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1. 发明授权

US5246451A Vascular prosthesis and method 失效
标题翻译：血管假体和方法
公开(公告)号：US5246451A
公开(公告)日：1993-09-21
申请号：US693753
申请日：1991-04-30
申请人： Paul V. Trescony , Patrick Cahalan , Kenneth Keeney
发明人： Paul V. Trescony , Patrick Cahalan , Kenneth Keeney
IPC分类号： A61F2/06 , A61L27/34 , A61L27/50 , A61L33/00
CPC分类号： A61L33/0076 , A61F2/06 , A61L27/34 , A61L27/507 , Y10S623/921
摘要： A vascular graft with improved endothelial cell adhesion can be achieved on a fluoropolymer surface of a vascular graft by treating the fluoropolymer with a plasma in the presence of a non-polymerizing gas capable of providing the fluoropolymer with anionic groups and binding a protein to the treated fluoropolymer. In a preferred embodiment, the fluoropolymer surface is a plasma deposited fluoropolymer. Also in a preferred embodiment, autologous endothelial cells are seeded onto the vascular graft prior to implantation of the vascular graft in the human body.
摘要翻译：可以在血管移植物的含氟聚合物表面上实现具有改善的内皮细胞粘附的血管移植物，其通过在能够提供含氟聚合物阴离子基团并将蛋白质与经处理的蛋白质结合的非聚合气体存在下用等离子体处理含氟聚合物。在优选的实施方案中，含氟聚合物表面是等离子体沉积的含氟聚合物。同样在优选的实施方案中，在将血管移植物植入人体内之前，将自体内皮细胞接种到血管移植物上。

2. 发明申请

US20070005127A1 Hinged tissue implant and related methods and devices for delivering such an implant 审中-公开
标题翻译：铰链组织植入物和用于递送这种植入物的相关方法和装置
公开(公告)号：US20070005127A1
公开(公告)日：2007-01-04
申请号：US11154710
申请日：2005-06-17
申请人： Peter Boekstegers , Patrick Cahalan , Laurence Roth , Jianlu Ma , Earl Bardsley , Justin Callaway , James Duronio , Steve Opolski , Wendy Graczyk
发明人： Peter Boekstegers , Patrick Cahalan , Laurence Roth , Jianlu Ma , Earl Bardsley , Justin Callaway , James Duronio , Steve Opolski , Wendy Graczyk
IPC分类号： A61F2/06
CPC分类号： A61F2/856 , A61F2/2493 , A61F2/91 , A61F2/915 , A61F2002/065 , A61F2002/067 , A61F2002/821 , A61F2002/828 , A61F2002/91525 , A61F2002/91533 , A61F2002/91558 , A61F2220/0091 , A61F2230/0052 , A61F2250/006 , A61F2250/0071
摘要： A device for treating a heart may comprise a myocardial section configured to be positioned in a heart wall between a coronary vessel and a chamber of the heart and a vessel section configured to be positioned in the coronary vessel. The vessel section may be connected to the myocardial section and be configured to articulate relative to the myocardial section. The myocardial section and the vessel section may form an integral, single piece structure.
摘要翻译：用于治疗心脏的装置可以包括构造成定位在冠状血管和心脏室之间的心脏壁中的心肌部分和构造成定位在冠状血管中的血管部分。血管部分可以连接到心肌部分并且被配置成相对于心肌部分进行铰接。心肌部分和血管部分可以形成整体的单件结构。

3. 发明授权

US06270788B1 Implantable medical device 有权
标题翻译：植入式医疗器械
公开(公告)号：US06270788B1
公开(公告)日：2001-08-07
申请号：US09411405
申请日：1999-10-04
申请人： Edouard Koulik , Larik Vincent , Patrick Cahalan , Eric Fogt , Kazuhiko Ishihara , Nobuo Nakabayashi
发明人： Edouard Koulik , Larik Vincent , Patrick Cahalan , Eric Fogt , Kazuhiko Ishihara , Nobuo Nakabayashi
IPC分类号： A61F1300
CPC分类号： A61L33/0047 , A61L27/34 , A61L31/10 , A61L33/0029 , C08L33/14
摘要： A method for making a biocompatible medical article, and preferably, a blood compatible medical article, through the use of a copolymer coating. The copolymer coating is synthesized using methacrylate or acrylate monomers with a functional group (primary amino group) for subsequent attachment of heparin. Synthesis of the copolymer coating is carried out using the proper proportion of hydrophobic monomer/hydrophilic monomer/functional monomer in order to optimize the solubility of the copolymer in alcohol, its insolubility in water (before and after heparin coupling), the heparin coupling efficacy and heparin bioactivity. Once the copolymer coating is fashioned, a medical article is coated with it. The coating is thereafter dried and heparin attached. In such a manner the present invention provides for a method for making a biocompatible medical article, and preferably, a blood compatible medical article.
摘要翻译：通过使用共聚物涂层制造生物相容性医疗用品，优选血液相容性医疗用品的方法。使用具有官能团（伯氨基）的甲基丙烯酸酯或丙烯酸酯单体合成用于随后连接肝素的共聚物涂层。共聚物涂层的合成使用适当比例的疏水单体/亲水单体/官能单体进行，以优化共聚物在醇中的溶解度，其在水中的不溶性（肝素偶联之前和之后），肝素偶联效力和肝素生物活性。一旦制成共聚物涂层，医用制品被涂覆。然后将涂层干燥并加入肝素。以这种方式，本发明提供了制造生物相容性医疗用品，优选血液兼容医疗制品的方法。

4. 发明授权

US5350800A Method for improving the biocompatibility of solid surfaces 失效
标题翻译：提高固体表面生物相容性的方法
公开(公告)号：US5350800A
公开(公告)日：1994-09-27
申请号：US5711
申请日：1993-01-19
申请人： Michel Verhoeven , Patrick Cahalan , Linda Cahalan , Marc Hendriks , Benedicte Foache
发明人： Michel Verhoeven , Patrick Cahalan , Linda Cahalan , Marc Hendriks , Benedicte Foache
IPC分类号： A61L27/00 , A61L29/00 , A61L33/00 , A61L33/10 , A61F2/54 , A61F2/02 , A61K9/22
CPC分类号： A61L33/0029 , A61L33/0041 , A61L33/0047 , A61L33/0088
摘要： A method for attaching a biomolecule having a plurality of carboxyl groups to an aminated solid surface by reacting the biomolecule with a carbodiimide to effect an activation of the carboxyl groups of the biomolecule, reacting the carbodiimide activated biomolecule with the solid surface to covalently bind the biomolecule to the aminated solid surface, and then selectively restoring carboxyl groups to the biomolecule. The selective restoration of carboxyl groups can be carried out by mild hydrolysis and restores the functionality of the biomolecule. The method is "selective" since the bonds between the biomolecule and the aminated solid surface remain intact.
摘要翻译：通过使生物分子与碳二亚胺反应以使生物分子的羧基活化，使碳二亚胺活化的生物分子与固体表面反应，使生物分子共价结合，将具有多个羧基的生物分子连接到胺化的固体表面上的方法到胺化的固体表面，然后选择性地将羧基还原成生物分子。羧基的选择性还原可以通过温和的水解进行，并恢复生物分子的功能。该方法是“选择性的”，因为生物分子和胺化的固体表面之间的键保持完整。

5. 发明申请

US20080241349A1 PROCESS FOR PREPARING A SUBSTRATE COATED WITH A BIOMOLECULE 有权
标题翻译：制备用生物分子涂覆的基材的方法
公开(公告)号：US20080241349A1
公开(公告)日：2008-10-02
申请号：US12061212
申请日：2008-04-02
申请人： Patrick Cahalan , Linda Cahalan , Greg Johnson , Mark Gartner
发明人： Patrick Cahalan , Linda Cahalan , Greg Johnson , Mark Gartner
IPC分类号： B05D3/04
CPC分类号： A61L31/10 , A61M1/1698 , C08L83/04
摘要： Processes are provided for preparing a substrate coated with a biomolecule, comprising: a) providing a substrate; b) coating the substrate with a polysiloxane, typically by exposing the substrate to a reactive gas containing siloxane functional groups and to plasma energy to yield a plasma-deposited polysiloxane surface on the substrate; c) rendering the polysiloxane surface amino functional; and d) contacting the amino-functional polysiloxane surface with a biomolecule under conditions effective to attach the biomolecule to the substrate. The coated substrate may be a medical device that demonstrates an ability to maintain gas permeability when in contact with blood or blood components, compared to a substantially identical medical device that has not been coated with a biomolecule using this process.
摘要翻译：提供了制备涂覆有生物分子的底物的方法，包括：a）提供底物; b）用聚硅氧烷涂覆基材，通常通过将基材暴露于含有硅氧烷官能团的反应性气体和等离子体能量，以在基材上产生等离子体沉积的聚硅氧烷表面; c）使聚硅氧烷表面具有氨基功能; 和d）在有效地将生物分子附着到底物的条件下，使氨基官能聚硅氧烷表面与生物分子接触。涂覆的基底可以是与使用该方法未用生物分子涂覆的基本相同的医疗装置相比，其表现出与血液或血液成分接触时保持透气性的能力的医疗装置。

6. 发明授权

US06258371B1 Method for making biocompatible medical article 失效
标题翻译：制作生物相容性医疗用品的方法
公开(公告)号：US06258371B1
公开(公告)日：2001-07-10
申请号：US09054389
申请日：1998-04-03
申请人： Edouard Koulik , Larik Vincent , Patrick Cahalan , Eric Fogt , Kazuhiko Ishihara , Nobuo Nakabayashi
发明人： Edouard Koulik , Larik Vincent , Patrick Cahalan , Eric Fogt , Kazuhiko Ishihara , Nobuo Nakabayashi
IPC分类号： A61F1300
CPC分类号： A61L33/0047 , A61L27/34 , A61L31/10 , A61L33/0029 , C08L33/14
摘要： A method for making a biocompatible medical article, and preferably, a blood compatible medical article, through the use of a copolymer coating. The copolymer coating is synthesized using methacrylate or acrylate monomers with a functional group (primary amino group) for subsequent attachment of heparin. Synthesis of the copolymer coating is carried out using the proper proportion of hydrophobic monomer/hydrophilic monomer/functional monomer in order to optimize the solubility of the copolymer in alcohol, its insolubility in water (before and after heparin coupling), the heparin coupling efficacy and heparin bioactivity. Once the copolymer coating is fashioned, a medical article is coated with it. The coating is thereafter dried and heparin attached. In such a manner the present invention provides for a method for making a biocompatible medical article, and preferably, a blood compatible medical article.
摘要翻译：通过使用共聚物涂层制造生物相容性医疗用品，优选血液相容性医疗用品的方法。使用具有官能团（伯氨基）的甲基丙烯酸酯或丙烯酸酯单体合成用于随后连接肝素的共聚物涂层。共聚物涂层的合成使用适当比例的疏水单体/亲水单体/官能单体进行，以优化共聚物在醇中的溶解度，其在水中的不溶性（肝素偶联之前和之后），肝素偶联效力和肝素生物活性。一旦制成共聚物涂层，医用制品被涂覆。然后将涂层干燥并加入肝素。以这种方式，本发明提供了制造生物相容性医疗用品，优选血液兼容医疗制品的方法。

7. 发明授权

US6166184A Process for making a bioprosthetic device 失效
标题翻译：制作生物假体装置的过程
公开(公告)号：US6166184A
公开(公告)日：2000-12-26
申请号：US912778
申请日：1997-08-18
申请人： Marc Hendriks , Verhoeven Michel , Patrick Cahalan , Mark W. Torrianni , Linda Cahalan , Benedicte Fouache
发明人： Marc Hendriks , Verhoeven Michel , Patrick Cahalan , Mark W. Torrianni , Linda Cahalan , Benedicte Fouache
IPC分类号： A61L27/36 , C08H1/06 , C07K13/00 , C07K15/00
CPC分类号： A61L27/3687 , C08H1/06
摘要： Methods for making bioprosthetic devices made of collagen-based material having collagen amine groups and collagen carboxyl groups are provided. The methods include blocking at least a portion of the collagen amine groups with a blocking agent, activating at least a portion of the collagen carboxyl groups after blocking at least a portion of the collagen amine groups to form activated carboxyl groups, and contacting the activated collagen carboxyl groups with a polyfunctional spacer to crosslink the collagen-based material.
摘要翻译：提供用于制造具有胶原胺基和胶原羧基的胶原基材料制成生物假体装置的方法。所述方法包括用封闭剂封闭至少一部分胶原胺基团，在封闭至少一部分胶原胺基团以形成活化的羧基之后激活至少一部分胶原羧基，并使活化的胶原羧基与多官能间隔基交联胶原基材料。

8. 发明授权

US09693841B2 Surface treated staples, sutures and dental floss and methods of manufacturing the same 有权
公开(公告)号：US09693841B2
公开(公告)日：2017-07-04
申请号：US14214248
申请日：2014-03-14
申请人： Ali Hussain , Linda Cahalan , Greg Johnson , Mark Gartner , Patrick Cahalan , Brian J Fill , Jeffrey W. Speakman
发明人： Ali Hussain , Linda Cahalan , Greg Johnson , Mark Gartner , Patrick Cahalan , Brian J Fill , Jeffrey W. Speakman
IPC分类号： A61C15/04 , A61B17/06 , A61B17/064 , A61L31/04 , A61L31/10 , A61L33/00 , B05D3/06 , A61M1/16 , B05D7/02 , B05D1/36 , B05D1/00
CPC分类号： A61C15/041 , A61B17/06 , A61B17/06166 , A61B17/064 , A61L31/048 , A61L31/10 , A61L33/0029 , A61L2400/18 , A61M1/1698 , B05D1/36 , B05D1/62 , B05D3/06 , B05D7/02 , B05D2256/00 , B05D2258/00 , C08L83/04 , C08L23/12
摘要： A variety of medical devices including staples sutures and dental floss with surface treatment on at least one tissue-facing surface to improve biologic function such as to control tissue adhesion are disclosed including heparin surface treatment which provides heparin present in an amount to yield heparin bioactivity of at least one of i) an ATIII binding of at least 2 pmol/cm2, and ii) a thrombin deactivation of at least 0.2 IU/cm2; an acrylic surface treatment for coupling thereto of a heparin surface treatment, a collagen surface treatment or both; and an amino-functional polysiloxane surface treatment for coupling thereto of a heparin surface treatment.

9. 发明授权

US08343567B2 Method of treating the surface of a medical device with a biomolecule 有权
标题翻译：用生物分子处理医疗器械表面的方法
公开(公告)号：US08343567B2
公开(公告)日：2013-01-01
申请号：US13345813
申请日：2012-01-09
申请人： Patrick Cahalan , Linda Cahalan , Greg Johnson , Mark Gartner
发明人： Patrick Cahalan , Linda Cahalan , Greg Johnson , Mark Gartner
IPC分类号： B05D3/04
CPC分类号： A61L31/10 , A61M1/1698 , C08L83/04
摘要： A method of treating the surface of a medical device with a biomolecule comprising the steps of: providing a polyolefin substrate forming a medical device; cleaning the polyolefin substrate; exposing the polyolefin substrate to a reactive gas containing acrylic acid and to plasma energy to yield a plasma-deposited polyacrylic acid coating on the polyolefin substrate; and attaching a biomolecule, such as heparin, to the polyolefin substrate following formation of the plasma-deposited polyacrylic acid coating on the polyolefin substrate.
摘要翻译：一种用生物分子处理医疗装置的表面的方法，包括以下步骤：提供形成医疗装置的聚烯烃基材; 清洗聚烯烃基材; 将聚烯烃基材暴露于含有丙烯酸的反应性气体和等离子体能量，以在聚烯烃基材上产生等离子体沉积的聚丙烯酸涂层; 以及在聚烯烃基材上形成等离子体沉积的聚丙烯酸涂层之后，将生物分子如肝素附着到聚烯烃基材上。

10. 发明申请

US20120107901A1 METHOD OF TREATING THE SURFACE OF A MEDICAL DEVICE WITH A BIOMOLECULE 有权
标题翻译：用生物分子处理医疗器械表面的方法
公开(公告)号：US20120107901A1
公开(公告)日：2012-05-03
申请号：US13345813
申请日：2012-01-09
申请人： Patrick Cahalan , Linda Cahalan , Greg Johnson , Mark Gartner
发明人： Patrick Cahalan , Linda Cahalan , Greg Johnson , Mark Gartner
IPC分类号： B05D3/10 , C12N11/08
CPC分类号： A61L31/10 , A61M1/1698 , C08L83/04
摘要： A method of treating the surface of a medical device with a biomolecule comprising the steps of: providing a polyolefin substrate forming a medical device; cleaning the polyolefin substrate; exposing the polyolefin substrate to a reactive gas containing acrylic acid and to plasma energy to yield a plasma-deposited polyacrylic acid coating on the polyolefin substrate; and attaching a biomolecule, such as heparin, to the polyolefin substrate following formation of the plasma-deposited polyacrylic acid coating on the polyolefin substrate.
摘要翻译：一种用生物分子处理医疗装置的表面的方法，包括以下步骤：提供形成医疗装置的聚烯烃基材; 清洗聚烯烃基材; 将聚烯烃基材暴露于含有丙烯酸的反应性气体和等离子体能量，以在聚烯烃基材上产生等离子体沉积的聚丙烯酸涂层; 以及在聚烯烃基材上形成等离子体沉积的聚丙烯酸涂层之后，将生物分子如肝素附着到聚烯烃基材上。

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