDE DERIVATIVES AND USE THEREOF IN MANUFACTURE OF MEDICAMENTS 有权
标题翻译：异丙肾上腺素衍生物及其在药物制造中的应用
公开(公告)号：US20110077295A1
公开(公告)日：2011-03-31
申请号：US12672476
申请日：2008-08-07
申请人： Yuqiang Wang , Xiaojian Jiang , Jie Jiang , Zaijun Zhang , Zhaoqi Yang , Pei Yu
发明人： Yuqiang Wang , Xiaojian Jiang , Jie Jiang , Zaijun Zhang , Zhaoqi Yang , Pei Yu
IPC分类号： A61K31/341 , C07D307/60 , A61P35/00 , A61P3/10 , A61P35/02
CPC分类号： C07D307/58 , C07D307/60 , C07D409/12
摘要： The present invention relates to an andrographolide derivative of the formula (I), wherein R1, R2 and R3 are same or different substituents selected from hydrogen, substituted or unsubstituted organic acid radicals, inorganic acid radicals, alkyl, aryl or heteroaryl, and at least one of R1, R2 and R3 is R-lipoic acid, S-lipoic acid or a mixture thereof, or corresponding dihydrolipoic acids thereof, or N-acetylcysteine radical. The derivative has good antitumor effect, can induce apoptosis of tumor cells, can directly kill Gram-positive bacteria (staphylococcus aureus) and drug resistance bacteria (MRSA5676 and MRSA5677), can inhibit the QS-system of Gram-negative bacteria (Pseudomonas aeruginosa), can inhibit and destroy the formation of biofilm of Pseudomonas aeruginosa; and exhibits significant hypoglycemic effect, so that it can be used in manufacture of medicaments for treatment of cancers, inflammation, diabetes, and bacterial and viral infections.
摘要翻译：本发明涉及式（I）的穿心莲内酯衍生物，其中R 1，R 2和R 3是相同或不同的选自氢，取代或未取代的有机酸基，无机酸基，烷基，芳基或杂芳基的取代基，至少 R1，R2和R3之一是R-硫辛酸，S-硫辛酸或其混合物，或其相应的二氢硫辛酸或N-乙酰半胱氨酸碱基。该衍生物具有良好的抗肿瘤作用，可诱导肿瘤细胞凋亡，可直接杀死革兰氏阳性菌（金黄色葡萄球菌）和耐药细菌（MRSA5676和MRSA5677），可抑制革兰氏阴性菌（绿脓假单胞菌）的QS系统，，可以抑制和破坏铜绿假单胞菌生物膜的形成; 并显示出显着的降血糖作用，因此可用于制造用于治疗癌症，炎症，糖尿病以及细菌和病毒感染的药物。

6. 发明授权

US08367720B2 Andrographolide derivatives and use thereof in manufacture of medicaments 有权
标题翻译：穿心莲内酯衍生物及其在药物制造中的应用
公开(公告)号：US08367720B2
公开(公告)日：2013-02-05
申请号：US12672476
申请日：2008-08-07
申请人： Yuqiang Wang , Xiaojian Jiang , Jie Jiang , Zaijun Zhang , Zhaoqi Yang , Pei Yu
发明人： Yuqiang Wang , Xiaojian Jiang , Jie Jiang , Zaijun Zhang , Zhaoqi Yang , Pei Yu
IPC分类号： A01N43/08 , A01N57/00 , A61K31/34 , A61K31/665 , A61K31/585 , C07D307/02 , C07D307/00
CPC分类号： C07D307/58 , C07D307/60 , C07D409/12
摘要： The present invention relates to an andrographolide derivative of the formula (I), wherein R1, R2 and R3 are same or different substituents selected from hydrogen, substituted or unsubstituted organic acid radicals, inorganic acid radicals, alkyl, aryl or heteroaryl, and at least one of R1, R2 and R3 is R-lipoic acid, S-lipoic acid or a mixture thereof, or corresponding dihydrolipoic acids thereof, or N-acetylcysteine radical. The derivative has good antitumor effect, can induce apoptosis of tumor cells, can directly kill Gram-positive bacteria (staphylococcus aureus) and drug resistance bacteria (MRSA5676 and MRSA5677), can inhibit the QS-system of Gram-negative bacteria (Pseudomonas aeruginosa), can inhibit and destroy the formation of biofilm of Pseudomonas aeruginosa; and exhibits significant hypoglycemic effect, so that it can be used in manufacture of medicaments for treatment of cancers, inflammation, diabetes, and bacterial and viral infections.
摘要翻译：本发明涉及式（I）的穿心莲内酯衍生物，其中R 1，R 2和R 3是相同或不同的选自氢，取代或未取代的有机酸基，无机酸基，烷基，芳基或杂芳基的取代基，至少 R1，R2和R3之一是R-硫辛酸，S-硫辛酸或其混合物，或其相应的二氢硫辛酸或N-乙酰半胱氨酸碱基。该衍生物具有良好的抗肿瘤作用，可诱导肿瘤细胞凋亡，可直接杀死革兰氏阳性菌（金黄色葡萄球菌）和耐药细菌（MRSA5676和MRSA5677），可抑制革兰氏阴性菌（绿脓假单胞菌）的QS系统，，可以抑制和破坏铜绿假单胞菌生物膜的形成; 并显示出显着的降血糖作用，因此可用于制造用于治疗癌症，炎症，糖尿病以及细菌和病毒感染的药物。

7. 发明申请

US20110034485A1 NITRONE COMPOUNDS, PROCESS OF PREPARATION THEREOF, AND USE THEREOF IN MEDICAMENT MANUFACTURE 有权
标题翻译：硝基化合物，其制备方法及其在药物制造中的应用
公开(公告)号：US20110034485A1
公开(公告)日：2011-02-10
申请号：US12937405
申请日：2009-04-16
申请人： Yuqiang Wang , Jie Jiang , Pei Yu , Yewei Sun , Linda Wang , Zaijun Zhang
发明人： Yuqiang Wang , Jie Jiang , Pei Yu , Yewei Sun , Linda Wang , Zaijun Zhang
IPC分类号： A61K31/505 , C07D239/30 , A61P25/00 , A61P9/00 , A61P27/02 , A61P29/00 , A61P35/00
CPC分类号： C07D241/12
摘要： The present invention provides novel nitrones, their preparation and use. The novel compounds have the following formula: I The compounds of the present invention have strong antioxidative activity, and are thrombolytic. These compounds can be used to treat and/or prevent diseases caused by overproduction of free radicals and/or formation of thrombus.
摘要翻译：本发明提供新的硝酮，其制备和用途。该化合物具有以下结构式：I本发明化合物具有较强的抗氧化活性，且具有血栓溶解作用。这些化合物可用于治疗和/或预防由过度产生自由基和/或形成血栓引起的疾病。

8. 发明申请

US20080021202A1 NOVEL APOPTOSIS PROTEINS 有权
标题翻译：新型疫苗蛋白
公开(公告)号：US20080021202A1
公开(公告)日：2008-01-24
申请号：US11739267
申请日：2007-04-24
申请人： Ying Luo , Betty Huang , Mary Shen , Pei Yu
发明人： Ying Luo , Betty Huang , Mary Shen , Pei Yu
IPC分类号： C07K16/18
CPC分类号： C07K14/4747 , A61K38/00
摘要： The present invention is directed to novel apoptosis polypeptides such as the Apop1, Apop2, and Apop3 proteins and related molecules which are involved in modulating apoptosis and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Further provided by the present invention are method for identifying novel compositions which modulate the biological activity of Apop1, Apop2, and Apop3, and the use of such compositions in diagnosis and treatment of disease.
摘要翻译：本发明涉及新的凋亡多肽，例如参与调节凋亡的Apop1，Apop2和Apop3蛋白和相关分子以及编码这些多肽的核酸分子。本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法发明。本发明还提供了鉴定调节Apop1，Apop2和Apop3的生物学活性的新组合物的方法，以及这些组合物在疾病诊断和治疗中的用途。

9. 发明授权

US07181669B2 Device and method for block code error correction 有权
标题翻译：块代码纠错的装置和方法
公开(公告)号：US07181669B2
公开(公告)日：2007-02-20
申请号：US10734286
申请日：2003-12-15
申请人： Yu-Cheng Shen , Kuo-Ming Wang , Pei Yu , Cheng-Yueh Hsiao
发明人： Yu-Cheng Shen , Kuo-Ming Wang , Pei Yu , Cheng-Yueh Hsiao
IPC分类号： H03M13/05 , H03M13/29
CPC分类号： H03M13/2707 , H03M13/15 , H03M13/1515 , H03M13/2915
摘要： A device and method for block code error correction. The device includes a block code input unit, an erasing address table, an error table and a decoder. The block code input unit is used to input a block code. The erasing address table and the error table have a plurality of erasing entities and error entities in rows and columns, respectively. The decoder decodes the block code in a row direction based on the erasing address table to find data errors on rows and update the error table, and updates the erasing address table in the row direction according to a first determination principle. Next, the decoder decodes the block code in a column direction based on the erasing address table to find data errors on columns and update the error table, and updates the erasing address table in the column direction according to a second determination principle.
摘要翻译：一种用于块码纠错的装置和方法。该装置包括块代码输入单元，擦除地址表，错误表和解码器。块代码输入单元用于输入块代码。擦除地址表和错误表分别具有行和列中的多个擦除实体和错误实体。解码器基于擦除地址表对行方向上的块码进行解码，以查找行上的数据错误并更新错误表，并根据第一确定原理更新行方向上的擦除地址表。接下来，解码器基于擦除地址表在列方向上解码块码，以查找列上的数据错误并更新错误表，并根据第二确定原理更新列方向上的擦除地址表。

10. 发明授权

US09938611B2 High strength nodular cast iron pole and preparation technology thereof 有权
公开(公告)号：US09938611B2
公开(公告)日：2018-04-10
申请号：US14416436
申请日：2014-08-14
申请人： Pei Yu
发明人： Pei Yu
IPC分类号： C22C37/10 , C22C37/06 , C22C33/08 , C22C37/04 , C21D5/00 , C21D9/00
CPC分类号： C22C37/10 , C21D5/00 , C21D9/0068 , C22C33/08 , C22C37/04 , C22C37/06
摘要： The invention discloses a high strength nodular cast iron pole and a preparation technology thereof. The preparation technology is characterized by comprising the following steps: (1) preparation before pole casting, to be specific, preparation of raw materials, smelting of iron, adding of alloying elements and nodulizing; (2) a pole casting procedure, to be specific, casting and inoculation treatment; and (3) heat treatment. The invention also provides the high strength nodular cast iron pole prepared by adopting the preparation technology, comprising multiple tower poles which are sequentially connected in an inserted manner, wherein each tower pole is a cone-frustum hollow column which has the conicity of 1000:11-26; the top end of the high strength nodular cast iron pole is equipped with a tower cap. The high strength nodular cast iron pole has the advantages of high bearing capacity, thin wall thickness, light weight, low manufacturing cost and the like.

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